Your Road to Wellness

Dementia

Is there a connection between Cardiovascular risk and the risk for Alzheimer’s disease?

Posted by on Alzheimer’s, Brain, Dementia, General Health | 0 comments

 

An increased risk for developing Alzheimer’s disease is linked to the presence of apoE4, a genetic factor, which is also strongly associated with developing atherosclerosis which increases the risk for Cardiovascular disease (Altman R, Rutledge JC, 2010).                                                                     

The authors of the same article state that cardiovascular risk factors, including elevated blood cholesterol and triglycerides, increase the likelihood of Alzheimer’s disease and vascular dementia.

 

Researchers have also found that atherosclerosis causing obstruction of arteries at the base of the brain was more extensive in a group with Alzheimer’s disease when compared with a control group without dementia (Roher AE, et.al., 2011).

 

Arterial stiffness, atherosclerosis, endothelial degeneration and dysfunction of the blood-brain barrier can induce several features of Alzheimer’s disease including atrophy of certain areas of the brain (Kalaria RN, et.al., 2012). The endothelium is the inner lining of the blood vessels.

 

 

There are also other risk factors for Alzheimer’s disease and dementia, I will write more about that later.

 

Making changes to the way you eat is the most effective way to reduce cardiovascular risk, and you would most likely also reduce your risk for Alzheimer’s disease and dementia at the same time.  

When we correct the reasons for chronic conditions, we see an improvement in many areas, since the same reasons are involved in most chronic conditions.

 

 

References

Altman R, Rutledge JC. The vascular contribution to Alzheimer’s disease. Clin Sci (Lond). 2010 Aug 5;119(10):407-21.

Kalaria RN, Akinyemi R, Ihara M. Does vascular pathology contribute to Alzheimer changes? J Neurol Sci. 2012 Nov 15;322(1-2):141-7.

Roher AE, Tyas SL, Maarouf CL, Daugs ID, Kokjohn TA, Emmerling MR, Garami Z, Belohlavek M, Sabbagh MN, Sue LI, Beach TG. Intracranial atherosclerosis as a contributing factor to Alzheimer’s disease dementia. Alzheimers Dement. 2011 Jul;7(4):436-44.

 

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Do You Want To Help Prevent The Risk Of Dementia?

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Have you noticed that you don’t remember things as easily as you used to? If you have, you are not alone.

As we live longer now, and also because most people don’t have the best diet and lifestyle, dementia and Alzheimer’s disease are getting to be more and more common.

You don’t have to accept that as something you can’t do anything about.

This research documents some interesting facts related to this.

Glutathione, the body’s main antioxidant was measured in patients with Alzheimer’s disease, patients with mild cognitive impairment, and in healthy controls (Mandal PK, et al. 2015).

The glutathione levels were measured in 2 areas, the hippocampus and the frontal cortex of the brain using proton magnetic resonance spectroscopy.

The results showed reduced glutathione levels in both of these brain areas for people with Alzheimer’s.

It also showed a robust difference when participants with mild cognitive impairment were compared with healthy controls.

In one way this is good news because we can supplement with glutathione to increase the body’s glutathione levels.

The body starts to make less glutathione as we get into our forties, and it is estimated that we make approximately 10% less every year.

We just have to be sure to take a form of glutathione that has been documented to get into the cells where it is needed.

It is not enough to absorb it into the blood, it needs to be transferred into the cells to be effective.

Patented S-Acetyl Glutathione is the only form of glutathione that has been shown to do that. (Cacciatore I, et al. 2010).


Cacciatore I1, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels. Molecules. 2010 Mar 3;15(3):1242-64. doi: 10.3390/molecules15031242.
Mandal PK1, Saharan S2, Tripathi M3, Murari G2. Brain glutathione levels–a novel biomarker for mild cognitive impairment and Alzheimer’s disease. Biol Psychiatry. 2015 Nov 15;78(10):702-10. doi: 10.1016/j.biopsych.2015.04.005. Epub 2015 Apr 14.

Effective S-Acetyl Glutathione

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Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomach) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection and may also help reduce the risk of dementia.

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Insulin resistance increases your risk for dementia

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Insulin resistance is another risk factor for chronic disease.

When study participants with the average age of only 40 years had cognitive tests and also a brain MRI done, the researchers concluded that hyperglycemia (elevated blood glucose) is associated with subtle brain injury, impaired attention and memory; even in young adults. Diabetes was associated with decreased total cerebral brain and occipital lobar gray matter volumes (Weinstein G, et al. 2015).

You don’t, however, have to have diabetes for insulin resistance to cause problems.

In this study the participants were older with an average age of 63.1 years and nondiabetic (Kerti L, et al. 2013). HbA1c (which is a test for long term glucose control), fasting glucose and insulin were checked and MRI scans were used to assess brain volume and microstructures.

Even without type 2 diabetes or impaired glucose tolerance, chronically higher blood glucose levels have a negative influence on cognition, possibly related to changes in learning –relevant brain areas.  A higher rate of brain atrophy was documented in individuals with higher HbA1c, higher body mass index and high alcohol intake (Enzinger C, et al. 2005).

A lot of people are probably not aware of these facts. The media tend to make it look like we can’t do much to affect memory and the risk of Alzheimer’s, but this is far from true.

You can do a lot to prevent these problems. One of the most important things you can do is to stay as insulin sensitive as possible.

If you have not implemented a diet and lifestyle which will accomplish that, I suggest you do it as soon as possible before you forget.

 

Learn to Eat:  Recommendations that work. This is not a regular diet program.

Blood Glucose Support

Blood Glucose Support transparent This formula contains Fenugreek and two other herbs traditionally known to help support normal blood sugar.

 

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Enzinger C1, Fazekas F, Matthews PM, Ropele S, Schmidt H, Smith S, Schmidt R. Risk factors for progression of brain atrophy in aging: six-year follow-up of normal subjects. Neurology. 2005 May 24;64(10):1704-11.
 Kerti L1, Witte AV, Winkler A, Grittner U, Rujescu D, Flöel A. Higher glucose levels associated with lower memory and reduced hippocampal microstructure. Neurology. 2013 Nov 12;81(20):1746-52. doi: 10.1212/01.wnl.0000435561.00234.ee. Epub 2013 Oct 23.
 Weinstein G1, Maillard P2, Himali JJ2, Beiser AS2, Au R2, Wolf PA2, Seshadri S2, DeCarli C2. Glucose indices are associated with cognitive and structural brain measures in young adults. Neurology. 2015 Jun 9;84(23):2329-37. doi: 10.1212/WNL.0000000000001655. Epub 2015 May 6. 

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Dementia, Inflammation and free radical damage.

Posted by on Cognition, Dementia, Inflammation, Memory | 0 comments


Low grade inflammation and free radical damage are risk factors for most chronic conditions and dementia is no exemption.

Vascular risk factors, markers of inflammation and endothelial dysfunction predicted lower performance in several cognitive areas in a study which included 747 participants older than 50 years (Miralbell J, et al. 2013).

Examination of study participants with an average age of 63 years found that higher levels of the inflammatory marker hs-CRP was associated with worse performance in executive function (Wersching H, et al. 2010).

The low grade inflammation was associated with cerebral microstructural disintegration. Even if you don’t know exactly what cerebral microstructural disintegration is, it does not sound good to me. It’s probably something you don’t want to get.

High level of hs-CRP can even be used to identify individuals at an increased risk for cognitive decline because it predicted poorer memory 12 years later in elderly women (Komulainen P, et al. 2007).

Oxidative stress also plays a role in chronic conditions. Advanced glycation end products and lipid peroxidation are markers of disease progression for both diabetes and Alzheimer’s disease (Reddy VP, et al. 2009).

Autopsies have shown increased lipid peroxidation as well as protein, DNA and RNA oxidation in multiple brain regions establishing oxidative damage as an early event in Alzheimer’s disease (Markesbery WR, Lovell MA, 2007).

For these reasons using effective antioxidants and plant derived anti-inflammatory substances make a lot of sense.

As an antioxidant I can’t think of anything more effective than the antioxidant glutathione which the body makes, but makes less of as we get older. You just have to be sure to take it in a form which works.

A plant derived anti-inflammatory substance with a lot of research behind it is curcumin.  This would also be beneficial, as long as you take it in a form which is well absorbed.

 

 Effective S-Acetyl GlutathioneEffective S-Acetyl Glutathione Transparent Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomache) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection.

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Better Curcumin

Better CurcuminResearch has documented the many benefits of curcumin (found in turmeric spice), but regular curcumin is hard to absorb. Our formula improves the intake of this beneficial substance into the cells.

