A recent study explored whether intensive lifestyle changes could help people with mild cognitive impairment (MCI) or early dementia due to Alzheimer's disease (AD) (Ornish D, et.al., 2024).
In this trial, 51 participants aged 45-90 were divided into two groups: one followed a strict lifestyle program, while the other received usual care.
After 20 weeks, the group making lifestyle changes showed significant improvements in cognition and function compared to the control group, which worsened.
Key tests like the Clinical Global Impression of Change and Alzheimer's Disease Assessment Scale supported these findings.
Additionally, the lifestyle group had better biomarker results and a healthier microbiome, indicating that lifestyle changes could be beneficial for those with early stages of AD.
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Reference: https://pubmed.ncbi.nlm.nih.gov/38849944/
Ornish D, Madison C, Kivipelto M, Kemp C, McCulloch CE, Galasko D, Artz J, Rentz D, Lin J, Norman K, Ornish A, Tranter S, DeLamarter N, Wingers N, Richling C, Kaddurah-Daouk R, Knight R, McDonald D, Patel L, Verdin E, E Tanzi R, Arnold SE. Effects of intensive lifestyle changes on the progression of mild cognitive impairment or early dementia due to Alzheimer's disease: a randomized, controlled clinical trial. Alzheimers Res Ther. 2024 Jun 7;16(1):122.