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What damage can high blood sugar and oxidative stress cause?

Posted by on 10:33 am Blood Pressure, Bloodsugar, Energy, General Health, Glucose, Health, Stress, Supplements, Wellness | 0 comments

It is common knowledge that having high blood sugar levels is damaging to our health, but in what way is it harmful to us?  

Having high blood glucose levels causes oxidation of glucose and a reaction causing glycation of proteins.  These reactions cause tissue damage and create a lot of free radicals. This also decreases the activity of superoxide dismutase–which is the body’s own antioxidant enzymes.  This decrease in antioxidant activity again will increase the oxidative stress in a seemingly endless cycle.

This oxidation and glycation reaction chain has shown to alter the mitochondria–which are the energy-producing entities of the cell–and has shown to be involved in a variety of diseases (Edeas, et. al., 2009).  The damaged mitochondria will produce less ATP (energy) than a normal mitochondria. Additionally, the damaged mitochondria cannot use glucose or lipids in a normal way. This means that a person with high blood sugar is unable to produce as much energy as they should.  

So what can be done to offset the production of these advanced glycation-end products?  The researchers of this study show that curcumin could suppress the advanced glycation-end products and also stimulate the synthesis of glutathione (Stefanska, 2012).

It is also important to eat food with a high nutrient content and low glycemic index, but you can take curcumin to help reduce damage from higher glucose levels. Just be sure that the curcumin you take is well absorbed since regular curcumin is not.  

Taking S-Acetyl Glutathione is also an excellent way to get protection from the negative effects of elevated blood glucose, it works really well.   Taking regular glutathione is not effective since it is oxidised in the stomach and not very bioavailable. Don’t waste your money.

References

Edeas, M, et al. “Maillard Reaction, Mitochondria and Oxidative Stress: Potential Role of Antioxidants.” Pathologie Biologie, Academic Press, 23 Dec. 2009, www.sciencedirect.com/science/article/pii/S0369811409001898.

Stefanska, B. “Curcumin Ameliorates Hepatic Fibrosis in Type 2 Diabetes Mellitus – Insights into Its Mechanisms of Action.” Addiction & Health, British Journal of Pharmacology , Aug. 2012, europepmc.org/articles/PMC3448887.

 

 

 

Curcumin is a good antioxidant but it is especially effective in helping to reduce inflammation. For these reasons, curcumin provides many health benefits.

The raw material used in the Better Curcumin formula is the only form of curcumin shown to pass through the blood-brain barrier and improve memory (Cox KH, et al. 2015).

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Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

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Stress shortens your telomeres…but why does that matter?

Posted by on 7:26 am Anti-Aging, General Health, Happiness, Health, Meditation, Stress, Wellness | 0 comments

A telomere is a region of repetitive nucleotides consisting of DNA and RNA at the end of a chromosome that protects the chromosome from deterioration.

Shorter telomeres are known to determine cell longevity and shorter telomeres lead to a shorter lifespan.  Telomeres can therefore give us information on how fast we age.

Several factors can affect the length of the telomeres. We will look at one of these factors here.

Psychological stress, both perceived stress and chronicity of stress. is significantly associated with higher oxidative stress, lower telomerase activity, and shorter telomere length (Epel ES, et.al., 2004).

In a study which included 2911 men and women aged 30-64, a significant association was found between work exhaustion and telomere length related to the acceleration of the rate of biological aging (Ahola K, et.al., 2012).

In this study the researchers  examined relative telomere length in a group of individuals experienced in Loving-Kindness Meditation, a practice derived from the Buddhist tradition (Hoge EA, et.al., 2013).

The meditation practitioners had longer telomeres than the group not practicing meditation indicating an effect on longevity.

When family dementia caregivers were practicing Kirtan Kriya meditation or listening to relaxation music for 12 min per day for 8 weeks, this was the results.

The meditation group showed 43% improvement in telomerase activity compared with 3.7% in the relaxation group (Lavretsky H, et. al., 2013).

The meditation group also improved mental and cognitive functioning and had lower levels of depressive symptoms.

This is one of the things you can do to keep your telomeres longer and counteract stress.  Starting to meditate regularly is well worth the time you spend on the meditating,

References

Ahola K, Sirén I, Kivimäki M, Ripatti S, Aromaa A, Lönnqvist J, Hovatta I.Work-related exhaustion and telomere length: a population-based study. PLoS One. 2012;7(7):e40186.

Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM, Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci USA. 2004 Dec 7;101(49):17312-5.

Hoge EA, Chen MM, Orr E, Metcalf CA, Fischer LE, Pollack MH, De Vivo I, Simon NM. Loving-Kindness Meditation practice associated with longer telomeres in women. Brain Behav Immun. 2013 Aug;32:159-63.

Lavretsky H, Epel ES, Siddarth P, Nazarian N, Cyr NS, Khalsa DS, Lin J, Blackburn E, Irwin MR. A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity. Int J Geriatr Psychiatry. 2013 Jan;28(1):57-65.

 

 

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This function is involved in a variety conditions from viral diseases to heart disease, stroke and diabetes

Posted by on 7:25 am Cardiovascular Disease, Diet, Diseases, Eating, General Health, Green tea, Health, Nut consumption, Stay healthy, The Learn to Eat Plan, Vegetables, Wellness | 0 comments

Vascular endothelial cells line the entire circulatory system, from the heart to the smallest capillaries.  

The endothelium is the inner layer of the blood vessels and is extremely important.

When the endothelium is functioning normally, it helps to regulate blood clotting, assists the body’s immune response, controls the volume of fluid and the amount of electrolytes and other substances that pass from the blood into the tissues, and produces dilation or constriction of the blood vessels.

The endothelium is directly involved in peripheral vascular disease, stroke, heart disease, diabetes, insulin resistance,  chronic kidney failure, tumor growth, metastasis, venous thrombosis, and severe viral infectious diseases (Rajendran P, et.al., 2013).

Free radicals can disrupt the balance of NO (Nitric Oxide), damage the endothelium, and leave it overly permeable, allowing toxins to pass into body tissues (Rubanyi GM, Vanhoutte PM. et.al., 1986).

How can you keep the endothelium healthy?

A high nutrient, low glycemic index plant based diet will go a long way.  In addition to that you can eat some blueberries.

In this double blind crossover study the researchers gave the participants blueberry flavonoids and measured flow-mediated dilation (Rodriguez-Mateos A, et.al., 2013).

They found a significant increase in flow-mediated dilation at 1-2 and 6 h after consumption of the blueberry polyphenols.

The researchers concluded that blueberry intake acutely improves vascular function in healthy men.

You can also drink green tea.

Low-mediated dilation significantly improved after drinking green tea, and has a beneficial effect on endothelial function (Alexopoulos N, et.al., 2008).

References

Alexopoulos N1, Vlachopoulos C, Aznaouridis K, Baou K, Vasiliadou C, Pietri P, Xaplanteris P, Stefanadi E, Stefanadis C.The acute effect of green tea consumption on endothelial function in healthy individuals. Eur J Cardiovasc Prev Rehabil. 2008 Jun;15(3):300-5.

Rajendran P, Rengarajan T, Thangavel J, Nishigaki Y, Sakthisekaran D, Sethi G, Nishigaki I.The vascular endothelium and human diseases. Int J Biol Sci. 2013 Nov 9;9(10):1057-69.

Rodriguez-Mateos A1, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, Spencer JP.Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activityAm J Clin Nutr. 2013 Nov;98(5):1179-91.

Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor.Am J Physiol. 1986 May;250(5 Pt 2):H822-7.

 

 

 

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What can you do to help your immune system to better protect yourself from pathogens like viruses?

Posted by on 9:52 am Anti-aging, General Health, General Health, Health, Supplements, Wellness | 0 comments

We are exposed to pathogens–especially viruses–all the time and our immune system is very effective at protecting us.  This means that most of the time, we don’t get sick.

Research has, however, found evidence of decreased levels of glutathione in several diseases–such as cancer, viral infections and immune dysfunction–as well as in aging (Fraternale A, et.al., 2006, Fraternale A, et. al., 2017).

Intra-cellular glutathione levels influence the Th1/Th2 immune response and the effectiveness of the immune system.

The body makes glutathione, which is involved in many cellular functions such as detoxification, amino acid transport, production of coenzymes, and the recycling of vitamins E and C.

Glutathione has also been found to inhibit viral replication (Fraternale, et.al., 2006).

It’s no doubt that glutathione is very important, and as long as your body is able to make what’s necessary to protect you, everything is fine.

The problem, however, is that the body is not able to provide adequate amounts of glutathione as we get older. The decrease is gradual.  Additionally, the rate of decrease depends on our exposure to pathogens, toxins, and oxidative stressors that require the protection of glutathione.  

