Your Road to Wellness

Energy

What damage can high blood sugar and oxidative stress cause?

Posted by on 10:33 am Blood Pressure, Bloodsugar, Energy, General Health, Glucose, Health, Stress, Supplements, Wellness | 0 comments

It is common knowledge that having high blood sugar levels is damaging to our health, but in what way is it harmful to us?  

Having high blood glucose levels causes oxidation of glucose and a reaction causing glycation of proteins.  These reactions cause tissue damage and create a lot of free radicals. This also decreases the activity of superoxide dismutase–which is the body’s own antioxidant enzymes.  This decrease in antioxidant activity again will increase the oxidative stress in a seemingly endless cycle.

This oxidation and glycation reaction chain has shown to alter the mitochondria–which are the energy-producing entities of the cell–and has shown to be involved in a variety of diseases (Edeas, et. al., 2009).  The damaged mitochondria will produce less ATP (energy) than a normal mitochondria. Additionally, the damaged mitochondria cannot use glucose or lipids in a normal way. This means that a person with high blood sugar is unable to produce as much energy as they should.  

So what can be done to offset the production of these advanced glycation-end products?  The researchers of this study show that curcumin could suppress the advanced glycation-end products and also stimulate the synthesis of glutathione (Stefanska, 2012).

It is also important to eat food with a high nutrient content and low glycemic index, but you can take curcumin to help reduce damage from higher glucose levels. Just be sure that the curcumin you take is well absorbed since regular curcumin is not.  

Taking S-Acetyl Glutathione is also an excellent way to get protection from the negative effects of elevated blood glucose, it works really well.   Taking regular glutathione is not effective since it is oxidised in the stomach and not very bioavailable. Don’t waste your money.

References

Edeas, M, et al. “Maillard Reaction, Mitochondria and Oxidative Stress: Potential Role of Antioxidants.” Pathologie Biologie, Academic Press, 23 Dec. 2009, www.sciencedirect.com/science/article/pii/S0369811409001898.

Stefanska, B. “Curcumin Ameliorates Hepatic Fibrosis in Type 2 Diabetes Mellitus – Insights into Its Mechanisms of Action.” Addiction & Health, British Journal of Pharmacology , Aug. 2012, europepmc.org/articles/PMC3448887.

 

 

 

Curcumin is a good antioxidant but it is especially effective in helping to reduce inflammation. For these reasons, curcumin provides many health benefits.

The raw material used in the Better Curcumin formula is the only form of curcumin shown to pass through the blood-brain barrier and improve memory (Cox KH, et al. 2015).

Click here to learn more!

 

 

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

 

Improve cognition and physical performance at the same time

Posted by on 3:00 pm Cognition, Eating, Energy, Exercise | 0 comments

Adding one thing can sometimes give you more than one benefit.

This research was conducted to find out if dietary nitrate supplementation would improve exercise performance and cognitive function during a prolonged intermittent sprint test (Thompson C.,et.al., 2015).

16 male team-sport players received either 140 ml a day of beetroot juice high in nitrate or a placebo beetroot juice low in nitrate for 7 days.

Using a stationary bike they repeatedly performed several 6 seconds “all-out” sprints with 100 seconds active recovery and 20 seconds of rest, while simultaneously performing cognitive tasks. The test went on for two 40 minutes “halves” simulating team sports.

The beetroot juice high in nitrate improved sprint performance compared with the placebo juice and also improved reaction time of response to the cognitive tasks.

In another study when the participants exercised for 6 weeks and either drank beetroot juice or a placebo drink,  the exercise and beetroot group had brain networks that more closely resembled those of younger adults (Petrie M, et.al., 2017).

When 450 ml beetroot juice was compared with a placebo drink cognitive performance was improved on a subtraction task 90 minutes later (Wightman EL, et.al., 2015). These results show that single doses of dietary nitrate can modulate the prefrontal cortex cerebral blood-flow response to task performance and potentially improve cognitive performance.

References

Thompson C, Wylie LJ, Fulford J, Kelly J, Black MI, McDonagh ST, Jeukendrup AE, Vanhatalo A, Jones AM. Dietary nitrate improves sprint performance and cognitive function during prolonged intermittent exercise. Eur J Appl Physiol. 2015 Sep;115(9):1825-34.

Petrie M, Rejeski WJ, Basu S, Laurienti PJ, Marsh AP, Norris JL, Kim-Shapiro DB, Burdette JH. Beet Root Juice: An Ergogenic Aid for Exercise and the Aging Brain. J Gerontol A Biol Sci Med Sci. 2017 Sep 1;72(9):1284-1289.

