Berberine, a natural substance used in Chinese medicine for a long time now has research to back up a lot of the claims (Song D, et, al., 2022).
Berberine regulates the glucose metabolism and lipid metabolism. It improves energy expenditure, reduces body weight, and alleviates nonalcoholic fatty liver disease. Berberine also improves cardiovascular hemodynamics, suppresses ischemic arrhythmias, attenuates the development of atherosclerosis, and reduces hypertension. It shows potent neuroprotective effects, including antioxidative, antiapoptotic, and anti-ischemic. Berberine has also been found to protect the intestinal epithelial barrier from injury.
Berberine has also shown to stimulate osteoblast activity and decrease osteoclasts which promotes bone regeneration (Zhang Y, et.al., 2021).
Song D, Hao J, Fan D. Biological properties and clinical applications of berberine. Front Med. 2020 Oct;14(5):564-582.
Yuhan Zhang, Jinlong Ma, Weifen Zhang, Berberine for bone regeneration: Therapeutic potential and molecular mechanisms, J Ethnopharmacol. 2021 Sep 15;277:114249