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Antioxidants in joint fluid are reduced in osteoarthritis. This is what you can do.

Posted by on 6:50 am Antioxidents, Arthritis, Exercise, General Health, Joint health, Supplements, Supplements for Conditions, Supplements List | 0 comments

Excess reactive oxygen species and oxidative damage have been associated with the pathogenesis of osteoarthritis.  Joint fluid from patients with osteoarthritis is characterized by significantly decreased extracellular superoxide dismutase (SOD) levels, a significantly decreased glutathione level, and ascorbate when compared to knee joints with intact cartilage (Regan EA, et.al., 2008).

SOD is one of the body’s antioxidant enzymes and glutathione is the body’s most effective antioxidant.  These changes in joint fluid antioxidants are likely to accelerate the oxidative damage of the cartilage.

The body needs copper, zinc, and manganese to produce SOD, so one of the things you can do to help prevent cartilage degeneration is to take these minerals.  The glutathione level was also reduced, and you can also take S-Acetyl Glutathione to increase cellular glutathione (Cacciatore I, et.al., 2010).

Don’t make the mistake and supplement with reduced glutathione which is the most common form on the market.  No significant changes were observed in biomarkers of oxidative stress, including glutathione status of oral glutathione supplementation (Allen J, Bradley RD, 2011).

References

Allen J, Bradley RD.Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33.

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels. Molecules. 2010 Mar 3;15(3):1242-64.

Regan EA, Bowler RP, Crapo JD.Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injuryOsteoarthritis Cartilage. 2008 Apr;16(4):515-21.

 

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

 

 

 

 

 

You may know that you need calcium, but maybe you have heard that taking calcium may cause calcification of blood vessels.

Taking calcium by itself is not a good idea. You need to take calcium in a formula that includes multiple nutrients, and it needs to include magnesium. That’s one of the reasons the BMJ contains a large amount of magnesium in a very well absorbed form.

Click here to improve your bone, muscle, and joint health!

Want to slow down brain atrophy?

Posted by on 5:46 am Anti-Aging, Cognition, Dementia, Fish Oil, Flaxseeds, General Health, Stay healthy, Supplements, Vitamin B, Vitamin B12, Vitamins | 0 comments

Most likely everybody would like to slow down brain atrophy.  Who wouldn’t like more brain power? But is that even possible?  Take a look at the results from this research.

168 elderly people (≥70 y) with mild cognitive impairment were included and randomly assigned to either a placebo group or to a group taking a high-dose of B vitamins.

This is what they  took daily, 0.8 mg of folic acid, 20 mg of vitamin B-6, and 0.5 mg of vitamin B-12 (Jernerén F, et.al., 2015).

The participants underwent cranial magnetic resonance imaging scans when they started and 2 years later. The omega 3 fatty acid levels of EPA and DHA was also measured.

This what the researchers found.

The B vitamin treatment slowed the average atrophy rate by 40.0% compared with the placebo group. This happened however only in the participants who had high levels of omega 3 fatty acids at the start of the study.

Another study investigating cognitive decline in 266 participants 70 years or older found similar interesting results (Oulhaj A, et.al., 2016).

When omega-3 fatty acid concentrations are low, treatment with B vitamins had no effect on cognitive decline, but when omega-3 levels were in the upper normal range, B vitamins slowed cognitive decline.

Eating a lot of fish is not a good way anymore to increase your omega 3 fatty acid levels because all fish is now contaminated. A better choice is to use a high quality fish oil with high amounts of EPA and DHA, since that would not expose you to the same levels of contaminants.

It is also a good idea to take a B-complex formula that has the metabolite of folic acid, 5-methyltetrahydrofolate, because many people does not metabolize folic acid effectively.

References

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Jul;102(1):215-21.

Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA.Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis. 2016;50(2):547-57.

 

This is not a regular B vitamin formula.

The B1 (thiamine), B2 (riboflavin), B6 (pyridoxine), and B12 (cobalamin) comes in their physiologically active form, making them easier to absorb.