Wightman EL, Haskell-Ramsay CF, Thompson KG, Blackwell JR, Winyard PG, Forster J, Jones AM, Kennedy DO. Dietary nitrate modulates cerebral blood flow parameters and cognitive performance in humans: A double-blind, placebo-controlled, crossover investigation. Physiol Behav. 2015 Oct 1;149:149-58.

.

 

Learn to Eat Program

Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more…

Osteoarthritis in women associated with deposits in Arteries

Posted by on 12:33 pm Asthma, Calories, Eating, Energy, Exercise, General Health, General Health, Health Risk, Heart disease, Muscles, Nervous System, Research, Wellness, Women, Womens health | 0 comments

Research sometimes find interesting connections we usually don’t think about.

A study including 3278 women found an association between plaque in the carotid artery and osteoarthritis in the knee and hands in women (Hoeven TA, et.al., 2013).

We know that inflammation is involved in osteoarthritis, even if it is less severe than in rheumatoid arthritis.

We also know that inflammation increases the risk for cardiovascular disease. Inflammation is an important factor in depositing cholesterol and fat into the inner lining of the vascular wall.

 

Another interesting connection found lower magnesium levels in rheumatoid arthritis patients compared to controls (Chavan VU, et.al., 2015).

Lower magnesium levels were also correlated with higher cholesterol and LDL, the so called bad cholesterol, and higher magnesium levels with better HDL cholesterol, the good cholesterol. This was in cases of rheumatoid arthritis.

 

Magnesium has also been found to be inversely associated with osteoarthritis documented on x-rays and joint space narrowing (Zeng C, et.al., 2015).

Glucosamine sulfate another nutritional substance has been used to treat osteoarthritis for many years.

When osteoarthritic chondrocytes (cartilage cells) and glucosamine sulfate were tested in different ways in a culture, it was found that glucosamine sulfate reduced the synthesis of proinflammatory mediators (Largo R, et.al., 2003).

Taking magnesium and glucosamine sulfate could according to this possibly benefit both your cardiovascular system and your joints.

The best form of magnesium is an amino acid chelate like magnesium glycinate.

The most common form of magnesium is magnesium oxide, but that is a gastrointestinal irritant and can give you diarrhea when taken in higher amounts.

 

REFERENCE

Chavan, V. U., Ramavataram, D. V. S. S., Patel, P. A., & Rupani, M. P. (2015). Evaluation of serum magnesium, lipid profile and various biochemical parameters as risk factors of cardiovascular diseases in patients with rheumatoid arthritis. Journal of clinical and diagnostic research: JCDR, 9(4), BC01.

Hoeven, T. A., Kavousi, M., Clockaerts, S., Kerkhof, H. J., van Meurs, J. B., Franco, O., … & Bierma-Zeinstra, S. (2012). Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study. Annals of the rheumatic diseases, annrheumdis-2011.

Largo R, Alvarez-Soria MA, Díez-Ortego I, Calvo E, Sánchez-Pernaute O, Egido J, Herrero-Beaumont G. Glucosamine inhibits IL-1beta-induced NFkappaB activation in human osteoarthritic chondrocytes.Osteoarthritis Cartilage. 2003 Apr;11(4):290-8.

Zeng C, Li H, Wei J, Yang T, Deng ZH, Yang Y, Zhang Y, Yang TB, Lei GH. Association between Dietary Magnesium Intake and Radiographic Knee Osteoarthritis. PLoS One. 2015 May 26;10(5):e0127666.

 

 

 

 

BMJ Bones, Muscles, and Joints

The BMJ (bone, muscle, joint) formula was designed to support bone formation and optimal joint function.

Click here for more info…

A benefit of exercise you may not be aware of.

Posted by on 5:10 pm Anti-aging, Energy, Exercise, Exercise, General Health, Get in shape, Inflammation, Inflammation, C-reactive protein, Inflammatory factor, Intensity Training, Muscles, The Learn to Eat Plan, Wellness | 0 comments

Jogging together - sport young coupleAs we get older inflammation usually increases. You don’t necessarily have to get increased inflammation as you age, but that’s what’s been observed in a lot of people. You probably know that inflammation is a risk factor for most chronic diseases, it can also make you more uncomfortable because it can contribute to pain.

