Better Fish Oil

We have updated our formula to a ratio of EPA and DHA that has shown to be the most beneficial (Liao Y, et.al., 2019).

The anti-inflammatory effects of Omega 3 fatty acids are well known. Most people that eat a western diet can benefit from increasing the intake of Omega 3 fatty acid since their diet usually contains too much Omega 6 from vegetable oils and saturated fat from dairy and other animal sources.  

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We changed our Better Fish Oil to an oil that has a more beneficial ratio of EPA and DHA and we also reduced the price.

Research has shown many health benefits from Omega 3 fat intake. Several studies are showing evidence that the protective benefits of fish oil prevent death from heart disease (Daviglus ML, et al. 1997, Burr ML, et al. 1989, Singh RB, et al. 1997).

The anti-inflammatory effects of Omega 3 fatty acids are well known. Several studies on rheumatoid arthritis using supplements with EPA/DHA, which is found in fish oil, have shown to decrease morning stiffness and reduce the number of painful and swollen joints (Kremer JM, et al. 1985, Kremer JM. 1996, Kremer JM, et al. 1995, Kremer JM, et al. 1990). Fish oil has also shown to help in the treatment of colitis (Stenson WF, et al. 1992).

Intake of Omega 3

Deficiencies of Omega 3 fatty acids have been linked to depression. An inverse relationship between fish consumption and the incidence of depression has been found (Hibbeln JR, et al. 1995). Another study showed that the ratio of arachidonic acids [a precursor for inflammatory chemicals] to EPA correlates with the severity of the symptoms of depression (Adams PB, et al. 1996).

It is also very important for pregnant women to have an adequate intake of Omega 3 fats because breast fed children have been found to score better than children fed by bottle on visual and developmental tests (Rodgers B. 1978).

Research indicates that omega 3 fish oil is effective for depression (Hallahan B, et al. 2016, Grosso G, et al. 2014).

Research has shown that the omega 3 fatty acids EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) can reduce the inflammatory cytocines COX-2, TNF-alpha and IL-1 beta (Kang JX, Weylandt KH, 2008, Adam O, 2003). EPA and DHA are the active ingredients of omega 3 fat, and fish oil comes in that form, so it is easy for the body to use them. Omega 3 fat from plant sources has to be converted to EPA and DHA by an enzymatic process which is not that efficient.

Using Fish Oil

Fish oil has also been found to significantly reduce the inflammatory markers CRP and IL-6 (Ciubotaru I, et al. 2003).

When buying fish oil it is important to be sure it is a quality product since fish oil oxidizes [gets rancid] very easily and can contain heavy metals and other toxins. Better Fish Oils is a pharmaceutical grade quality product. To prevent rancidity antioxidants are added and the oil checked for oxidization to ensure product stability.

Extensive testing of the oil is carried out assuring exceptional high quality. The following is an example of some of the contaminants tested for: mercury, lead, arsenic, pesticides, PCBs and dioxins. 

References:

Adam O¹. Dietary fatty acids and immune reactions in synovial tissue. Eur J Med Res. 2003 Aug 20;8(8):381-7.
Adams PB, Lawson S, Sanigorski A, Sinclair AJ. Arachiodonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression. Lipids 1996;116(Suppl):157-61.

Burr ML, Fehily AM, Gilbert JF, et al. Effects of changes in fat, fish, and fiber intakes on death and myocardial reinfarction: diet and reinfarction trail. Lancet 1989;l2:757-61.

Ciubotaru I¹, Lee YS, Wander RC. Dietary fish oil decreases C-reactive protein, interleukin-6, and triacylglycerol to HDL-cholesterol ratio in postmenopausal women on HRT. J Nutr Biochem. 2003 Sep;14(9):513-21.

Daviglus ML, Stamler J, Orencia AJ, et al. Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med 1997;336:1046-53.

Grosso G¹, Pajak A², Marventano S³, Castellano S¹, Galvano F¹, Bucolo C¹, Drago F¹, Caraci F⁴. Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials. PLoS One. 2014 May 7;9(5):e96905. doi: 10.1371/journal.pone.0096905. eCollection 2014.

Hallahan B¹, Ryan T², Hibbeln JR², Murray IT², Glynn S², Ramsden CE², SanGiovanni JP², Davis JM². Efficacy of omega-3 highly unsaturated fatty acids in the treatment of depression. Br J Psychiatry. 2016 Apr 21. pii: bjp.bp.114.160242. [Epub ahead of print]

Hibbeln JR, Salem N Jr. Dietary polyunsaturated fatty acids and depression: when cholesterol does not satisfy. Am J Clin Nutr 1995;62(1):1-9.

Kang JX¹, Weylandt KH. Modulation of inflammatory cytokines by omega-3 fatty acids. Subcell Biochem. 2008;49:133-43. doi: 10.1007/978-1-4020-8831-5_5.

Kremer JM, et al. Effects of manipulation of dietary fatty acids on clinical manifestations of rheumatic and inflammatory disease receiving dietary supplementation of n-3 and n-6 fatty acids. Lancet Jan 1985:184.

Kremer JM. Effects of modulation of inflammatory and immune parameters in patients with rheumatic and inflammatory disease receiving dietary supplementation of n-3 and n-6 fatty acids. Lipids 1996;31 (Suppl):243-47.

Kremer JM, Lawrence DA, Jubiz W, DiGiacomo R, Rynes R, Bartholomew LE, Sherman M. Dietary fish oil and olive oil supplementation in patients with rheumatoid arthritis. Clinical and immunologic effects. Arthritis Rheum 1990;33(6):810-20.

Kremer JM, Lawrence DA, Petrillo GF, Litts LL, Mullaly PM, Rynes R, Stocker RP, Parhami N, Greenstein NS, Fuchs BR, et al. Effects of high-dose fish oil on rheumatoid arthritis after stopping nonsteroidal anti-inflammatory drugs. Clinical and immune correlates. Arthritis Rheum 1995;38(8):1107-114.

Rodgers B. Feeding in infancy and later ability and attainment: a longitudinal study. Dev Med Child Neurol 1978;20(4):421-26.

Liao Yuhua, Bo Xie, Huimin Zhang, Qian He, Lan Guo, Mehala Subramanieapillai, Beifang Fan, Ciyong Lu, Roger S McIntyre, Efficacy of omega-3 PUFAs in depression: A meta-analysis, Transl Psychiatry. 2019 Aug 5;9(1):190.

Singh RB, Niaz MA, Sharma JP, et al. Randomized, double-blind, placebo-controlled trial of fish oil and mustard oil in patients with suspected acute myocardial infarction: The Indian experiment of infarct survival-4. Cardiovasc Drugs 1997;11:485-91.

Stenson WF, Cort D, Rodgers J, Burakoff R, DeSchryver-Kecskemeti K, Gramlich TL, Beeken W. Dietary supplementation with fish oil in ulcerative colitis. Ann Intern Med 1992;116(8):609-14.