Your Road to Wellness

General Health

Imagine How It would Be To Have a Great Memory For Life?

Posted by on General Health, Health | 0 comments

That’s what we all would like to have.

We want to be able to communicate well and have the right answer quickly when questions come up.

We want to know that we can rely on our brain as long as we need it and that it will not let us down.

Years ago, without a good

function brain, we would not have survived.

The body has for that reason built-in mechanisms that will protect it.

 

Research has documented that glutathione is crucial if you want to keep your brain healthy.

Glutathione is a very effective antioxidant the body is making to protect your tissue, including the brain. Glutathione is also very important for effective liver detoxification and a well-functioning immune system.

When study participants with Alzheimer’s disease, participants with mild cognitive impairment and healthy controls were compared, this is what the researchers found.

Magnetic resonance spectroscopy showed that areas of the brain in Alzheimer’s disease and mild cognitive impairment have reduced glutathione levels (Mandal PK, et.al., 2015).

Hippocampal glutathione levels discriminated between mild cognitive impairment and controls with 87.5% sensitivity. Cortical glutathione levels differentiated mild cognitive impairment and Alzheimer’s disease with 91.7% sensitivity.

The researchers concluded the study showed compelling evidence that estimation of glutathione levels in specific brain areas is a relevant biomarker for a mild cognitive decline and Alzheimer’s disease.

 

Alzheimer’s disease is associated with increased oxidative stress which has been attributed to decreased levels of the brain’s antioxidant glutathione (Saharan S, Mandal PK, 2014).

Glutathione deficiency contributes to oxidative stress, which plays a key role in aging and many diseases, Alzheimer’s disease, Parkinson’s disease, liver disease, cancer, heart attack, stroke, and diabetes are some (Wu G, et.al.,2004).

 

How would you know if you are deficient in glutathione?

It is fairly easy to figure out since we start to produce less glutathione in our twenties. If you are 40 or 50 years old or older, you would benefit from additional glutathione.

How much you would need is individual, but you can find that level by experimenting with different doses because you will feel a difference in a day or two if you have an effective form of glutathione.

Glutathione needs to get into the cells, that’s where it is needed.

 

S-Acetyl Glutathione has been shown to get into the cells and is for that reason very effective (Cacciatore I, et.al., 2010).

Most of the glutathione on the market does not produce any noticeable effect since regular glutathione is oxidized in the stomach and does not get into the cells.

This research did not show any changes after taking 500 mg twice daily of regular glutathione for 4 weeks (Allen J, Bradley RD, 2011).

 

 

Reference

  1. Cacciatore, I., Cornacchia, C., Pinnen, F., Mollica, A., & Di Stefano, A. (2010). Prodrug approach for increasing cellular glutathione levels. Molecules, 15(3), 1242-1264.
  2. Allen, J., & Bradley, R. D. (2011). Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. The Journal Of Alternative And Complementary Medicine, 17(9), 827-833
  3. . Brain glutathione levels–a novel biomarker for mild cognitive impairment and Alzheimer’s disease. Mandal PK, Saharan S, Tripathi M, Murari G.
    Biol Psychiatry. 2015 Nov 15;78(10):702-10. doi: 10.1016/j.biopsych.2015.04.005. Epub 2015 Apr 14. Erratum in: Biol Psychiatry. 2016 Jan 1;79(1):71.
    PMID: 26003861 [PubMed – indexed for MEDLINE]
  4.  The emerging role of glutathione in Alzheimer’s disease. Saharan S, Mandal PK.J Alzheimers Dis. 2014;40(3):519-29. doi: 10.3233/JAD-132483. Review.PMID: 24496077 [PubMed – indexed for MEDLINE]Similar articles
  5. Glutathione metabolism and its implications for health. Wu G, Fang YZ, Yang S, Lupton JR, Turner ND.J Nutr. 2004 Mar;134(3):489-92. Review.PMID: 14988435 [PubMed – indexed for MEDLINE] Free ArticleSimilar articles

 

 

 

 

 

 

 

 

Effective S-Acetyl Glutathione

As we get older, our cells begin to lose their ability to repair themselves. We make less glutathione, and we actually need more. In certain conditions, younger people may need more glutathione as well.

 

Reduce Inflammation By Adding 1 Food

Posted by on Anti-aging, General Health, Health Risk, Inflammation, Inflammatory factor | 0 comments

You can reduce inflammation by adding just 1 type of food to your diet.

