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What can you do to help your immune system to better protect yourself from pathogens like viruses?

Posted by on 9:52 am Anti-aging, General Health, General Health, Health, Supplements, Wellness | 0 comments

We are exposed to pathogens–especially viruses–all the time and our immune system is very effective at protecting us.  This means that most of the time, we don’t get sick.

Research has, however, found evidence of decreased levels of glutathione in several diseases–such as cancer, viral infections and immune dysfunction–as well as in aging (Fraternale A, et.al., 2006, Fraternale A, et. al., 2017).

Intra-cellular glutathione levels influence the Th1/Th2 immune response and the effectiveness of the immune system.

The body makes glutathione, which is involved in many cellular functions such as detoxification, amino acid transport, production of coenzymes, and the recycling of vitamins E and C.

Glutathione has also been found to inhibit viral replication (Fraternale, et.al., 2006).

It’s no doubt that glutathione is very important, and as long as your body is able to make what’s necessary to protect you, everything is fine.

The problem, however, is that the body is not able to provide adequate amounts of glutathione as we get older. The decrease is gradual.  Additionally, the rate of decrease depends on our exposure to pathogens, toxins, and oxidative stressors that require the protection of glutathione.  

You would not usually need to supplement with glutathione in your twenties, but as you get into your forties, the need for supplementation will increase.

Reduced glutathione–which is the most common form on the market–is not very effective since it is oxidized in your stomach and very little is absorbed.

S-Acetyl Glutathione a patented substance is however very effective and gets into the cells where it is needed (Cacciatore I, et.al., 2010).

Researchers have proposed molecules able to increase glutathione levels as new tools to more effectively hinder different pathogens by acting as both immunomodulators and antimicrobials.

References

Cacciatore I1, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levelsMolecules. 2010 Mar 3;15(3):1242-64.

Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55.

Fraternale A, Brundu S, Magnani M. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275.

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

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How To Favorably Change The Expression Of Your Genes In 4 Weeks

Posted by on 11:55 am General Health, Supplements | 0 comments

How your genes are expressed will determine how you feel and if you will be healthy.

Years ago it was believed that we could not change that, but that has been proven wrong.

While we can’t change our genes, we can change gene expression, and it does not have to take long.

In this research, the participants were given either 500 mg per day of magnesium or a placebo for 4 weeks (Chacko SA, et al. 2011).

After 4 weeks it was found that magnesium up-regulated 24 genes and down-regulated 36, including genes related to metabolic and inflammatory pathways.

It was concluded that magnesium supplementation for 4 weeks led to favorable changes in gene expression on several metabolic pathways.

When taking magnesium remember to take it as an amino acid chelate since that is much better absorbed and will not cause gastrointestinal irritation like magnesium oxide can.

Magnesium bisglycenate has shown to be both better absorbed and well tolerated.

It is also better to take magnesium in a formula which includes the other most common minerals because they tend to affect each other.

Taking only one may result in decreased levels of another one.

 

Reference:

Chacko SA1, Sul J, Song Y, Li X, LeBlanc J, You Y, Butch A, Liu S. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am J Clin Nutr. 2011 Feb;93(2):463-73. doi: 10.3945/ajcn.110.002949. Epub 2010 Dec 15.


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The BMJ Formula contains magnesium in an easy absorb-able form.

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How To Easily And Favorably Affect Your Gene Expression

Posted by on 9:45 am BMJ Formula, Supplements | 0 comments

Wouldn’t it be nice if you could express your genes in a way that made you feel better?

If you could do it both quickly and easily, that would be great. I think everybody agrees on that.

According to this research, you can actually do that (Chacko SA, et al. 2011).

This was an experimental study where healthy, overweight volunteers either received 500 mg of elemental magnesium per day or a placebo supplement for 4 weeks.

After 4 weeks, the group taking elemental supplement had lower fasting insulin.

This is important, since that is associated with better glucose and insulin metabolism.

In addition, the researchers also found that the group taking the supplementation showed up-regulation of 24 genes and down-regulation of 36 genes. This included genes related to metabolic and inflammatory pathways.

Therefore, the researchers concluded that magnesium supplementation for 4 weeks led to changes in gene expression, This is consistent with favorable effects on several metabolic pathways.

Moreover, it is important to know that magnesium oxide, the most common form of magnesium, can cause gastrointestinal irritation in high doses. In addition, it is also not well absorbed.

Hence, a better choice is an amino acid chelate like magnesium dis-glycinate since it is much better absorbed and also well tolerated.


Reference:

Chacko SA1, Sul J, Song Y, Li X, LeBlanc J, You Y, Butch A, Liu S. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am J Clin Nutr. 2011 Feb;93(2):463-73. doi: 10.3945/ajcn.110.002949. Epub 2010 Dec 15.


BMJ Formula

The BMJ Formula contains magnesium in an easy absorb-able form.

The BMJ Formula an easy way to effectively support bone, joints, connective tissue and neuromuscular function.

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Low Levels Of This Mineral Increases Cardiovascular Risk

Posted by on 9:45 am BMJ Formula, Supplements | 0 comments

When 9,820 study participants were tested for blood magnesium levels, this is what was found.

The participants with low magnesium levels had increased atherosclerosis (Kieboom BC, et al. 2016). The carotid intima media thickness was increased, that’s the inner layer of the blood vessel wall.