You would not usually need to supplement with glutathione in your twenties, but as you get into your forties, the need for supplementation will increase.

Reduced glutathione–which is the most common form on the market–is not very effective since it is oxidized in your stomach and very little is absorbed.

S-Acetyl Glutathione a patented substance is however very effective and gets into the cells where it is needed (Cacciatore I, et.al., 2010).

Researchers have proposed molecules able to increase glutathione levels as new tools to more effectively hinder different pathogens by acting as both immunomodulators and antimicrobials.

References

Cacciatore I1, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levelsMolecules. 2010 Mar 3;15(3):1242-64.

Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55.

Fraternale A, Brundu S, Magnani M. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275.

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

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Feel more relaxed, improve your focus and be more stress resistant by controlling your breathing.

Posted by on 8:43 am Blood Pressure, Breathing, General Health, Happiness, Health, Pain, Research, Stress | 0 comments

The way you breathe has a strong effect on how you feel and function. Research has shown that the amount of times you breath and also how you breathe is important.

The following study included 47 healthy college students which implemented different breathing patterns (Lin IM, et., al., 2014). Anxiety and relaxation levels were measured as well as heart rate variability (HRV).

The reason HRV was measured is because research has shown a relationship between low HRV and worsening of depression or anxiety. A low HRV has even been associated with an increased risk of death and cardiovascular disease. People who have a high HRV may have greater cardiovascular fitness and be more resilient to stress.

In this study the researchers showed that breathing at a rate of 5.5 breaths per minute and with an equal time used to breathe in and out resulted in a higher HRV and an increased feeling of relaxation. The other breathing patterns were not as effective.

A breathing frequency of 6 breaths per minute has been the frequency found to be most effective in most of the studies.

Using your diaphragm when breathing is also important. Implementing that with slow breathing increased sustained attention and lowered cortisol levels–cortisol is a stress hormone– in another study (Ma X, et.al., 2017).

When you use your diaphragm in breathing, you will see your abdomen raising when you breathe in.

This type of breathing has even shown to improve sleep when practiced before bed time (Tsai HJ,et.al., 2015).

 

References

Lin IM, Tai LY, Fan SY,Breathing at a rate of 5.5 breaths per minute with equal inhalation-to-exhalation ratio increases heart rate variability, Int J Psychophysiol. 2014 Mar;91(3):206-11.

Ma X, Yue ZQ, Gong ZQ, Zhang H, Duan NY, Shi YT, Wei GX, Li YF, The Effect of Diaphragmatic Breathing on Attention, Negative Affect and Stress in Healthy Adults,Front Psychol. 2017 Jun 6;8:874. doi: 10.3389/fpsyg.2017.00874.

Tsai HJ1, Kuo TB, Lee GS, Yang CC,Efficacy of paced breathing for insomnia: enhances vagal activity and improves sleep qualityPsychophysiology. 2015 Mar;52(3):388-96. doi: 10.1111/psyp.12333.

 

 

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This is not difficult and it does not require expensive equipment. You can, without a doubt, do this. 

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How to protect the cartilage of your joints from oxidative stress and degeneration.

Posted by on 10:02 am Health, Joint health | 0 comments

Oxidative stress tends to increase as we get older and contributes to cell death of cartilage. It also damages other tissue. This leads to increased cartilage degeneration, which can lead to arthritis, and you don’t want to get arthritis.

In the following study, the researchers took samples of cartilage cells–which are called chondrocytes–isolated from the articular cartilage of young and older adult human tissue donors (Carlo MD Jr, Loeser RF, 2003).

These cells were then exposed to oxidative stress. Twice as many chondrocytes died from donors 50 years or older compared to those derived from 18-49 years old donors.

The researchers found that cells depleted of intracellular glutathione were more susceptible to cell death when exposed to oxidative stress.

They concluded that this may represent an important contributing factor to the development of osteoarthritis in older adults.

The most common form of glutathione is not well absorbed; most of it is oxidized in the stomach.

The good news is that you now can take an effective form of glutathione called S-Acetyl Glutathione, a patented form of glutathione shown to get into the cells which need protection from oxidative stress (Cacciatore I, et al. 2010).

References

Carlo MD Jr, Loeser RF, Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels.Arthritis Rheum. 2003 Dec;48(12):3419-30.

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levelsMolecules. 2010 Mar 3;15(3):1242-64

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!