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We have replaced the BMJ with two new formulas.
The “Ultra Joint Flex” for joint and connective tissue support and the “Magnesium Glycinate” which supports joint cartilage, and bone, reduces the risk for vascular calcification, and helps prevent magnesium deficiencies common with anxiety and stress.
We recommend taking these formulas together for the best results, and we created a bundle with two Ultra Joint Flex and one Magnesium Glycinate. This will last 45 days when taken as recommended and save you money.
An easy way to effectively support joints and connective tissue.
We use the original form of glucosamine, glucosamine sulfate, because this formulation was used in the research documenting good results.
Two studies conducted over three years by different research groups documented that cartilage degeneration stopped in the treatment group taking glucosamine sulfate while the control group experienced further degeneration (Reginster JY, et al. 2001, Pavelka K, et al. 2002).
Research has documented that glucosamine sulfate supplies cartilage with building materials. Glucosamine sulfate caused a significant stimulation of proteoglycan production by chondrocytes (cartilage cells) in samples obtained from human osteoarthritic cartilage (Basleer C, et al, 1998).
It has also been demonstrated that treatment of osteoarthritic chondrocytes with glucosamine sulfate resulted in an increased cell-mediated GAG (glycosaminoglycan’s) content (Dodge GR, Jimenez SA, 2003). GAG is a common building block both for cartilage, ligaments, and tendons.
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Glucosamine sulfate has been found to inhibit gene expression of COX-2 an inflammatory cytokine, and also inhibit PGE2 a pain-producing prostaglandin (Largo R, et al. 2003).
Chondroitin (alone or in combination with glucosamine) was better than placebo in improving pain in participants with osteoarthritis in short-term studies (Singh JA, et.al.2015).
Magnesium Glycinate
Increased magnesium intake is associated with better knee cartilage architecture (Veronese N, et.al., 2019).
Magnesium has shown to prevent fractures and increase bone density (Sojka JE, Weaver CM. 1995, Stendig-Lindberg G, et al. 1993).
Research has documented that increasing magnesium levels significantly reduced vascular calcification (Louvet L, et al. 2013, Hruby A, et al. 2014).
Anxiety and stress have been associated with magnesium deficiencies (Grases G, et.al., 2006, Cernak I, et.al., 2000).
![Magnesium Glycinate supplement facts label](https://cdn.shopify.com/s/files/1/0351/7172/9452/files/magnesium-glycinate-supplement-facts-label_1024x1024.jpg?v=1721073906)
References:
Sojka JE, Weaver CM. Magnesium supplementation and osteoporosis. Nutr Rev. 1995 Mar;53(3):71-4.