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How long does it take to reduce cardiovascular risk by changing what you eat?

Posted by on 9:00 am Blood Pressure, Cholesterol, Diet, Eating, General Health, Health, Health Risk, Research, Stay healthy | 0 comments

How long does it take to reduce cardiovascular risk by changing what you eat?

Posted by on 9:00 am Blood Pressure, Cholesterol, Diet, Eating, General Health, Health, Health Risk, Research, Stay healthy | 0 comments

 

How long does it take to reduce cardiovascular risk by changing what you eat?

 

 

This research was conducted to investigate the effect on cardiovascular risk factors using only
food (McDougall J, et.al., 2014).
1615 people participated in this research.
The protocol was implemented for only 7 days, and measurements of weight, blood pressure,
blood sugar, and blood lipids were measured at the start of the study and 7 days later.
The participants consumed a low-fat (≤10% of calories), high-carbohydrate (~80% of calories),
plant-based diet.
Most antihypertensive and antihyperglycemic medications were reduced or discontinued at the
beginning of the study.

 

 

After 7 days the average weight loss was 1.4 kg, total cholesterol decreased by an
average of 29 mg/dl, systolic blood pressure decreased on average by 18 mm Hg,
diastolic blood pressure by an average of 10 mm Hg, and blood glucose by an average of
11 mg/dL.

 

 

This was implementing a plant based vegan diet.
Most people think it will take quite a while to see changes on laboratory tests from dietary
changes, but as you can see, that is not the case at all. You just have to follow an effective
protocol.

Reference:

McDougall J1, Thomas LE, McDougall C, Moloney G, Saul B, Finnell JS, Richardson K,
Petersen KM. Effects of 7 days on an ad libitum low-fat vegan diet: the McDougall Program
cohort. Nutr J. 2014 Oct 14;13:99. doi: 10.1186/1475-2891-13-99.

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What is TMAO, and why should you avoid it?

Posted by on 9:00 am Cardiovascular Disease, Diet, Eating, General Health, Health, Health Risk, Research | 0 comments

What is TMAO, and why should you avoid it?

Posted by on 9:00 am Cardiovascular Disease, Diet, Eating, General Health, Health, Health Risk, Research | 0 comments

 

What is TMAO, and why should you avoid it?

 

The bacterial flora of the intestines convert choline into trimethylamine, which again is
converted into TMAO (trimethylamine-N-oxide) by the involvement of an enzyme from
the liver.

 

Choline is found in animal-derived products like eggs, dairy products, and meat.
The following study investigated the involvement of TMAO and major adverse cardiovascular
events (death, myocardial infarction, or stroke) during 3 years of follow-up in 4007 patients
(Tang WH, et.al., 2013).

 

 

The researchers found that increased plasma levels of TMAO were associated with an
increased risk of a major adverse cardiovascular event. An elevated TMAO level predicted an
increased risk of major adverse cardiovascular events after adjustment for traditional risk
factors, as well as in lower-risk subgroups.

 

 

In other words, TMAO is an additional cardiovascular risk factor many are not aware of.
This research documents that TMAO triggers inflammation and is involved in the process of
forming atherosclerosis (Seldin MM, et.al., 2016).
The bacterial flora of people eating animal-derived products is producing TMAO, vegans and
vegetarians don’t produce much, because they have a different bacterial flora of the intestinal
tract (Koeth RA, et.al., 2019).

 

References:

Koeth RA, Lam-Galvez BR, Kirsop J, Wang Z, Levison BS, Gu X, Copeland MF, Bartlett D,
Cody DB, Dai HJ, Culley MK, Li XS, Fu X, Wu Y, Li L, DiDonato JA, Tang WHW, Garcia-Garcia
JC, Hazen SL. l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in
humans. J Clin Invest. 2019 Jan 2;129(1):373-387.

Seldin MM, Meng Y, Qi H, Zhu W, Wang Z, Hazen SL, Lusis AJ, Shih DM. Trimethylamine
N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein
Kinase and Nuclear Factor-κB. J Am Heart Assoc. 2016 Feb 22;5(2). pii: e002767.

