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Osteoarthritis in women associated with deposits in Arteries

Posted by on 12:33 pm Asthma, Calories, Eating, Energy, Exercise, General Health, General Health, Health Risk, Heart disease, Muscles, Nervous System, Research, Wellness, Women, Womens health | 0 comments

Research sometimes find interesting connections we usually don’t think about.

A study including 3278 women found an association between plaque in the carotid artery and osteoarthritis in the knee and hands in women (Hoeven TA, et.al., 2013).

We know that inflammation is involved in osteoarthritis, even if it is less severe than in rheumatoid arthritis.

We also know that inflammation increases the risk for cardiovascular disease. Inflammation is an important factor in depositing cholesterol and fat into the inner lining of the vascular wall.

 

Another interesting connection found lower magnesium levels in rheumatoid arthritis patients compared to controls (Chavan VU, et.al., 2015).

Lower magnesium levels were also correlated with higher cholesterol and LDL, the so called bad cholesterol, and higher magnesium levels with better HDL cholesterol, the good cholesterol. This was in cases of rheumatoid arthritis.

 

Magnesium has also been found to be inversely associated with osteoarthritis documented on x-rays and joint space narrowing (Zeng C, et.al., 2015).

Glucosamine sulfate another nutritional substance has been used to treat osteoarthritis for many years.

When osteoarthritic chondrocytes (cartilage cells) and glucosamine sulfate were tested in different ways in a culture, it was found that glucosamine sulfate reduced the synthesis of proinflammatory mediators (Largo R, et.al., 2003).

Taking magnesium and glucosamine sulfate could according to this possibly benefit both your cardiovascular system and your joints.

The best form of magnesium is an amino acid chelate like magnesium glycinate.

The most common form of magnesium is magnesium oxide, but that is a gastrointestinal irritant and can give you diarrhea when taken in higher amounts.

 

REFERENCE

Chavan, V. U., Ramavataram, D. V. S. S., Patel, P. A., & Rupani, M. P. (2015). Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis. Journal of clinical and diagnostic research: JCDR, 9(4), BC01.

Hoeven, T. A., Kavousi, M., Clockaerts, S., Kerkhof, H. J., van Meurs, J. B., Franco, O., … & Bierma-Zeinstra, S. (2012). Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study. Annals of the rheumatic diseases, annrheumdis-2011.

Largo R, Alvarez-Soria MA, Díez-Ortego I, Calvo E, Sánchez-Pernaute O, Egido J, Herrero-Beaumont G. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes.Osteoarthritis Cartilage. 2003 Apr;11(4):290-8.

Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, Zhang Y, Yang TB, Lei GH. Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis. PLoS One. 2015 May 26;10(5):e0127666.

 

 

 

 

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A benefit of exercise you may not be aware of.

Posted by on 5:10 pm Anti-aging, Energy, Exercise, Exercise, General Health, Get in shape, Inflammation, Inflammation, C-reactive protein, Inflammatory factor, Intensity Training, Muscles, The Learn to Eat Plan, Wellness | 0 comments

Jogging together - sport young coupleAs we get older inflammation usually increases. You don’t necessarily have to get increased inflammation as you age, but that’s what’s been observed in a lot of people. You probably know that inflammation is a risk factor for most chronic diseases, it can also make you more uncomfortable because it can contribute to pain.

It would be great if you had a way to reduce inflammation without taking any medication. In fact there are ways you can do that, and instead of side effects you even get a lot of additional benefits.

Exercise is one of the things that can reduce inflammation. That is exactly what the reviewed study investigated, by looking at data from a lot of research on this specific topic(Woods JA, et al. 2012). Data on the participants activity level, as well as measurements of several inflammatory markers, were used.

As you may have guessed, exercise was found to reduce some of these inflammatory markers, especially highly sensitive C-reactive protein (hs-CRP).

One of the studies they looked at also investigated the effects of antioxidants on inflammation. They found that the participants who took antioxidants had reduced inflammation, even if they did not exercise(Colbert LH, et al. 2004).

The logical thing would be to both exercise and take antioxidants.

The most effective antioxidant the body makes is glutathione, but the problem is that it  produces less of it as we get older, when we actually need more.

You can read more about this by clicking here.

 

 

 

Colbert LH1, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, Rubin S, Harris TB. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2004 Jul;52(7):1098-104.
Woods JA1, Wilund KR, Martin SA, Kistler BM. Exercise, inflammation and aging. Aging Dis. 2012 Feb;3(1):130-40. Epub 2011 Oct 29.

 

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Smaller waist and impressive health benefits from minutes of exercise instead of hours.

Posted by on 9:53 am Energy, Exercise, Fat, Get in shape, Health | 0 comments

In the last few years quite a few studies have been published on the benefits of high intensity short interval training.

The research reviewed here investigated the effects of very high intensity sprint interval training on metabolic and vascular risk factors in overweight/obese sedentary men (Whyte LJ, et al. 2010).

The exercise consisted of 4 to 6 sets of 30 second sprints on a stationary bike 3 times weekly for 2 weeks. The participants cycled as hard as they could with a resistance set according to what’s called the Wingate protocol and they rested for 4.5 minutes between the 30 second sprints.

This is very intense exercise, but the time spent exercising is not more than 2 to 3 minutes per exercise session. Per week it would not be more than 6 to 9 minutes total exercise time.

This is what the researchers found. After 2 weeks both maximum oxygen uptake and power output had increased significantly. Insulin sensitivity and resting fat oxidation rate (burning of fat for energy) were significantly higher and systolic blood pressure significantly lower.

Very interesting was also that both the waist and hip circumference decreased significantly compared with what it was when they started.

 

Eating irregularly is a risk factor for the metabolic syndrome and insulin resistance.

Posted by on 1:14 pm Bloodsugar, Eating, Energy, Glucose, Insulin resistance, Sugar, Weight gain | 0 comments


The metabolic syndrome is a condition consisting of multiple symptoms including elevated blood glucose, triglycerides, cholesterol, LDL (the bad cholesterol) and decreased HDL (the good cholesterol). A part of the metabolic syndrome is insulin resistance which occurs when the insulin is not able to transfer the blood sugar into the cells as efficiently as it used to. This will first result in elevated insulin levels as the pancreas compensates trying to transfer the glucose into the cells so it can be used for energy. Later the blood glucose may also increase as the pancreas is not able to compensate and the insulin resistance get worse. Symptoms are usually weight gain especially around the waist, less energy and increased low grade inflammation.

Risk factors associated both insulin resistance and the metabolic syndrome are not enough physical activity, stress and high glycemic index foods. Skipping meals can also be added to the list of risk factors, this was documented in a Swedish study recently (Sierra-Johnson J, et al, 2008). This makes sense since going a long time without eating results in glucose production in the liver to avoid low blood sugar. With time, the liver may produce more glucose than needed which will result in increased blood sugar.

Triggering this response is the hormone glucagone which stimulates the body to break down its own protein. The protein (amino acids) are then converted to glucose in the liver. This is a quicker way to produce energy than using fat which the body also will do.

The results is usually weight gain especially around the waist, the break down of muscle tissue because that is a big source of protein, and lack of energy.

The best way to ensure that you have high energy and stay lean is to eat high nutrient, low glycemic index foods regularly and not skip meals. Many smaller meals are better than 1 or 2 big meals. Exercise should of course also be a part of your routine.

References:

Sierra-Johnson J, et al, 2008. Eating meals irregularly: a novel environmental risk factor for the metabolic syndrome. Obesity (Silver Spring). 2008 Jun;16(6): 1302-7.