A randomized, double-blind, placebo-controlled study showed that taking oral glutathione can potentially improve skin health (Weschawalit S, et.al., 2017).
In this 12-week trial, healthy women took 250 mg/day of either reduced glutathione, its oxidized form, or a placebo.
The results indicated that both forms of glutathione might lower melanin and ultraviolet spots, which are related to skin pigmentation and damage.
Also, glutathione could reduce wrinkles and possibly enhance skin elasticity, with no serious side effects reported. This suggests that daily glutathione is safe and could positively affect skin appearance.
The placebo group did not show these results.
Because reduced glutathione is oxidized in the stomach and not much gets into the cells, it’s recommended that you take S-Acetyl Glutathione which gets into the cells where you need protection.
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Weschawalit S, Thongthip S, Phutrakool P, Asawanonda P. Glutathione and its antiaging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017 Apr 27;10:147-153.