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The Danger of Oxidized Cholesterol and How to Avoid It

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The Danger of Oxidized Cholesterol and How to Avoid It

Posted by on Cardiovascular Disease, Eating, General Health | 0 comments

The danger of oxidized cholesterol and how to avoid it.

Maybe you have read that there is no reason to worry about cholesterol being high, because we need cholesterol, and there is no evidence that it will cause cardiovascular disease.

There is however a lot of evidence showing the danger of certain types of cholesterol. Circulating oxidized LDL cholesterol was found to be associated with all stages of atherosclerosis, from early atherogenesis to hypertension, coronary and peripheral arterial disease, acute coronary syndromes and ischemic cerebral infarction (Trpkovic A, et.al., 2015).

A high waist circumference has been associated with high concentrations of oxidized LDL independently of body mass index (Weinbrenner T, et.al., 2006).

What kind of foods contain oxidized cholesterol?

Eight cholesterol oxides are commonly found in foods with high cholesterol content, such as meat, egg yolk and full fat dairy products (Savage GP, et.al., 2002).

Certain procedures will also increase the oxidation of cholesterol. Heat, light, radiation, oxygen, moisture, low pH, certain pro-oxidizing agents and the storage of food at room temperature will increase the production of cholesterol oxides in foods. Pre-cooking, freeze-drying, dehydration and irradiation, have all been reported to result in increased production of cholesterol oxides in meats. These are methods used by the food industry to prevent bacterial contamination and to increase the shelf life of these products.

How do you reduce your exposure to oxidized cholesterol?

The most effective way is to avoid eating the food where oxidized cholesterol is found.

References
Savage GP1, Dutta PC, Rodriguez-Estrada MT. Cholesterol oxides: their occurrence and methods to prevent their generation in foods. Asia Pac J Clin Nutr. 2002;11(1):72-8.
Trpkovic A, Resanovic I, Stanimirovic J, Radak D, Mousa SA, Cenic-Milosevic D, Jevremovic D, Isenovic ER. Oxidized low-density lipoprotein as a biomarker of cardiovascular diseases. Crit Rev Clin Lab Sci. 2015;52(2):70-85.
Weinbrenner T, Schröder H, Escurriol V, Fito M, Elosua R, Vila J, Marrugat J, Covas MI. Circulating oxidized LDL is associated with increased waist circumference independent of body mass index in men and women. Am J Clin Nutr. 2006 Jan;83(1):30-5; quiz 181-2.

 

 

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Timing your meals is important for your health. Here’s how:

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Timing your meals is important for your health. Here’s how:

Posted by on Eating, General Health | 0 comments

 

 

 

Time-restricting when you eat can affect your appetite, blood pressure and insulin sensitivity

We tend to focus all our attention on what we eat, and while that is important, when we eat will also have a big impact on our health.

This study evaluated eating earlier in the day to be in alignment with circadian rhythms in metabolism (Sutton EF, et.al., 2108).

The participants were men with prediabetes. They were fed 3 meals either within a 6-hour period were the last meal was eaten before 3:00PM, or they were fed the 3 meals within a 12-hour period.

This was done for 5 weeks, then the schedule was switched so the ones eating within a 6-hour period were switched to the 12-hour period. The diet was kept the same.

When they ate within the 6-hour period, the participants improved their insulin sensitivity, β cell responsiveness, blood pressure, oxidative stress, and appetite.

To be sure that the benefits were not due to weight loss, the participants were given enough food to maintain their weight.

Food intake during a shorter time period without changing the calorie intake can provide metabolic benefits and prevent weight gain (Zarrinpar A, et.al, 2016).

 

References

Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. Cell Metab. 2018 May 8. pii: S1550-4131(18)30253-5.

Zarrinpar A, Chaix A, Panda S. Daily Eating Patterns and Their Impact on Health and Disease. Trends Endocrinol Metab. 2016 Feb;27(2):69-83.

 

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How does our diet affect our heart health?

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How does our diet affect our heart health?

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This is very important. These are the biggest nutrient factors influencing cardiovascular mortality.

This research may surprise you.

