Your Road to Wellness

Energy

2 important things to help you stay healthy and feel good.

Posted by on 9:00 am Diabetes, Diet, Eating, Energy, Health, Health Risk, Inflammation, Inflammatory factor, Low glycemic meals, Stay healthy, Supplements, Supplements for Conditions, Supplements List, Type 1 diabetes, Type 2 diabetes | 0 comments

blood glucose food

 

You need to keep your glucose metabolism healthy by keeping your blood glucose at a low and
normal level.
There are several reasons why this is important. When your blood glucose is elevated to a high
level as it tends to be when we get insulin resistant, and when we eat high glycemic index food,
we usually get tired.
Elevated blood glucose also leads to increased low-grade inflammation, and inflammation is the
the second thing you need to keep low to stay healthy.
Increasing CRP, an inflammatory marker, has been found with higher fasting glucose levels,
even among subjects with fasting glucose in the normal range (Aronson D. et.al., 2004).

 

 

Eating high nutrient, low glycemic index meals are important, and so is exercise.
There is however something else you also can do to keep your blood glucose lower.
You can take berberine, a natural plant derivative.
Berberine has shown to provide several health benefits. One of them is keeping the blood
glucose at a lower, normal level.

In the following study participants with type 2 diabetes were randomized to take either berberine
or metformin (a diabetic medication) for 3 months (Yin J, et.al., 2008).
The effect of berberine was found to be similar to metformin.
A significant decrease in hemoglobin A1c from 9.5% to 7.5% was found when taking berberine.
Hemoglobin A1c is a measurement of long term glucose control.
Fasting blood glucose was reduced with 34.9%, postprandial blood glucose with 43.9%, and
plasma triglycerides with 21.2%. Postprandial glucose is the blood glucose measured after a
meal.
The insulin resistance index was reduced by 44.7%.
Another study which included 116 patients also with type 2 diabetes showed similar results
(Zhang Y, et.al., 2008).
In these studies, the participants had type 2 diabetes which means they were severely insulin
resistant.
There is no reason to wait until we get a serious disease before taking action.
Berberine can be used to help keep glucose metabolism healthy.

 

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References

Aronson D, Bartha P, Zinder O, Kerner A, Shitman E, Markiewicz W, Brook GJ, Levy
Y. Association between fasting glucose and C-reactive protein in middle-aged subjects.
Diabet Med. 2004 Jan;21(1):39-44.

Zhang Y, Li X, Zou D, Liu W, Yang J, Zhu N, Huo L, Wang M, Hong J, Wu P, Ren G, Ning
G. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine.
J Clin Endocrinol Metab. 2008 Jul;93(7):2559-65.

Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism.
2008 May;57(5):712-7. doi: 10.1016/j.metabol.2008.01.013.

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This formula was designed to support healthy glucose metabolism and the cardiovascular system.

The research referred to below was conducted with participants who had type 2 diabetes. This does not mean that you have to have type 2 diabetes to take this formula.

It’s very important to have a healthy glucose metabolism and keep the blood glucose low. You want to take this formula and keep your glucose metabolism healthy.

Healthy glucose metabolism is important to keep your cardiovascular system healthy.

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What damage can high blood sugar and oxidative stress cause?

Posted by on 10:33 am Blood Pressure, Bloodsugar, BMJ Formula, Energy, Glucose, Health, Stress, Supplements, Wellness | 0 comments

It is common knowledge that having high blood sugar levels is damaging to our health, but in what way is it harmful to us?  

Having high blood glucose levels causes oxidation of glucose and a reaction causing glycation of proteins.  These reactions cause tissue damage and create a lot of free radicals. This also decreases the activity of superoxide dismutase–which is the body’s own antioxidant enzymes.  This decrease in antioxidant activity again will increase the oxidative stress in a seemingly endless cycle.

This oxidation and glycation reaction chain has shown to alter the mitochondria–which are the energy-producing entities of the cell–and has shown to be involved in a variety of diseases (Edeas, et. al., 2009).  The damaged mitochondria will produce less ATP (energy) than a normal mitochondria. Additionally, the damaged mitochondria cannot use glucose or lipids in a normal way. This means that a person with high blood sugar is unable to produce as much energy as they should.  

So what can be done to offset the production of these advanced glycation-end products?  The researchers of this study show that curcumin could suppress the advanced glycation-end products and also stimulate the synthesis of glutathione (Stefanska, 2012).

It is also important to eat food with a high nutrient content and low glycemic index, but you can take curcumin to help reduce damage from higher glucose levels. Just be sure that the curcumin you take is well absorbed since regular curcumin is not.  

