Oxidized low-density lipoprotein (oxidized LDL) plays an important role in atherosclerosis by promoting inflammation and the deposits of lipids in the arterial wall (Trpkovic A, et al., 2014). LDL is especially harmful when it gets oxidized.

Glutathione is a very effective antioxidant the body is producing, but we produce less as we get older. Under certain circumstances, we may also need more than the body is able to produce.



In the following study the researchers investigated the association between fasting plasma total glutathione levels and cardiovascular disease (Shimizu H, et al., 2004).

The results suggest that reduced plasma total glutathione levels are a risk factor for cardiovascular disease and especially for strokes.

Glutathione is important for many reasons; some are listed below.

Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and the pathology of many diseases , some examples are Alzheimer's disease, Parkinson's disease, liver disease, cancer, heart attack, stroke, and diabetes (Wu G, et al., 2004).

Reduced glutathione, the most common form of glutathione is oxidized in the stomach and not much gets into the cells, so don’t make the mistake of using that.

S-Acetyl Glutathione is getting into the cells and is a good choice.


Andreja Trpkovic 1, Ivana Resanovic, Julijana Stanimirovic, Djordje Radak, Shaker A Mousa, Desanka Cenic-Milosevic, Danimir Jevremovic, Esma R Isenovic, Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases, Crit Rev Clin Lab Sci. 2015;52(2):70-85.

Shimizu H, Kiyohara Y, Kato I, Kitazono T, Tanizaki Y, Kubo M, Ueno H, Ibayashi S, Fujishima M, Iida M. Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study. Stroke. 2004 Sep;35(9):2072-7.

Guoyao Wu 1, Yun-Zhong Fang, Sheng Yang, Joanne R Lupton, Nancy D Turner, Glutathione metabolism and its implications for health, J Nutr. 2004 Mar;134(3):489-92.


 Glutathione is your primary defense against aging.


As we get older, our cells begin to lose their ability to repair themselves. We make less glutathione, and we actually need more. In certain conditions, younger people may need more glutathione as well.

 Glutathione helps your cells function and supports a healthy immune system.

  • Category: News
  • Author: Didrik Sopler, Ph.D., L.Ac.
  • Published: 2020-11-27
  • Comments: 0
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