Anti-Aging, reinvented


OneSkin is buya longevity company dedicated to reinventing the approach to skin health and skin aging. Instead of focusing on surface-level appearances or short-term benefits, we use science to go deeper—targeting the root causes of aging to extend skin health at the molecular level. Our goal is to keep your skin healthier, and longer. Reducing wrinkles? That’s just a nice bonus.


Most skincare companies claim to be “science- backed” but are actually led by marketing teams who outsource their scientific research to external labs.
OneSkin is different because we're rooted in science.

Founded and led by a team of 4 female PhDs, we perform our end-to-end
R&D process in-house and have adhered to a rigorous scientific methodology throughout all phases of development. The result? Research first. Products
second. Data-validated claims always.


OS-01 FACE Topical Supplement

The first topical skin supplement scientifically proven to promote skin health, strength, and resilience for the long-term. Formulated for areas of your skin that are most exposed to environmental damage, including your face, hands, and neck.

- Vegan & Cruelty-Free

- For All Skin Types

- Fragrance-Free

- Developed by longevity scientists

- Safe & Clean

After studying over 1,000 molecules, we discovered OS-01: a revolutionary peptide that works on the cellular level to reverse skin’s biological age, making your skin cells function healthier and younger, longer. 

WHAT IT IS: OS-01 is the first peptide proven to reduce skin's biological age by targeting aging at the source, effectively extending your skin span, the length of time that your skin is healthy and strong.

HOW IT WORKS: As we age, our body becomes less efficient at clearing away senescent (aged) cells. Like rotten apples in a basket of fresh ones,
senescent cells damage the healthy cells around them, accelerating aging. The OS-01 peptide reduces the accumulation of senescent cells by supporting cellular repair mechanisms so that skin stays healthier for longer.

WHAT YOU SEE: Smoother, firmer, younger-looking (and feeling) skin.

Biological Age: Every organ in your body, including your skin, has both a chronological age (how old you actually are) and a biological age (how old your
cells act). Unlike chronological age, biological age can be reversed or accelerated based on your daily habits. For example, if you smoke cigarettes, your skin cells might act older than you actually are. By reducing your skin's biological age, your skin will stay healthier and act younger for longer.

Topical Supplement: We like to think of our daily moisturizers as topical supplements because just like taking supplements to improve your body's health, using Oneskin’s OS-01 Topical Supplements will improve your skin's health. Skinspan: The length of time that skin is healthy and strong.


Clinical Study Results

We performed a 12-week clinical study to evaluate the impact of OS-01 Topical Supplement FACE on skin health and appearance. We’ll let the results speak for

The OS-01 Peptide Supports DNA Damage
Repair Mechanisms.

The OS-01 peptide repairs cellular damage from UVB radiation by 100% in 79-year-old skin.

We measured levels of cellular damage in skin cells that were exposed to UV radiation then treated with the OS-01 peptide... and the results were groundbreaking. The OS-01 peptide repaired cellular damage to the same level as before UV exposure occurred. This is revolutionary for your skin health, because it means that the OS-01 peptide can actually repair damage was done by the strongest natural DNA aggressor known to man, UV rays. The takeaway? In combination with sunscreen, OneSkin’s OS-01 Topical Supplements are poised to offer a comprehensive defense and repair strategy against the sun

The OS-01 Peptide suppresses a key aging gene and activates collagen and hyaluronic acid production genes.

After treating ex vivo skin with the OS-01 peptide, we extracted and analyzed its genetic material to see which genes were affected. The results were significant, with one of the hallmarks aging genes, P16, being suppressed, and hyaluronic acid and collagen production genes being activated. This is particularly exciting, because not only is the OS-01 peptide actually causing skin cells to act younger on a molecular level, it’s also promoting some of the first mechanisms that break down with age. This means big things for both appearance and overall health. With increased collagen and hyaluronic acid production, your skin the barrier will become stronger and more equipped to protect your body from external pathogens, your epidermis will become thicker causing the appearance of fine lines and wrinkles to be diminished, and your skin will see significant improvements in its overall hydration, strength, and firmness.

Water (Aqua), Glycerin, Calycophyllum Spruceanum Bark Oleic Extract (Pau Mulato), Sorbitan Olivate, Cetearyl Olivate, Squalane, Carapa Guianensis Seed (Andiroba) Oil, Vitis Vinifera (Grape) Seed Oil, Pentaclethra Macroloba (Pracaxi) Oil, Rosa Canina (Rose hips) Fruit Oil, Prunus Domestica (Plum) Seed Oil, Caprylhydroxamic Acid, Glyceryl Caprylate, Decapep- tide-52*, Hyaluronic Acid, Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Niacinamide, Allantoin, Bentonite, Tocoph- eryl Acetate, Tocopherol, Cellulose, Cetyl Palmitate, Sorbitan Palmitate, Xanthan Gum, Potassium Sorbate, Phenoxyethanol,

Sorbic Acid, Caprylyl Glycol, Tetrasodium Glutamate Diacetate. *OS-01 Peptide