Taking S-Acetyl Glutathione is also an excellent way to get protection from the negative effects of elevated blood glucose, it works really well.   Taking regular glutathione is not effective since it is oxidised in the stomach and not very bioavailable. Don’t waste your money.

References

Edeas, M, et al. “Maillard Reaction, Mitochondria and Oxidative Stress: Potential Role of Antioxidants.” Pathologie Biologie, Academic Press, 23 Dec. 2009, www.sciencedirect.com/science/article/pii/S0369811409001898.

Stefanska, B. “Curcumin Ameliorates Hepatic Fibrosis in Type 2 Diabetes Mellitus – Insights into Its Mechanisms of Action.” Addiction & Health, British Journal of Pharmacology , Aug. 2012, europepmc.org/articles/PMC3448887.

 

 

 

Curcumin is a good antioxidant but it is especially effective in helping to reduce inflammation. For these reasons, curcumin provides many health benefits.

The raw material used in the Better Curcumin formula is the only form of curcumin shown to pass through the blood-brain barrier and improve memory (Cox KH, et al. 2015).

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Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

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Improve cognition and physical performance at the same time

Posted by on 3:00 pm Cognition, Eating, Energy, Exercise | 0 comments

Adding one thing can sometimes give you more than one benefit.

This research was conducted to find out if dietary nitrate supplementation would improve exercise performance and cognitive function during a prolonged intermittent sprint test (Thompson C.,et.al., 2015).

16 male team-sport players received either 140 ml a day of beetroot juice high in nitrate or a placebo beetroot juice low in nitrate for 7 days.

Using a stationary bike they repeatedly performed several 6 seconds “all-out” sprints with 100 seconds active recovery and 20 seconds of rest, while simultaneously performing cognitive tasks. The test went on for two 40 minutes “halves” simulating team sports.

The beetroot juice high in nitrate improved sprint performance compared with the placebo juice and also improved reaction time of response to the cognitive tasks.

In another study when the participants exercised for 6 weeks and either drank beetroot juice or a placebo drink,  the exercise and beetroot group had brain networks that more closely resembled those of younger adults (Petrie M, et.al., 2017).

When 450 ml beetroot juice was compared with a placebo drink cognitive performance was improved on a subtraction task 90 minutes later (Wightman EL, et.al., 2015). These results show that single doses of dietary nitrate can modulate the prefrontal cortex cerebral blood-flow response to task performance and potentially improve cognitive performance.

References

Thompson C, Wylie LJ, Fulford J, Kelly J, Black MI, McDonagh ST, Jeukendrup AE, Vanhatalo A, Jones AM. Dietary nitrate improves sprint performance and cognitive function during prolonged intermittent exercise. Eur J Appl Physiol. 2015 Sep;115(9):1825-34.

Petrie M, Rejeski WJ, Basu S, Laurienti PJ, Marsh AP, Norris JL, Kim-Shapiro DB, Burdette JH. Beet Root Juice: An Ergogenic Aid for Exercise and the Aging Brain. J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1284-1289.

Wightman EL, Haskell-Ramsay CF, Thompson KG, Blackwell JR, Winyard PG, Forster J, Jones AM, Kennedy DO. Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation. Physiol Behav. 2015 Oct 1;149:149-58.

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Osteoarthritis in women associated with deposits in Arteries

Posted by on 12:33 pm Asthma, BMJ Formula, Calories, Diet, Energy, Exercise, General Health, Health Risk, Heart disease, Muscles, Nervous System, Research, Wellness, Women, Womens health | 0 comments

Research sometimes find interesting connections we usually don’t think about.

A study including 3278 women found an association between plaque in the carotid artery and osteoarthritis in the knee and hands in women (Hoeven TA, et.al., 2013).

We know that inflammation is involved in osteoarthritis, even if it is less severe than in rheumatoid arthritis.

We also know that inflammation increases the risk for cardiovascular disease. Inflammation is an important factor in depositing cholesterol and fat into the inner lining of the vascular wall.

 

Another interesting connection found lower magnesium levels in rheumatoid arthritis patients compared to controls (Chavan VU, et.al., 2015).

Lower magnesium levels were also correlated with higher cholesterol and LDL, the so called bad cholesterol, and higher magnesium levels with better HDL cholesterol, the good cholesterol. This was in cases of rheumatoid arthritis.

 

Magnesium has also been found to be inversely associated with osteoarthritis documented on x-rays and joint space narrowing (Zeng C, et.al., 2015).