If you also remove another food, you will get even better results.

When a group of type 2 diabetes patients replaced 2 servings of red meat with different types of legumes like lentils, chickpeas, peas and beans for only 3 days per week for 8 weeks, this was the result (Hosseinpour-Niazi S, et.al., 2015).

 

heart shape by various vegetables and fruits

The legumes resulted in significantly reduced levels of the inflammatory markers hs-CRP, IL-6 and TNF-alpha, compared to when they ingested the red meat instead of the legumes.

 

After consuming a legume diet for 6 weeks, comparing it to their regular diet, first-degree relatives of patients with diabetes had significantly reduced levels of hs-CRP (Saraf-Bank F, et.al., 2015).

Women with the highest legume intake had lower levels of hs-CRP, IL-6 and TNF-alpha compared to the ones with the lowest intake (Ezmaillzadeh A, Azakbakht L, 2012).

 

Just by adding beans or lentils to your meals, you can reduce low-grade inflammation significantly.

That is not difficult. Adding beans to a salad is easy, and if you substitute potatoes or rice with beans or lentils, you should notice a nice difference in your inflammatory markers.

Not only will you see a difference there, but most likely you will also see a reduction in cholesterol and triglyceride levels as well.

 

 

References:

  1. Hosseinpour-Niazi, S., Mirmiran, P., Fallah-Ghohroudi, A., & Azizi, F. (2015). Non-soya legume-based therapeutic lifestyle change diet reduces inflammatory status in diabetic patients: a randomised cross-over clinical trial. British Journal of Nutrition, 114(2), 213-219.
  2. Saraf-Bank, S., Esmaillzadeh, A., Faghihimani, E., & Azadbakht, L. (2015). Effect of non-soy legume consumption on inflammation and serum adiponectin levels among first-degree relatives of patients with diabetes: A randomized, crossover study. Nutrition, 31(3), 459-465.
  3. Esmaillzadeh, A., & Azadbakht, L. (2012). Legume consumption is inversely associated with serum concentrations of adhesion molecules and inflammatory biomarkers among Iranian women. The Journal of nutrition, 142(2), 334-339.

Learn To Eat Program:

Recommendations that work. Foods that can reduce inflammation. This is not a regular diet.

Osteoarthritis in women associated with deposits in Arteries

Posted by on Asthma, Calories, Eating, Energy, Exercise, General Health, General Health, Health Risk, Heart disease, Muscles, Nervous System, Research, Wellness, Women, Womens health | 0 comments

Research sometimes find interesting connections we usually don’t think about.

A study including 3278 women found an association between plaque in the carotid artery and osteoarthritis in the knee and hands in women (Hoeven TA, et.al., 2013).

We know that inflammation is involved in osteoarthritis, even if it is less severe than in rheumatoid arthritis.

We also know that inflammation increases the risk for cardiovascular disease. Inflammation is an important factor in depositing cholesterol and fat into the inner lining of the vascular wall.

 

Another interesting connection found lower magnesium levels in rheumatoid arthritis patients compared to controls (Chavan VU, et.al., 2015).

Lower magnesium levels were also correlated with higher cholesterol and LDL, the so called bad cholesterol, and higher magnesium levels with better HDL cholesterol, the good cholesterol. This was in cases of rheumatoid arthritis.

 

Magnesium has also been found to be inversely associated with osteoarthritis documented on x-rays and joint space narrowing (Zeng C, et.al., 2015).

Glucosamine sulfate another nutritional substance has been used to treat osteoarthritis for many years.

When osteoarthritic chondrocytes (cartilage cells) and glucosamine sulfate were tested in different ways in a culture, it was found that glucosamine sulfate reduced the synthesis of proinflammatory mediators (Largo R, et.al., 2003).

Taking magnesium and glucosamine sulfate could according to this possibly benefit both your cardiovascular system and your joints.

The best form of magnesium is an amino acid chelate like magnesium glycinate.

The most common form of magnesium is magnesium oxide, but that is a gastrointestinal irritant and can give you diarrhea when taken in higher amounts.

 

REFERENCE

Chavan, V. U., Ramavataram, D. V. S. S., Patel, P. A., & Rupani, M. P. (2015). Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis. Journal of clinical and diagnostic research: JCDR, 9(4), BC01.

