Your Road to Wellness

Nervous System

This antioxidant is lower in neurodegenerative diseases like Alzheimer’s.

Posted by on 8:32 am Alzheimer’s, Antioxidents, Brain, Dementia, Depression, Nervous System | 0 comments

 

This antioxidant is lower in neurodegenerative diseases like Alzheimer’s.

 

There are good reasons why the body produces its own antioxidant enzymes.

All tissues including the nervous system and the brain are exposed to free radical damage.

The most important antioxidant the body is making is probably glutathione.

Humans with neurodegenerative and neuropsychiatric disorders have demonstrated altered levels of glutathione and oxidized glutathione (Gu F, et.al., 2015).  A decreased ratio of glutathione to oxidized glutathione has been found in the blood and brain of these individuals.

 

 

Glutathione depletion can lead to abnormalities of a mitochondrial function where the cells make energy. A few studies have shown that glutathione deficiency occurs prior to neuropathological abnormalities.

These researchers found that glutathione was significantly decreased in the red blood cells from male patients with Alzheimer’s disease (Liu H, et.al., 2004).

 

 

The most common form of glutathione is reduced glutathione, but don’t take that. This form of glutathione is oxidized in the stomach and does not provide many benefits.

S-acetyl glutathione on the other hand gets into the cells where it’s needed (Cacciatore I, et al., 2010).

 

References:

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A.Prodrug approach for increasing cellular glutathione levels.Molecules. 2010 Mar 3;15(3):1242-64.

Gu F, Chauhan V, Chauhan A.Glutathione redox imbalance in brain disorders.Curr Opin Clin Nutr Metab Care. 2015 Jan;18(1):89-95.

Liu H, Wang H, Shenvi S, Hagen TM, Liu RM.Glutathione metabolism during aging and in Alzheimer disease.Ann N Y Acad Sci. 2004 Jun;1019:346-9.

 

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The neurovascular system, oxidative stress and neurodegenerative diseases like Alzheimer’s. What can you do to protect yourself?

Posted by on 7:31 am Alzheimer’s, Cardiovascular Disease, Dementia, Nervous System | 0 comments

oxidative stress

 

It is very important to have a good blood supply to every tissue in the body.  All tissues, but especially the brain, depending on the good blood supply to function properly.  This is most important for the brain because it has a very high energy demand.

Neurons, glial cells, and blood vessels communicate with each other to regulate cerebral blood flow.

This study gathered information on the importance of oxidative stress as it relates to vascular changes observed in brain aging and neurodegenerative conditions like Alzheimer’s (Carvalho C, Moreira PI, 2018).

 

 

One of the emerging causative factors associated with Alzheimer’s pathology is oxidative stress.  This Alzheimer’s-related increase in oxidative stress has been attributed to decreased levels of the brain antioxidant, glutathione (Saharan S, Mandal PK, 2014).

Glutathione protects cells against oxidative stress, and protecting brain endothelial cells under oxidative stress is key to treating cerebrovascular diseases and neurodegenerative diseases including Alzheimer’s disease (Song J, et.al., 2014).  The endothelium is the inner layer of the blood vessel wall.

The body makes glutathione, but it is making less as we get older, and that’s when we need more.

We can, however, take glutathione orally.   Regularly reduced glutathione which is the most common form you will find for sale is not very bioavailable, most of it is oxidized in the stomach and is not going to provide much protection.

You can instead take S-Acetyl Glutathione which gets into the cells and provides very valuable protection from free radical damage.

 

References:

Carvalho C, Moreira PI, Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events.Front Physiol. 2018 Jul 3;9:806.

Saharan S, Mandal PK. The emerging role of glutathione in Alzheimer’s disease. J Alzheimers Dis. 2014;40(3):519-29.

Song J, Kang SM, Lee WT, Park KA, Lee KM, Lee JE.Glutathione protects brain endothelial cells from hydrogen peroxide-induced oxidative stress by increasing nrf2 expression.Exp Neurobiol. 2014 Mar;23(1):93-103. 

 

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Osteoarthritis in women associated with deposits in Arteries

Posted by on 12:33 pm Asthma, BMJ Formula, Calories, Diet, Energy, Exercise, General Health, Health Risk, Heart disease, Muscles, Nervous System, Research, Wellness, Women, Womens health | 0 comments

Research sometimes find interesting connections we usually don’t think about.

A study including 3278 women found an association between plaque in the carotid artery and osteoarthritis in the knee and hands in women (Hoeven TA, et.al., 2013).

We know that inflammation is involved in osteoarthritis, even if it is less severe than in rheumatoid arthritis.

We also know that inflammation increases the risk for cardiovascular disease. Inflammation is an important factor in depositing cholesterol and fat into the inner lining of the vascular wall.

 

Another interesting connection found lower magnesium levels in rheumatoid arthritis patients compared to controls (Chavan VU, et.al., 2015).

Lower magnesium levels were also correlated with higher cholesterol and LDL, the so called bad cholesterol, and higher magnesium levels with better HDL cholesterol, the good cholesterol. This was in cases of rheumatoid arthritis.

 

Magnesium has also been found to be inversely associated with osteoarthritis documented on x-rays and joint space narrowing (Zeng C, et.al., 2015).

Glucosamine sulfate another nutritional substance has been used to treat osteoarthritis for many years.

When osteoarthritic chondrocytes (cartilage cells) and glucosamine sulfate were tested in different ways in a culture, it was found that glucosamine sulfate reduced the synthesis of proinflammatory mediators (Largo R, et.al., 2003).

