Your Road to Wellness

Wellness

What factors are playing a role in Alzheimer’s, cognitive decline and cardiovascular disease?

Posted by on 9:58 pm Alzheimer’s, Eating, General Health, Get in shape, Health Risk, Heart disease, Stay healthy, Wellness | 0 comments

Alongside oxidative stress and inflammation, altered cholesterol metabolism and hypercholesterolemia also significantly contribute to neuronal damage and to the progression of Alzheimer’s disease (Gamba P, et.al., 2015).

Levels of  oxysterols derived from cholesterol oxidation and inflammatory mediators have been found to be increased in the brains of Alzheimer’s patients (Testa G, et.al., 2016).

Oxysterols, the major component of oxidized LDL is responsible for the increase in endothelial stiffness and is a key step in atherosclerosis development (Shentu TP, et.al., 2012).

When 70 people with mild cognitive impairment were compared with 140 normal individuals, oxysterol levels were significantly higher in the people with mild cognitive impairment (Liu Q, et.al., 2016).

Where do we find oxidized cholesterol?

Oxidized cholesterol are commonly found in foods with high cholesterol content, such as meat, egg yolk and full fatdairy products (Savage GP, et.al., 2002).

Factors known to increase the production of free radicals and therefore oxidized cholesterol in foods are heat, light, radiation, oxygen, moisture and the storage of food at room temperature.

Processes, such as pre-cooking, freeze-drying, dehydration and irradiation, have all been reported to result in increased production of oxidized cholesterol in meats.

What can you do to reduce oxidized cholesterol?

The most obvious way to do it is to avoid the foods that contain the oxidized cholesterol.

The best way to do that is to eat plant based foods, since animal source protein is where you find oxidized cholesterol.

It would also be beneficial to take S-Acetyl Gutathione and Curcumin to reduce free radical damage and inflammation further.

References

Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G.Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease. Front Aging Neurosci. 2015 Jun 19;7:119.

Liu Q, An Y, Yu H, Lu Y, Feng L, Wang C, Xiao R.Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.Lipids Health Dis. 2016 Oct 10;15(1):177.

Savage GP1, Dutta PC, Rodriguez-Estrada MT, Cholesterol oxides: their occurrence and methods to prevent their generation in foods. Asia Pac J Clin Nutr. 2002;11(1):72-8

Shentu TP, Singh DK, Oh MJ, Sun S, Sadaat L, Makino A, Mazzone T, Subbaiah PV, Cho M, Levitan I.The role of oxysterols in control of endothelial stiffness.J Lipid Res. 2012 Jul;53(7):1348-58.

Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G, Fantò F, Poli G, Leonarduzzi G, Gamba P.Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation.Redox Biol. 2016 Dec;10:24-33.

 

 

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Can Omega 3 Fatty Acids Affect Your Mood?

Posted by on 11:42 am Body fat, Fish Oil, General Health, Omega-3, fish oil, Stay healthy, Stress, Wellness, Womens health | 0 comments

Omega 3 fatty acids have been demonstrated to significantly influence the nervous system and affect brain structures.

Can omega 3 fat also impact the way you feel emotionally?

This was evaluated in young adults with depressive symptoms by giving them 1.4 g of EPA and DHA, the active ingredients of omega 3 fat, or a placebo (Ginty AT, Conclin SM, 2015).

The participants took the omega 3 fatty acids for 21 days, and the results showed a significant difference between the treatment group and the placebo group.

67% of the participant taking the omega 3 fatty acids no longer met the criteria for being depressed, while only 20% in the placebo group were no longer depressed.

 

When medical students were given either 2085 mg of EPA and 348 mg of DHA or a placebo, the ones who received the omega 3 fatty acids experienced a 20% reduction in anxiety symptoms and a 14% reduction in IL-6 and TNF-alpha, both markers of inflammation (Kiecolt-Glaser JK et.al., 2011).

 

The fatty acid composition of the red blood cells in patients with recurrent major depression was found to be significantly lower in the patients compared to the control group without depression ( Assies J, et.al., 2010).