Hoeven, T. A., Kavousi, M., Clockaerts, S., Kerkhof, H. J., van Meurs, J. B., Franco, O., … & Bierma-Zeinstra, S. (2012). Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study. Annals of the rheumatic diseases, annrheumdis-2011.

Largo R, Alvarez-Soria MA, Díez-Ortego I, Calvo E, Sánchez-Pernaute O, Egido J, Herrero-Beaumont G. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes.Osteoarthritis Cartilage. 2003 Apr;11(4):290-8.

Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, Zhang Y, Yang TB, Lei GH. Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis. PLoS One. 2015 May 26;10(5):e0127666.

 

 

 

 

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3 Important Benefits of Flax Seeds

Posted by on Anti-Aging, Anti-aging, Antioxidents, Blood Pressure, Bloodsugar, Body fat, Bone density, bone loss, Diabetes, Flaxseeds, General Health, General Health, Glucose, Green tea, Happiness, HDL, HDL Level, Health, Health Risk | 0 comments

 

One of the impressive health benefits of flax seeds is the ability to decrease blood pressure (Rodriguez-Leyva D, et.al., 2013).

In a double-blinded, placebo-controlled study, 30 g of flax seeds daily for 6 months reduced the systolic blood pressure of 10 mm Hg and the diastolic blood pressure with 7 mm Hg.

 This is as good as some blood pressure medications, and instead of side-effects, you get even additional benefits.

13 g of flax seeds daily has shown to decrease blood glucose and insulin and improve insulin sensitivity in obese individuals with pre-diabetes (Hutchins AM, et.al., 2013).

Flax seeds can also lower cholesterol. 

In just 7 days a drink made of flax seeds lowered total cholesterol by 12% and LDL cholesterol (the bad cholesterol) 15% (Kristensen M, et.al., 2012).

Even if many people are not aware of these health benefits, it’s been known for a long time that flax seeds can reduce total cholesterol, LDL and decrease the blood glucose after a meal (Cunnane SC, et.al., 1993).

 

It is very important to keep the blood glucose in a good range even after a meal, it is not enough to only have good fasting blood glucose.

I recommend grinding 2 tablespoons of flax seeds in a coffee grinder and put them in a glass with water, stir it and drink it thick. You can of course also sprinkle it on food, like a salad if you prefer.

 

References

Cunnane, S. C., Ganguli, S., Menard, C., Liede, A. C., Hamadeh, M. J., Chen, Z. Y., … & Jenkins, D. J. (1993). High α-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humansBritish Journal of Nutrition69(2), 443-453.

Hutchins, A. M., Brown, B. D., Cunnane, S. C., Domitrovich, S. G., Adams, E. R., & Bobowiec, C. E. (2013). Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutrition research33(5), 367-375.

Kristensen, M., Jensen, M. G., Aarestrup, J., Petersen, K. E., Søndergaard, L., Mikkelsen, M. S., & Astrup, A. (2012). Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but the magnitude of the effect depends on food typeNutrition & Metabolism9(1), 8.

Rodriguez-Leyva, D., Weighell, W., Edel, A. L., LaVallee, R., Dibrov, E., Pinneker, R., … & Pierce, G. N. (2013). Potent Antihypertensive Action of Dietary Flaxseed in Hypertensive PatientsNovelty and Significance. Hypertension62(6), 1081-1089.

Decreasing Inflammation is 1 Important Way to Increase Your Life Expectancy

Posted by on Anti-Aging, Antioxidents, Cardiovascular Disease, Cardiovascular disease & waist-hip ratio, General Health | 0 comments

The process of atherosclerosis is a risk factor for cardiovascular disease and involves deposits of fat and especially LDL cholesterol into the blood vessel wall (Salisbury D, Bronas U, 2014).

These researchers state that when the LDL cholesterol gets deposited into the vascular wall it can oxidize and cause injury creating inflammation which drives the atherosclerotic process.

Higher levels of chronic low-grade inflammation result in a stronger inflammatory response.

 

Low-grade inflammation which you may not be aware of needs to be kept low, as an important way to increase your life expectancy.

To decrease low-grade inflammation, let’s look at what can contribute to it.

Highly processed, nutrient depleted food will cause a spike in the blood glucose and fat shortly after it is eaten.

