132 patients with IBS (irritable bowel syndrome) participated in this double-blinded study (Chen C, et.al., 2015).
They either received 400 mg of berberine hydrochloride twice daily or a placebo supplement for 8 weeks. Their symptoms were predominantly diarrhea and abdominal pain.
The researchers concluded that berberine hydrochloride was well tolerated and reduced IBS symptoms, which effectively improved patients’ quality of life.
Berberine is a remarkable plant compound that has been found to also reduce blood glucose levels, cholesterol, LDL (low density lipoprotein) and triglycerides. It also regulates the immune system, reduces inflammation and waist circumference. These effects have been covered more in detail earlier with the inclusion of references.
Berberine can be provided in more than one form, so be sure you get berberin hydrochloride (HCL).
Chunqiu Chen, Chunhua Tao, Zhongchen Liu, Meiling Lu, Qiuhui Pan, Lijun Zheng 1, Qing Li, Zhenshun Song, Jakub Fichna, A Randomized Clinical Trial of Berberine Hydrochloride in Patients with Diarrhea-Predominant Irritable Bowel Syndrome, Phytother Res. 2015 Nov;29(11):1822-7.
Berberine significantly down-regulates cyclo-oxygenase-2 (COX-2) expression in microglia cells. COX-2 are inflammatory promoting enzymes. Microglia cells are located throughout the brain and spinal cord.