 

According to these studies, just by taking some capsules of a high-quality omega 3 fish oil daily, you should see a positive effect on your mood.

 

References

Assies J, Pouwer F, Lok A, Mocking RJ, Bockting CL, Visser I, Abeling NG, Duran M, Schene AH Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study. PLoS One. 2010 May 14;5(5):e10635.

Ginty AT, Conklin SM. Short-term supplementation of acute long-chain omega-3 polyunsaturated fatty acids may alter depression status and decrease symptomology among young adults with depression: A preliminary randomized and placebo controlled trial.
Psychiatry Res. 2015 Sep 30;229(1-2):485-9.

Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011 Nov;25(8):1725-34.

 

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Osteoarthritis in women associated with deposits in Arteries

Posted by on 12:33 pm Asthma, Calories, Eating, Energy, Exercise, General Health, General Health, Health Risk, Heart disease, Muscles, Nervous System, Research, Wellness, Women, Womens health | 0 comments

Research sometimes find interesting connections we usually don’t think about.

A study including 3278 women found an association between plaque in the carotid artery and osteoarthritis in the knee and hands in women (Hoeven TA, et.al., 2013).

We know that inflammation is involved in osteoarthritis, even if it is less severe than in rheumatoid arthritis.

We also know that inflammation increases the risk for cardiovascular disease. Inflammation is an important factor in depositing cholesterol and fat into the inner lining of the vascular wall.

 

Another interesting connection found lower magnesium levels in rheumatoid arthritis patients compared to controls (Chavan VU, et.al., 2015).

Lower magnesium levels were also correlated with higher cholesterol and LDL, the so called bad cholesterol, and higher magnesium levels with better HDL cholesterol, the good cholesterol. This was in cases of rheumatoid arthritis.

 

Magnesium has also been found to be inversely associated with osteoarthritis documented on x-rays and joint space narrowing (Zeng C, et.al., 2015).

Glucosamine sulfate another nutritional substance has been used to treat osteoarthritis for many years.

When osteoarthritic chondrocytes (cartilage cells) and glucosamine sulfate were tested in different ways in a culture, it was found that glucosamine sulfate reduced the synthesis of proinflammatory mediators (Largo R, et.al., 2003).

Taking magnesium and glucosamine sulfate could according to this possibly benefit both your cardiovascular system and your joints.

The best form of magnesium is an amino acid chelate like magnesium glycinate.

The most common form of magnesium is magnesium oxide, but that is a gastrointestinal irritant and can give you diarrhea when taken in higher amounts.

 

REFERENCE

Chavan, V. U., Ramavataram, D. V. S. S., Patel, P. A., & Rupani, M. P. (2015). Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis. Journal of clinical and diagnostic research: JCDR, 9(4), BC01.

Hoeven, T. A., Kavousi, M., Clockaerts, S., Kerkhof, H. J., van Meurs, J. B., Franco, O., … & Bierma-Zeinstra, S. (2012). Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study. Annals of the rheumatic diseases, annrheumdis-2011.

Largo R, Alvarez-Soria MA, Díez-Ortego I, Calvo E, Sánchez-Pernaute O, Egido J, Herrero-Beaumont G. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes.Osteoarthritis Cartilage. 2003 Apr;11(4):290-8.

Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, Zhang Y, Yang TB, Lei GH. Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis. PLoS One. 2015 May 26;10(5):e0127666.

 

 

 

 

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Surprising way artificial sweeteners induce glucose intolerance.

Posted by on 9:02 am Artificial Sweeteners, Bloodsugar, Diabetes, Eating, Eating, Glucose, Health, Insulin resistance, Tissue Recovery Blog, Type 2 diabetes, Wellness | 0 comments

Artificial sweeteners are used as an additive in both beverages, as well as food, to improve taste since most people prefer a sweet taste.
 

sweeteners picSince these sweeteners contain very few calories, they are also popular in diet beverages and diet foods. They are even used in products marketed to people with diabetes and promoted as a good alternative to sugar.

This seems to be a big mistake according to the reviewed research(Suez J, et al. 2014).
The results demonstrated that consumption of these sweeteners are causing glucose intolerance because they alter the composition of the intestinal bacterial flora in a negative way.
These results have been reproduced in both humans and mice.

