Resveratrol is found in the skin of grapes, but also in other various plants. It is known as an antioxidant and got a lot of attention when a study on mice showed that resveratrol increased their lifespan spite of a high fat, high-calorie diet. Some of the changes included improved insulin sensitivity, increased number of mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).
Methylated Resveratrol Formula
This is all very exciting, but the problem with resveratrol is that it has low bioavailability, metabolic stability because it is eliminated quickly (Walle T, et al, 2004). That problem is however solved by using methylated resveratrol. When the resveratrol is methylated it has shown to have approximately 5-to-8-fold higher permeability meaning absorption and also increased bioavailability (Wen X, Walle T. 2006, Walle T, 2007).
Resveratrol EF is a methylated resveratrol formula for increased bio-availability which also includes quercetin.
Resveratrol EF 60 capsules
Serving Size 1 Capsule
Amount Per Capsule
% Daily Value
Japanese Knotweed Extract (Polygonum cuspidatum)(root)(standardized to 50%
* Daily value not established
Vegetarian capsule (hydroxypropyl methylcellulose, water), microcrystalline cellulose, ascorbyl palmitate, and silicon dioxide
Resveratrol is found in the skin of grapes, but also in other various plants. It is known as an antioxidant and got a lot of attention when a study on mice showed that resveratrol increased the lifespan of these animals in spite of being fed a high fat, high-calorie diet (Baur JA, et al. 2006). Resveratrol was found to stimulate SIRT-1, one of the longevity genes. Some of the other changes also include improved insulin sensitivity, increased number of mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).
Mice and people are however not the same, but there are also several studies on humans as well.
Resveratrol and quercetin have also demonstrated a dose-dependent inhibition of platelet aggregation (formation of blood clots) which may prove protective benefits against atherosclerosis (Pace-Asciak CR, et al, 2005).
Resveratrol has demonstrated antifungal activity against candida albicans (Jung HJ, et al, 2007).
Moreover, Resveratrol has been documented to be able to modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resveratrol inhibits carcinogens (Chow HH, et al. 2011).
Benefits of Resveratrol
Resveratrol EF is a methylated resveratrol formula for increased bioavailability which also includes quercetin.
The following are some examples of research on the benefits of resveratrol in humans.
Flow-mediated dilatation of the brachial artery is a biomarker of endothelial function and cardiovascular health, and resveratrol has shown to increase flow-mediated dilatation up to 35% (Wong RH, et al. 2013 ,Wong RH, et al. 2013, Wong RH, et al. 2011).
Taking resveratrol supplements for a year significantly reduced hs-CRP and several other inflammatory markers (Tome-Carneiro J, et al. 2012).
Several metabolic markers were improved after 30 days of resveratrol supplementation, including reduced inflammation and reduced blood pressure (Timmers S, et al. 2011).
Baur, JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. Vol 444, 16 Nov. 2006. dol:10.1038/nature05354.
Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila). 2010 Sep;3(9):1168-75. Epub 2010 Aug 17.
Donnelly LE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. 2004 Oct;187(4):L774-83.
Jung HJ, et al. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J Microbiol Biotechnol. 2007 Aug;17(8):1324-9.
Le Corre L, et al. Resveratrol and breast cancer chemoprevention: molecular mechanisms. Mol Nutr Food Res. 2005 May;49(5):462-71.
Pace-Asciak CR, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 1995 Mar 31; 235(2):207-19.
Richer S1, Stiles W, Ulanski L, Carroll D, Podella C. Observation of human retinal remodeling in octogenarians with a resveratrol based nutritional supplement. Nutrients. 2013 Jun 4;5(6):1989-2005. doi: 10.3390/nu5061989.
Richer S1, Patel S2, Sockanathan S3, Ulanski LJ 2nd4, Miller L5, Podella C6. Resveratrol based oral nutritional supplement produces long-term beneficial effects on structure and visual function in human patients. Nutrients. 2014 Oct 17;6(10):4404-20. doi: 10.3390/nu6104404.
Roncoroni L, et al. Resveratrol inhibits cell growth in a human cholangiocarcinoma cell line. Liver Int. 2008 Apr 5.
Takada Y, et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9; 23(57):9247-58.
Tang FY, et al. Resveratrol inhibits migration and invasion of human breast-cancer cells. Mol Nutr Food Res. 2008 Apr 8.
Timmers S1, Konings E, Bilet L, Houtkooper RH, van de Weijer T, Goossens GH, Hoeks J, van der Krieken S, Ryu D, Kersten S, Moonen-Kornips E, Hesselink MK, Kunz I, Schrauwen-Hinderling VB, Blaak EE, Auwerx J, Schrauwen P. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab. 2011 Nov 2;14(5):612-22. doi: 10.1016/j.cmet.2011.10.002.
Tomé-Carneiro J1, Gonzálvez M, Larrosa M, Yáñez-Gascón MJ, García-Almagro FJ, Ruiz-Ros JA, García-Conesa MT, Tomás-Barberán FA, Espín JC. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol. 2012 Aug 1;110(3):356-63. doi: 10.1016/j.amjcard.2012.03.030. Epub 2012 Apr 19.
Walle T, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004 Dec;32(12):1377-82.
Walle T. Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption. Mol Pharm. 2007 Nov-Dec;4(6):862-32.
Wen X, Walle T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos. 2006 Oct;34(10):1786-92.
Wong RH1, Howe PR, Buckley JD, Coates AM, Kunz I, Berry NM. Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure. Nutr Metab Cardiovasc Dis. 2011 Nov;21(11):851-6. doi: 10.1016/j.numecd.2010.03.003. Epub 2010 Jul 31.
Wong RH1, Coates AM, Buckley JD, Howe PR. Evidence for circulatory benefits of resveratrol in humans. Ann N Y Acad Sci. 2013 Jul;1290:52-8. doi: 10.1111/nyas.12155.
Wong RH1, Berry NM, Coates AM, Buckley JD, Bryan J, Kunz I, Howe PR. Chronic resveratrol consumption improves brachial flow-mediated dilatation in healthy obese adults. J Hypertens. 2013 Sep;31(9):1819-27. doi: 10.1097/HJH.0b013e328362b9d6.