Senthong V, Li XS, Hudec T, Coughlin J, Wu Y, Levison B, Wang Z, Hazen SL, Tang
WH. Plasma Trimethylamine N-Oxide, a Gut Microbe-Generated Phosphatidylcholine Metabolite,
Is Associated With Atherosclerotic Burden. J Am Coll Cardiol. 2016 Jun 7;67(22):2620-8.

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Can certain foods increase your risk for advanced prostate cancer?

Posted by on 8:06 am Cancer, cancer risk, Health Risk, Prostate cancer, Tissue Recovery Blog | 0 comments

Can certain foods increase your risk for advanced prostate cancer?

Posted by on 8:06 am Cancer, cancer risk, Health Risk, Prostate cancer, Tissue Recovery Blog | 0 comments

 

Can certain foods increase your risk for advanced prostate cancer?

 

Avoid these foods if you have a prostate. It’s a good idea even if you don’t have a prostate.

Can certain foods increase your risk for advanced prostate cancer?

According to this research, it can. The researchers examined total, unprocessed, and processed red meat, poultry, and eggs in relation to the risk of lethal prostate cancer (Richman EL, et al., 2011).

 

 

They started following 27,607 men without cancer from 1994 to 2008 who developed distant organ metastases (it spread to other parts of the body), and men who died from prostate cancer during the follow-up. This is what the researchers found.

Men who consumed 2.5 or more eggs per week had an 81% increased risk of lethal prostate cancer compared with men who consumed less than 0.5 an egg per week.

 

 

It was also found suggestive, but not statistically significant, positive associations between poultry 3.5 servings or more compared to 1.5 servings or less per week, and processed red meat 3 or more servings a week compared to 0.5 serving or less per week. The following study is also interesting.

The researchers examined whether dietary choline or choline-containing compounds increased the risk of lethal prostate cancer (Richman EL, et.al., 2012). These men were followed for 22 years.

 

 

47,896 men were included in the study, and they found that the highest quintile choline intake was associated with an increased risk of lethal prostate cancer.

Where do we find high amounts of choline? You may have guessed it, especially in eggs.

We do need choline since the body doesn’t produce enough, but we can get adequate amounts from plant-based food.

 

References:

Richman EL, Kenfield SA, Stampfer MJ, Giovannucci EL, Chan JM.Egg, red meat, and poultry intake and risk of lethal prostate cancer in the prostate-specific antigen-era: incidence and survival.Cancer Prev Res (Phila). 2011 Dec;4(12):2110-21.

Richman EL, Kenfield SA, Stampfer MJ, Giovannucci EL, Zeisel SH, Willett WC, Chan JM.Choline intake and risk of lethal prostate cancer: incidence and survival.Am J Clin Nutr. 2012 Oct;96(4):855-63.

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This antioxidant is lower in neurodegenerative diseases like Alzheimer’s.

Posted by on 8:32 am Alzheimer’s, Antioxidents, Brain, Dementia, Depression, Nervous System | 0 comments

This antioxidant is lower in neurodegenerative diseases like Alzheimer’s.

Posted by on 8:32 am Alzheimer’s, Antioxidents, Brain, Dementia, Depression, Nervous System | 0 comments

 

This antioxidant is lower in neurodegenerative diseases like Alzheimer’s.

 

There are good reasons why the body produces its own antioxidant enzymes.

All tissues including the nervous system and the brain are exposed to free radical damage.

The most important antioxidant the body is making is probably glutathione.

Humans with neurodegenerative and neuropsychiatric disorders have demonstrated altered levels of glutathione and oxidized glutathione (Gu F, et.al., 2015).  A decreased ratio of glutathione to oxidized glutathione has been found in the blood and brain of these individuals.

 

 

Glutathione depletion can lead to abnormalities of mitochondrial function where the cells make energy. A few studies have shown that a glutathione deficiency occurs prior to neuropathological abnormalities.

These researchers found that glutathione was significantly decreased in the red blood cells from male patients with Alzheimer’s disease (Liu H, et.al., 2004).

