This natural ingredient has shown anti-aging properties.

A lot of scientists are working on solutions to slow down and even reverse the aging process.

The following study investigated if Berberine a natural ingredient would affect aging.

Key pathologies of aging, including oxidative stress, mitochondrial malfunction, and the associated mTOR, AMPK and NAD+ signaling pathways have been verified to be regulated by berberine (Xu Z,, 2017}. These proteins are all involved in the aging process.


Matrix metalloproteinases (MMPs) have been found to increase and type 1 procollagen to be reduced in photoaging of the skin due to exposure to ultraviolet (UV) irradiation.

This research found that Berberine decreased MMPs and increased type 1 procollagen acting as an anti-skin aging agent (Kim S, Chung JH, 2008).

This study showed that activation of AMPK by both metformin (a diabetic drug) and Berberine significantly prevented the development of senescence (loss of a cells power of division and growth) (Han X,, 2016).

Berberine has been used in traditional Chinese medicine for centuries to treat many conditions, and now we are getting the research verifying how effective this natural ingredient is.


Kim S, Chung JH. Berberine prevents UV-induced MMP-1 and reduction of type I procollagen expression in human dermal fibroblasts. Phytomedicine. 2008 Sep;15(9):749-53.

Xiaojuan Han, Haoran Tai, Xiaobo Wang, Zhe Wang 1, Jiao Zhou, Xiawei Wei, Yi Ding, Hui Gong, Chunfen Mo, Jie Zhang, Jianqiong Qin, Yuanji Ma, Ning Huang, Rong Xiang, Hengyi Xiao. AMPK activation protects cells from oxidative stress-induced senescence via autophagic flux restoration and intracellular NAD(+) elevation. Aging Cell. 2016 Jun;15(3):416-27.

Xu Z, Feng W, Shen Q, Yu N, Yu K, Wang S, Chen Z, Shioda S, Guo Y. Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation. Aging Dis. 2017 Dec 1;8(6):760-777


  • Category: News
  • Author: Didrik Sopler, Ph.D., L.Ac.
  • Published: 2022-04-29
  • Comments: 0
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