Resveratrol is found in the skin of grapes, but also in other various plants. It is known as an antioxidant and got a lot of attention when a study on mice showed that resveratrol increased the lifespan of these animals in spite of being fed a high fat, high calorie diet (Baur JA, et al. 2006). Resveratrol was found to stimulate SIRT-1, one of the longevity genes. Some of the other changes also include improved insulin sensitivity, increased number of mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).

When tested, resveratrol was found to be a potent anti-inflammatory agent (Takada Y, et al, 2004).

Resveratrol and quercetin have also demonstrated a dose-dependent inhibition of platelet aggregation (formation of blood cloths) which may prove protective benefits against atherosclerosis (Pace-Asciak CR, et al, 2005).

Resveratrol has shown to inhibit cancer in human cell lines including breast cancer (Roncoroni L, et al, 2008, Tang FY, et al, 2008, Le Corre L, et al, 2005).

Resveratrol has demonstrated antifungal activity against candida albicans (Jung HJ, et al, 2007).

Resveratrol has been documented to be able to modulate enzyme systems involved in carcinogen activation and detoxification, which may be one mechanism by which resveratrol inhibits carcinogens (Chow HH, et al. 2011).

Nutritional Facts:

Serving Size 1 Capsule
Amount Per Capsule		% Daily Value
Japanese Knotweed Extract (Polygonum cuspidatum)(root)(standardized to 50% [250 mg trans-resveratrol])	500 mg	*

* Daily value not established

Other Ingredients:

Vegetarian capsule (hydroxypropyl methylcellulose, water), microcrystalline cellulose, ascorbyl palmitate, and silicon dioxide

References:

Baur, JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. Vol 444, 16 Nov. 2006. dol:10.1038/nature05354.

Chow HH, Garland LL, Hsu CH, Vining DR, Chew WM, Miller JA, Perloff M, Crowell JA, Alberts DS. Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. Cancer Prev Res (Phila). 2010 Sep;3(9):1168-75. Epub 2010 Aug 17.

Donnelly LE, et al. Anti-inflammatory effects of resveratrol in lung epithelial cells: molecular mechanisms. Am J Physiol Lung Cell Mol Physiol. 2004 Oct;187(4):L774-83.

Jung HJ, et al. Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans. J Microbiol Biotechnol. 2007 Aug;17(8):1324-9.

Le Corre L, et al. Resveratrol and breast cancer chemoprevention : molecular mechanisms. Mol Nutr Food Res. 2005 May;49(5):462-71.

Pace-Asciak CR, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta. 1995 Mar 31; 235(2):207-19.

Roncoroni L, et al. Resveratrol inhibits cell growth in a human cholangiocarcinoma cell line. Liver Int. 2008 Apr 5.

Takada Y, et al. Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation. Oncogene. 2004 Dec 9; 23(57):9247-58.

Tang FY, et al. Resveratrol inhibits migration and invasion of human breast-cancer cells. Mol Nutr Food Res. 2008 Apr 8.

Walle T, et al. High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 2004 Dec;32(12):1377-82.

Walle T. Methylation of dietary flavones greatly improves their hepatic metabolic stability and intestinal absorption. Mol Pharm. 2007 Nov-Dec;4(6):862-32.

Wen X, Walle T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos. 2006 Oct;34(10):1786-92.

Resveratrol EF