The effects of elevated blood glucose and what you can do about it.
Elevated blood glucose induces what is called non-enzymatic glycation of proteins, yielding advanced glycation end-products (AGEs).
This happens when the glucose reacts with proteins in the body.
It leads to tissue damage.
We have receptors for AGEs and one type is associated with oxidative stress and inflammation.
In other words, we end up with both increased oxidative stress and inflammation when we have elevated blood glucose.
We also have another type of receptors which are involved in detoxification and clearance of AGEs.
Research has been done in this area to see if anything could affect these processes.
In the liver, AGEs can activate certain cells which through several steps can lead to fibrosis of the liver. That’s not a good thing.
One study found that curcumin could eliminate the effect of AGEs on these cells (Tang Y, Chen A, 2014).
This through some other steps elevate the level of cellular glutathione, leading to a reduction in oxidative stress.
This research indicates that by taking curcumin you may be able to greatly reduce the side effects of high glucose levels.
By also taking glutathione, you may be able to protect yourself even more.
The best thing would, of course, be to avoid walking around with high blood glucose levels in the first place.
You also need to remember that curcumin is not well absorbed, you need a formula with improved absorption.
When it comes to glutathione, you need a formula containing S-Acetyl Glutathione which gets into the cells, since regular glutathione is oxidized (destroyed) in the stomach.
Tang Y1, Chen A1. Curcumin eliminates the effect of advanced glycation end-products (AGEs) on the divergent regulation of gene expression of receptors of AGEs by interrupting leptin signaling. Lab Invest. 2014 May;94(5):503-16. doi: 10.1038/labinvest.2014.42. Epub 2014 Mar 10.
Research on curcumin has documented the ability of this natural substance to regulate numerous inflammatory pathways (Gupta SC, et al. 2013, Aggarval BB, Harikumar KB, 2009). It is also a good antioxidant.
Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection.