CoQ10 (Coenzyme Q10) is an enzyme involved in the energy metabolism in the mitochondria producing adenosine triphosphate (ATP). It is also a powerful antioxidant. While the body is producing CoQ10, it tends to produce less as we age.
CoQ10 supports the energy metabolism and provides antioxidant support.
We have increased the amount of CoQ10 per capsule in the COQ10 Extra to 200mg.
The Benefits of CoQ10 Supplementation
CoQ10 has shown via a direct antioxidant effect to preserve endothelium-dependent (layer inside the blood vessels) vasorelaxation by improving tolerance to injuries from ischemia (lack of blood supply) (Yokoyama H, et al. 1996).
Data on cardiomyopathy (dysfunction of the heart muscle) revealed a myocardial (heart muscle) deficiency of CoQ10, which was higher with increasing severity of disease and was reduced with therapy (Folkers K, et al. 1985).
In a study at the University of Texas, the researchers concluded that CoQ10 is a safe and effective adjunct treatment for a broad range of cardiovascular diseases (Langsjoen H, et al. 1994).
CoQ10 supplementation doubles the number of CoQ10 containing LDL molecules and may, therefore, have an inhibitory effect on LDL oxidation (Aejmelaeus R, et al. 1997).
Oxidation of low-density lipoprotein (LDL), the so-called bad cholesterol, may play an important role in the pathogenesis (disease process) of atherosclerosis (hardening of the arteries).
Lovastatin used to lower cholesterol also lowers the levels of CoQ10 which would induce a new risk of cardiac disease. Supplementation of CoQ10 increased blood levels of CoQ10 and was generally accompanied by an improvement in cardiac function (Folkers K, et al. 1990).
Supplement Facts
Serving Size: 1 Capsule Servings Per Container: 30
Amount Per Serving: Coenzyme Q10 (Ubiquinone) 200 mg
Suggested use: 1 capsule, 1 to 2 times daily with food or as recommended by a healthcare professional.
References:
Aejmelaeus R, Metsa-Ketela T, Laippala P, et al. Ubiquinol-10 and total peroxyl radical trapping capacity of LDL lipoproteins during aging: the effects of Q-10 supplementation. Mol Aspects Med. 1997;18 Suppl:S113-20.
Folkers K, Langsjoen P, Willis R, Richardson P, et al. Lovastatin decreases coenzyme Q levels in humans. Proc Natl Acad Sci USA. 1990 Nov;87(22):8931-4.
Folkers K, Vadhanavikit S, Mortensen SA. Biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme Q10. Proc Natl Sci USA. 1985 Feb;82(3):901-4.
Langsjoen H, Lansjoen P, Willis R, Folkers K. Usefulness of coenzyme Q10 in clinical cardiology: a long-term study. Mol Aspects Med. 1994;15 Suppl:s165-75.
Yokoyama H, Lingle DM, Crestanello JA, et al. Coenzyme Q10 protects coronary endothelial function from ischemia reperfusion injury via an antioxidant effect. Surgery. 1996 Aug;120(2):189-96.
