This research tested whether supplementation of resveratrol would enhance memory
performance in older adults (Witte AV, et.al., 2014).
The participants were 23 healthy overweight females and males 50-75 years old which were
matched to 23 participants given a placebo.
The study went on for 26 weeks, and the dose of resveratrol used was 200 mg per day.
At the beginning and at the end of the study period, the participants underwent memory tasks
and neuroimaging to assess volume, microstructure, and functional connectivity of the
hippocampus, a key region implicated in memory functions.
Glucose, lipid metabolism, inflammation, neurotrophic factors, and vascular parameters were
The researchers reported a significant effect from taking resveratrol on retention of words over
30 min compared with the placebo.
In addition, resveratrol led to significant increases in hippocampal functional connectivity,
decreases in glycosylated hemoglobin (HbA1c) and body fat, and increases in leptin when
compared with the placebo.
HbA1c is a measurement of long term glucose control, and leptin is a hormone that regulates
appetite. An increase in leptin will usually make you less hungry. To both see an improvement in memory and glucose metabolism just from taking resveratrol is very interesting.
Resveratrol supplementation has shown to improve executive function and memory in older adults (Thaung Zaw JJ., et.al., 2017).
The benefits were due to improved cerebral perfusion, circulation in the brain.
When 80 post-menopausal women were supplementing with trans-resveratrol or a placebo for 14 weeks, the researchers found that the women taking the resveratrol had significant improvements in verbal memory and overall cognitive function (Evans HM, et.al., 2017).
The researchers also measured cerebrovascular responsiveness and found an increase of 17% in the women taking resveratrol.
The dosage producing the improvements was low.
Only 75 mg of resveratrol taken twice a day was required to produce the results.
Post-menopausal women are at a higher risk for memory loss because of hormonal changes.
The bioavailability of resveratrol is low. That can, however, be greatly improved by using a methylated form of resveratrol (Wen X, Walle T, 2017).
Resveratrol is found in the skin of grapes, but also in other various plants. It is known as an antioxidant and got a lot of attention when a study on mice showed that resveratrol increased their lifespan spite of a high fat, high-calorie diet. Some of the changes included improved insulin sensitivity, increased number of mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).
Women are especially prone to bone loss after menopause, but men can also develop osteoporosis.
The reviewed research investigated bone loss in men with metabolic syndrome (Ornstrup MJ, et al. 2014). The metabolic syndrome is associated with increased low grade inflammation and an increased risk for osteoporosis.
The participants were given a daily dose of either 1000 mg of Resveratrol, 150 mg of Resveratrol or a placebo for 16 weeks. Assessments were done for changes in bone turnover markers and bone mineral density.
It was found that Resveratrol had a dose dependent, positive effect on bone by stimulating bone formation or mineralization. The higher dose of Resveratrol showed a significant change.
Because there are now ways to increase the bio-availability of Resveratrol, you don’t necessarily have to take such a high dose.
Resveratrol is found in the skin of grapes, but also in other various plants.
It is known as an antioxidant.
Resveratrol was found to stimulate SIRT-1, one of the longevity genes.
Some of the other changes also include improved insulin sensitivity, increased number of
mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).
Research has documented huge benefits from resveratrol, but that has been in animals. Human research, however, has been lacking until now. In the reviewed study the researchers investigated the effects of 200 mg per day of resveratrol in 23 healthy, overweight individuals between the age of 50 and 75 years (Witte AV et al. 2014). The participants were compared with a placebo group over a period of 26 weeks. Before the investigation started, neuroimaging to assess volume, micro-structure and functional connectivity of the hippocampus; a key region associated with memory, was performed in addition to several other tests.
The results were impressive. The participants had a significant improvement in memory performance and hippocampal functional connectivity. There was also noted a significant decrease in HbA1c and body fat, and an increase in leptin.
HbA1c is a long term measurement of glucose control and leptin is a hormone involved in the regulation of hunger and the amount of fat stored.
That looks like an easy way to improve both memory and glucose control.