Your Road to Wellness

General Health

What factors are playing a role in Alzheimer’s, cognitive decline and cardiovascular disease?

Posted by on 9:58 pm Alzheimer’s, Eating, General Health, Get in shape, Health Risk, Heart disease, Stay healthy, Wellness | 0 comments

Alongside oxidative stress and inflammation, altered cholesterol metabolism and hypercholesterolemia also significantly contribute to neuronal damage and to the progression of Alzheimer’s disease (Gamba P, et.al., 2015).

Levels of  oxysterols derived from cholesterol oxidation and inflammatory mediators have been found to be increased in the brains of Alzheimer’s patients (Testa G, et.al., 2016).

Oxysterols, the major component of oxidized LDL is responsible for the increase in endothelial stiffness and is a key step in atherosclerosis development (Shentu TP, et.al., 2012).

When 70 people with mild cognitive impairment were compared with 140 normal individuals, oxysterol levels were significantly higher in the people with mild cognitive impairment (Liu Q, et.al., 2016).

Where do we find oxidized cholesterol?

Oxidized cholesterol are commonly found in foods with high cholesterol content, such as meat, egg yolk and full fatdairy products (Savage GP, et.al., 2002).

Factors known to increase the production of free radicals and therefore oxidized cholesterol in foods are heat, light, radiation, oxygen, moisture and the storage of food at room temperature.

Processes, such as pre-cooking, freeze-drying, dehydration and irradiation, have all been reported to result in increased production of oxidized cholesterol in meats.

What can you do to reduce oxidized cholesterol?

The most obvious way to do it is to avoid the foods that contain the oxidized cholesterol.

The best way to do that is to eat plant based foods, since animal source protein is where you find oxidized cholesterol.

It would also be beneficial to take S-Acetyl Gutathione and Curcumin to reduce free radical damage and inflammation further.

References

Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G.Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease. Front Aging Neurosci. 2015 Jun 19;7:119.

Liu Q, An Y, Yu H, Lu Y, Feng L, Wang C, Xiao R.Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.Lipids Health Dis. 2016 Oct 10;15(1):177.

Savage GP1, Dutta PC, Rodriguez-Estrada MT, Cholesterol oxides: their occurrence and methods to prevent their generation in foods. Asia Pac J Clin Nutr. 2002;11(1):72-8

Shentu TP, Singh DK, Oh MJ, Sun S, Sadaat L, Makino A, Mazzone T, Subbaiah PV, Cho M, Levitan I.The role of oxysterols in control of endothelial stiffness.J Lipid Res. 2012 Jul;53(7):1348-58.

Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G, Fantò F, Poli G, Leonarduzzi G, Gamba P.Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation.Redox Biol. 2016 Dec;10:24-33.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
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Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

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How meal times and light exposure affects cancer risk

Posted by on 6:08 am cancer risk, Eating, General Health | 0 comments

 

When the timing of meals was assessed to see if it affected the risk for breast and prostate cancer, something interesting was found.

The research was carried out between 2008 and 2013 in Spain (Kogevinas M, et.al., 2018). Included in the study was 621 cases of prostate cancer and 1205 cases of breast cancer compared with controls.

When participants sleeping immediately after dinner were compared to those sleeping 2 or more hours after dinner, the ones waiting 2 or more hours after dinner before they went to sleep had a 20% reduction in cancer risk for breast and prostate cancer combined.

A similar protection was observed in subjects having dinner before 9 pm compared with those having dinner after 10 pm. Not only does the food we eat affect cancer risk, but how late we eat and how long we wait before we go to bed after the last meal are all factors associated with cancer risk.

How does light exposer during the night affect cancer risk? Exposure to outdoor light in the blue spectrum during the night was associated with breast cancer when comparing the highest versus the lowest tertile (Garcia-Saenz A, et.al., 2018).

Men who slept in “quite illuminated” bedrooms had a higher risk of prostate cancer than men who slept in total darkness.

These are factors most of us can easily control.

References

Kogevinas M, Espinosa A, Castelló A, Gómez-Acebo I, Guevara M, Martin V, Amiano P, Alguacil J, Peiro R, Moreno V, Costas L, Fernández-Tardón G, Jimenez JJ, Marcos-Gragera R, Perez-Gomez B, Llorca J, Moreno-Iribas C, Fernández-Villa T, Oribe M, Aragones N, Papantoniou K, Pollán M4, Castano-Vinyals G, Romaguera
D. Effect of mistimed eating patterns on breast and prostate cancer risk (MCCSpain Study). Int J Cancer. 2018 Jul 17.