 

 

The most common form of glutathione is reduced glutathione, but don’t take that. This form of glutathione is oxidised in the stomach and does not provide much benefits.

S-acetyl glutathione on the other hand gets into the cells where it’s needed (Cacciatore I, et al., 2010).

 

References:

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A.Prodrug approach for increasing cellular glutathione levels.Molecules. 2010 Mar 3;15(3):1242-64.

Gu F, Chauhan V, Chauhan A.Glutathione redox imbalance in brain disorders.Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):89-95.

Liu H, Wang H, Shenvi S, Hagen TM, Liu RM.Glutathione metabolism during aging and in Alzheimer disease.Ann N Y Acad Sci. 2004 Jun;1019:346-9.

 

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  • Glutathione is your primary defense against aging.
  • Glutathione helps detoxify your body.
  • Regular glutathione is not very bio-available, but this problem has now been solved when using S-Acetyl Glutathione which is very effective.
  • Increased oxidative stress and lower antioxidant levels are associated with mood disorders and depression.

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What works best to keep cardiovascular risk factors low, a high fat diet, a Mediterranean diet or a high carbohydrate low fat diet?

Posted by on 8:31 am Body fat, Diet, Eating, General Health, Health, Health Risk, The Learn to Eat Plan | 0 comments

What works best to keep cardiovascular risk factors low, a high fat diet, a Mediterranean diet or a high carbohydrate low fat diet?

Posted by on 8:31 am Body fat, Diet, Eating, General Health, Health, Health Risk, The Learn to Eat Plan | 0 comments

 

 

What works best to keep cardiovascular risk factors low, a high-fat diet, a Mediterranean diet or a high carbohydrate low-fat diet?

 

Research has compared these different approaches a while back, and we have had the results for a while. The reason why they’re still are questions about the best approach is probably that there are many ways to lose weight, and especially a high-fat diet also called a ketogenic diet has been promoted as a solution to almost everything including weight loss.

What did the research show when it comes to cardiovascular risk?

The participants of this study completed each 4-week diet intervention with a 4 week washout period between each approach (Miller M, et.al., 2009).

 

 

 

Food records were analyzed, fasting blood samples, and brachial artery reactivity testing was performed. During the Mediterranean and the high carbohydrate, low-fat diets maintenance phase, there were significant reductions in low-density lipoprotein cholesterol (LDL).

For the Mediterranean diet the LDL decreased 11.8%, and for the high carbohydrate, low-fat diet the LDL decreased by 16.6%.

The LDL increased on the high-fat diet.

CRP, an inflammatory marker decreased the most on the high carbohydrate, low-fat diet and increased on the high-fat diet.

 

 

Brachial artery testing revealed an inverse correlation between flow-mediated vasodilatation and intake of saturated fat. This means decreased vasodilation with increased fat intake.

The science does not back up the promoted benefits of a high-fat diet.

According to the research, a high-fat diet increases cardiovascular risk.

It is, however, important to remember that not all carbohydrates are equal.

Avoid processed high glycemic index carbohydrates, and increase the intake of plant-based food.

 

 

Reference:

Miller M1, Beach V, Sorkin JD, Mangano C, Dobmeier C, Novacic D, Rhyne J, Vogel RA. Comparative effects of three popular diets on lipids, endothelial function, and C-reactive protein during weight maintenance.J Am Diet Assoc. 2009 Apr;109(4):713-7.

Learn to eat program

  • How and why different foods affect you
  • How to put together meals that will produce the results you’re looking for
  • How to lose weight effortlessly by eating the foods your body needs
  • How to gain muscle and improve sports performance.
  • How to reduce inflammation and pain
  • How to stabilize your moods so you feel happier
  • How to lower cholesterol and triglycerides

read more

Is a high fat, ketogenic diet good for your cardiovascular system?

Posted by on 8:39 am Cholesterol, Diet, Eating, Lose fat, The Learn to Eat Plan, Weight loss | 0 comments

Is a high fat, ketogenic diet good for your cardiovascular system?