The researchers evaluated the association between specific patterns of protein intake and
cardiovascular mortality in 81.337 men and women, and they found some interesting associations
(Tharrey M, et.al., 2018).

The risk for cardiovascular mortality was 61% higher for those who had the highest intake of meat protein, but it was 60% lower for those who had the highest protein intake from nuts and seeds (highest versus lowest quintile scores).

Adjustments for the participant’s vegetarian dietary pattern and nutrients related to cardiovascular disease outcomes did not change the results.

This is very important.

The researchers concluded that the associations between the ‘Meat’ and ‘Nuts & Seeds’ protein factors and cardiovascular outcomes were strong and could not be ascribed to other associated nutrients considered to be important for cardiovascular health.

In the following study the researchers looked at the association between protein intake and ischemic heart disease in 43.960 healthy men (Preis SR, et.al., 2010). They categorized healthy men as those free of hypertension, hypercholesterolemia and diabetes at the start of the study.

When they compared the intake of animal protein with vegetable protein, they found higher intake of animal protein to be associated with an increased risk for ischemic heart disease. The follow up was 18 years.

There are also other studies indicating the same thing. This is worthwhile paying attention to.

This is good news when you think about it. You have a lot of control when it comes to significantly reducing your risk for cardiovascular disease. No medication can offer you these kind of benefits, and there are no side effects.

References
Preis SR, Stampfer MJ, Spiegelman D, Willett WC, Rimm EB. Dietary protein and risk of ischemic heart
disease in middle-aged men. Am J Clin Nutr. 2010 Nov;92(5):1265-72.

Tharrey M, Mariotti F, Mashchak A, Barbillon P, Delattre M, Fraser GE. Patterns of plant and animal
protein intake are strongly associated with cardiovascular mortality: the Adventist Health Study-2
cohort. Int J Epidemiol. 2018 Apr 2.

 

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Can Garlic reduce Vascular Plaque?

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Can Garlic reduce Vascular Plaque?

Can Garlic reduce Vascular Plaque?

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Plaque is a term used for deposits in the arteries.

Not all plaque is equally dangerous. It depends on the thickness and what it is made of. The most dangerous plaque is unstable and may create a blood clot causing an obstruction of an artery if it breaks loose.

When 1469 patients with low to intermediate cardiovascular risk were evaluated with coronary CT angiography, the researchers found that the risk for major adverse cardiac events increased with a non-calcifying plaque component (Feuchtner G, et.al., 2017)

 

What is termed low-attenuation plaque is plaque with lower density, below a certain thickness. This is what the researchers found to be one of the most powerful predictors of major adverse cardiac events.

 

What follows now is the most important information, because the researchers in the next study documented an easy way to stabilize vulnerable plaque and decrease adverse cardiovascular events (Matsumoto S, et.al., 2016).


The researchers evaluated patients with metabolic syndrome using cardiac computed tomography angiography at the beginning of the study. Then they gave them either 2400 mg of aged garlic extract per day, or a placebo for approximately one year before evaluating them again.

 

They found that the participants taking the aged garlic had significantly reduced low-attenuation plaque, which is the dangerous type.

 

Sometimes there are easy steps you can take to reduce your cardiovascular risk. The best way to use information like this is not only to take garlic extract, but to add that to a diet documented to reduce risk factors for cardiovascular disease.

 

References

Feuchtner G, Kerber J, Burghard P, Dichtl W, Friedrich G, Bonaros N, Plank F. The high-risk criteria low-attenuation plaque <60 HU and the napkin-ring sign are the most powerful predictors of MACE: a long-term follow-up study. Eur Heart J Cardiovasc Imaging. 2017 Jul 1;18(7):772-779.

Matsumoto S, Nakanishi R, Li D, Alani A, Rezaeian P, Prabhu S, Abraham J, Fahmy MA, Dailing C, Flores F, Hamal S, Broersen A, Kitslaar PH, Budoff MJ. Aged Garlic Extract Reduces Low Attenuation Plaque in Coronary Arteries of Patients with Metabolic Syndrome in a Prospective Randomized Double-Blind Study. J Nutr. 2016 Feb;146(2):427S-432S.