Garcia-Saenz A, Sánchez de Miguel A, Espinosa A, Valentin A, Aragonés N, Llorca J, Amiano P, Martín Sánchez V, Guevara M, Capelo R, Tardón A, Peiró-Perez R, Jiménez-Moleón JJ, Roca-Barceló A, Pérez-Gómez B, Dierssen-Sotos T, FernándezVilla T, Moreno-Iribas C, Moreno V, García-Pérez J, Castaño-Vinyals G, Pollán M, Aubé M, Kogevinas M, Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study). Environ Health Perspect. 2018 Apr 23;126(4):047011.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more

 

Reduce memory loss by taking this

Posted by on 11:55 pm Anti-aging, Brain, General Health, Memory | 0 comments

Homocysteine, a toxic amino acid, is a risk factor for brain atrophy, cognitive impairment and dementia. Homocysteine can however be lowered by using certain B vitamins.

The reason for the following research was to investigate if B vitamins can slow the rate of brain atrophy in subjects with mild cognitive impairment (Smith AD, et.al., 2017).

The participants were over 70 years old and had mild cognitive impairment. MRI scans of the brain were used to measure the rate of atrophy over 2 years.

The treatment group was given vitamin B12, folic acid and B6 and compared to a placebo group.

The researchers concluded that elderly people with mild cognitive impairment can slow brain atrophy using homocysteine lowering B vitamins.

Research with a 3 year follow up on men, found that high homocysteine levels were associated with cognitive decline (Tucker KL, et.al., 2005).

Blood levels of vitamin B6, B12 and folate were associated with cognitive decline and especially folate was found to be protective in this study.

Taking a high-quality vitamin B complex can be very helpful. Ideally you should take a formula which contains the metabolite of folic acid, 5-methyltetrahydrofolate, since it is quite common not to metabolize folic acid well.

References
Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010 Sep 8;5(9):e12244.

Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A 3rd. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005 Sep;82(3):627-35

 

 

This is not a regular B vitamin formula.

The B1 (thiamine), B2 (riboflavin), B6 (pyridoxine), and B12 (cobalamin) comes in their physiologically active form, making them easier to absorb.

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Support your brain the easy way

Posted by on 7:20 pm Brain, Eating, General Health | 0 comments

This is an easy way to support your brain health.

The sooner you take action to support a healthy brain function the better it is.

In the following study 2313 participants had their brains scanned using MRI and re-scanned 5 years later (Virtanen JK, et.al., 2013). Blood plasma was also measured for fatty acid content.

The researchers found that a higher long-chain omega-3 fatty acid content was associated with better white matter grade and with lower prevalence of subclinical infarcts. White matter grade on magnetic resonance imaging (MRI) is a way to evaluate the risk for dementia, stroke and disability (Kuller LH, et.al., 2007).

This is also interesting. When omega-3 fatty acid concentrations are low, B vitamin treatment has no effect on cognitive decline, but when omega-3 levels are in the upper normal range, B vitamins interact to slow cognitive decline (Oulhaj A, et.al., 2016).

It used to be healthy to eat fish. The fish itself and more specifically the omega 3 fat in fish is still healthy, but the problem now is that fish is full of contaminants. Contaminated fish is not healthy, and that’s most likely why some research on fish consumption does not show health benefits.

We do however need omega 3 fatty acids, they are especially important for the brain. A good quality fish oil tested for contaminants with high amounts of EPA and DHA, the active ingredients in fish oil, is an easy way to increase omega 3 fat intake without being exposed to a lot of toxins.

References
Kuller LH1, Arnold AM, Longstreth WT Jr, Manolio TA, O’Leary DH, Burke GL, Fried LP, Newman AB,
White matter grade and ventricular volume on brain MRI as markers of longevity in the cardiovascular health study. Neurobiol Aging. 2007 Sep;28(9):1307-15.

Oulhaj A1, Jernerén F2, Refsum H2,3, Smith AD2, de Jager CA4, Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis.
2016;50(2):547-57.

Virtanen JK, Siscovick DS, Lemaitre RN, Longstreth WT, Spiegelman D, Rimm EB, King IB, Mozaffarian D.Circulating omega-3 polyunsaturated fatty acids and subclinical brain abnormalities on MRI in older adults: the Cardiovascular Health Study. J Am Heart Assoc. 2013 Oct 10;2(5):e000305.

 

Better Fish Oil

The anti-inflammatory effects of Omega 3 fatty acids are well known. Most people that eat a western diet can benefit from increasing the intake of Omega 3 fatty acid. Most fish oils on the market are ethyl esters because that’s cheaper to produce.

The Better Fish Oil comes in the form of triglycerides which offers better stability to the fatty acids and prevents breakdown and oxidation.