This results in increased free radicals and inflammation together with other factors which increase the risk for cardiovascular disease (O’Keefe JH, et.al., 2008).

The increase in blood glucose, free radicals and inflammation will last for several hours. That’s important to keep in mind if you eat these types of meals several times a day, it results in elevated levels of these substances throughout the day.

 

The best solution would be to eat minimally processed, high fiber, plant-based food. Vegetables, legumes, nuts, seeds and a few berries are excellent choices.

 

Just adding some nuts after a meal may provide good benefits. 

When 60 g of raw almonds were added to a meal consisting of white bread, the almonds reduced the increase in blood sugar and insulin (Jenkins DJ, et.al., 2006).

It was the antioxidants the almonds contained that was responsible for the benefits.


References:

Salisbury, D., & Bronas, U. (2014). Inflammation and immune system contribution to the etiology of atherosclerosis: mechanisms and methods of assessment. Nursing Research63(5), 375-385.

Jenkins, D. J., Kendall, C. W., Josse, A. R., Salvatore, S., Brighenti, F., Augustin, L. S., … & Rao, A. V. (2006). Almonds decrease postprandial glycemia, insulinemia, and oxidative damage in healthy individuals. The Journal of nutrition136(12), 2987-2992.

O’Keefe, J. H., Gheewala, N. M., & O’Keefe, J. O. (2008). Dietary strategies for improving post-prandial glucose, lipids, inflammation, and cardiovascular health. Journal of the American College of Cardiology51(3), 249-255.

 

How To Use Flax Seeds To Help Fight Prostate Cancer

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Flax seeds do not only have an effect on breast cancer, but there is also research showing how to use flax seeds to fight prostate cancer.

Patients with prostate cancer, who were scheduled for surgery to remove the prostate, were randomly assigned to either their usual diet, a diet supplemented with 30 g of flax seeds daily, a low-fat diet or a flax seed supplemented low-fat diet (Demark-Wahnefried W, et.al., 2008).

Male patients followed this protocol for approximately 30 days.

It was found that the cell growth rates of cancer cells were significantly lower in the participants using the flax seeds when compared to the ones on the control diet.

This was only after using the flax seeds for 30 days.

The researchers concluded that flax seeds are both safe and associated with alterations that may be protective for prostate cancer.

After that, men were scheduled for repeat of prostate biopsy in the following study (Demark-Wahnefried W, et.al., 2004).

These men also needed to follow a low-fat diet and include 30 g of flax seeds per day for 6 months. At the end of 6 months they had their follow up biopsy.

The results showed significant decreases in cholesterol and PSA (prostate-specific antigen). The male participants did not show any significant change in total testosterone. PSA is a measurement of improvement or worsening in someone with prostate cancer or at risk for prostate cancer.

This study did not evaluate the effect of the low-fat diet separately. But, we know now that the major benefits are from the flax seeds.

 

In addition, an earlier study showed similar results (Demark-Wahnefried W, et.al., 2001).

The majority of studies on the lignan found in flax demonstrates interferences with the development of some major diseases. These diseases also include prostate cancer (Imran M, et.al., 2015).

 

It is amazing how you can use flax seeds to fight prostate cancer.

It’s easy and inexpensive to incorporate, and research has documented some impressive benefits.


References:

Imran M, Ahmad N, Anjum FM, Khan MK, Mushtaq Z, Nadeem M, Hussain S. Potential protective properties of flax lignan secoisolariciresinol diglucoside. Nutr J. 2015 Jul 28;14:71. doi: 10.1186/s12937-015-0059-3.

Demark-Wahnefried W, Polascik TJ, George SL, Switzer BR, Madden JF, Ruffin MT 4th, Snyder DC, Owzar K, Hars V, Albala DM, Walther PJ, Robertson CN, Moul JW, Dunn BK, Brenner D, Minasian L, Stella P, Vollmer RT. Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery. Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3577-87. doi: 10.1158/1055-9965.EPI-08-0008.

Demark-Wahnefried W, Robertson CN, Walther PJ, Polascik TJ, Paulson DF, Vollmer RT. Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen. Urology. 2004 May;63(5):900-4.

Demark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, Walther PJ, Gannon M, Vollmer RT. Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features. Urology. 2001 Jul;58(1):47-52.


Learn To Eat Program:

Recommendations that work. Improve your lifestyle with the food you eat. This is not a regular