Your Road to Wellness

Vitamin B

Can B Vitamins Affect Your Mood?

Posted by on 10:51 am Anti-Aging, Depression, Health, Vitamin B, Vitamin B12 | 0 comments

You would most likely prefer to feel happy and excited about life and ready to get going to accomplish your goals when you wake up. Do you think almost everybody feels that way?

No, that is not the case, because depression is the second leading cause of disability, and it is increasing.

There can be many reasons for depression, and if you know why your mood is not good, you should of cause take action to correct the reason if possible. It is however not always easy to pinpoint the exact reason, and it may also be several things contributing.

 

When depressed adults were given either a vitamin B complex or a placebo and were accessed at the beginning and at 30 and 60 days from when they started, the treatment group showed significant and more continuous improvements in depressive and anxiety symptoms, compared to the placebo group (Lewis JE, et.al., 2013).

 

If you, however, have a genetic polymorphism (genetic variation) making it more difficult to metabolize folic acid, you can experience even better results if you take a metabolite of folic acid.

There are several genetic variations that can make it difficult for the body to utilize folic acid, and this is not that uncommon.

After 8 weeks of taking metabolites of B vitamins and micronutrients, these patients showed a 12-point improvement on a depression scale, and 42% achieved full remission.

A good vitamin B complex formula which includes metabolites is easy to take. This can for some people make a big difference.

 

 

References

Lewis JE, Tiozzo E, Melillo AB, Leonard S, Chen L, Mendez A, Woolger JM, Konefal J. The effect of methylated vitamin B complex on depressive and anxiety symptoms and quality of life in adults with depression. ISRN Psychiatry. 2013 Jan 21;2013:621453

Mech AW, Farah A. Correlation of clinical response with homocysteine reduction during therapy with reduced B vitamins in patients with MDD who are positive for MTHFR C677T or A1298C polymorphism: a randomized, double blind, placebo-controlled study. J Clin Psychiatry. 2016 May;77(5):668-71.

 

Vitamin B Complex

The B1 (thiamine), B2 (riboflavin), B6 (pyridoxine), and B12 (cobalamin) comes in their physiologically active form, making them easier to absorb.

Read more..

What can B Vitamins do for your cardiovascular system?

Posted by on 11:23 am General Health, Health, Vitamin B, Vitamin B12, Vitamins | 0 comments

You may have read that B Vitamins don’t provide any benefits for the cardiovascular system.

 

Is that true, or is the reason instead a lack of knowledge?

 

Decide for yourself, but read this first.

While there is research showing no benefits for the cardiovascular system, could the reason be that the research methodology used in those studies were not the best?

 

2 of the references you will find here will give you access to the full article if you want to dive in deeper.

This is what was found in a double-blind randomized controlled trial of 390 participants (Wang L., et.al., 2015).

400 mcg of folic acid, 2 mg of B6 and 10 mcg of B12 were given for 12 months and resulted in a 9.6 % increase in HDL cholesterol, the so called good cholesterol. The Framingham risk score was also reduced by 7.6 %.

 

This was a low dose of B Vitamins which the researchers pointed out, so even at a low dose, there are benefits.

The following research is interesting because the participants were 46 patients with coronary artery disease given 400 mcg of folic acid daily or high dose folic acid of 5 mg daily for 7 weeks before coronary artery bypass grafting (Shirodaria C, et.al., 2007).

They were evaluated very thoroughly with MRI and vascular tissue levels of 5- Methyltetrahydrofolate levels, the metabolically active form of folate.

 

The researchers found that both the low dose and the high dose of folic acid equally improved vascular function through effects on endothelial nitric oxide synthase and vascular oxidative stress.

The MRI showed that the folic acid significantly improved both aortic and carotid artery distensibility compared to the placebo.

Aortic pulse-wave velocity, a measure of vascular stiffness was also significantly reduced compared to the placebo.

A significant reduction in vascular superoxide production was found from taking folic acid, which means that it had biologically important effects on vascular oxidative stress.

When 553 patients after having angioplasty because of coronary artery stenosis (blocked artery) were given 1000 mcg of folic acid, 400 mcg of   B12 and 10 mg of B6 per day or a placebo for 6 months , the B vitamins significantly decreased the incidence of major adverse events (Schnyder G, et.al., 2002).

This shows that when we have well designed clinical studies with a thorough evaluation, B vitamins provide important cardiovascular benefits.

If you only took 1 capsule a day of a high-quality B-Complex formula, you would receive important cardiovascular benefits according to the above studies.

 

 

References

Schnyder G, Roffi M, Flammer Y, Pin R, Hess OM. Effect of homocysteine-lowering therapy with folic acid, vitamin B12, and vitamin B6 on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial. JAMA. 2002 Aug 28;288(8):973-9.

Shirodaria C, Antoniades C, Lee J, Jackson CE, Robson MD, Francis JM, Moat SJ, Ratnatunga C, Pillai R, Refsum H, Neubauer S, Channon KM. Global improvement of vascular function and redox state with low-dose folic acid: implications for folate therapy in patients with coronary artery disease. Circulation. 2007 May 1;115(17):2262-70.

Wang L, Li H, Zhou Y, Jin L, Liu J. Low-dose B vitamins supplementation ameliorates cardiovascular risk: a double-blind randomized controlled trial in healthy Chinese elderly. Eur J Nutr. 2015 Apr;54(3):455-64.

 

Vitamin B Complex

The B1 (thiamine), B2 (riboflavin), B6 (pyridoxine), and B12 (cobalamin) comes in their physiologically active form, making them easier to absorb. 

Read more.. 

Prevent strokes the easy way.

Posted by on 5:53 pm Stroke, Vitamin B | 0 comments

Brain, strokes, preventionYou don’t want to experience a stroke: you may not survive it, or it may leave you disabled. There are several things you can implement to help prevent strokes, but the research reviewed here investigated one very simple prevention technique.

The investigators used published research to assess stroke events and the association between vitamin B supplementation in 54,913 participants (Ji Y, et al. 2013). They found that B vitamin supplementation significantly reduced stroke events because it reduced homocysteine, which is a toxic amino acid. Interestingly, no significant benefit was found using vitamin B12 alone.

It can’t be much simpler, just take a good quality vitamin B-complex every day!

Be aware that not all vitamin B-complex formulas are equal. There is more than one form of the B vitamins, and some forms provide more benefits than others. Providing the metabolites of the B vitamins is also an additional way of ensuring that you receive all the benefits you can from your B vitamin formula.You can read more about this by clicking here.

 

 

 

Ji Y, Tan S, Xu Y, Chandra A, Shi C, Song B, Qin J, Gao Y. Vitamin B supplementation, homocysteine levels, and the risk of cerebrovascular disease: A meta-analysis. Neurology. 2013 Oct 8;81(15):1298-307. doi: 10.1212/WNL.0b013e3182a823cc. Epub 2013 Sep 18.

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