Your Road to Wellness

Cardiovascular Disease

What is an easy way to reduce calcification of your arteries?

Posted by on 9:00 am BMJ Formula, Cardiovascular Disease, Health, Health Risk, magnesium, Supplements | 0 comments

Artery calcification

 

Most people get some degree of buildup, calcification of their arteries as they get older which is
not a good thing.
To stay healthy and live longer, it is crucial to have a good blood supply to all tissue, because that
is how we get nutrients and oxygen to the tissue.
We have all had the experience of a temporary restriction of the blood flow to an arm or a leg by
unknowingly laying in a position that cut off the circulation. It does not feel good.
If the heart muscle is not getting enough blood, we get a heart attack.
We know that eating a healthy diet and exercising regularly is important, but what else can you
do?
The following study investigated if magnesium may prevent calcification of the coronary arteries
(Hruby A, et al, 2014).
2,695 participants with an average age of 53 years who were free of cardiovascular disease
underwent Multi-Detector Computed Tomography of the heart and abdomen.
Multiple risk factors were accounted for in the evaluation.
Even the intake of vitamin K which has shown to help prevent artery calcification was accounted for.

 

 

The researchers found that the odds of having any coronary artery calcification were 58%
lower and having any abdominal aortic calcification were 34% lower, in those with the
highest compared to those with the lowest magnesium intake.

The authors said this may play a contributing role in magnesium’s protective associations in
stroke and fatal coronary heart disease.

When supplementing with magnesium, an amino acid chelate like magnesium glycinate is
recommended. The most common form of magnesium used in supplements is magnesium
oxide which is not absorbed well and can cause gastrointestinal irritation.

Magnesium is also important for many other reasons such as energy production and bone
formation. Ideally, it is better to combine magnesium with other important minerals since
supplementing with only one may cause an imbalance, and the other minerals are also
important for a variety of reasons.

Reference

Adela Hruby, Christopher J O’Donnell, Paul F Jacques, James B Meigs, Udo Hoffmann, Nicola
M McKeown, Magnesium Intake Is Inversely Associated With Coronary Artery Calcification: The
Framingham Heart Study,JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69.

 

The BMJ Formula contains a large amount of magnesium in a very well-absorbed form.
.

👉🏻 BUY NOW👈🏻

What’s important for the cardiovascular system is also important for the immune system.

Posted by on 9:00 am BMI, Body fat, Body mass index, Cardiovascular Disease, Cardiovascular disease & waist-hip ratio, Diet, Eating, General Health, Health Risk, Inflammation, Weight, Weight loss | 0 comments

obese man with burgers

 

In this study, participants taking berberine when compared to the placebo group saw a
reduction in triglycerides by 35.9% total cholesterol by 18.1% and LDL (low-density lipoprotein),
the so-called bad cholesterol by 21.1% (Zhang Y, et.al., 2008).

Patients with metabolic syndrome treated with berberine for 3 months showed a decrease in
their BMI (body mass index) from 31.5 to 27.4 in this study (Yang J, et.al., 2012).
Patients diagnosed with the metabolic syndrome usually have several symptoms, they are
insulin resistant, have increased waist circumference and high blood pressure.
The same research also showed that berberine decreased leptin levels from 8.01 to 5.12 μg/L.
Leptin is a hormone that suppresses food intake and induces weight loss. Obese patients are
usually leptin-resistant.

 

 

When 10 studies were reviewed both BMI and waist circumference decreased in participants
taking berberine (Xiong P, et.al.,2020).

It is important to produce a balanced immune response when needed.
An overreaction of the immune system will cause damage and is harmful. It can actually kill us.
Some people are killed by an overreaction of their immune system, not from the invading virus
or bacteria.

This research showed that berberine had an anti-inflammatory effect and initiated a more
balanced immune response (Kalmarzi RN, et.al.,2019).
Inflammation is also a risk factor for cardiovascular disease.

When researchers treated patients with the acute coronary syndrome with berberine, they found
that several inflammatory markers were reduced, C-reactive protein and interleukin-6 were 2 of
them (Meng S, et.al., 2012).

Berberine has shown to be a very useful plant-derived compound benefitting important
functions from blood glucose metabolism, cardiovascular function, fat storage, immune
system and inflammation.

These functions are interconnected, that is why berberine is such a valuable substance.

 

Scroll down

 

References:

Kalmarzi RN, Naleini SN, Ashtary-Larky D, Peluso I, Jouybari L, Rafi A, Ghorat F, Heidari N,
Sharifian F, Mardaneh J, Aiello P4, Helbi S, Kooti W.Anti-Inflammatory and Immunomodulatory
Effects of Barberry ( Berberis vulgaris ) and Its Main Compounds.Oxid Med Cell Longev. 2019
Nov 19;2019:6183965.