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Protect your cardiovascular health and your joint health with one substance

Posted by on 10:47 pm Anti-aging, Brain, General Health, Memory | 0 comments

Interesting and surprising research suggests you can reduce cardiovascular risk and protect your joints
by taking the same substance.

More and more research provides evidence that oxidative stress alters many functions of the endothelium, the inner layer of the blood vessels (Cai H, Harrison DG, 2000).

Nitric oxide which opens blood vessels and improves circulation is inactivated by free radicals. This seems to occur in conditions such as hypertension, high cholesterol, diabetes, and smoking.

The use of glucosamine has been associated with reduced total mortality and a significant decreased risk of death from cancer and with a large risk reduction for death from respiratory diseases (Bell GA, et.al.,
2012).

Glucosamine sulfate has for many years been used to support joint cartilage and treat osteoarthritis.

The following study is interesting because the researchers investigated if glucosamine could improve endothelial function (Katoh A, et.al., 2017).They stated that vascular endothelial function is a potent surrogate marker of atherosclerosis and cardiovascular mortality where oxidative stress could be involved.

Endothelial function was evaluated using flow mediated dilation and oxidative, antioxidant status was evaluated by measuring the ratio of glutathione to the oxidized form of glutathione.

The results showed that glucosamine administration improved endothelial function and the ratio of
glutathione to the oxidized form of glutathione.

According to this research by reducing oxidative stress, the vascular function improved.

What if you could take both glucosamine and an effective form of glutathione?

It looks like that would be even more effective.

The patented form of S-Acetyl Glutathione is an effective form of glutathione shown to enter the cell.

References
Bell GA, Kantor ED, Lampe JW, Shen DD, White E. Use of glucosamine and chondroitin in relation to
mortality. Eur J Epidemiol. 2012 Aug;27(8):593-603.

Cai H1, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ
Res. 2000 Nov 10;87(10):840-4.

Katoh A, Kai H, Harada H, Niiyama H, Ikeda H, Oral Administration of Glucosamine Improves Vascular
Endothelial Function by Modulating Intracellular Redox State. Int Heart J. 2017 Dec 12;58(6):926-932.

 

 

 

 

Glutathione helps your cells function and supports a healthy immune system

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to maintain your levels of glutathione!

 

 

 

 

You may know that you need calcium, but maybe you have heard that taking calcium may cause calcification of blood vessels.

Taking calcium by itself is not a good idea. You need to take calcium in a formula that includes multiple nutrients, and it needs to include magnesium. That’s one of the reasons the BMJ contains a large amount of magnesium in a very well absorbed form.

Click here to improve your bone, muscle, and joint health!

 

 

 

This substance is decreased in neurodegeneration and Alzheimer’s disease.

Posted by on 10:18 pm Anti-aging, Brain, General Health, Memory | 0 comments

 

This substance is decreased in neurodegeneration and Alzheimer’s disease.

There is especially 1 substance which is very important for the brain and the nervous system, and that is
glutathione, a very effective antioxidant as well as an immune system regulator.

Glutathione is a substance the body is producing, and it is involved in many functions throughout the body. The body is however producing less as we get older, and that’s when we need more.

In the brain glutathione also regulates cell signaling, protein function, gene expression, and cell differentiation/proliferation.

Decreased levels of glutathione and increased oxidative stress are common in major neurodegenerative diseases (Ayoama K, Nakaki T, 2013).

In the following study proton magnetic resonance spectroscopy was used to measure brain glutathione levels in healthy controls, in patients with mild cognitive decline and in patients with Alzheimer’s disease
(Mandal PK, et.al., 2015).

The researchers concluded that the present study provided compelling evidence that glutathione levels in specific brain regions is a clinically relevant biomarker for mild cognitive decline and Alzheimer’s disease.

It is very important to do what we can early on to help prevent memory problems and Alzheimer’s disease, as these neurological problems are getting more and more common.

Changes in the brain start to occur many years before any symptoms are noticed.

Some years ago, glutathione could only be supplied by IV because the only oral form available, reduced glutathione is not very bioavailable, and does not produce results.

That however changed when S-Acetyl Glutathione, a patented form of glutathione, became available. S-Acetyl Glutathione gets transferred into the cells where it is needed.

References
Aoyama K, Nakaki T. Impaired glutathione synthesis in neurodegeneration. Int J Mol Sci. 2013 Oct
18;14(10):21021-44.
Mandal PK, Saharan S, Tripathi M, Murari G. Brain glutathione levels–a novel biomarker for mild
cognitive impairment and Alzheimer’s disease. Biol Psychiatry. 2015 Nov 15;78(10):702-10.

 

 

 

 

Glutathione helps your cells function and supports a healthy immune system

BioPro, Inc. Tissue Recovery is using  the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to maintain your levels of glutathione!