Resveratrol is found in the skin of grapes, but also in other various plants. It is known as an antioxidant and got a lot of attention when a study on mice showed that resveratrol increased the lifespan of these animals in spite of being fed a high fat, high calorie diet (Baur JA, et al. 2006). Resveratrol was found to stimulate SIRT-1, one of the longevity genes. Some of the other changes also include improved insulin sensitivity, increased number of mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).

When tested,  resveratrol was found to be a potent anti-inflammatory agent (Takada Y, et al, 2004).

Resveratrol and quercetin have also demonstrated a dose-dependent inhibition of platelet aggregation (formation of blood cloths) which may prove protective benefits against atherosclerosis (Pace-Asciak CR, et al, 2005).

Resveratrol has shown to inhibit cancer in human cell lines including breast cancer (Roncoroni L, et al, 2008, Tang FY, et al, 2008, Le Corre L, et al, 2005).

Resveratrol has demonstrated antifungal activity against candida albicans (Jung HJ, et al, 2007).

Resveratrol has been documented to be able to modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resveratrol inhibits carcinogens (Chow HH, et al. 2011).

Nutritional Facts:

Other Ingredients:

Vegetarian capsule (hydroxypropyl methylcellulose, water), microcrystalline cellulose, ascorbyl palmitate, and silicon dioxide

Donnelly LE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. 2004 Oct;187(4):L774-83.

Jung HJ, et al. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J Microbiol Biotechnol. 2007 Aug;17(8):1324-9.

Takada Y, et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9; 23(57):9247-58.

Tang FY, et al. Resveratrol inhibits migration and invasion of human breast-cancer cells. Mol Nutr Food Res. 2008 Apr 8.

Walle T, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004 Dec;32(12):1377-82.

Walle T. Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption. Mol Pharm. 2007 Nov-Dec;4(6):862-32.