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 Komulainen P1, Lakka TA, Kivipelto M, Hassinen M, Penttilä IM, Helkala EL, Gylling H, Nissinen A, Rauramaa R. Serum high sensitivity C-reactive protein and cognitive function in elderly women. Age Ageing. 2007 Jul;36(4):443-8. Epub 2007 May 30.
 Markesbery WR1, Lovell MA. Damage to lipids, proteins, DNA, and RNA in mild cognitive impairment. Arch Neurol. 2007 Jul;64(7):954-6.
Miralbell J1, López-Cancio E, López-Oloriz J, Arenillas JF, Barrios M, Soriano-Raya JJ, Galán A, Cáceres C, Alzamora M, Pera G, Toran P, Dávalos A, Mataró M. Cognitive patterns in relation to biomarkers of cerebrovascular disease and vascular risk factors. Cerebrovasc Dis. 2013;36(2):98-105. doi: 10.1159/000352059. Epub 2013 Sep 11.
Reddy VP1, Zhu X, Perry G, Smith MA. Oxidative stress in diabetes and Alzheimer’s disease. J Alzheimers Dis. 2009;16(4):763-74. doi: 10.3233/JAD-2009-1013.
Wersching H1, Duning T, Lohmann H, Mohammadi S, Stehling C, Fobker M, Conty M, Minnerup J, Ringelstein EB, Berger K, Deppe M, Knecht S. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology. 2010 Mar 30;74(13):1022-9. doi: 10.1212/WNL.0b013e3181d7b45b.

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Reasons for dementia.

Posted by on Dementia | 0 comments


Dementia and Alzheimer’s disease are rapidly increasing worldwide.

While we don’t know everything about the causes for these conditions, research has documented several reasons and risk factors involved.

I will go through these risk factors and explain what you can do to help prevent memory loss and Alzheimer’s as you get older. The sooner you use the research available and implement these suggestions, the better off you will be.

If you have followed what I have written about reasons for chronic conditions, you have probably seen a pattern. I have systematically showed you what research has documented, and the reasons involved turn out to be the same. This actually makes things easier, as you will see improvement in several areas when you start to implement these recommendations.

Vascular impairment is also one of the reasons for cognitive impairment and Alzheimer’s disease (Gorelick PB, et al. 2011).

This should not be a surprise since every tissue in the body needs proper nutrition, and without a healthy vascular system the nutrient and energy supply to the tissue will be compromised. The brain uses a lot of energy and when you get deposits in the vascular system (endothelial dysfunction), your memory will also be affected.

It is interesting that saturated fat and trans fat have been associated with an increased risk for Alzheimer’s disease (Morris MC, et al. 2003).

Persons in the upper fifth of saturated fat intake had 2.2 times the risk for Alzheimer’s disease compared to persons in the lowest fifth intake. For the intake of trans fat starting with the second fifth intake, the risk increased 2.4 times.

Research has also associated higher intakes of these fats to vascular impairment. On the other hand, monounsaturated and polyunsaturated fat from vegetables were found to decrease the risk for Alzheimer’s.

Good sources of vegetable fat are avocados, nuts and seeds. Vegetable fat also acts as an energy source for the brain in addition to glucose.

The first thing you should do is to adjust your diet so it will provide you with high nutrient, low glycemic index food, including healthy fat.

Learn to Eat:  Recommendations that work. This is not a regular diet program.

 

Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S; American Heart Association Stroke Council, Council on Epidemiology and Prevention, Council on Cardiovascular Nursing, Council on Cardiovascular Radiology and Intervention, and Council on Cardiovascular Surgery and Anesthesia. Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke. 2011 Sep;42(9):2672-713. doi: 10.1161/STR.0b013e3182299496. Epub 2011 Jul 21.
 
Morris MC1, Evans DA, Bienias JL, Tangney CC, Bennett DA, Aggarwal N, Schneider J, Wilson RS. Dietary fats and the risk of incident Alzheimer disease. Arch Neurol. 2003 Feb;60(2):194-200.
 

 

Protect your memory with something you enjoy eating.

Posted by on Anti-aging, Brain, Cognition, Dementia, Memory | 0 comments

pieces of chocolate on whiteThe reviewed research first mapped out the precise brain location for age-related dysfunction using functional MRI.
The researchers then had 50-69 year old participants either consume a high or a low cocoa flavanol diet for 3 months(Brickman AM,et al. 2014).

The results showed that a high flavanol diet was found to enhance dentate gurus function, that is the function related to memory dysfunction, when measured with functional MRI and cognitive testing.

To increase your cocoa flavanol intake you can either eat some dark chocolate with a high flavanol content or drink some cocoa. Dark chocolate and cocoa are bitter; for that reason sugar is added of course, so be sure to watch your sugar levels with chocolate. The more bitter you can handle the better.

 

Brickman AM, Khan UA, Provenzano FA, Yeung LK, Suzuki W, Schroeter H, Wall M, Sloan RP, Small SA. Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults. Nat Neurosci. 2014 Dec;17(12):1798-803. doi: 10.1038/nn.3850. Epub 2014 Oct 26.

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