Evidence has established a significant correlation between osteoarthritic progression and oxidative stress, causing prolonged inflammation.

This is described as a disturbance in the balanced between oxidative stress and antioxidant defenses. When this occurs tissue damage and inflammation is the result.

This research was based on numerous studies (Setti T, et al., 2021).

The researchers found that glutathione and its precursor N-acetylcysteine demonstrated significant protective effects from oxidative stress as seen in chronic inflammatory musculoskeletal disorders such as osteoarthritis.


Glutathione is a very effective antioxidant produced by your body, and because N-acetylcysteine is a precursor, increased production of glutathione as a result of taking N-acetylcysteine is not necessarily the result.

Taking glutathione in a bioavailable form like S-Acetyl Glutathione is more effective.

Reduced glutathione the most common form of glutathione on the market is however not that effective since most of it is oxidized in the stomach (destroyed).


Thiago Setti, Miguel Gustavo Luz Arab, Gabriel Silva Santos, Natasha Alkass, Marco Antonio Percope Andrade, José Fábio Santos Duarte Lana, The protective role of glutathione in osteoarthritis, J Clin Orthop Trauma. 2020 Sep 9;15:145-151.



Glutathione is your primary defense against aging.

 As we get older, our cells begin to lose their ability to repair themselves. We make less glutathione, and we actually need more. In certain conditions, younger people may need more glutathione as well.

  • Category: News
  • Author: Didrik Sopler, Ph.D., L.Ac.
  • Published: 2021-05-28
  • Comments: 0
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