To get your bottle, click here.

 

 

 

Better Fish Oil

The anti-inflammatory effects of Omega 3 fatty acids are well known. Most people that eat a western diet can benefit from increasing the intake of Omega 3 fatty acid. Most fish oils on the market are ethyl esters because that’s cheaper to produce.

The Better Fish Oil comes in the form of triglycerides which offers better stability to the fatty acids and prevents breakdown and oxidation.

Get your bottle here.

Do you know about this important cardiovascular risk factor?

Posted by on 12:09 am Cardiovascular Disease, General Health, Supplements | 0 comments

This post is about a cardiovascular risk factor you may not have heard about, even though it may be one of the most important ones.

Research has indicated that oxidation of low-density lipoprotein (LDL) is a key factor in atherosclerosis.

This means that free radicals and the resulting inflammatory process are driving factors creating plaque in the vascular system.

The following study included 636 patients with suspected coronary artery disease, with an average follow-up period of 4.7 years (Blankenburg S, et.al., 2003).

The researchers found that the level of glutathione peroxidase 1 activity was significantly lower among those who died from cardiac causes or had a nonfatal myocardial infarction than among those who did not.

Glutathione is the major antioxidant that the body produces. Glutathione is also involved in liver detoxification and regulates immune function. It’s a very important substance.

It did not used to be any effective way to supply glutathione because the most common form, reduced glutathione, is oxidized in the stomach and does not provide benefits unless it is given with an IV.

However, now we have a very bioavailable form S-Acetyl Glutathione which gets into the cells where it is needed.

As we get older, we benefit from glutathione supplementation since the body produces less as we get older, and we use more, especially under certain circumstances.

Reference

Blankenberg S, Rupprecht HJ, Bickel C, Torzewski M, Hafner G, Tiret L, Smieja M, Cambien F, Meyer J, Lackner KJ; Glutathione peroxidase 1 activity and cardiovascular events in patients with coronary artery disease. N Engl J Med. 2003 Oct 23;349(17):1605-13.

 

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

What damage can high blood sugar and oxidative stress cause?

Posted by on 10:33 am Blood Pressure, Bloodsugar, Energy, General Health, Glucose, Health, Stress, Supplements, Wellness | 0 comments

It is common knowledge that having high blood sugar levels is damaging to our health, but in what way is it harmful to us?  

Having high blood glucose levels causes oxidation of glucose and a reaction causing glycation of proteins.  These reactions cause tissue damage and create a lot of free radicals. This also decreases the activity of superoxide dismutase–which is the body’s own antioxidant enzymes.  This decrease in antioxidant activity again will increase the oxidative stress in a seemingly endless cycle.

This oxidation and glycation reaction chain has shown to alter the mitochondria–which are the energy-producing entities of the cell–and has shown to be involved in a variety of diseases (Edeas, et. al., 2009).  The damaged mitochondria will produce less ATP (energy) than a normal mitochondria. Additionally, the damaged mitochondria cannot use glucose or lipids in a normal way. This means that a person with high blood sugar is unable to produce as much energy as they should.  

So what can be done to offset the production of these advanced glycation-end products?  The researchers of this study show that curcumin could suppress the advanced glycation-end products and also stimulate the synthesis of glutathione (Stefanska, 2012).

It is also important to eat food with a high nutrient content and low glycemic index, but you can take curcumin to help reduce damage from higher glucose levels. Just be sure that the curcumin you take is well absorbed since regular curcumin is not.  

Taking S-Acetyl Glutathione is also an excellent way to get protection from the negative effects of elevated blood glucose, it works really well.   Taking regular glutathione is not effective since it is oxidised in the stomach and not very bioavailable. Don’t waste your money.

References

Edeas, M, et al. “Maillard Reaction, Mitochondria and Oxidative Stress: Potential Role of Antioxidants.” Pathologie Biologie, Academic Press, 23 Dec. 2009, www.sciencedirect.com/science/article/pii/S0369811409001898.

