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Your Road to Wellness

Wellness

Heart Health and How to Fight Back Against Disease

Posted by on 11:00 am Antioxidents, General Health, Glutathione, Wellness | 0 comments

 

This substance is very important for the cardiovascular system.

Oxidative stress has been found to be a factor involved in many chronic diseases, and cardiovascular disease is one of them.

This is what was found in the following research when glutathione levels were measured in patients with cardiac disease and compared with a healthy control group. 

The researchers wrote that this study provides evidence that cardiac and systemic glutathione deficiency is related to the functional status and structural cardiac abnormalities of patients with cardiac diseases (Damy T, et.al., 2009).

Another study found that glutathione concentrations were lower in all cardiovascular disease cases when compared to the control group (Shimizu H, et.al., 2004). 

Both the cerebral infarction cases and cerebral hemorrhage cases had significantly lower total glutathione levels when compared to the control groups.

The researchers wrote that these findings suggest that reduced plasma total glutathione levels are a risk factor for cardiovascular disease, especially for cerebral small vessel disease.

In patients with coronary artery disease, a low level of activity of red-cell glutathione peroxidase 1 was independently associated with an increased risk of cardiovascular events.

The risk of cardiovascular events was inversely associated with increasing quartiles of glutathione peroxidase 1 activity (Blankenberg S, et.al., 2003).  

The researchers found that glutathione peroxidase 1 activity was among the strongest univariate predictors of the risk of cardiovascular events. 

 

They also wrote that  increasing glutathione peroxidase 1 activity might lower the risk of cardiovascular events.  

References

Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Smieja M, Cambien F, Meyer J, Lackner KJ; AtheroGene Investigators.Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease.N Engl J Med. 2003 Oct 23;349(17):1605-13.

Damy T, Kirsch M, Khouzami L, Caramelle P, Le Corvoisier P, Roudot-Thoraval F, Dubois-Randé JL, Hittinger L, Pavoine C, Pecker F .Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities. PLoS One. 2009;4(3):e4871.

Shimizu H, Kiyohara Y, Kato I, Kitazono T, Tanizaki Y, Kubo M, Ueno H, Ibayashi S, Fujishima M, Iida M. Relationship between plasma glutathione levels and cardiovascular disease in a defined population: the Hisayama study. Stroke. 2004 Sep;35(9):2072-7.

 

 

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Do you want to feel less anxious? This has shown to help.

Posted by on 11:00 am Fish Oil, HDL, Omega-3, fish oil, Wellness | 0 comments

No one wants to feel anxious, so what can you do?  The aim of this research was to find out if omega 3 fatty acids would reduce inflammatory markers and symptoms of anxiety in healthy young adults (Kiecolt-Glaser JK, et.al., 2011).

The participants of this double blind placebo controlled study were 68 medical students. The research took 12 weeks.

They provided blood samples during lower-stress periods and also on days before an exam.

The students  received either 2.5 g per day of omega 3 fish oil capsules consisting of 2085 mg of EPA (eicosapentaenoic acid) and 348 mg of DHA (docosahexanoic acid) or placebo capsules. 

Compared to controls, the students who received the omega 3 fatty acids showed a 14% decrease in lipopolysaccharide stimulated interleukin 6 (IL-6) production which is an inflammatory marker, and a 20% reduction in anxiety symptoms.

Because the absorption and metabolism of omega 3 fatty acid supplements can differ, a secondary analysis was also performed. This showed that a lower omega 6 to omega 3 fatty acid ratio led to lower anxiety and reductions in stimulated IL-6 and TNF-alpha production, both inflammatory markers.

Supplementation with omega 3 fatty acids if the dose of EPA is high enough can reduce both inflammation and symptoms of anxiety even in young and healthy people.

Reference

Kiecolt-Glaser JK, Belury MA, Andridge R, Malarkey WB, Glaser R. Omega-3 supplementation lowers inflammation and anxiety in medical students: a randomized controlled trial. Brain Behav Immun. 2011 Nov;25(8):1725-34. 