 

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Can your bacterial flora clog up your arteries?

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Can your bacterial flora clog up your arteries?

Can your bacterial flora clog up your arteries?

Posted by on Eating, General Health, Health, Inflammation | 0 comments

 

As more and more research is being conducted on the bacterial flora of the intestines, the more we realize how important it is to have an abundant and diverse bacterial population of the healthy kind. The researchers of the following study found that patients with symptomatic atherosclerosis had more of certain gut bacteria than healthy controls (Karlsson FH, et.al., 2012).

The bacterial flora is associated with our inflammatory status, that’s what these researchers suggested, and we know that inflammation in the gastrointestinal tract creates inflammation other places in the body and is a risk factor for atherosclerosis.

Your bacterial flora can for that reason clog up your arteries if you have the wrong type of bacteria.

When bacteria in atherosclerotic plaques were examined, specific types were identified, and some types correlated with total cholesterol and fibrinogen levels (Ziganshina EE, et.al., 2016). Periodontal disease has also been associated with atherosclerosis.

Bacterial DNA was detected in atherosclerotic plaque, and the amount of DNA correlated with the number of leukocytes (a type of white blood cell), found in the atherosclerotic plaque (Koren O, et.al., 2011). Leukocytes are involved in the inflammatory response.

Several types of bacteria in the mouth and the gut correlated with blood cholesterol levels. How can you increase the number of friendly bacteria in the gastrointestinal tract?

These bacteria feed on a variety of plant fiber. When you eat a plant-based diet with a variety of vegetables, legumes, nuts and seeds, your healthy flora will increase, and these bacteria reduce inflammation.

References

Karlsson FH, Fåk F, Nookaew I, Tremaroli V, Fagerberg B, Petranovic D, Bäckhed F, Nielsen J. Symptomatic atherosclerosis is associated with an altered gut metagenome. Nat Commun. 2012;3:1245.

Koren O, Spor A, Felin J, Fåk F, Stombaugh J, Tremaroli V, Behre CJ, Knight R, Fagerberg B, Ley RE, Bäckhed F. Human oral, gut, and plaque microbiota in patients with atherosclerosis. Proc Natl Acad Sci U S A. 2011 Mar 15;108 Suppl 1:4592-8.

Ziganshina EE, Sharifullina DM, Lozhkin AP, Khayrullin RN, Ignatyev IM, Ziganshin AM. Bacterial Communities Associated with Atherosclerotic Plaques from Russian Individuals with Atherosclerosis. PLoS One. 2016 Oct 13;11(10):e0164836.

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Green Tea Provides many Benefits, but you Need to Know this Before you Drink it.

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Green Tea Provides many Benefits, but you Need to Know this Before you Drink it.

Green Tea Provides many Benefits, but you Need to Know this Before you Drink it.

Posted by on Bloodsugar, Cholesterol, General Health | 0 comments

The antioxidants called catechins in green tea is the main reason for the many benefits green tea provides.

It is very important to be insulin sensitive and have good glucose control because elevated blood glucose levels and insulin resistance cause inflammation and damage tissue.

When 17 studies were reviewed which included 1133 participants, the researchers found that green tea consumption significantly reduced fasting blood glucose and hemoglobin A1c (Hb A1c) (Liu K, et.al., 2013). Subgroup analysis also found that green tea significantly reduced fasting insulin.

 

As you get more insulin sensitive, you don’t need as much insulin to transfer the blood glucose into the cells. As blood levels of insulin go down, you will also start to use more fat for energy.
The following study investigated green tea extract in capsule form instead of drinking green tea. (Bogdanski P, et.al., 2012).The participants were obese, had high blood pressure and took either a capsule of 379 mg of green tea extract or a placebo capsule for 3 months. This was the results.

 

 

 

Total cholesterol, LDL (low-density lipoprotein) and triglycerides decreased, while HDL (high-density lipoprotein) increased in the treatment group, but not in the placebo group. The group taking the green tea extract also had a significant decrease in diastolic and systolic blood pressure as well as a significant decrease in TNF-alpha and CRP, both inflammatory markers. Glucose, insulin and insulin resistance also improved.

