Low back pain is very common, and everybody that has experienced it can confirm that in addition to being very unpleasant, it can also interfere with your daily activities.

That’s why this research is interesting because it looked at reasons for disc degeneration, and what possibly could be done to help prevent it.

These researchers found that inflammation and free radical formation caused damage to the cells in the nucleus of the intervertebral disc (Mavrogonatou E, et al. 2014).

They then used a cell culture where they added glucosamine sulfate to the cells of the disc.

The reason that they picked glucosamine sulfate was that in a previous study they found that glucosamine sulfate stimulated glycosaminoglycan synthesis in the disc (Mavrogonatou E, Kletsas D, 2013).

Glycosaminoglycan synthesis is what stimulates the growth of the disc tissue.

The last research they did, which was published in 2014, showed that the main inflammatory cytokine causing damage to the disc was TNF-alpha.

What they also found was that glucosamine sulfate was protective against TNF-alpha’s degenerative (destructive) effects on the disc.

The researchers stated that glucosamine sulfate for that reason could potentially be used to prevent disc degeneration.

Since we know that inflammation and free radical damage are two important reasons for disc degeneration, what else could be helpful?

Curcumin in a well-absorbed form which has shown to reduce inflammation, and S-Acetyl Glutathione a very effective antioxidant which has been shown to get into the cells where it is needed.

Mavrogonatou E1, Angelopoulou MT, Kletsas D. The catabolic effect of TNFα on bovine nucleus pulposus intervertebral disc cells and the restraining role of glucosamine sulfate in the TNFα-mediated up-regulation of MMP-3. J Orthop Res. 2014 Dec;32(12):1701-7. doi: 10.1002/jor.22725. Epub 2014 Sep 12.
Mavrogonatou E1, Kletsas D. The effect of glucosamine sulfate on the proliferative potential and glycosaminoglycan synthesis of nucleus pulposus intervertebral disc cells. Spine (Phila Pa 1976). 2013 Feb 15;38(4):308-14. doi: 10.1097/BRS.0b013e31826a0a8d.

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  • Category: News
  • Author: Didrik Sopler
  • Published: 2020-03-28
  • Comments: 0
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