Glucosamine sulfate another nutritional substance has been used to treat osteoarthritis for many years.

When osteoarthritic chondrocytes (cartilage cells) and glucosamine sulfate were tested in different ways in a culture, it was found that glucosamine sulfate reduced the synthesis of proinflammatory mediators (Largo R, et.al., 2003).

Taking magnesium and glucosamine sulfate could according to this possibly benefit both your cardiovascular system and your joints.

The best form of magnesium is an amino acid chelate like magnesium glycinate.

The most common form of magnesium is magnesium oxide, but that is a gastrointestinal irritant and can give you diarrhea when taken in higher amounts.

 

REFERENCE

Chavan, V. U., Ramavataram, D. V. S. S., Patel, P. A., & Rupani, M. P. (2015). Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis. Journal of clinical and diagnostic research: JCDR, 9(4), BC01.

Hoeven, T. A., Kavousi, M., Clockaerts, S., Kerkhof, H. J., van Meurs, J. B., Franco, O., … & Bierma-Zeinstra, S. (2012). Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study. Annals of the rheumatic diseases, annrheumdis-2011.

Largo R, Alvarez-Soria MA, Díez-Ortego I, Calvo E, Sánchez-Pernaute O, Egido J, Herrero-Beaumont G. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes.Osteoarthritis Cartilage. 2003 Apr;11(4):290-8.

Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, Zhang Y, Yang TB, Lei GH. Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis. PLoS One. 2015 May 26;10(5):e0127666.

 

 

 

 

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A benefit of exercise you may not be aware of.

Posted by on 5:10 pm Anti-aging, BMJ Formula, Energy, Exercise, Exercise, Get in shape, Inflammation, Inflammation, C-reactive protein, Inflammatory factor, Intensity Training, Muscles, The Learn to Eat Plan, Wellness | 0 comments

Jogging together - sport young coupleAs we get older inflammation usually increases. You don’t necessarily have to get increased inflammation as you age, but that’s what’s been observed in a lot of people. You probably know that inflammation is a risk factor for most chronic diseases, it can also make you more uncomfortable because it can contribute to pain.

It would be great if you had a way to reduce inflammation without taking any medication. In fact there are ways you can do that, and instead of side effects you even get a lot of additional benefits.

Exercise is one of the things that can reduce inflammation. That is exactly what the reviewed study investigated, by looking at data from a lot of research on this specific topic(Woods JA, et al. 2012). Data on the participants activity level, as well as measurements of several inflammatory markers, were used.

As you may have guessed, exercise was found to reduce some of these inflammatory markers, especially highly sensitive C-reactive protein (hs-CRP).

One of the studies they looked at also investigated the effects of antioxidants on inflammation. They found that the participants who took antioxidants had reduced inflammation, even if they did not exercise(Colbert LH, et al. 2004).

The logical thing would be to both exercise and take antioxidants.

The most effective antioxidant the body makes is glutathione, but the problem is that it  produces less of it as we get older, when we actually need more.

You can read more about this by clicking here.

 

 

 

Colbert LH1, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, Rubin S, Harris TB. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2004 Jul;52(7):1098-104.
Woods JA1, Wilund KR, Martin SA, Kistler BM. Exercise, inflammation and aging. Aging Dis. 2012 Feb;3(1):130-40. Epub 2011 Oct 29.

 

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Smaller waist and impressive health benefits from minutes of exercise instead of hours.

Posted by on 9:53 am Energy, Exercise, Fat, Get in shape, Health | 0 comments

In the last few years quite a few studies have been published on the benefits of high intensity short interval training.

The research reviewed here investigated the effects of very high intensity sprint interval training on metabolic and vascular risk factors in overweight/obese sedentary men (Whyte LJ, et al. 2010).

The exercise consisted of 4 to 6 sets of 30 second sprints on a stationary bike 3 times weekly for 2 weeks. The participants cycled as hard as they could with a resistance set according to what’s called the Wingate protocol and they rested for 4.5 minutes between the 30 second sprints.

This is very intense exercise, but the time spent exercising is not more than 2 to 3 minutes per exercise session. Per week it would not be more than 6 to 9 minutes total exercise time.

This is what the researchers found. After 2 weeks both maximum oxygen uptake and power output had increased significantly. Insulin sensitivity and resting fat oxidation rate (burning of fat for energy) were significantly higher and systolic blood pressure significantly lower.

Very interesting was also that both the waist and hip circumference decreased significantly compared with what it was when they started.