 

This is all very good, but you need to be careful when you buy green tea.

 

 

When black, green, white and oolong tea sold in tea bags were steeped for 3-4 minutes and the tea tested, this is what was found (Schwalfenberg G, et.al., 2013).

73% of teas brewed for 3 minutes and 83% brewed for 15 minutes had lead levels considered unsafe for consumption during pregnancy and lactation. Aluminum levels were above recommended guidelines in 20% of the brewed teas. 

 

No mercury was found at detectable levels in any of the brewed samples.

Tea can possibly also be contaminated with pesticides.

You need to be sure that the tea you buy is of high quality and not grown in contaminated soil. This is something to keep in mind when you buy green tea extract also.

 

 

References

Bogdanski P, Suliburska J, Szulinska M, Stepien M, Pupek-Musialik D, Jablecka A. Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients. Nutr Res. 2012 Jun;32(6):421-7. doi: 10.1016/j.nutres.2012.05.007.

Liu K, Zhou R, Wang B, Chen K, Shi LY, Zhu JD, Mi MT. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Am J Clin Nutr. 2013 Aug;98(2):340-8.

Schwalfenberg G, Genuis SJ, Rodushkin I.The benefits and risks of consuming brewed tea: beware of toxic element contamination. J Toxicol. 2013;2013:370460.

 

 

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Polyphenols (catechins) are the active ingredients in green tea providing a variety of benefits.

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Magnesium is Even More Important than We Used to Think

Posted by on Brain, Cardiovascular Disease, Eating, Gastrointestinal Health, General Health, Health, magnesium, Vitamin D | 0 comments

Magnesium is Even More Important than We Used to Think

Posted by on Brain, Cardiovascular Disease, Eating, Gastrointestinal Health, General Health, Health, magnesium, Vitamin D | 0 comments

Research is documenting how functions, organs, and nutrients are all interconnected. We cannot look at anything as separate entities anymore if we are going to get an accurate impression of what happens physiologically from the input of nutrient intake as well as exercise. The GI tract is one example where researchers have documented communication between the GI tract and the brain. We know the brain also communicates with the GI tract.

Intestinal absorption and subsequent metabolism of a nutrient, to a certain extent, is dependent on the availability of other nutrients.

The following research is showing us how the intake and the impact of magnesium are affecting vitamin D levels.

Image result for magnesium

Magnesium assists in the activation of vitamin D because all of the enzymes that metabolize vitamin D seem to require magnesium (Uwitonze AM, Razzaque MS, 2018).

Deficiency in either of these nutrients is reported to be associated with skeletal deformities, cardiovascular diseases, and the metabolic syndrome.

The next study indicates the same thing. The researchers found that higher intake of magnesium resulted in higher blood levels of 25 hydroxyvitamin D (25(OH)D), which is the most reliable way to measure vitamin D status (Deng X, et.al., 2013).

They also found associations of serum 25(OH)D with mortality, particularly due to cardiovascular disease and colorectal cancer, and they were modified by magnesium intake. Magnesium has shown to reduce calcification of the arteries (Hruby A, et.al., 2014).

This means that if you must take a very high amount of vitamin D to keep your vitamin D level in a good range, you most likely need magnesium. If you take enough magnesium in a well-absorbed form, you should not need to take high amounts of vitamin D to keep it at a good level. What we also learn from research like this, is how important it is to take magnesium or any of the other common minerals in a formula that combines these minerals, since they affect each other. Amino acid chelates are the best form to take minerals because they are better absorbed and better tolerated. They don’t cause gastrointestinal irritation.

 

 

References
Deng X, Song Y, Manson JE, Signorello LB, Zhang SM, Shrubsole MJ, Ness RM, Seidner DL, Dai Q. Magnesium, vitamin D status and mortality: results from US National Health and Nutrition Examination Survey (NHANES) 2001 to 2006 and NHANES III. BMC Med. 2013 Aug 27;11:187.

Hruby A1, O’Donnell CJ2, Jacques PF1, Meigs JB3, Hoffmann U4, McKeown NM5. Magnesium intake is inversely associated with coronary artery calcification: the Framingham Heart Study. JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69.