Posted by on 8:39 am Cholesterol, Diet, Eating, Lose fat, The Learn to Eat Plan, Weight loss | 0 comments

 

Is a high fat, ketogenic diet good for your cardiovascular system?

 

Let’s see what science says about the effect of the ketogenic diet on the cardiovascular system.
The goal of this study was to measure changes in glucose, lipid, and inflammation (Rosenbaum
M, et al., 2019).
17 men were put on a baseline control diet for 4 weeks and then switched to a ketogenic diet for
4 weeks.
This is what the researchers found.
Total and low-density lipoprotein cholesterol and C-reactive protein were significantly
increased on the ketogenic diet.
These are all cardiovascular disease risk markers. Especially LDL cholesterol and C-reactive
protein which is an inflammatory marker.

 

 

Flow-mediated dilation is another indicator of vascular health.
In this study, obese participants were either consuming high fat or low-fat meals for 6 weeks
(Varady KA, et al., 2011).
After 6 weeks, flow-mediated dilation improved in the low-fat group with a 32% increase and was
impaired in the high-fat group with a 19% reduction.
When 42 participants consumed a ketogenic diet for 6 week LDL cholesterol increased
significantly with 10.7% (Urbain P, et al., 2017).

 

 

Research, in general, has shown an increase in LDL cholesterol with a high-fat diet.
Negative effects on the cardiovascular system seem to be a concern with high-fat diets even if
some people may respond more favorably to a ketogenic diet than others.

References:

Rosenbaum M, Hall KD, Guo J, Ravussin E, Mayer LS, Reitman ML, Smith SR, Walsh BT, Leibel
RL, Glucose and Lipid Homeostasis and Inflammation in Humans Following an Isocaloric
Ketogenic Diet. Obesity (Silver Spring). 2019 Jun;27(6):971-981.

Urbain P, Strom L, Morawski L, Wehrle A, Deibert P, Bertz H, Impact of a 6-week
non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical
parameters in healthy adults. Nutr Metab (Lond). 2017 Feb 20;14:17.

Varady KA, Bhutani S, Klempel MC, Phillips SA. Improvements in vascular health by a low-fat
diet, but not a high-fat diet, are mediated by changes in adipocyte biology. Nutr J. 2011 Jan
20;10:8.

 

Learn to eat program

  • How and why different foods affect you
  • How to put together meals that will produce the results you’re looking for
  • How to lose weight effortlessly by eating the foods your body needs
  • How to gain muscle and improve sports performance.
  • How to reduce inflammation and pain
  • How to stabilize your moods so you feel happier
  • How to lower cholesterol and triglycerides

 

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How does a high fat, ketogenic diet affect your muscles?

Posted by on 9:00 am Blood triglycerides, Body fat, Body mass index, Diet, Eating, Exercise, Fat, General Health, Get in shape, Health Risk, Muscles, Sports performance, The Learn to Eat Plan, Weight loss | 0 comments

How does a high fat, ketogenic diet affect your muscles?

Posted by on 9:00 am Blood triglycerides, Body fat, Body mass index, Diet, Eating, Exercise, Fat, General Health, Get in shape, Health Risk, Muscles, Sports performance, The Learn to Eat Plan, Weight loss | 0 comments

ketogenic diet

 

How does a high fat, ketogenic diet affect your muscles?

 

There is a lot of promotion and talk about the benefits of restricting carbohydrate intake and eating a high fat, ketogenic diet.

When you read things like that, always ask, where is the evidence? Is there any science supporting the claims?

There is agreement on that more lean muscle mass and a lower body fat percentage are beneficial. This is true for everybody, but especially athletes.

Before you go on a high-fat diet, you want to know how a regime like that will affect your lean muscle mass.

The following research included 42 healthy individuals that followed a ketogenic diet for 6 weeks consisting of the same calorie intake as their regular diet (Urbain P, et.al., 2017).

They were tested for several things at the start of the study and after 6 weeks.

 

 

VO2peak and peak power decreased after the ketogenic diet.