The last thing you want to do is to consume a substance that will make you more glucose intolerant. This is very important for diabetics, but also for non diabetics because you don’t want to develop diabetes.

 

 

Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza O, Israeli D, Zmora N, Gilad S, Weinberger A, Kuperman Y, Harmelin A, Kolodkin-Gal I, Shapiro H, Halpern Z, Segal E, Elinav E. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature. 2014 Sep 17. doi: 10.1038/nature13793. [Epub ahead of print]

How healthy is green tea?

Posted by on 9:07 am Antioxidents, Bloodsugar, Diabetes, General Health, Glucose, Green tea, Insulin resistance, Insulin resistance, metabolic syndrome, Supplements, The Learn to Eat Plan, Tissue Recovery Blog, Weight loss, Wellness | 0 comments

Grüner TeeGreen tea seems to be one of the best things you can drink for your health. One of the reasons is that it contains a lot of antioxidants.

One of the most important things we can do to stay healthy is to be sure we stay insulin sensitive. When we are insulin sensitive the glucose is transferred from the blood into the cells very easily without the pancreas having to release a lot of insulin. This will keep the blood glucose at a low and normal level, and also help to keep inflammation low, both are very important if we want to be healthy.

The reviewed research investigated if green tea could improve glucose control and increase insulin sensitivity(Liu K, et.al.,2013). 17 studies were included in the analysis. It showed that green tea consumption significantly reduced the fasting glucose and Hemoglobin A1c. Hemoglobin A1c is a test for long-term glucose control.

If you don’t like green tea and if you want to be sure your green tea does not contain a lot of pesticides, you can take it in capsule form like our Better Green Tea formula which meets the German standards for pesticide content, which is very strict.

 

 

 

Liu K1, Zhou R, Wang B, Chen K, Shi LY, Zhu JD, Mi MT. Effect of green tea on glucose control and insulin sensitivity: a meta-analysis of 17 randomized controlled trials. Am J Clin Nutr. 2013 Aug;98(2):340-8. doi: 10.3945/ajcn.112.052746. Epub 2013 Jun 26.

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Could gluten cause problems for everybody?

Posted by on 8:17 am Eating, Inflammation, Inflammatory factor, Insulin resistance, metabolic syndrome, Low glycemic meals, The Learn to Eat Plan, Weight loss, Wellness | 0 comments

3d render of digestive systemThere is more and more information published every day on adverse reactions to gluten.

We used to believe that if you did not have celiac disease, you would not have any issues with gluten. This does not seem to be true since there are different degrees of gluten intolerance. People who have celiac disease just have a very severe reaction to it.

A gastroenterologist and researcher at Harvard University has published a very interesting article on this subject(Fasano,A,2011).

The intestinal mucosa act as a barrier to protect us from pathogens and other particles that are not supposed to be absorbed into the blood. This is called intestinal permeability. Dr. Fasano explains that gliadin (a protein found in gluten) trigger IL-8 (an inflammatory cytokine) leading to recruitment of neutrophils. Neutrophils are a type of white blood cell which are activated as a part of the body’s defense mechanism.

Gliadin increases intestinal permeability through the release of a substance called zonulin. When the intestinal permeability increases we may absorb both pathogens (bacterias) and larger proteins not intended to be absorbed, triggering an inflammatory response.

Gliadin also interacts with macrophages, another type of white blood cell. This establishes an inflammatory environment in the intestinal mucosa. Depending on genetic predisposition, we will then experience a more or less severe reaction. This may, for example, trigger an autoimmune response in someone who is predisposed to that.

In other words, it looks like gluten is triggering an inflammatory response in everybody, but because we don’t have exactly the same genes, we will not have exactly the same reaction.

Gluten is found in common grains, but gluten free grains are not without problems either because they elevate the blood glucose high.

There are; however, solutions to this which you will find in the Learn to Eat program.

 

 

 Fasano A.  Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev. 2011 Jan;91(1):151-75. doi: 10.1152/physrev.00003.2008.