We have updated our formula to a ratio of EPA and DHA that has shown to be the most beneficial (Liao Y, et.al., 2019).
We changed our Better Fish Oil to an oil that has a more beneficial ratio of EPA and DHA and we also reduced the price.
Research has shown many health benefits from Omega 3 fat intake. Several studies are showing evidence that the protective benefits of fish oil prevent death from heart disease (Daviglus ML, et al. 1997, Burr ML, et al. 1989, Singh RB, et al. 1997).
The anti-inflammatory effects of Omega 3 fatty acids are well known. Several studies on rheumatoid arthritis using supplements with EPA/DHA, which is found in fish oil, have shown to decrease morning stiffness and reduce the number of painful and swollen joints (Kremer JM, et al. 1985, Kremer JM. 1996, Kremer JM, et al. 1995, Kremer JM, et al. 1990). Fish oil has also shown to help in the treatment of colitis (Stenson WF, et al. 1992).
Intake of Omega 3
Deficiencies of Omega 3 fatty acids have been linked to depression. An inverse relationship between fish consumption and the incidence of depression has been found (Hibbeln JR, et al. 1995). Another study showed that the ratio of arachidonic acids [a precursor for inflammatory chemicals] to EPA correlates with the severity of the symptoms of depression (Adams PB, et al. 1996).
It is also very important for pregnant women to have an adequate intake of Omega 3 fats because breast fed children have been found to score better than children fed by bottle on visual and developmental tests (Rodgers B. 1978).
Research has shown that the omega 3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) can reduce the inflammatory cytocines COX-2, TNF-alpha and IL-1 beta (Kang JX, Weylandt KH, 2008, Adam O, 2003). EPA and DHA are the active ingredients of omega 3 fat, and fish oil comes in that form, so it is easy for the body to use them. Omega 3 fat from plant sources has to be converted to EPA and DHA by an enzymatic process which is not that efficient.
Using Fish Oil
Fish oil has also been found to significantly reduce the inflammatory markers CRP and IL-6 (Ciubotaru I, et al. 2003).
When buying fish oil it is important to be sure it is a quality product since fish oil oxidizes [gets rancid] very easily and can contain heavy metals and other toxins. Better Fish Oils is a pharmaceutical grade quality product. To prevent rancidity antioxidants are added and the oil checked for oxidization to ensure product stability.
Extensive testing of the oil is carried out assuring exceptional high quality. The following is an example of some of the contaminants tested for: mercury, lead, arsenic, pesticides, PCBs and dioxins.
Adam O1. Dietary fatty acids and immune reactions in synovial tissue. Eur J Med Res. 2003 Aug 20;8(8):381-7.
Adams PB, Lawson S, Sanigorski A, Sinclair AJ. Arachiodonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996;116(Suppl):157-61.
Ciubotaru I1, Lee YS, Wander RC. Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT. J Nutr Biochem. 2003 Sep;14(9):513-21.
Grosso G1, Pajak A2, Marventano S3, Castellano S1, Galvano F1, Bucolo C1, Drago F1, Caraci F4. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014 May 7;9(5):e96905. doi: 10.1371/journal.pone.0096905. eCollection 2014.
Hallahan B1, Ryan T2, Hibbeln JR2, Murray IT2, Glynn S2, Ramsden CE2, SanGiovanni JP2, Davis JM2. Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression. Br J Psychiatry. 2016 Apr 21. pii: bjp.bp.114.160242. [Epub ahead of print]
Kremer JM, et al. Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatic and inflammatory disease receiving dietary supplementation of n-3 and n-6 fatty acids. Lancet Jan 1985:184.
Kremer JM. Effects of modulation of inflammatory and immune parameters in patients with rheumatic and inflammatory disease receiving dietary supplementation of n-3 and n-6 fatty acids. Lipids 1996;31 (Suppl):243-47.
Kremer JM, Lawrence DA, Jubiz W, DiGiacomo R, Rynes R, Bartholomew LE, Sherman M. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum 1990;33(6):810-20.
Kremer JM, Lawrence DA, Petrillo GF, Litts LL, Mullaly PM, Rynes R, Stocker RP, Parhami N, Greenstein NS, Fuchs BR, et al. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal anti-inflammatory drugs. Clinical and immune correlates. Arthritis Rheum 1995;38(8):1107-114.
Liao Yuhua, Bo Xie, Huimin Zhang, Qian He, Lan Guo, Mehala Subramanieapillai, Beifang Fan, Ciyong Lu, Roger S McIntyre, Efficacy of omega-3 PUFAs in depression: A meta-analysis, Transl Psychiatry. 2019 Aug 5;9(1):190.
Singh RB, Niaz MA, Sharma JP, et al. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: The Indian experiment of infarct survival-4. Cardiovasc Drugs 1997;11:485-91.