This study included 1048 participants between the age of 50 and 80 years old without cardiovascular disease (Hu T, et. al., 2023).
The researchers investigated the associations of 2-year changes in fat percentage and fat-free mass percentage with occurring cardiovascular events.
This is what they found. The participants with a fat% gain of 2% or more had an increased risk of cardiovascular events when compared with participants with a stable fat%.
They also found that fat-free mass percentage loss of 2% was associated with an increased risk of cardiovascular events.
Tingting Hu, Yun Shen, Weijie Cao, Yiting Xu, Yufei Wang, Xiaojing Ma, Yuqian Bao. Two-year changes in body composition and future cardiovascular events: a longitudinal community-based study. Nutr Metab (Lond). 2023 Jan 31;20(1):4.
Berberine significantly down-regulates cyclo-oxygenase-2 (COX-2) expression in microglia cells. COX-2 are inflammatory promoting enzymes. Microglia cells are located throughout the brain and spinal cord.