 

 

 

 

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One good reason it is important to have a low omega 6 to omega 3 fatty acid ratio

Posted by on 10:00 am Fish Oil, Flaxseeds, General Health, HDL, HDL Level, Health Risk, Omega-3, fish oil, telomeres, Wellness | 0 comments

Both omega 3 and omega 6 fatty acids are essential which means we have to get them through the diet, since the body cannot make them.  The omega 6 fatty acid intake is quite a bit higher than the omega 3 intake the way most people eat now.

Omega 6 fatty acids are precursors for arachidonic acid which again is a part of the inflammatory cascade which is producing the inflammatory cytokines (substances). The omega 3 fatty acids are more known for reducing inflammation.

Both of these fatty acids are important and they are incorporated into the cell membranes.

The following research is interesting because it measured telomere length as it relates to aging, and how this is affected by the ratio of omega 6 to omega 3 fatty acids (Kiecolt-Glaser JK, et.al., 2013).

Telomeres are the caps at the end of each strand of DNA that protect our chromosomes. If DNA strands become damaged our cells will not function properly.  Longer telomeres are generally related to better health.

This was a double-blind four-month study, and included 106 healthy sedentary overweight middle-aged older adults who received either 2.5g/day, l.25g/day or a placebo capsule for 4 months. Oxidative stress and telomere length were measured.

The researchers found that oxidative stress was reduced, and that telomere length increased with decreasing omega 6 to omega 3 fatty acid ratio.   This data suggests that a lower omega 6 to omega 3 fatty acid ratio can impact cell aging.

Other research has documented that omega 3 fatty acids also reduce inflammation.

The omega 3 fatty acids used in this research were from fish oil and had a high amount of EPA.

Reference

Kiecolt-Glaser JK. Brain Behav Immun. 2013 Feb;28:16-24, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS, Blackburn E. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A randomized controlled trial. Brain Behav Immun. 2013 Feb;28:16-24.

 

Better Fish Oil

The anti-inflammatory effects of Omega 3 fatty acids are well known. Most people that eat a western diet can benefit from increasing the intake of Omega 3 fatty acid. Most fish oils on the market are ethyl esters because that’s cheaper to produce.

The Better Fish Oil comes in the form of triglycerides which offers better stability to the fatty acids and prevents breakdown and oxidation.

Get your bottle here.

Can your blood glucose regulation affect your memory?

Posted by on 12:45 pm Bloodsugar, Cognition, Dementia, Diabetes, Diet, Eating, General Health, Glucose, Health Risk, Insulin resistance, Memory, Wellness | 0 comments

This study investigated how the ability to control the levels of blood glucose was related to mood and cognition (Young H, Benton D, 2014).

155 adults, aged 45-85 years,  without a diagnosis of diabetes, were given an oral glucose tolerance test and cognitive tests. 

The researchers found that those with poorer glucose tolerance forgot more words and had slower decision times, but only if they were 61 years or older. 

The next study on the same topic included 93 healthy male and female non-diabetic participants who ranged in age from 55 to 88 years (Messier C, 2010). 

The researchers measured cognitive function as well as other things. The participants also had a glucose tolerance test during which glucose and insulin were measured.This was done after drinking a saccharin solution and on another occasion after drinking a glucose solution (50 g).

The results showed that progressively worse glucose regulation predicted poorer performance on measures of working memory and executive function.

The researchers stated that the results suggest that cognitive functions may be impaired before gluco-regulatory impairment reaches levels consistent with a type 2 diabetes diagnosis.

The change from being insulin sensitive to being insulin resistant is a gradual process. This shows that it is really important to keep your blood glucose at a low and normal level not only after you have fasted, but also after eating. Ideally it should be below 90 two hours after a meal.

The sooner you  implement strategies to stay insulin sensitive the better it is.

You can stay insulin sensitive by making changes to the way you eat and by incorporating exercise into your routine.

