It is well established that oxidized LDL cholesterol (oxidized low density lipoprotein) is a risk factor for cardiovascular disease.
This research was a randomized, crossover, controlled feeding trial (Wang L, et al., 2020). The participants were 45 men and women, aged 21-70 years. They were overweight or obese and had elevated LDL.
3 different diets were implemented for 5 weeks. One diet included 24% fat, the other 2, 34% fat with one using a vegetable oil matching the fatty acid profile of 1 avocado which was included in the other diet.
Compared with the baseline, the avocado diet significantly decreased circulating oxidized LDL and increased plasma lutein concentration. It was also associated with a reduction in small dense LDL particles.
Lutein is an antioxidant, and small dense LDL particles are related to cardiovascular risk.
It is not only the type of fatty acids the avocados contain that makes a difference, but also the antioxidants it includes.
Li Wang, Ling Tao, Lei Hao, Todd H Stanley, Kuan-Hsun Huang, Joshua D Lambert, Penny M Kris-Etherton, A Moderate-Fat Diet with One Avocado per Day Increases Plasma Antioxidants and Decreases the Oxidation of Small, Dense LDL in Adults with Overweight and Obesity: A Randomized Controlled Trial, J Nutr. 2020 Feb 1;150(2):276-284.
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