The following study scanned 39 healthy old participants, 22 with mild cognitive impairment, and 37 Alzheimer’s patients for hippocampal glutathione levels (Shulka D, et.al., 2021).
The hippocampus is an area of the brain.
The researchers found significant glutathione depletion in the left and right hippocampus among the groups with mild cognitive impairment and Alzheimer’s as compared to the healthy group.
When supplementing with glutathione keep in mind that the glutathione needs to get into the cells to provide benefits. Regular reduced glutathione is oxidized in the stomach and is not an effective way of supplying glutathione.
S-Acetyl glutathione on the other hand is getting into the cells and is very effective ((Cacciatore I, et al., 2010).
Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels.Molecules. 2010 Mar 3;15(3):1242-64.
Shukla D, Mandal PK, Mishra R, Punjabi K, Dwivedi D, Tripathi M, Badhautia V.Hippocampal Glutathione Depletion and pH Increment in Alzheimer's Disease: An in vivo MRS Study. JAlzheimerDis.2021;84(3):1139-1152.
As we get older, our cells begin to lose their ability to repair themselves. We make less glutathione, and we actually need more. In certain conditions, younger people may need more glutathione as well.