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Increasing evidence is now supporting the hypothesis that oxidized cholesterol is the driving force behind the development of Alzheimer’s disease and oxysterols, which are the oxidized form of cholesterol, are the link connecting the disease to altered cholesterol metabolism in the brain and to high cholesterol; this is because of...

Increased oxidative stress has been documented in the frontal cortex in individuals with Alzheimer’s disease and in patients with mild cognitive impairment (Ansari, MA 2010).  One of the emerging causative factors associated with Alzheimer’s pathology is oxidative stress. This AD-related increase in oxidative stress has been attributed to decreased levels...

Alongside oxidative stress and inflammation, altered cholesterol metabolism and hypercholesterolemia also significantly contribute to neuronal damage and to the progression of Alzheimer’s disease (Gamba P, et.al., 2015). Levels of oxysterols derived from cholesterol oxidation and inflammatory mediators have been found to be increased in the brains of Alzheimer’s patients (Testa...