Meng S, Wang LS, Huang ZQ, Zhou Q, Sun YG, Cao JT, Li YG, Wang CQ. Berberine
ameliorates inflammation in patients with acute coronary syndrome following percutaneous
coronary intervention. Clin Exp Pharmacol Physiol. 2012 May;39(5):406-11.

Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning
G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65.

Yang J, Yin J, Gao H, Xu L, Wang Y, Xu L, Li M. Berberine improves insulin sensitivity by
inhibiting fat store and adjusting adipokines profile in human preadipocytes and metabolic
syndrome patients. Evid Based Complement Alternat Med. 2012;2012:363845

Xiong P, Niu L, Talaei S, Kord-Varkaneh H, Clark CCT, Găman MA, Rahmani J, Dorosti M,
Mousavi SM, Zarezadeh M, Taghizade-Bilondi H, Zhang J. The effect of berberine
supplementation on obesity indices: A dose- response meta-analysis and systematic review of
randomized controlled trials. Complement Ther Clin Pract. 2020 May;39:101113.

 

glucose metabolism supportThis formula was designed to support healthy glucose metabolism and the cardiovascular system.

The research referred to below was conducted with participants who had type 2 diabetes. This does not mean that you have to have type 2 diabetes to take this formula.

It’s very important to have a healthy glucose metabolism and keep the blood glucose low. You want to take this formula and keep your glucose metabolism healthy.

Healthy glucose metabolism is important to keep your cardiovascular system healthy.

👉🏻 BUY NOW 👈🏻

How to improve endothelial function?

Posted by on 9:00 am Cardiovascular Disease, Green tea, Health Risk | 0 comments

Easy way to improve endothelial function which affects cardiovascular risk.

 

endothelial cells

 

Endothelial function is an independent predictor of cardiovascular risk.
The endothelium is the inner layer of the blood vessels.
One way of evaluating endothelial function is by measuring flow-mediated dilation which relates
to the artery’s ability to open and close. This affects the circulation and blood flow to the tissues.
Better circulation leads to improved nutrient delivery to all tissues including the heart
and the brain.

 

 

In this research flow-mediated dilation was measured on three separate occasions where the
participants ingested either 6 g of green tea, 125 mg of caffeine (the amount contained in 6 g of
tea), or hot water (Alexopoulos N, et.al., 2008).
Flow-mediated dilation increased significantly with the green tea but did not change
significantly with caffeine.

 

green tea

This may be one of the reasons that green tea has a beneficial effect on cardiovascular risk.
By making some simple changes to your daily habits, you may find that several small changes
for the better ads up, and in the long run, it can really make a difference.

Reference:

Alexopoulos N1, Vlachopoulos C, Aznaouridis K, Baou K, Vasiliadou C, Pietri P, Xaplanteris P,
Stefanadi E, Stefanadis C.The acute effect of green tea consumption on endothelial function in
healthy individuals.Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):300-5.

 

better green tea

  • If you don’t like to drink green tea, Better Green Tea is a good alternative.
  • The Better Green Tea formula meets the German standards for pesticide content which is very strict.
  • Research has documented many health benefits of green tea ranging from the reduction of oxidative stress, reduced risk of cancer, reduced cholesterol, and lower blood pressure.

👉  Click here  👈

What is TMAO, and why should you avoid it?

Posted by on 9:00 am Cardiovascular Disease, Diet, Diet, General Health, Health, Health Risk, Research | 0 comments

 

What is TMAO, and why should you avoid it?

 

The bacterial flora of the intestines convert choline into trimethylamine, which again is
converted into TMAO (trimethylamine-N-oxide) by the involvement of an enzyme from
the liver.

 

 

Choline is found in animal-derived products like eggs, dairy products, and meat.
The following study investigated the involvement of TMAO and major adverse cardiovascular
events (death, myocardial infarction, or stroke) during 3 years of follow-up in 4007 patients
(Tang WH, et.al., 2013).

 

 

The researchers found that increased plasma levels of TMAO were associated with an
increased risk of a major adverse cardiovascular event. An elevated TMAO level predicted an
increased risk of major adverse cardiovascular events after adjustment for traditional risk
factors, as well as in lower-risk subgroups.

 

 

In other words, TMAO is an additional cardiovascular risk factor many are not aware of.
This research documents that TMAO triggers inflammation and is involved in the process of
forming atherosclerosis (Seldin MM, et.al., 2016).
The bacterial flora of people eating animal-derived products is producing TMAO, vegans and
vegetarians don’t produce much, because they have a different bacterial flora of the intestinal
tract (Koeth RA, et.al., 2019).