The participants lost equal amounts of fat and fat-free mass, which means they lost some muscle mass.

Total cholesterol and LDL-cholesterol increased significantly, LDL by 10.7% which is quite a lot, especially since LDL is a major risk factor for cardiovascular disease.

Glucose, insulin, and IGF-1 (a growth factor) dropped significantly by 3.0, 22.2 and 20.2%.

Another non-significant change was also seen.

 

ketogenic diet 2

 

Similar results were found when seventeen overweight or obese men were admitted to metabolic wards where they consumed a high-carbohydrate baseline diet for 4 weeks followed by 4 weeks of a ketogenic diet (Hall KD, et.al., 2016).

 

Body fat loss slowed during the ketogenic diet and coincided with increased protein utilization and loss of fat-free mass. These participants also lost muscle mass, and this study was done under very strict control.

 

Apparently a high-fat diet is not producing the amazing results some would want you to believe.

 

References

 

Hall KD, Chen KY, Guo J, Lam YY, Leibel RL, Mayer LE, Reitman ML, Rosenbaum M, Smith SR, Walsh BT, Ravussin E. Energy expenditure and body composition changes after an isocaloric ketogenic diet in overweight and obese men. Am J Clin Nutr. 2016 Aug;104(2):324-33.

 

Urbain P, Strom L, Morawski L, Wehrle A, Deibert P, Bertz H.Impact of a 6-week non-energy-restricted ketogenic diet on physical fitness, body composition and biochemical parameters in healthy adults.Nutr Metab (Lond). 2017 Feb 20;14:17

Learn to eat program

  • How and why different foods affect you
  • How to put together meals that will produce the results you’re looking for
  • How to lose weight effortlessly by eating the foods your body needs
  • How to gain muscle and improve sports performance.
  • How to reduce inflammation and pain
  • How to stabilize your moods so you feel happier
  • How to lower cholesterol and triglycerides

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This mineral can influence muscle strength, be sure you get enough of it!

Posted by on 9:15 am BMJ Formula, General Health, General Health, Intensity Training, Joint health, magnesium, Muscles, Supplements | 0 comments

This mineral can influence muscle strength, be sure you get enough of it!

Posted by on 9:15 am BMJ Formula, General Health, General Health, Intensity Training, Joint health, magnesium, Muscles, Supplements | 0 comments

This mineral can influence muscle strength, be sure you get enough of it!

 

 

We lose minerals when we perspire. Hot weather and exercise will for that reason make us lose
more.

Some minerals are also more important than others. Magnesium is one of the most important
ones and many people don’t get enough of it.

Magnesium is involved in energy metabolism and numerous enzymatic reactions.

 

 

Athletes often don’t get enough magnesium to compensate for what they lose. This study investigated the impact magnesium can have on muscle strength in elite male
basketball, handball, and volleyball players (Santos DA, et. al, 2011).

It was found that the intake of magnesium was directly associated with maximal isometric
trunk flexion, rotation, and handgrip strength.

Magnesium does not only work for athletes.
The following research included 1138 men and women with an average age of 66.7 years
(Dominguez LJ, et.al., 2006).

The participants were evaluated by testing grip strength, lower-leg muscle power, knee
extension torque, and ankle extension isometric strength.

The researchers found that blood levels of magnesium were significantly associated with
muscle strength and performance as evaluated with the above tests.

 

strength

 

Magnesium in the form of an amino acid chelate is a good choice since it is both well tolerated
and better absorbed than the more common form of magnesium oxide which can cause GI
irritation.

References:

Dominguez LJ, Barbagallo M, Lauretani F, Bandinelli S, Bos A, Corsi AM, Simonsick EM,
Ferrucci L. Magnesium and muscle performance in older persons: the InCHIANTI study. Am J
Clin Nutr. 2006 Aug;84(2):419-26.
Santos DA, Matias CN, Monteiro CP, Silva AM, Rocha PM, Minderico CS, Bettencourt Sardinha
L, Laires MJ. Magnesium intake is associated with strength performance in elite basketball,
handball and volleyball players. Magnes Res. 2011 Dec;24(4):215-9.