Stefanska, B. “Curcumin Ameliorates Hepatic Fibrosis in Type 2 Diabetes Mellitus – Insights into Its Mechanisms of Action.” Addiction & Health, British Journal of Pharmacology , Aug. 2012, europepmc.org/articles/PMC3448887.

 

 

 

Curcumin is a good antioxidant but it is especially effective in helping to reduce inflammation. For these reasons, curcumin provides many health benefits.

The raw material used in the Better Curcumin formula is the only form of curcumin shown to pass through the blood-brain barrier and improve memory (Cox KH, et al. 2015).

Click here to learn more!

 

 

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

 

What can you do to help your immune system to better protect yourself from pathogens like viruses?

Posted by on 9:52 am Anti-aging, General Health, General Health, Health, Supplements, Wellness | 0 comments

We are exposed to pathogens–especially viruses–all the time and our immune system is very effective at protecting us.  This means that most of the time, we don’t get sick.

Research has, however, found evidence of decreased levels of glutathione in several diseases–such as cancer, viral infections and immune dysfunction–as well as in aging (Fraternale A, et.al., 2006, Fraternale A, et. al., 2017).

Intra-cellular glutathione levels influence the Th1/Th2 immune response and the effectiveness of the immune system.

The body makes glutathione, which is involved in many cellular functions such as detoxification, amino acid transport, production of coenzymes, and the recycling of vitamins E and C.

Glutathione has also been found to inhibit viral replication (Fraternale, et.al., 2006).

It’s no doubt that glutathione is very important, and as long as your body is able to make what’s necessary to protect you, everything is fine.

The problem, however, is that the body is not able to provide adequate amounts of glutathione as we get older. The decrease is gradual.  Additionally, the rate of decrease depends on our exposure to pathogens, toxins, and oxidative stressors that require the protection of glutathione.  

You would not usually need to supplement with glutathione in your twenties, but as you get into your forties, the need for supplementation will increase.

Reduced glutathione–which is the most common form on the market–is not very effective since it is oxidized in your stomach and very little is absorbed.

S-Acetyl Glutathione a patented substance is however very effective and gets into the cells where it is needed (Cacciatore I, et.al., 2010).

Researchers have proposed molecules able to increase glutathione levels as new tools to more effectively hinder different pathogens by acting as both immunomodulators and antimicrobials.

References

Cacciatore I1, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levelsMolecules. 2010 Mar 3;15(3):1242-64.

Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55.

Fraternale A, Brundu S, Magnani M. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275.

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

How To Favorably Change The Expression Of Your Genes In 4 Weeks

Posted by on 11:55 am General Health, Supplements | 0 comments

How your genes are expressed will determine how you feel and if you will be healthy.

Years ago it was believed that we could not change that, but that has been proven wrong.

While we can’t change our genes, we can change gene expression, and it does not have to take long.

In this research, the participants were given either 500 mg per day of magnesium or a placebo for 4 weeks (Chacko SA, et al. 2011).

After 4 weeks it was found that magnesium up-regulated 24 genes and down-regulated 36, including genes related to metabolic and inflammatory pathways.

It was concluded that magnesium supplementation for 4 weeks led to favorable changes in gene expression on several metabolic pathways.

When taking magnesium remember to take it as an amino acid chelate since that is much better absorbed and will not cause gastrointestinal irritation like magnesium oxide can.

Magnesium bisglycenate has shown to be both better absorbed and well tolerated.

It is also better to take magnesium in a formula which includes the other most common minerals because they tend to affect each other.

Taking only one may result in decreased levels of another one.

 

Reference:

Chacko SA1, Sul J, Song Y, Li X, LeBlanc J, You Y, Butch A, Liu S. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am J Clin Nutr. 2011 Feb;93(2):463-73. doi: 10.3945/ajcn.110.002949. Epub 2010 Dec 15.


BMJ Formula

The BMJ Formula contains magnesium in an easy absorb-able form.

The BMJ Formula an easy way to effectively support bone, joints, connective tissue and neuromuscular function.

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