 

References:

Koeth RA, Lam-Galvez BR, Kirsop J, Wang Z, Levison BS, Gu X, Copeland MF, Bartlett D,
Cody DB, Dai HJ, Culley MK, Li XS, Fu X, Wu Y, Li L, DiDonato JA, Tang WHW, Garcia-Garcia
JC, Hazen SL. l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in
humans. J Clin Invest. 2019 Jan 2;129(1):373-387.

Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis AJ, Shih DM. Trimethylamine
N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein
Kinase and Nuclear Factor-κB. J Am Heart Assoc. 2016 Feb 22;5(2). pii: e002767.

Senthong V, Li XS, Hudec T, Coughlin J, Wu Y, Levison B, Wang Z, Hazen SL, Tang
WH. Plasma Trimethylamine N-Oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite,
Is Associated With Atherosclerotic Burden. J Am Coll Cardiol. 2016 Jun 7;67(22):2620-8.

The neurovascular system, oxidative stress and neurodegenerative diseases like Alzheimer’s. What can you do to protect yourself?

Posted by on 7:31 am Alzheimer’s, Cardiovascular Disease, Dementia, Nervous System | 0 comments

oxidative stress

 

It is very important to have a good blood supply to every tissue in the body.  All tissues, but especially the brain, depending on the good blood supply to function properly.  This is most important for the brain because it has a very high energy demand.

Neurons, glial cells, and blood vessels communicate with each other to regulate cerebral blood flow.

This study gathered information on the importance of oxidative stress as it relates to vascular changes observed in brain aging and neurodegenerative conditions like Alzheimer’s (Carvalho C, Moreira PI, 2018).

 

 

One of the emerging causative factors associated with Alzheimer’s pathology is oxidative stress.  This Alzheimer’s-related increase in oxidative stress has been attributed to decreased levels of the brain antioxidant, glutathione (Saharan S, Mandal PK, 2014).

Glutathione protects cells against oxidative stress, and protecting brain endothelial cells under oxidative stress is key to treating cerebrovascular diseases and neurodegenerative diseases including Alzheimer’s disease (Song J, et.al., 2014).  The endothelium is the inner layer of the blood vessel wall.

The body makes glutathione, but it is making less as we get older, and that’s when we need more.

We can, however, take glutathione orally.   Regularly reduced glutathione which is the most common form you will find for sale is not very bioavailable, most of it is oxidized in the stomach and is not going to provide much protection.

You can instead take S-Acetyl Glutathione which gets into the cells and provides very valuable protection from free radical damage.

 

References:

Carvalho C, Moreira PI, Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events.Front Physiol. 2018 Jul 3;9:806.

Saharan S, Mandal PK. The emerging role of glutathione in Alzheimer’s disease. J Alzheimers Dis. 2014;40(3):519-29.

Song J, Kang SM, Lee WT, Park KA, Lee KM, Lee JE.Glutathione protects brain endothelial cells from hydrogen peroxide-induced oxidative stress by increasing nrf2 expression.Exp Neurobiol. 2014 Mar;23(1):93-103. 

 

Click on the link below 👇

Effective S-Acetyl Glutathione

Can being exposed to heat help your memory, and reduce your risk for Alzheimer’s disease?

Posted by on 9:00 am Alzheimer’s, Cardiovascular Disease, Dementia | 0 comments

 

If you follow us regularly you saw that the stress of high heat as in sauna use provided protection against cardiovascular disease. Cardiovascular disease and memory disorders share some of the same risk factors. Does that mean sauna use would provide some protection from Alzheimer’s disease as well? The following research investigated just that.

 

 

2,315 apparently healthy men aged 42-60 years at the start of the study, were followed for an
average of 20.7 years (LaukkanenT, et al., 2017). Of these men, 204 ended up being diagnosed with dementia and 123 were diagnosed with
Alzheimer’s disease. 4-7 sauna bathing sessions per week were found to be associated with lowered risks of
dementia and Alzheimer’s disease. This was the same frequency of sauna use that helped prevent death from cardiovascular
disease. Sauna baths also make you very relaxed afterward. Give it a try.

 

Reference:
Laukkanen T, Kunutsor S, Kauhanen J, Laukkanen JA, Sauna bathing is inversely associated
with dementia and Alzheimer’s disease in middle-aged Finnish men. Age Ageing. 2017 Mar
1;46(2):245-249.

Check out our learn to eat program.

👉Click here!👈