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How To Favorably Change The Expression Of Your Genes In 4 Weeks

Posted by on 11:55 am General Health, Supplements | 0 comments

How your genes are expressed will determine how you feel and if you will be healthy.

Years ago it was believed that we could not change that, but that has been proven wrong.

While we can’t change our genes, we can change gene expression, and it does not have to take long.

In this research, the participants were given either 500 mg per day of magnesium or a placebo for 4 weeks (Chacko SA, et al. 2011).

After 4 weeks it was found that magnesium up-regulated 24 genes and down-regulated 36, including genes related to metabolic and inflammatory pathways.

It was concluded that magnesium supplementation for 4 weeks led to favorable changes in gene expression on several metabolic pathways.

When taking magnesium remember to take it as an amino acid chelate since that is much better absorbed and will not cause gastrointestinal irritation like magnesium oxide can.

Magnesium bisglycenate has shown to be both better absorbed and well tolerated.

It is also better to take magnesium in a formula which includes the other most common minerals because they tend to affect each other.

Taking only one may result in decreased levels of another one.

 

Reference:

Chacko SA1, Sul J, Song Y, Li X, LeBlanc J, You Y, Butch A, Liu S. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am J Clin Nutr. 2011 Feb;93(2):463-73. doi: 10.3945/ajcn.110.002949. Epub 2010 Dec 15.


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The BMJ Formula contains magnesium in an easy absorb-able form.

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How To Easily And Favorably Affect Your Gene Expression

Posted by on 9:45 am BMJ Formula, Supplements | 0 comments

Wouldn’t it be nice if you could express your genes in a way that made you feel better?

If you could do it both quickly and easily, that would be great. I think everybody agrees on that.

According to this research, you can actually do that (Chacko SA, et al. 2011).

This was an experimental study where healthy, overweight volunteers either received 500 mg of elemental magnesium per day or a placebo supplement for 4 weeks.

After 4 weeks, the group taking elemental supplement had lower fasting insulin.

This is important, since that is associated with better glucose and insulin metabolism.

In addition, the researchers also found that the group taking the supplementation showed up-regulation of 24 genes and down-regulation of 36 genes. This included genes related to metabolic and inflammatory pathways.

Therefore, the researchers concluded that magnesium supplementation for 4 weeks led to changes in gene expression, This is consistent with favorable effects on several metabolic pathways.

Moreover, it is important to know that magnesium oxide, the most common form of magnesium, can cause gastrointestinal irritation in high doses. In addition, it is also not well absorbed.

Hence, a better choice is an amino acid chelate like magnesium dis-glycinate since it is much better absorbed and also well tolerated.


Reference:

Chacko SA1, Sul J, Song Y, Li X, LeBlanc J, You Y, Butch A, Liu S. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am J Clin Nutr. 2011 Feb;93(2):463-73. doi: 10.3945/ajcn.110.002949. Epub 2010 Dec 15.


BMJ Formula

The BMJ Formula contains magnesium in an easy absorb-able form.

The BMJ Formula an easy way to effectively support bone, joints, connective tissue and neuromuscular function.

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Low Levels Of This Mineral Increases Cardiovascular Risk

Posted by on 9:45 am BMJ Formula, Supplements | 0 comments

When 9,820 study participants were tested for blood magnesium levels, this is what was found.

The participants with low magnesium levels had increased atherosclerosis (Kieboom BC, et al. 2016). The carotid intima media thickness was increased, that’s the inner layer of the blood vessel wall.

There seems, however, to be even more to the benefits of magnesium than that of decreased buildup in the arteries, even if that’s quite a nice benefit by itself.

The relationship with magnesium, coronary heart disease and sudden cardiac death could still not be explained fully.

There is plenty of evidence showing that low magnesium levels are associated with coronary artery calcification.

Measuring blood magnesium levels and using computed tomography in 34,553 study participants, documented that low magnesium levels were associated with coronary artery calcification (Lee SY, et al. 2015).

Even if blood levels of magnesium is within normal limits, it’s still possible to not have enough in other tissue.

This is easy to correct by taking magnesium in a well absorbed form that does not cause gastrointestinal irritation. Magnesium oxide(which is the most common form because it’s cheap) tends to cause gastrointestinal irritation.

The best form is an amino acid chelate like magnesium glycinate which is better absorbed without causing irritation.


References:

Kieboom BC1, Niemeijer MN2, Leening MJ3, van den Berg ME4, Franco OH2, Deckers JW5, Hofman A6, Zietse R7, Stricker BH1, Hoorn EJ7. Serum Magnesium and the Risk of Death From Coronary Heart Disease and Sudden Cardiac Death. J Am Heart Assoc. 2016 Jan 22;5(1). pii: e002707. doi: 10.1161/JAHA.115.002707.

Lee SY1, Hyun YY2, Lee KB3, Kim H3.  Low serum magnesium is associated with coronary artery calcification in a Korean population at low risk for cardiovascular disease. Nutr Metab Cardiovasc Dis. 2015 Nov;25(11):1056-61. doi: 10.1016/j.numecd.2015.07.010. Epub 2015 Aug 13.


BMJ Formula

The BMJ Formula contains magnesium in an easy absorb-able form.

The BMJ Formula an easy way to effectively support bone, joints, connective tissue and neuromuscular function.

