Inflammation may be the most important factor affecting how we age, but inflammation is also directly tied to free radical damage.
We cannot really separate the two since we will always have increased inflammation when we have increased free radical damage.
Some times it can be difficult to tell what came first, the inflammation or the free radical damage.
When several biomarkers were examined in 1,554 individuals ranging in age from 85 years to over 100 years old, inflammation was the marker which predicted all-cause mortality the best (Arai Y, et al. 2015).
Centenarians had also maintained long telomeres.
Telomeres are the DNA-protein caps at the end of chromosomes which protects the genomic DNA from damage.
We know that the food we eat can have a major effect on inflammation, but what else can you do that will have a measurable effect on inflammation?
You can take curcumin.
Research on curcumin, a component of turmeric, has documented the ability of this natural substance to regulate numerous inflammatory pathways (Gupta SC, et al. 2013, Aggarval BB, Harikumar KB, 2009).
Some of the inflammatory cytokines it has shown to reduce are NF-kappaB, TNF-alpha, IL-1, IL-6, cox-2 and CRP.
The list is quite impressive, especially since curcumin has been found to be very safe.
It does not produce any of the side effects anti-inflammatory drugs do.
You just have to remember that regular curcumin is not well absorbed, so be sure you take a formula proven to be better absorbed.
Aggarwal BB1, Harikumar KB. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol. 2009 Jan;41(1):40-59. doi: 10.1016/j.biocel.2008.06.010. Epub 2008 Jul 9.
Arai Y1, Martin-Ruiz CM2, Takayama M3, Abe Y1, Takebayashi T4, Koyasu S5, Suematsu M6, Hirose N1, von Zglinicki T2. Inflammation, But Not Telomere Length, Predicts Successful Ageing at Extreme Old Age: A Longitudinal Study of Semi-supercentenarians. EBioMedicine. 2015 Jul 29;2(10):1549-58. doi: 10.1016/j.ebiom.2015.07.029. eCollection 2015.
Gupta SC1, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10.
Research on curcumin has documented the ability of this natural substance to regulate numerous inflammatory pathways (Gupta SC, et al. 2013, Aggarval BB, Harikumar KB, 2009). It is also a good antioxidant.