The mitochondria are the energy producing enties of the cell and the primary intracellular site of oxygen consumption. For that reason, the exposure to free radical damage is also is also high.
Among the antioxidants and detoxifying enzymes existing in
mitochondria, mitochondrial glutathione emerges as the main line of defense (Mari M, et.al., 2009).
It is important to maintain a high glutathione level since that will especially affect aging and neurologic disorders.
Humans with neurodegenerative and neuropsychiatric disorders have demonstrated altered levels of glutathione (Gu F, et.al., 2015).
Studies have also showed that a deficiency of glutathione occurs prior to neuropathological abnormalities in these diseases.
Impairment of glutathione function in the brain is linked to loss of neurons during the aging process (Iskusnykh IY, et.al., 2022).
When taking glutathione, it is important that you take it in a form that is highly bioavailable and gets into the cells.
S-Acetyl Glutathione gets into the cells and produces fast results.
Feng Gu 1, Ved Chauhan, Abha Chauhan, Glutathione redox imbalance in brain disorders, Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):89-95.
Igor Y Iskusnykh 1, Anastasia A Zakharova 2, Dhruba Pathak, Glutathione in Brain Disorders and Aging, Molecules. 2022 Jan 5;27(1):324.
Montserrat Marí 1, Albert Morales, Anna Colell, Carmen García-Ruiz, José C Fernández-Checa, Mitochondrial glutathione, a key survival antioxidant, Antioxid Redox Signal. 2009 Nov;11(11):2685-700.
It’s a very effective antioxidant the body makes to protect itself from free radical damage (oxidative stress). It can help repair cells that are damaged by stress, radiation, pollution, infection, and other illnesses.
As we get older, our cells begin to lose their ability to repair themselves. We make less glutathione, and we actually need more. In certain conditions, younger people may need more glutathione as well.
Glutathione helps your cells function, and supports a healthy immune system. Research shows that glutathione deficiency can lead to increased susceptibility to diseases such as cancer, Parkinson’s disease and Alzheimer’s disease.