There seems, however, to be even more to the benefits of magnesium than that of decreased buildup in the arteries, even if that’s quite a nice benefit by itself.

The relationship with magnesium, coronary heart disease and sudden cardiac death could still not be explained fully.

There is plenty of evidence showing that low magnesium levels are associated with coronary artery calcification.

Measuring blood magnesium levels and using computed tomography in 34,553 study participants, documented that low magnesium levels were associated with coronary artery calcification (Lee SY, et al. 2015).

Even if blood levels of magnesium is within normal limits, it’s still possible to not have enough in other tissue.

This is easy to correct by taking magnesium in a well absorbed form that does not cause gastrointestinal irritation. Magnesium oxide(which is the most common form because it’s cheap) tends to cause gastrointestinal irritation.

The best form is an amino acid chelate like magnesium glycinate which is better absorbed without causing irritation.


References:

Kieboom BC1, Niemeijer MN2, Leening MJ3, van den Berg ME4, Franco OH2, Deckers JW5, Hofman A6, Zietse R7, Stricker BH1, Hoorn EJ7. Serum Magnesium and the Risk of Death From Coronary Heart Disease and Sudden Cardiac Death. J Am Heart Assoc. 2016 Jan 22;5(1). pii: e002707. doi: 10.1161/JAHA.115.002707.

Lee SY1, Hyun YY2, Lee KB3, Kim H3.  Low serum magnesium is associated with coronary artery calcification in a Korean population at low risk for cardiovascular disease. Nutr Metab Cardiovasc Dis. 2015 Nov;25(11):1056-61. doi: 10.1016/j.numecd.2015.07.010. Epub 2015 Aug 13.


BMJ Formula

The BMJ Formula contains magnesium in an easy absorb-able form.

The BMJ Formula an easy way to effectively support bone, joints, connective tissue and neuromuscular function.

                                Buy Now

What, Besides Inflammation, Causes Damage In Osteoarthritis?

Posted by on 9:45 am Supplements | 0 comments

Osteoarthritis is a very common condition, and we don’t have to be very old before we can detect signs of cartilage degeneration.

Hip and knee osteoarthritis is considered one of the leading causes of disability (Cross M, et al. 2014).

In addition to inflammation, which is probably the first thing you are thinking about when you hear the word arthritis, free radical damage is also involved.

According to this study, participants with osteoarthritis and a control group were measured for lipid peroxidation products to assess oxidative stress, indicating free radical damage (Surapaneni KM, Venkataramana G, 2007).

Moreover, glutathione, ascorbic acid, vitamin E and activities of antioxidant enzymes were also measured.

The results suggested higher free radical production with increased lipid peroxidation products, lower levels of glutathione, ascorbic acid and vitamin E among other things, in the group with osteoarthritis.

Glutathione is a very powerful antioxidant the body is making, but it makes less as we get older, and we actually need more.

Glutathione can be a very effective way of reducing free radical damage.

Therefore, Glutathione needs to get into the cells. Hence, you can now supplement with S-Acetyl Glutathione. It is the only available form of glutathione that gets into the cells where it is needed.


References:

Cross M1, Smith E1, Hoy D2, Nolte S3, Ackerman I4, Fransen M5, Bridgett L5, Williams S6, Guillemin F7, Hill CL8, Laslett LL9, Jones G9, Cicuttini F10, Osborne R11, Vos T12, Buchbinder R13, Woolf A14, March L1. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014 Jul;73(7):1323-30. doi: 10.1136/annrheumdis-2013-204763. Epub 2014 Feb 19.

Surapaneni KM1, Venkataramana G. Status of lipid peroxidation, glutathione, ascorbic acid, vitamin E and antioxidant enzymes in patients with osteoarthritis. Indian J Med Sci. 2007 Jan;61(1):9-14.


Effective S-Acetyl Glutathione

Protect yourself

Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection and may also help reduce the risk of dementia. It is also the only form of glutathione shown to get into the cells where it is needed.

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This Is One Of The Most Important Substances In Your Cells

Posted by on 9:45 am Supplements | 0 comments

Glutathione is one of the most important substances in the body, and it’s found for the most part in your cells.

It plays important roles in the antioxidant defense, nutrient metabolism, and it regulates cellular events including gene expression (Wu G, et al. 2004).

Glutathione is also involved in the DNA and protein synthesis, cell proliferation and apoptosis  (cell death), signal transduction and the immune response.

Glutathione deficiency will therefore have a big impact on your health and the way you age.

A deficiency increases oxidative stress which plays a big role in aging and is a part of the process of many diseases from Alzheimer’s disease to other neurological conditions, liver disease, immune disorders, inflammation, cancer, cardiovascular disease, and diabetes.

Years ago there were no effective ways to supply glutathione, except intravenously.

This has now changed.

Glutathione can be taken orally, but it is only one form available which has shown to get into the cells where it is needed, and that is S-Acetyl Glutathione.


Wu G1, Fang YZ, Yang S, Lupton JR, Turner ND. Glutathione metabolism and its implications for health. J Nutr. 2004 Mar;134(3):489-92.

Effective S-Acetyl Glutathione

Protect yourself

Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection and may also help reduce the risk of dementia. It is also the only form of glutathione shown to get into the cells where it is needed.

Read More

Save

Save