It would be great if you had a way to reduce inflammation without taking any medication. In fact there are ways you can do that, and instead of side effects you even get a lot of additional benefits.

Exercise is one of the things that can reduce inflammation. That is exactly what the reviewed study investigated, by looking at data from a lot of research on this specific topic(Woods JA, et al. 2012). Data on the participants activity level, as well as measurements of several inflammatory markers, were used.

As you may have guessed, exercise was found to reduce some of these inflammatory markers, especially highly sensitive C-reactive protein (hs-CRP).

One of the studies they looked at also investigated the effects of antioxidants on inflammation. They found that the participants who took antioxidants had reduced inflammation, even if they did not exercise(Colbert LH, et al. 2004).

The logical thing would be to both exercise and take antioxidants.

The most effective antioxidant the body makes is glutathione, but the problem is that it  produces less of it as we get older, when we actually need more.

You can read more about this by clicking here.

 

 

 

Colbert LH1, Visser M, Simonsick EM, Tracy RP, Newman AB, Kritchevsky SB, Pahor M, Taaffe DR, Brach J, Rubin S, Harris TB. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2004 Jul;52(7):1098-104.
Woods JA1, Wilund KR, Martin SA, Kistler BM. Exercise, inflammation and aging. Aging Dis. 2012 Feb;3(1):130-40. Epub 2011 Oct 29.

 

Save

Save

Smaller waist and impressive health benefits from minutes of exercise instead of hours.

Posted by on 9:53 am Energy, Exercise, Fat, Get in shape, Health | 0 comments

In the last few years quite a few studies have been published on the benefits of high intensity short interval training.

The research reviewed here investigated the effects of very high intensity sprint interval training on metabolic and vascular risk factors in overweight/obese sedentary men (Whyte LJ, et al. 2010).

The exercise consisted of 4 to 6 sets of 30 second sprints on a stationary bike 3 times weekly for 2 weeks. The participants cycled as hard as they could with a resistance set according to what’s called the Wingate protocol and they rested for 4.5 minutes between the 30 second sprints.

This is very intense exercise, but the time spent exercising is not more than 2 to 3 minutes per exercise session. Per week it would not be more than 6 to 9 minutes total exercise time.

This is what the researchers found. After 2 weeks both maximum oxygen uptake and power output had increased significantly. Insulin sensitivity and resting fat oxidation rate (burning of fat for energy) were significantly higher and systolic blood pressure significantly lower.

Very interesting was also that both the waist and hip circumference decreased significantly compared with what it was when they started.

 

Eating irregularly is a risk factor for the metabolic syndrome and insulin resistance.

Posted by on 1:14 pm Bloodsugar, Eating, Energy, Glucose, Insulin resistance, Sugar, Weight gain | 0 comments


The metabolic syndrome is a condition consisting of multiple symptoms including elevated blood glucose, triglycerides, cholesterol, LDL (the bad cholesterol) and decreased HDL (the good cholesterol). A part of the metabolic syndrome is insulin resistance which occurs when the insulin is not able to transfer the blood sugar into the cells as efficiently as it used to. This will first result in elevated insulin levels as the pancreas compensates trying to transfer the glucose into the cells so it can be used for energy. Later the blood glucose may also increase as the pancreas is not able to compensate and the insulin resistance get worse. Symptoms are usually weight gain especially around the waist, less energy and increased low grade inflammation.

Risk factors associated both insulin resistance and the metabolic syndrome are not enough physical activity, stress and high glycemic index foods. Skipping meals can also be added to the list of risk factors, this was documented in a Swedish study recently (Sierra-Johnson J, et al, 2008). This makes sense since going a long time without eating results in glucose production in the liver to avoid low blood sugar. With time, the liver may produce more glucose than needed which will result in increased blood sugar.

Triggering this response is the hormone glucagone which stimulates the body to break down its own protein. The protein (amino acids) are then converted to glucose in the liver. This is a quicker way to produce energy than using fat which the body also will do.

The results is usually weight gain especially around the waist, the break down of muscle tissue because that is a big source of protein, and lack of energy.

The best way to ensure that you have high energy and stay lean is to eat high nutrient, low glycemic index foods regularly and not skip meals. Many smaller meals are better than 1 or 2 big meals. Exercise should of course also be a part of your routine.

References:

Sierra-Johnson J, et al, 2008. Eating meals irregularly: a novel environmental risk factor for the metabolic syndrome. Obesity (Silver Spring). 2008 Jun;16(6): 1302-7.