Your Road to Wellness

Dementia

Want to slow down brain atrophy?

Posted by on 5:46 am Anti-Aging, Cognition, Dementia, Fish Oil, Flaxseeds, General Health, Stay healthy, Supplements, Vitamin B, Vitamin B12, Vitamins | 0 comments

Most likely everybody would like to slow down brain atrophy.  Who wouldn’t like more brain power? But is that even possible?  Take a look at the results from this research.

168 elderly people (≥70 y) with mild cognitive impairment were included and randomly assigned to either a placebo group or to a group taking a high-dose of B vitamins.

This is what they  took daily, 0.8 mg of folic acid, 20 mg of vitamin B-6, and 0.5 mg of vitamin B-12 (Jernerén F, et.al., 2015).

The participants underwent cranial magnetic resonance imaging scans when they started and 2 years later. The omega 3 fatty acid levels of EPA and DHA was also measured.

This what the researchers found.

The B vitamin treatment slowed the average atrophy rate by 40.0% compared with the placebo group. This happened however only in the participants who had high levels of omega 3 fatty acids at the start of the study.

Another study investigating cognitive decline in 266 participants 70 years or older found similar interesting results (Oulhaj A, et.al., 2016).

When omega-3 fatty acid concentrations are low, treatment with B vitamins had no effect on cognitive decline, but when omega-3 levels were in the upper normal range, B vitamins slowed cognitive decline.

Eating a lot of fish is not a good way anymore to increase your omega 3 fatty acid levels because all fish is now contaminated. A better choice is to use a high quality fish oil with high amounts of EPA and DHA, since that would not expose you to the same levels of contaminants.

It is also a good idea to take a B-complex formula that has the metabolite of folic acid, 5-methyltetrahydrofolate, because many people does not metabolize folic acid effectively.

References

Jernerén F, Elshorbagy AK, Oulhaj A, Smith SM, Refsum H, Smith AD. Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. Am J Clin Nutr. 2015 Jul;102(1):215-21.

Oulhaj A, Jernerén F, Refsum H, Smith AD, de Jager CA.Omega-3 Fatty Acid Status Enhances the Prevention of Cognitive Decline by B Vitamins in Mild Cognitive Impairment. J Alzheimers Dis. 2016;50(2):547-57.

 

This is not a regular B vitamin formula.

The B1 (thiamine), B2 (riboflavin), B6 (pyridoxine), and B12 (cobalamin) comes in their physiologically active form, making them easier to absorb.

To get your bottle, click here.

 

 

 

Better Fish Oil

The anti-inflammatory effects of Omega 3 fatty acids are well known. Most people that eat a western diet can benefit from increasing the intake of Omega 3 fatty acid. Most fish oils on the market are ethyl esters because that’s cheaper to produce.

The Better Fish Oil comes in the form of triglycerides which offers better stability to the fatty acids and prevents breakdown and oxidation.

Get your bottle here.

Do you want a bigger brain and better memory?

Posted by on 7:33 am Alzheimer’s, Anti-Aging, Cognition, Dementia, Exercise, General Health, Memory, Research, Stay healthy, Wellness | 0 comments

 

Is it really possible to increase the size of the brain later in life?

Data from a randomized controlled study of 155 older women, who participated in 52 weeks of resistance training showed reduced cortical white matter atrophy on MRI scans when compared with the control  group (Best JR, et.al., 2015).

This means that they ended up with a bigger brain than they would have had if they had not done the resistance exercise.

Twice-weekly resistance training also promoted memory and increased peak muscle power when they were followed up after 2 years.

The control group did balance and toning.

If you instead prefer aerobic type of exercise, that may also improve your cognition.

Research showed that an individual’s cardio-respiratory fitness was a better predictor of cognitive gains than the exercise dose (Vidoni ED, et.al., 2015).

To improve cardio-respiratory function you can do regular aerobic exercise, or you can do high intensity short interval training which will save you time.

This study compared the effects of long slow distance training with high-intensity interval training in rowers (Ní Chéilleachair NJ, et.al., 2017).

High intensity short interval training was more effective than long and slow distance training in improving performance and aerobic characteristics.

References

Best JR, Chiu BK, Liang Hsu C, Nagamatsu LS, Liu-Ambrose T.Long-Term Effects of Resistance Exercise Training on Cognition and Brain Volume in Older Women: Results from a Randomized Controlled Trial. J Int Neuropsychol Soc. 2015 Nov;21(10):745-56.

Vidoni ED, Johnson DK, Morris JK, Van Sciver A, Greer CS, Billinger SA, Donnelly JE, Burns JM,Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled TrialPLoS One. 2015 Jul 9;10(7):e0131647.

Ní Chéilleachair NJ1,2, Harrison AJ2, Warrington GD,HIIT enhances endurance performance and aerobic characteristics more than high-volume training in trained rowers.J Sports Sci. 2017 Jun;35(11):1052-1058

 

Research has shown that sitting for a long time can be bad, but you don’t have to be active for very long to reap huge benefits.

The program Exercise for Maximum Benefits incorporates the latest research to be sure that you really get maximum benefits.

