Your Road to Wellness

Better Curcumin

Curcumin is a good antioxidant. It is especially effective in helping to reduce inflammation. For these reasons, Curcumin provides many health benefits. The raw material used in the Better Curcumin formula is the only form of curcumin shown to pass through the blood brain barrier and improve memory (Cox KH, et al. 2015).

Moreover, this study also showed a significant reduction in both total cholesterol and LDL cholesterol, the so-called bad cholesterol.

Hence, data show that this form of curcumin is at least  65 times more bioavailable than regular curcumin (Gota VS, et al. 2010).

 

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Curcumin

Curcumin has an anti-inflammatory effect. Given that, it protects the human chondrocytes (cartilage cells) from degradation (breakdown) affecting several biochemical pathways (Henrotin Y, et al. 2010). Also, it is a good antioxidant.

In addition, curcumin has been found to reduce IL-1beta induced NF-kappaB activation (Burhmann C, et al. 2011). Therefore, people with tendinitis have these are inflammatory cytokines.

Moreover, curcumin also down regulated MMP-1, 9 and 13, enzymes involved in tendon degradation.

More health benefits of Curcumin

Curcumin has been documented to improve flow-mediated dilation which is an indicator of endothelial function as much as exercise (Akazava N, et al. 2012). Consequently, the health and function of the blood vessels improved because the endothelium is the inner lining of the blood vessels.

Moreover, higher levels of the inflammatory marker hs-CRP have been associated with worse performance in executive function (Wersching H, et al. 2010). High levels of hs-CRP can be used to identify individuals at an increased risk for cognitive decline (Komulainen P, et al. 2007).

Compared with a placebo, participants was associated with a significant reduction in C-reactive protein (CRP) with supplementation of curcumin (Sahebkar A, 2014).

Based on another research, working memory and mood were found to be significantly better after taking curcumin for 4 weeks. Total cholesterol and LDL cholesterol were also significantly reduced (Cox KH, et al. 2015).

Using Curcumin Extracts

As suggested, individuals took 500 mg of a patented curcumin extract twice daily for 8 weeks was associated with a decrease in depressive symptoms. According to this research, the results are obtained when compared with a placebo treatment in participants with major depression (Lopresti AL, et al. 2015).

In another research, it has shown a significant effect of curcumin in lowering IL-6, an inflammatory marker (Derosa G, et al. 2016). IL-6 is one of the inflammatory markers involved in a symptomatic disc of the low back (Kim J.H., et al. 2008).

Also, curcumin has been found to reduce IL-1beta induced NF-kappaB activation (Burhmann C, et al. 2011). Individuals with tendonitis have these as inflammatory cytokines. Moreover, people with diabetes have increased inflammation.  Hence, Curcumin reduces inflammation and may help to reduce some of the destructive effects of diabetes (Gupta SC, et al. 2013).

Some evidence suggests a beneficial effect of curcumin on insulin resistance (Jimenez-Osorio AS, et al. 2016). Based on this evidence, diabetes and insulin resistance will increase both low-grade inflammation and free radical damage.

For those reasons, people, who are suffering from diabetes are recommended to take curcumin since it acts as an antioxidant. Moreover, curcumin also helps reduce inflammation. Highly suggested, individuals may take curcumin for bone health because inflammation is a risk factor for bone loss.

In another research, older men with increased TNF-alpha, an inflammatory marker, have a significant increase in the risk of fractures (Cauley JA, et al. 2016). Elevated inflammatory markers have also been found to increase the risk of fractures in women (Cauley JA, et al. 2007).

 

References:

Akazawa N1, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct;32(10):795-9. doi: 10.1016/j.nutres.2012.09.002. Epub 2012 Oct 15.
Antony B1, Merina B, Iyer VS, Judy N, Lennertz K, Joyal S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax),  A Novel Bioenhanced Preparation of Curcumin.Indian J Pharm Sci. 2008 Jul-Aug;70(4):445-9. doi: 10.4103/0250-474X.44591.
Buhrmann C(1), Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, Shakibaei M. Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway. J Biol Chem. 2011 Aug 12;286(32):28556-66. doi: 10.1074/jbc.M111.256180. Epub 2011 Jun 13.
Cauley JA1, Danielson ME, Boudreau RM, Forrest KY, Zmuda JM, Pahor M, Tylavsky FA, Cummings SR, Harris TB, Newman AB; Health ABC Study. Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study.  J Bone Miner Res. 2007 Jul;22(7):1088-95.
Cauley JA1, Barbour KE2, Harrison SL3, Cloonan YK1, Danielson ME1, Ensrud KE4,5,6, Fink HA5,6,7, Orwoll ES8, Boudreau R1. Inflammatory Markers and the Risk of Hip and Vertebral Fractures in Men: the Osteoporotic Fractures in Men (MrOS). J Bone Miner Res. 2016 Jul 2. doi: 10.1002/jbmr.2905. [Epub ahead of print]
Cox KH(1), Pipingas A(1), Scholey AB(2). Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015 May;29(5):642-51. doi: 10.1177/0269881114552744. Epub 2014 Oct 2.
Derosa G1, Maffioli P2, Simental-Mendía LE3, Bo S4, Sahebkar A5. Effect of curcumin on circulating interleukin-6 concentrations: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2016 Jul 5;111:394-404. doi: 10.1016/j.phrs.2016.07.004. [Epub ahead of print]
Gota VS1, Maru GB, Soni TG, Gandhi TR, Kochar N, Agarwal MG. Safety and pharmacokinetics of a solid lipid curcumin particle formulation in osteosarcoma patients and healthy volunteers. J Agric Food Chem. 2010 Feb 24;58(4):2095-9. doi: 10.1021/jf9024807.
Gupta SC1, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10.
Henrotin Y, Clutterbuck AL, Allaway D, Lodwig EM, Harris P, Mathy-Hartert M, Shakibaei M, Mobasheri A. Biological actions of curcumin on articular chondrocytes. Osteoarthritis Cartilage. 2010 Feb;18(2):141-9.
Jiménez-Osorio AS1, Monroy A2, Alavez S1. Curcumin and insulin resistance-Molecular targets and clinical evidences.  Biofactors. 2016 Jun 21. doi: 10.1002/biof.1302. [Epub ahead of print]
Kim JH, et.al., Activated macrophage-like THP-1 cells modulate anulus fibrosus cell production of inflammatory mediators in response to cytokines. Spine (Phila Pa 1976). 2008 Oct 1;33(21):2253-9
 Komulainen P1, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing. 2007 Jul;36(4):443-8. Epub 2007 May 30.
Lopresti AL1, Maes M2, Meddens MJ3, Maker GL4, Arnoldussen E3, Drummond PD5. Curcumin and major depression: a randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change. Eur Neuropsychopharmacol. 2015 Jan;25(1):38-50. doi: 10.1016/j.euroneuro.2014.11.015. Epub 2014 Dec 5.
Sahebkar A1. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis.  Phytother Res. 2014 May;28(5):633-42. doi: 10.1002/ptr.5045. Epub 2013 Aug 7.
Wersching H1, Duning T, Lohmann H, Mohammadi S, Stehling C, Fobker M, Conty M, Minnerup J, Ringelstein EB, Berger K, Deppe M, Knecht S. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology. 2010 Mar 30;74(13):1022-9. doi: 10.1212/WNL.0b013e3181d7b45b.