Uwitonze AM, Razzaque MS. Role of Magnesium in Vitamin D Activation and Function. J Am Osteopath Assoc. 2018 Mar 1;118(3):181-189.

The BMJ Formula
an easy way to effectively support bone, joints, connective tissue and neuromuscular function.

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This has Shown to Improve Memory, and it is Easy to Implement

Posted by on Alzheimer’s, Arthritis, Brain, Cancer, Cardiovascular Disease, Diabetes, General Health, Health, Inflammation, Memory | 0 comments

This has Shown to Improve Memory, and it is Easy to Implement

Posted by on Alzheimer’s, Arthritis, Brain, Cancer, Cardiovascular Disease, Diabetes, General Health, Health, Inflammation, Memory | 0 comments

Image result for low grade inflammationLow grade inflammation, the type of inflammation you usually don’t know you have, is harmful for all tissue, including the brain. Curcumin found in the spice turmeric has been shown to decrease inflammation and was for that reason studied to determine if it could provide protection for the brain.

40 participants were given either curcumin in a bioavailable form twice daily or a placebo for 18 months (Small GW, et.al., 2018). The participants did not have dementia, and the researchers found that taking curcumin twice daily, improved their memory and attention.

PET scanning suggested that the improvements were associated with a decrease in amyloid and tau accumulation in brain areas regulating mood and memory. Image result for amyloid and tau alzheimers brain

Amyloid and tau accumulation are usually found in the brains of patients with Alzheimer’s disease.

Earlier research with another bioavailable form of curcumin showed that 1 hour after taking the curcumin, the participants experienced significant improvement in attention and working memory (Cox KH, et.al., 2015).

Taking a capsule twice a day is very easy and something everybody can do.

References
Small GW1, Siddarth P2, Li Z2, Miller KJ2, Ercoli L2, Emerson ND2, Martinez J2, Wong KP2, Liu J2, Merrill DA2, Chen ST2, Henning SM2, Satyamurthy N2, Huang SC2, Heber D2, Barrio JR2. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018 Mar;26(3):266 277.

Cox KH1, Pipingas A1, Scholey AB2. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J Psychopharmacol. 2015 May;29(5):642-51.

Better Curcumin

Curcumin is a good antioxidant, but it is especially effective in helping to reduce inflammation. For these reasons, curcumin provides many health benefits.

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Your Blood Glucose Level after You Eat can Affect Your Risk for Cardiovascular Disease.

Posted by on Bloodsugar, Cardiovascular Disease, Diabetes, Eating, General Health, Glucose, Health, Heart disease | 0 comments

Your Blood Glucose Level after You Eat can Affect Your Risk for Cardiovascular Disease.

Posted by on Bloodsugar, Cardiovascular Disease, Diabetes, Eating, General Health, Glucose, Health, Heart disease | 0 comments

Your blood glucose level after you eat can affect your risk for cardiovascular disease. Several studies show a correlation between blood glucose levels and what happens to your arteries. The most common ways to evaluate the blood glucose metabolism is to measure fasting blood glucose and Hemoglobin A1c (HbA1c). Hemoglobin A1c is usually used to monitor long-term glucose control, 2-3 months.

Image result for blood glucoseMore and more research is, however, documenting the importance of also knowing what the blood glucose level is after a meal, and that is not checked routinely.

In the following study, the participants were divided into 4 groups based on coronary angiography (Sasso FC, et.al., 2004). One group had no significant stenosis (calcification), the other groups had documented disease in 1 and up to 3 vessels. Several tests were performed to evaluate the glucose metabolism, including the glucose and insulin levels after eating.

For patients with a so-called normal glucose tolerance, it was interesting that the most important test correlating with cardiovascular risk was the glucose level after eating, and the next was Hemoglobin A1c.

In patients with coronary artery disease the researchers showed that even with normal Hemoglobin A1c levels, the participants with an abnormal glucose tolerance test (glucose after a meal) had greater progression of coronary artery lesions (Wang H, et.al., 2014).