 

BMJ

 

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BMJ Bones, Muscles, and Joints

 

 

 

 

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The neurovascular system, oxidative stress and neurodegenerative diseases like Alzheimer’s. What can you do to protect yourself?

Posted by on 7:31 am Alzheimer’s, Cardiovascular Disease, Dementia, Nervous System | 0 comments

The neurovascular system, oxidative stress and neurodegenerative diseases like Alzheimer’s. What can you do to protect yourself?

Posted by on 7:31 am Alzheimer’s, Cardiovascular Disease, Dementia, Nervous System | 0 comments

oxidative stress

 

It is very important to have a good blood supply to every tissue in the body.  All tissues, but especially the brain, depending on the good blood supply to function properly.  This is most important for the brain because it has a very high energy demand.

Neurons, glial cells, and blood vessels communicate with each other to regulate cerebral blood flow.

This study gathered information on the importance of oxidative stress as it relates to vascular changes observed in brain aging and neurodegenerative conditions like Alzheimer’s (Carvalho C, Moreira PI, 2018).

One of the emerging causative factors associated with Alzheimer’s pathology is oxidative stress.  This Alzheimer’s-related increase in oxidative stress has been attributed to decreased levels of the brain antioxidant, glutathione (Saharan S, Mandal PK, 2014).

Glutathione protects cells against oxidative stress, and protecting brain endothelial cells under oxidative stress is key to treating cerebrovascular diseases and neurodegenerative diseases including Alzheimer’s disease (Song J, et.al., 2014).  The endothelium is the inner layer of the blood vessel wall.

The body makes glutathione, but it is making less as we get older, and that’s when we need more.

We can, however, take glutathione orally.   Regularly reduced glutathione which is the most common form you will find for sale is not very bioavailable, most of it is oxidized in the stomach and is not going to provide much protection.

You can instead take S-Acetyl Glutathione which gets into the cells and provides very valuable protection from free radical damage.

 

References:

Carvalho C, Moreira PI, Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events.Front Physiol. 2018 Jul 3;9:806.

Saharan S, Mandal PK. The emerging role of glutathione in Alzheimer’s disease. J Alzheimers Dis. 2014;40(3):519-29.

Song J, Kang SM, Lee WT, Park KA, Lee KM, Lee JE.Glutathione protects brain endothelial cells from hydrogen peroxide-induced oxidative stress by increasing nrf2 expression.Exp Neurobiol. 2014 Mar;23(1):93-103. 

 

Click on the link below 👇

Effective S-Acetyl Glutathione

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Can being exposed to heat help your memory, and reduce your risk for Alzheimer’s disease?

Posted by on 9:00 am Alzheimer’s, Cardiovascular Disease, Dementia | 0 comments

Can being exposed to heat help your memory, and reduce your risk for Alzheimer’s disease?

Posted by on 9:00 am Alzheimer’s, Cardiovascular Disease, Dementia | 0 comments

 

If you follow us regularly you saw that the stress of high heat as in sauna use provided protection against cardiovascular disease. Cardiovascular disease and memory disorders share some of the same risk factors. Does that mean sauna use would provide some protection from Alzheimer’s disease as well? The following research investigated just that.

 

 

2,315 apparently healthy men aged 42-60 years at the start of the study, were followed for an
average of 20.7 years (LaukkanenT, et al., 2017). Of these men, 204 ended up being diagnosed with dementia and 123 were diagnosed with
Alzheimer’s disease. 4-7 sauna bathing sessions per week were found to be associated with lowered risks of
dementia and Alzheimer’s disease. This was the same frequency of sauna use that helped prevent death from cardiovascular
disease. Sauna baths also make you very relaxed afterward. Give it a try.

 

Reference:
Laukkanen T, Kunutsor S, Kauhanen J, Laukkanen JA, Sauna bathing is inversely associated
with dementia and Alzheimer’s disease in middle-aged Finnish men. Age Ageing. 2017 Mar
1;46(2):245-249.

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