Click here to learn more.

Is there a connection between Cardiovascular risk and the risk for Alzheimer’s disease?

Posted by on 5:33 pm Alzheimer’s, Brain, Dementia, General Health | 0 comments

 

An increased risk for developing Alzheimer’s disease is linked to the presence of apoE4, a genetic factor, which is also strongly associated with developing atherosclerosis which increases the risk for Cardiovascular disease (Altman R, Rutledge JC, 2010).                                                                     

The authors of the same article state that cardiovascular risk factors, including elevated blood cholesterol and triglycerides, increase the likelihood of Alzheimer’s disease and vascular dementia.

 

Researchers have also found that atherosclerosis causing obstruction of arteries at the base of the brain was more extensive in a group with Alzheimer’s disease when compared with a control group without dementia (Roher AE, et.al., 2011).

 

Arterial stiffness, atherosclerosis, endothelial degeneration and dysfunction of the blood-brain barrier can induce several features of Alzheimer’s disease including atrophy of certain areas of the brain (Kalaria RN, et.al., 2012). The endothelium is the inner lining of the blood vessels.

 

 

There are also other risk factors for Alzheimer’s disease and dementia, I will write more about that later.

 

Making changes to the way you eat is the most effective way to reduce cardiovascular risk, and you would most likely also reduce your risk for Alzheimer’s disease and dementia at the same time.  

When we correct the reasons for chronic conditions, we see an improvement in many areas, since the same reasons are involved in most chronic conditions.

 

 

References

Altman R, Rutledge JC. The vascular contribution to Alzheimer’s disease. Clin Sci (Lond). 2010 Aug 5;119(10):407-21.

Kalaria RN, Akinyemi R, Ihara M. Does vascular pathology contribute to Alzheimer changes? J Neurol Sci. 2012 Nov 15;322(1-2):141-7.

Roher AE, Tyas SL, Maarouf CL, Daugs ID, Kokjohn TA, Emmerling MR, Garami Z, Belohlavek M, Sabbagh MN, Sue LI, Beach TG. Intracranial atherosclerosis as a contributing factor to Alzheimer’s disease dementia. Alzheimers Dement. 2011 Jul;7(4):436-44.

 

Learn to Eat Program

Here’s What You Will Get:

  • A simple program that explains food that helps you lose weight and become healthy.
  • Fast, easy and delicious recipes…

Read more

Do You Want To Help Prevent The Risk Of Dementia?

Posted by on 9:45 am Dementia | 0 comments

Have you noticed that you don’t remember things as easily as you used to? If you have, you are not alone.

As we live longer now, and also because most people don’t have the best diet and lifestyle, dementia and Alzheimer’s disease are getting to be more and more common.

You don’t have to accept that as something you can’t do anything about.

This research documents some interesting facts related to this.

Glutathione, the body’s main antioxidant was measured in patients with Alzheimer’s disease, patients with mild cognitive impairment, and in healthy controls (Mandal PK, et al. 2015).

The glutathione levels were measured in 2 areas, the hippocampus and the frontal cortex of the brain using proton magnetic resonance spectroscopy.

The results showed reduced glutathione levels in both of these brain areas for people with Alzheimer’s.

It also showed a robust difference when participants with mild cognitive impairment were compared with healthy controls.

In one way this is good news because we can supplement with glutathione to increase the body’s glutathione levels.

The body starts to make less glutathione as we get into our forties, and it is estimated that we make approximately 10% less every year.

We just have to be sure to take a form of glutathione that has been documented to get into the cells where it is needed.

It is not enough to absorb it into the blood, it needs to be transferred into the cells to be effective.

Patented S-Acetyl Glutathione is the only form of glutathione that has been shown to do that. (Cacciatore I, et al. 2010).


Cacciatore I1, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels. Molecules. 2010 Mar 3;15(3):1242-64. doi: 10.3390/molecules15031242.
Mandal PK1, Saharan S2, Tripathi M3, Murari G2. Brain glutathione levels–a novel biomarker for mild cognitive impairment and Alzheimer’s disease. Biol Psychiatry. 2015 Nov 15;78(10):702-10. doi: 10.1016/j.biopsych.2015.04.005. Epub 2015 Apr 14.

Effective S-Acetyl Glutathione

Protect yourself

Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection and may also help reduce the risk of dementia.

Read More

Save

Save

Insulin resistance increases your risk for dementia

Posted by on 6:04 pm Dementia | 0 comments


Insulin resistance is another risk factor for chronic disease.

When study participants with the average age of only 40 years had cognitive tests and also a brain MRI done, the researchers concluded that hyperglycemia (elevated blood glucose) is associated with subtle brain injury, impaired attention and memory; even in young adults. Diabetes was associated with decreased total cerebral brain and occipital lobar gray matter volumes (Weinstein G, et al. 2015).

You don’t, however, have to have diabetes for insulin resistance to cause problems.

In this study the participants were older with an average age of 63.1 years and nondiabetic (Kerti L, et al. 2013). HbA1c (which is a test for long term glucose control), fasting glucose and insulin were checked and MRI scans were used to assess brain volume and microstructures.

