Does reduced circulation in the brain increase the risk for Alzheimer’s disease?

Every tissue in the body needs nutrients including the brain and the nervous system.
To deliver an optimal amount of nutrients to the tissue, we need a vascular system that
provide good circulation.
Atherosclerosis and stenosis of the vascular system will decrease blood circulation.
The following research investigated the impact of intracranial arterial stenosis on the
progression from mild cognitive impairment to Alzheimer’s disease (Zhu J, et.al., 2014).
423 participants with mild cognitive impairment were included in the study, and they were
evaluated with clinical and neuropsychological examinations every year for 4 years.
CT angiography was used to measure the stenosis of major intracranial arteries.
At the last follow up, the researchers found that 116 participants had progressed to
dementia due to Alzheimer’s disease.

They also found that the presence of moderate or severe intracranial arterial stenosis
significantly increased the risk of dementia progression and also the risk of developing
Alzheimer’s disease.

It’s important to start early to prevent the buildup of plaque in the vascular system since it can
start at an early age and is a gradual process. As you see it’s not only important for the heart,
but also for the brain.

Reference:

Zhu J, Wang Y, Li J, Deng J, Zhou H. Intracranial artery stenosis and progression from mild
cognitive impairment to Alzheimer’s disease. Neurology. 2014 Mar 11;82(10):842-9.

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