For best results take 2 capsules once a day, This is more effective to ensure more of the lipoic is delivered to the tissues that need it since the liver eliminates it quickly.

Provides neurological benefits (Liu J. 2008).

Lipoic N is an effective, fast-release alpha lipoic-acid formula.

Alpha-lipoic acid is a coenzyme involved in carbohydrate metabolism and the production of ATP (adenosine triphosphate). Lipoic acid is an effective antioxidant that scavages free radicals both intra and extra-cellular (Packer L, et al. 1995). It is both fat and water-soluble and can regenerate antioxidants such as vitamin E, C, and glutathione preventing oxidative damage.

Research has documented that in diabetic patients lipoic acid improves insulin sensitivity and glucose disposal after four weeks (Konrad T, et al. 1999, Jacob S, et al. 1999).

In cases of neuropathy 600 – 1200 mg per day of lipoic acid has been documented to improve symptoms such as burning, numbness, and pain. It has also been shown to improve objective measurements of neurological deficit and disability within 3-5 weeks (Ruhnau KJ, et al. 1999).

Patients with sciatic pain caused by a herniated disc have shown improvements in symptoms and improvement in neuropathy on electromyography when using 600 mg of lipoic acid daily (Memeo A, Loiero M, 2008).

600 mg of alpha-lipoic acid and 360 mg of GLA have been documented to improve symptoms and electro-myography readings in patients with moderately severe carpal tunnel syndrome (Di Geronimo G, et al. 2009).

A researcher at the University of California listed the following neurological benefits of lipoic acid: Improvement of the age-associated decline in memory, improvement of mitochondrial structure and function, inhibition of age-associated increase of oxidative damage, the elevation of the levels of antioxidants, and restoration of the activity of key enzymes (Liu J, 2008).

Lipoic acid is absorbed quickly, but it is also removed quickly by the liver. For lipoic acid to be effective, it needs to reach the tissue it is supposed to protect. Most studies have used a fast release form which is what you find in Lipoic N. The most common dosage used in the research has been 600-1200mg once or twice daily. That's why we recommend 2 capsules of Lipoic N once daily. This dosage allows more lipoic acid to reach the target tissue for better results.

Nutritional Facts
Serving Size: 1 Capsule
Servings Per Container: 90

Alpha-Lipoic Acid………………………………………………………………………………………..500 mg

References:

Packer L, et al. Alpha-lipoic acid as a biological antioxidant. Free Radic Biol Med. 1995 Aug;19(2):227-50.

Konrad T, et al. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care. 1999 Feb;22(2):280-7.

Jacob S, et al. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med. 1999 Aud;27(3-4):309-14.

Ruhnau KJ, et al. Effects of 3-week oral treatment with the antioxidant thioctic acid (alpha-lipoic acid) in symptomatic diabetic polyneuropathy. Diabet Med. 1999 Dec:16(12):1040-3.

Liu J. The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview. 2008 Jan:33(1):194-203.

Memeo A, Loiero M. Thioctic Acid and acetyl-L-carnitine in the treatment of sciatic pain caused by herniated disc: a randomized, double-blind, comparative study. Clin Drug Investig. 2008;28(8):495-500.

Di Geronimo D, Caccase AF, Caruso L, Soldati A, Passaretti U. Treatment of carpal tunnel syndrome with alpha-lipoic acid. Eur Rev Med Pharmacol Sci. 2009 Mar-Apr;13(2):133-9.