Why would we need to take glutathione if the body is making it?
The reason is that we make less as we get older, and under certain circumstances, we also use more.
Altered intracellular glutathione levels are observed in a wide range of pathologies, including
several viral infections, as well as in aging (Fraternale A. et.al., 2017).
Glutathione is a very powerful antioxidant the body is making, but glutathione does a lot more
than reducing free radical damage.
This is what the researchers of this article say about glutathione.
Glutathione is often referred to as “the master antioxidant,” and it participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be
overstated (Teskey G., et.al., 2018).
The following research showed that the depletion of glutathione prevented the activation of the antiviral response and its inhibition of influenza virus infection (Diotallevi M,et.al., 2017).
The researchers of this study write that their data suggest the antioxidant glutathione has an
anti-influenza activity in vitro and in vivo (Cai J, et.al., 2003). Oxidative stress or other conditions
that deplete glutathione in the epithelium of the oral, nasal, and upper airway may, therefore,
enhance susceptibility to influenza infection.
Reduced glutathione, the most common form found on the market, is not well absorbed.
S-Acetyl-glutathione is a glutathione precursor, it is more stable than glutathione itself in plasma and is taken up directly by cells and later converted to
glutathione (Fanelli S, et.al., 2018)
The acetylation prevents the decomposition of glutathione and facilitates its absorption through
the intestinal wall as-is, thus enabling the molecule to pass extensively into the cells.
S-Acetyl-Glutathione has been found to be more bioavailable (Cacciatore I, et.al., 2010).
When supplementing with glutathione, it is important to use a form that is well absorbed, if you
want to get the benefits.
How much we need varies from person to person. 400 mg daily of S-Acetyl-Glutathione taken in
2 divided doses are probably the minimum of what most people need to take, to notice a difference.
When we experience an immune response the body will use more glutathione and somebody who has insulin resistance will also need more.
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Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing
cellular glutathione levels. Molecules. 2010 Mar 3;15(3):1242-64.
Cai J, Chen Y, Seth S, Furukawa S, Compans RW, Jones DP. Inhibition of influenza infection by
glutathione. Free Radic Biol Med. 2003 Apr 1;34(7):928-36.
Sergio Fanelli, Antonio Francioso, Rosaria A. Cavallaro, Maria d’Erme, Pietro Putignano,
Niccolò Miraglia and Luciana Mosca, Oral Administration of S-acetyl-glutathione: Impact on the
Levels of Glutathione in Plasma and in Erythrocytes of Healthy Volunteers,Int J Clin Nutr Diet
2018,Published: July 06, 2018. Fraternale A, Brundu S, Magnani M. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275
Teskey G, Abrahem R, Cao R, Gyurjian K, Islamoglu H, Lucero M, Martinez A, Paredes E,
Salaiz O, Robinson B, Venketaraman V. Glutathione as a Marker for Human Disease. Adv Clin
Diotallevi M, Checconi P, Palamara AT, Celestino I, Coppo L, Holmgren A, Abbas K, Peyrot F,
Mengozzi M, Ghezzi P. Glutathione Fine-Tunes the Innate Immune Response toward Antiviral
Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties. Front Immunol.
2017 Sep 29;8:1239.
- Glutathione defends you if you get enough of it into your cells.
- Under certain conditions, we need more, because the body is using more.
- Glutathione is your primary defense against aging.
- The challenge is getting glutathione into your system.
- Glutathione helps detoxify your body.
- Why not start turning back the clock, little by little?