References

Messier C, Tsiakas M, Gagnon M, Desrochers A. Effect of age and glucoregulation on cognitive performance. J Clin Exp Neuropsychol. 2010 Oct;32(8):809-21.

Young H, Benton D.The nature of the control of blood glucose in those with poorer glucose tolerance influences mood and cognition. Metab Brain Dis. 2014 Sep;29(3):721-8.

 

 

 

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This is affected by too little quality sleep

Posted by on 8:03 am General Health, Research, Sleep, Wellness | 0 comments

The following was a small study, but it is interesting because the participants were young females and males with an average age of 28.8 years (Montesinos L, et.al., 2018).

Their average body mass index was 23.4 and their resting heart rate was 63.1 which are considered good.  Sleep and balance were assessed over two days, and balance was assessed in a gait lab.

Even in young people like, this decreased sleep quality for only a short time was causing problems.

The participants with a day-to-day deterioration in sleep quantity and quality saw significant changes in balance.  

Sleep quantity and quality were defined by decreased duration and increased fragmentation, increased night time activity and decreased heart rate variability.  As more and more research is done in the area of sleep, we discover how important sleep really is, even balance is affected by sleep. Maybe that’s one of the reasons why some people lose their balance as they get older.

If you have problems relaxing, try meditation, especially in the evening in a room without bright light.

Reduce your exposure to bright light and light from computer screens some time before you go to bed.   Exposure to bright light in the evening can alter your circadian rhythm and affect the release of the hormone melatonin, making it more difficult to get quality sleep.

Reference

Montesinos L, Castaldo R, Cappuccio F, Pecchia L, Day-to-day variations in sleep quality affect standing balance in healthy adults. Sci Rep. 2018 Nov 30;8(1):17504.

 

 

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Why is it important to know the immediate effects of your meals?

Posted by on 12:00 pm Bloodsugar, Calories, Eating, Fat, General Health, HDL, Omega-3, fish oil, Tissue Recovery Blog, Wellness | 0 comments

When you have your yearly medical checkup, your doctor usually runs a blood test to see how your biochemistry is when you are in a fasted state.  You should have the blood drawn in the morning before you eat anything.

While this gives both your doctor and you an idea about your health status and certain health risks, is it the most accurate way to collect information to see how well you are doing?

It is certainly a good to have those data, but think about it: we are not in a fasting state during the day. Most people eat several times during the day and may even snack between their meals.

There are several important factors to take into account when it comes to the more immediate after-effect of the meals we eat. We will look specifically at cholesterol here, which is interesting because a new study related to cholesterol and egg consumption was just published.

Let’s, however, look at another paper first.

The authors found the following.

Diet is not just about fasting cholesterol; it is mainly about the after-meal effects of cholesterol, saturated fats, oxidative stress and inflammation (Spence JD, et.al., 2010).  Focusing on fasting cholesterol obscures three key issues:

  • Dietary cholesterol increases the susceptibility of low-density lipoprotein (LDL) to oxidation
  • increases the after-meal effect of excess fat
  • increases the adverse effects of dietary saturated fat

Oxidized LDL is a major risk factor for cardiovascular disease.

These researchers also said dietary cholesterol, including egg yolks, is harmful to the arteries.

Now, let’s look at the more recent study.

29 615 participants were followed for an average of 17.5 years (Zhong VW, et al., 2019).  This is what the researchers concluded.

Among US adults, higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of cardiovascular disease and all-cause mortality in a dose-response manner.

References

Spence JD, Jenkins DJ, Davignon J.Dietary cholesterol and egg yolks: not for patients at risk of vascular disease.Can J Cardiol. 2010 Nov;26(9):e336-9.

Zhong VW, Van Horn L, Cornelis MC, Wilkins JT, Ning H, Carnethon MR, Greenland P, Mentz RJ, Tucker KL, Zhao L, Norwood AF, Lloyd-Jones DM, Allen NB.Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality. JAMA. 2019 Mar 19;321(11):1081-1095.

 

 

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Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more…