                                Buy Now

What, Besides Inflammation, Causes Damage In Osteoarthritis?

Posted by on 9:45 am Supplements | 0 comments

Osteoarthritis is a very common condition, and we don’t have to be very old before we can detect signs of cartilage degeneration.

Hip and knee osteoarthritis is considered one of the leading causes of disability (Cross M, et al. 2014).

In addition to inflammation, which is probably the first thing you are thinking about when you hear the word arthritis, free radical damage is also involved.

According to this study, participants with osteoarthritis and a control group were measured for lipid peroxidation products to assess oxidative stress, indicating free radical damage (Surapaneni KM, Venkataramana G, 2007).

Moreover, glutathione, ascorbic acid, vitamin E and activities of antioxidant enzymes were also measured.

The results suggested higher free radical production with increased lipid peroxidation products, lower levels of glutathione, ascorbic acid and vitamin E among other things, in the group with osteoarthritis.

Glutathione is a very powerful antioxidant the body is making, but it makes less as we get older, and we actually need more.

Glutathione can be a very effective way of reducing free radical damage.

Therefore, Glutathione needs to get into the cells. Hence, you can now supplement with S-Acetyl Glutathione. It is the only available form of glutathione that gets into the cells where it is needed.


References:

Cross M1, Smith E1, Hoy D2, Nolte S3, Ackerman I4, Fransen M5, Bridgett L5, Williams S6, Guillemin F7, Hill CL8, Laslett LL9, Jones G9, Cicuttini F10, Osborne R11, Vos T12, Buchbinder R13, Woolf A14, March L1. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014 Jul;73(7):1323-30. doi: 10.1136/annrheumdis-2013-204763. Epub 2014 Feb 19.

Surapaneni KM1, Venkataramana G. Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with osteoarthritis. Indian J Med Sci. 2007 Jan;61(1):9-14.


Effective S-Acetyl Glutathione

Protect yourself

Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection and may also help reduce the risk of dementia. It is also the only form of glutathione shown to get into the cells where it is needed.

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This Is One Of The Most Important Substances In Your Cells

Posted by on 9:45 am Supplements | 0 comments

Glutathione is one of the most important substances in the body, and it’s found for the most part in your cells.

It plays important roles in the antioxidant defense, nutrient metabolism, and it regulates cellular events including gene expression (Wu G, et al. 2004).

Glutathione is also involved in the DNA and protein synthesis, cell proliferation and apoptosis  (cell death), signal transduction and the immune response.

Glutathione deficiency will therefore have a big impact on your health and the way you age.

A deficiency increases oxidative stress which plays a big role in aging and is a part of the process of many diseases from Alzheimer’s disease to other neurological conditions, liver disease, immune disorders, inflammation, cancer, cardiovascular disease, and diabetes.

Years ago there were no effective ways to supply glutathione, except intravenously.

This has now changed.

Glutathione can be taken orally, but it is only one form available which has shown to get into the cells where it is needed, and that is S-Acetyl Glutathione.


Wu G1, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004 Mar;134(3):489-92.

Effective S-Acetyl Glutathione

Protect yourself

Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection and may also help reduce the risk of dementia. It is also the only form of glutathione shown to get into the cells where it is needed.

Read More

Save

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This was found to damage harmful bacteria.

Posted by on 11:05 am Supplements | 0 comments

The danger of antibiotic resistant bacteria is increasing, and we need to find  other substances with antibacterial activity.

Curcumin has attracted a lot of attention since research has found it to lower inflammation.

It reduces several inflammatory cytokines.

Curcumin is also a potent antioxidant.

Curcumin has also been found to have anti-microbial activity against both fungi as well as several Gram-positive and Gram-negative bacteria (Neelofar K, et al. 2011, Liang G, et al. 2008).

The following research was especially interesting since it was focused on the antibacterial activity of curcumin and the possible reasons for that (Tyagi P, et al. 2015).

The study confirmed the broad-spectrum antibacterial properties of curcumin.

It found that curcumin damaged the cell membrane of these bacteria.

Remember when you use curcumin that regular curcumin is not well absorbed.

You need to take a formula with increased absorption.

I don’t recommend taking a formula with black pepper extract since that will inhibit the secondary detox pathway in the liver.

This will make toxins that are eliminated by that pathway stay in your body longer.

Liang G1, Yang S, Jiang L, Zhao Y, Shao L, Xiao J, Ye F, Li Y, Li X. Synthesis and anti-bacterial properties of mono-carbonyl analogues of curcumin. Chem Pharm Bull (Tokyo). 2008 Feb;56(2):162-7.
Neelofar K1, Shreaz S, Rimple B, Muralidhar S, Nikhat M, Khan LA. Curcumin as a promising anticandidal of clinical interest. Can J Microbiol. 2011 Mar;57(3):204-10. doi: 10.1139/W10-117.
Tyagi P1, Singh M1, Kumari H1, Kumari A1, Mukhopadhyay K1. Bactericidal activity of curcumin I is associated with damaging of bacterial membrane. PLoS One. 2015 Mar 26;10(3):e0121313. doi: 10.1371/journal.pone.0121313. eCollection 2015.

new-curcumin-2-croppedBetter Curcumin

The raw material in the new Better Curcumin is absorbed 65 times better than regular Curcumin and is very bio-available. Research has also shown that curcumin has broad-spectrum antibacterial properties.

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