It was not even a difference in risk between patients with an impaired glucose tolerance and patients who had type 2 diabetes. This shows that you don’t have to have progressed to having diabetes to have an increased risk for cardiovascular disease. Researchers have found that there is a linear relationship between the risk of cardiovascular death and the 2-hour glucose tolerance test (Leiter LA, et.al., 2005).

Image result for cardiovascular disease and glucose level

The 2 -hour glucose tolerance test measures the blood glucose level 2 hours after a test drink has been ingested.

These researchers found increased mortality at an oral 2-hour glucose tolerance test of approximately 90 mg/dl which is well below the level of what type 2 diabetes patients have.

Research is showing us that what we used to think of as normal and good test results are not good enough. That’s probably why we see a lot of people dying from a cardiovascular disease with laboratory values in the normal range.

References
Leiter LA, Ceriello A, Davidson JA, Hanefeld M, Monnier L, Owens DR, Tajima N, Tuomilehto J ; International Prandial Glucose Regulation Study Group. Clin Ther. 2005;27 Suppl B:S42-56.

Sasso FC, Carbonara O, Nasti R, Campana B, Marfella R, Torella M, Nappi G, Torella R, Cozzolino D, Glucose metabolism and coronary heart disease in patients with normal glucose tolerance. JAMA. 2004 Apr 21;291(15):1857-63.

Wang H, Tang Z, Li X, Hu B, Feng B. Angiographic evaluation of the effects of glucose metabolic status on progression of coronary artery lesions in patients with coronary artery disease. J Diabetes. 2014 Nov;6(6):541-6.

 

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Decrease Inflammation after a Meal by Including These 2 Ingredients

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Decrease Inflammation after a Meal by Including These 2 Ingredients

Posted by on Eating, General Health, Health, Inflammation | 0 comments

Inflammation and oxidative stress are usually connected, and both can affect your blood vessels in a negative way. Both are known to cause damage to the endothelium, the inner lining of the blood vessels.

Depending on what kind of food the meal includes, both inflammation and oxidative stress can increase. To evaluate if adding processed tomato products would make a difference, the participants of this study consumed high fat meals known to induce oxidative stress on 2 separate occasions (Burton-Freeman B, et.al., 2012).

Image result for beans and tomato pictureOne time a processed tomato product was added, and the other time a non-tomato product was used.

Several tests were performed before and after, and it was found that the tomato product significantly
reduced the high fat meal induced LDL oxidation and the rise in IL-6, an inflammatory marker. 

Beans is another food that has shown to modify cardiovascular risk.

Image result for black bean pasta tomato

When meals containing either black beans, fiber matched meals or antioxidant capacity matched meals were compared this was the result (Reverri EJ, et.al., 2015).

Insulin was lower after the black bean meal and a trend for decreasing oxidized LDL was found for both the the beans and the antioxidant matched meal.

Oxidized LDL is the most harmful form of LDL cholesterol.

If you like pasta, you can make the meal healthier by adding beans to a sauce which includes
processed tomatoes.

By taking a well absorbed form of curcumine you can further decrease inflammation (Sahebkar A, 2014).

 

References

Burton-Freeman B, Talbot J, Park E, Krishnankutty S, Edirisinghe I. Protective activity of processed tomato products on postprandial oxidation and inflammation: a clinical trial in healthy weight men and women. Mol Nutr Food Res. 2012 Apr;56(4):622-31.

Reverri EJ, Randolph JM, Steinberg FM, Kappagoda CT, Edirisinghe I, Burton-Freeman BM. Black Beans, Fiber, and Antioxidant Capacity Pilot Study: Examination of Whole Foods vs. Functional Components on Postprandial Metabolic, Oxidative Stress, and Inflammation in Adults with Metabolic Syndrome. Nutrients. 2015 Jul 27;7(8):6139-54.

Sahebkar A1. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phytother Res. 2014 May;28(5):633-42.

Image result for reduce inflammation photo

 

Better Curcumin

Curcumin is a good antioxidant, but it is especially effective in helping to reduce inflammation. For these reasons, curcumin provides many health benefits.

Read more…

 

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