This is a good formula to use when taking antibiotics. It is convenient to take since it does not require refrigeration. A dose of 2 capsules twice daily is equivalent to what’s been used in most of the research.
The probiotic yeast Saccharomyces boulardii has shown to exert an anti-inflammatory effect on intestinal epithelial cells (Sougioultzis S, et al. 2006).
Saccharomyces has shown to significantly reduce the frequency and duration of acute diarrhea in children (Billoo AG, et al. 2006. Kurugol Z, et al. 2005).
There is evidence that Saccharomyces reduces the risk of antibiotic-associated diarrhea in children (Kotowska M, et al. 2005).
Saccharomyces boulardii stimulates the release of immunoglobulins, cytokines and also induces the maturation of immune cells ( Stier H, Bischoff SC, 2017).
This suggests that Saccharomyces boulardii is capable of activating the unspecific immune system.
In the case of an infection, Saccharomyces boulardii is able to bind pathogenic bacteria and to neutralize their toxins.
Research also showed that Saccharomyces boulardii significantly reduced the duration of diarrhea approximately 24 hours (Dinleyici EC, et.al., 2012).
Dinleyici EC, Eren M, Ozen M, Yargic ZA, Vandenplas Y. Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea. Expert Opin Biol Ther. 2012 Apr;12(4):395-410.
Kotowska M, Albrecht P, Szajewska H. Saccharomyces boulardii in the prevention of antibiotic-associated diarrhoea in children: a randomized double-blind placebo-controlled trial. Aliment Pharmacol Ther. 2005 Mar 1;21(5):583-90.
Sougioultzis S1, Simeonidis S, Bhaskar KR, Chen X, Anton PM, Keates S, Pothoulakis C, Kelly CP.Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun. 2006 Apr 28;343(1):69-76. Epub 2006Feb 23.
Stier H, Bischoff SC. [Saccharomyces boulardii CNCM I-745 influences the gut-associated immune system]. MMW Fortschr Med. 2017 Jun;159(Suppl 5):1-6.