Even without type 2 diabetes or impaired glucose tolerance, chronically higher blood glucose levels have a negative influence on cognition, possibly related to changes in learning –relevant brain areas.  A higher rate of brain atrophy was documented in individuals with higher HbA1c, higher body mass index and high alcohol intake (Enzinger C, et al. 2005).

A lot of people are probably not aware of these facts. The media tend to make it look like we can’t do much to affect memory and the risk of Alzheimer’s, but this is far from true.

You can do a lot to prevent these problems. One of the most important things you can do is to stay as insulin sensitive as possible.

If you have not implemented a diet and lifestyle which will accomplish that, I suggest you do it as soon as possible before you forget.

 

Learn to Eat:  Recommendations that work. This is not a regular diet program.

Blood Glucose Support

Blood Glucose Support transparent This formula contains Fenugreek and two other herbs traditionally known to help support normal blood sugar.

 

Read More

Enzinger C1, Fazekas F, Matthews PM, Ropele S, Schmidt H, Smith S, Schmidt R. Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology. 2005 May 24;64(10):1704-11.
 Kerti L1, Witte AV, Winkler A, Grittner U, Rujescu D, Flöel A. Higher glucose levels associated with lower memory and reduced hippocampal microstructure. Neurology. 2013 Nov 12;81(20):1746-52. doi: 10.1212/01.wnl.0000435561.00234.ee. Epub 2013 Oct 23.
 Weinstein G1, Maillard P2, Himali JJ2, Beiser AS2, Au R2, Wolf PA2, Seshadri S2, DeCarli C2. Glucose indices are associated with cognitive and structural brain measures in young adults. Neurology. 2015 Jun 9;84(23):2329-37. doi: 10.1212/WNL.0000000000001655. Epub 2015 May 6. 

Save

Dementia, Inflammation and free radical damage.

Posted by on 5:41 pm Cognition, Dementia, Inflammation, Memory | 0 comments


Low grade inflammation and free radical damage are risk factors for most chronic conditions and dementia is no exemption.

Vascular risk factors, markers of inflammation and endothelial dysfunction predicted lower performance in several cognitive areas in a study which included 747 participants older than 50 years (Miralbell J, et al. 2013).

Examination of study participants with an average age of 63 years found that higher levels of the inflammatory marker hs-CRP was associated with worse performance in executive function (Wersching H, et al. 2010).

The low grade inflammation was associated with cerebral microstructural disintegration. Even if you don’t know exactly what cerebral microstructural disintegration is, it does not sound good to me. It’s probably something you don’t want to get.

High level of hs-CRP can even be used to identify individuals at an increased risk for cognitive decline because it predicted poorer memory 12 years later in elderly women (Komulainen P, et al. 2007).

Oxidative stress also plays a role in chronic conditions. Advanced glycation end products and lipid peroxidation are markers of disease progression for both diabetes and Alzheimer’s disease (Reddy VP, et al. 2009).

Autopsies have shown increased lipid peroxidation as well as protein, DNA and RNA oxidation in multiple brain regions establishing oxidative damage as an early event in Alzheimer’s disease (Markesbery WR, Lovell MA, 2007).

For these reasons using effective antioxidants and plant derived anti-inflammatory substances make a lot of sense.

As an antioxidant I can’t think of anything more effective than the antioxidant glutathione which the body makes, but makes less of as we get older. You just have to be sure to take it in a form which works.

A plant derived anti-inflammatory substance with a lot of research behind it is curcumin.  This would also be beneficial, as long as you take it in a form which is well absorbed.

 

 Effective S-Acetyl GlutathioneEffective S-Acetyl Glutathione Transparent Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomache) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection.

Read More

Better Curcumin

Better CurcuminResearch has documented the many benefits of curcumin (found in turmeric spice), but regular curcumin is hard to absorb. Our formula improves the intake of this beneficial substance into the cells.

 Read More

 

 

 Komulainen P1, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing. 2007 Jul;36(4):443-8. Epub 2007 May 30.
 Markesbery WR1, Lovell MA. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol. 2007 Jul;64(7):954-6.
Miralbell J1, López-Cancio E, López-Oloriz J, Arenillas JF, Barrios M, Soriano-Raya JJ, Galán A, Cáceres C, Alzamora M, Pera G, Toran P, Dávalos A, Mataró M. Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors. Cerebrovasc Dis. 2013;36(2):98-105. doi: 10.1159/000352059. Epub 2013 Sep 11.
Reddy VP1, Zhu X, Perry G, Smith MA. Oxidative stress in diabetes and Alzheimer’s disease. J Alzheimers Dis. 2009;16(4):763-74. doi: 10.3233/JAD-2009-1013.
Wersching H1, Duning T, Lohmann H, Mohammadi S, Stehling C, Fobker M, Conty M, Minnerup J, Ringelstein EB, Berger K, Deppe M, Knecht S. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology. 2010 Mar 30;74(13):1022-9. doi: 10.1212/WNL.0b013e3181d7b45b.

Save