Wouldn’t it be nice if you could express your genes in a way that made you feel better?

If you could do it both quickly and easily, that would be great. I think everybody agrees on that.

According to this research, you can actually do that (Chacko SA, et al. 2011).

This was an experimental study where healthy, overweight volunteers either received 500 mg of elemental magnesium per day or a placebo supplement for 4 weeks.

After 4 weeks, the group taking elemental supplement had lower fasting insulin.

This is important, since that is associated with better glucose and insulin metabolism.

In addition, the researchers also found that the group taking the supplementation showed up-regulation of 24 genes and down-regulation of 36 genes. This included genes related to metabolic and inflammatory pathways.

Therefore, the researchers concluded that magnesium supplementation for 4 weeks led to changes in gene expression, This is consistent with favorable effects on several metabolic pathways.

Moreover, it is important to know that magnesium oxide, the most common form of magnesium, can cause gastrointestinal irritation in high doses. In addition, it is also not well absorbed.

Hence, a better choice is an amino acid chelate like magnesium dis-glycinate since it is much better absorbed and also well tolerated.


Chacko SA1, Sul J, Song Y, Li X, LeBlanc J, You Y, Butch A, Liu S. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am J Clin Nutr. 2011 Feb;93(2):463-73. doi: 10.3945/ajcn.110.002949. Epub 2010 Dec 15.

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  • Category: News
  • Author: Didrik Sopler
  • Published: 2020-03-28
  • Comments: 0
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