A recent systematic review analyzed the effects of B vitamins and omega 3 fatty acids supplementation on cognition in older adults (Fairbairn P, et.al., 2022).
Drawing from 14 studies (involving 4913 participants aged 60-70), the review found that multi-nutrient formulas containing both B vitamins and omega 3 fatty acids significantly improved global cognition and episodic memory compared to a placebo.
This implies that these nutrients could potentially interact to prevent cognitive decline in the elderly.
When taking omega 3 fatty acids, choose a formula which contains high amounts of EPA and DHA, the most important active ingredients in omega 3 fatty acids. Also take a high-quality B-complex or Multivitamin formula which includes the type of B12 (methyl cobalamin) important for the nervous system. Ideally it should also include the metabolite of folic acid, 5-methyltetrahydrofolate.
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Reference Link: https://pubmed.ncbi.nlm.nih.gov/35473808/
Paul Fairbairn 1, Simon C Dyall 2, Fotini Tsofliou 1. The effects of multi-nutrient formulas containing a combination of n-3 PUFA and B vitamins on cognition in the older adult: a systematic review and meta- analysis. Br J Nutr. 2023 Feb 14;129(3):428-441.