A study of nearly half a million people found that those who regularly took glucosamine supplements had a lower risk of dying from any cause, especially from heart disease, cancer, lung, or digestive system diseases (Li CH, et.al., 2020).
Over about nine years, people taking glucosamine had a 15% lower chance of dying overall and were less likely to die from heart disease and lung conditions than those who didn't take glucosamine.
The inverse associations of glucosamine use with all-cause mortality seemed to be somewhat stronger among current than non-current smokers.
This suggests that glucosamine, often used for joint health, could have other health benefits too.
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Reference: https://pubmed.ncbi.nlm.nih.gov/32253185/
Associations of regular glucosamine use with all-cause and cause-specific mortality: a large prospective cohort study. Li ZH, Gao X, Chung VC, Zhong WF, Fu Q, Lv YB, Wang ZH, Shen D, Zhang XR, Zhang PD, Li FR, Huang QM, Chen Q, Song WQ, Wu XB, Shi XM, Kraus VB, Yang X, Mao C. Ann Rheum Dis. 2020 Jun;79(6):829-836.