Taking magnesium and glucosamine sulfate could according to this possibly benefit both your cardiovascular system and your joints.

The best form of magnesium is an amino acid chelate like magnesium glycinate.

The most common form of magnesium is magnesium oxide, but that is a gastrointestinal irritant and can give you diarrhea when taken in higher amounts.

 

REFERENCE

Chavan, V. U., Ramavataram, D. V. S. S., Patel, P. A., & Rupani, M. P. (2015). Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis. Journal of clinical and diagnostic research: JCDR, 9(4), BC01.

Hoeven, T. A., Kavousi, M., Clockaerts, S., Kerkhof, H. J., van Meurs, J. B., Franco, O., … & Bierma-Zeinstra, S. (2012). Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study. Annals of the rheumatic diseases, annrheumdis-2011.

Largo R, Alvarez-Soria MA, Díez-Ortego I, Calvo E, Sánchez-Pernaute O, Egido J, Herrero-Beaumont G. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes.Osteoarthritis Cartilage. 2003 Apr;11(4):290-8.

Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, Zhang Y, Yang TB, Lei GH. Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis. PLoS One. 2015 May 26;10(5):e0127666.

 

 

 

 

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Protect your brain and nervous system from damage.

Posted by on 9:45 am Nervous System | 0 comments

Oxidative stress from free radicals can damage all tissue including the brain and the nervous system.

In addition to that, there are many substances that could be damaging to the brain and the nervous system.

For these reasons the body has been equipped with certain protective mechanisms, the blood-cerebrospinal fluid barrier and the blood-brain barrier are two such mechanisms.

If we could support the protective functions of both the brain and the nervous system, it would be beneficial, I think we all can agree on that.

The good news is that there are several things we can do, and there is one thing which is both very effective and also easy to implement.

The blood-cerebrospinal fluid barrier efficiency can be enhanced by increasing glutathione within the epithelial cells (Ghersi-Egea JF, et al. 2006).

Epithelial cells line the surface of the blood vessels.

Glutathione is the most effective antioxidant the body is making, but as we get older we make less and need more.

Oxidative stress has been associated with both mild cognitive impairment and Alzheimer disease (Pocemich CB, Butterfield DA, 2012).

This makes a good case for supplementing with glutathione.

Some years back we were not able to do that in a meaningful way, since the glutathione on the market was not very effective in raising blood levels of glutathione.

Actually most of the glutathione on the market is still in a form which is oxidized in the stomach (destroyed) and does not do much good.

The glutathione needs to get into the cells which need protection.

S-Acetyl Glutathione is such a substance and is for that reason a very effective antioxidant.

The good news, it is also very easy to take since it comes in small capsules.

Ghersi-Egea JF1, Strazielle N, Murat A, Jouvet A, Buénerd A, Belin MF. Brain protection at the blood-cerebrospinal fluid interface involves a glutathione-dependent metabolic barrier mechanism. J Cereb Blood Flow Metab. 2006 Sep;26(9):1165-75. Epub 2006 Jan 4.
Pocernich CB1, Butterfield DA. Elevation of glutathione as a therapeutic strategy in Alzheimer disease. Biochim Biophys Acta. 2012 May;1822(5):625-30. doi: 10.1016/j.bbadis.2011.10.003. Epub 2011 Oct 12.

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Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection.

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Protect your nervous system.

Posted by on 10:51 am Nervous System | 0 comments

There are many things that can damage the nervous system.

I am going to cover the most common and important factors here.

A good model to use is to look at what’s causing diabetic neuropathy. It’s very common, and even if you don’t have diabetes, you are affected by the same factors.

The mechanisms underlying the development of neuronal damage are high blood glucose, oxidative stress and inflammation (Rahman MH, et al. 2016, Sandireddy R, et al. 2014).

These facts are well documented.

You don’t have to have high blood glucose levels, oxidative stress, and inflammation as high as somebody who has diabetes for the nervous system to be negatively impacted.

If you eat high glycemic index food regularly (which elevates your blood glucose high), it will create advanced glycation end products and cause tissue damage.

Not only that, but it will also cause oxidative stress and inflammation.

The type of inflammation I am talking about here is the low grade inflammation which affects your whole body and is a risk factor for all chronic diseases.

A high nutrient low glycemic index diet(ideally vegan), is a very effective way to correct that.

Regular physical activity also helps, and it does not have to take a lot of time if you do it in an effective way.

There is also a couple of other things you can do.

To help protect yourself further from oxidative stress, you can take glutathione in the form of S-Acetyl Glutathione which gets into the cells.

To help protect yourself further from inflammation, curcumin in a well absorbed form is very useful.

Rahman MH, Jha MK, Suk K1. Evolving Insights into the Pathophysiology of Diabetic Neuropathy: Implications of Malfunctioning Glia and Discovery of Novel Therapeutic Targets. Curr Pharm Des. 2016;22(6):738-57.
Sandireddy R1, Yerra VG1, Areti A1, Komirishetty P1, Kumar A1. Neuroinflammation and oxidative stress in diabetic neuropathy: futuristic strategies based on these targets. Int J Endocrinol. 2014;2014:674987. doi: 10.1155/2014/674987. Epub 2014 Apr 30.

 Effective S-Acetyl GlutathioneEffective S-Acetyl Glutathione Transparent

Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection.

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Better Curcumin

IMG_11002Research on curcumin has documented the ability of this natural substance to regulate numerous inflammatory pathways (Gupta SC, et al. 2013, Aggarval BB, Harikumar KB, 2009). It is also a good antioxidant.

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