Can Berberine Offer Protection From Alzheimer’s Disease?

A watercolor painting of a healthy brain cell with vibrant mitochondria, juxtaposed against decaying cells affected by amyloid-beta. Berberine molecules depicted as a protective barrier. Background: soft, blurred botanical elements symbolizing the natural origin of berberine.

In Alzheimer's disease, brain cells lose their connections and functions, partly because of issues with mitochondria — the cell's powerhouses.

Healthy mitochondria ensure brain cells have enough energy and maintain proper cell signaling. One of the culprits in Alzheimer's is a toxic protein called amyloid-beta, which harms these mitochondria, leading to cell damage.

This study focuses on berberine, a compound from a plant used in traditional medicine, which might shield brain cells from this damage (Zhao C, et.al., 2019).

Berberine appears to help maintain mitochondrial health and prevent energy loss in brain cells. This discovery points to berberine's potential as a protective treatment against the brain damage seen in Alzheimer's.

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Reference: https://pubmed.ncbi.nlm.nih.gov/31191803/

Zhao C, Su P, Lv C, Guo L, Cao G, Qin C, Zhang W. Berberine Alleviates Amyloid β-Induced Mitochondrial Dysfunction and Synaptic Loss. Oxid Med Cell Longev. 2019 May 2;2019:7593608.