Your Road to Wellness

Breast cancer

Cancer: What supplements make sense.

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Low grade inflammation and oxidative stress have been found to increase the risk of cancer (Suhr YJ, et al. 2005).

The cell signaling component NF-kappaB involved in the inflammatory response has been implicated in the development of cancer.

The natural compound curcumin has been found to reduce NF-kappaB.

Research using breast cancer cells found that curcumin decreased metastasis and it indicates that the reason was for this was that curcumin affects NF-kappaB (Bachmeier BE, et al. 2008).

Regular curcumin is not well absorbed and is metabolically not that stable.

These are the reasons why regular curcumin has a limited therapeutic effect.

New and more effective formulations are however now available, greatly improving the effect of curcumin (Mimeault M, Batra SK, 2011).

Since oxidative stress also increases the risk for cancer it makes sense to take an effective antioxidant.

The body makes the antioxidant glutathione which is very effective, but it makes less as we get older.

We are, however, using more glutathione as we get older and when we are exposed to more oxidative stress.

You can take glutathione as a supplement, but regular reduced glutathione, which has been available for many years, produces little if any results, since it is oxidized (destroyed) in the stomach.

There is however other ways to take glutathione now. S-acetyl glutathione is glutathione in a form that is not oxidized in the stomach, but gets to the tissue it needs to protect.

 

 Effective S-Acetyl Glutathione

Effective S-Acetyl Glutathione Transparent

 Glutathione is your primary defense against aging, but regular glutathione is oxidized (destroyed in the stomache) and provides little value. S-Acetyl Glutathione is easily absorbed and provides protection.

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Better Curcumin

Better Curcumin

Research has documented the many benefits of curcumin (found in turmeric spice), but regular curcumin is hard to absorb. Our formula improves the intake of this beneficial substance into the cells.

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 Bachmeier BE1, Mohrenz IV, Mirisola V, Schleicher E, Romeo F, Höhneke C, Jochum M, Nerlich AG, Pfeffer U. Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis. 2008 Apr;29(4):779-89. Epub 2007 Nov 13.
Mimeault M1, Batra SK. Potential applications of curcumin and its novel synthetic analogs and nanotechnology-based formulations in cancer prevention and therapy. Chin Med. 2011 Aug 23;6:31. doi: 10.1186/1749-8546-6-31.
Surh YJ1, Kundu JK, Na HK, Lee JS.J  Redox-sensitive transcription factors as prime targets for chemoprevention with anti-inflammatory and antioxidative phytochemicals. Nutr. 2005 Dec;135(12 Suppl):2993S-3001S.

 

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Breast cancer: The influence of diet

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The protein complex mTORC is an important regulator of cellular metabolism, growth and proliferation.

Higher mTORC expression has been found in breast cancer tissue and has been associated with worse overall survival (Wazir U, et al. 2013).

mTORC opposes apoptosis were dysfunctional cells are removed and may for that reason promote cancer growth.

One of the things you can do is to make changes to what you eat because low protein plant based diets have been linked to decreased risk for various cancers (McArthy MF, 2011).

One of the reasons why this type of food reduces cancer risk may be because it reduces the activity of mTORC1.

Data from 91,779 women showed that greater consumption of a plant based dietary pattern is associated with reduced breast cancer risk (Link LB, et al. 2013).

A lower intake of saturated fat and trans fat after diagnosis of breast cancer is associated with improved survival (Beasley JM, et al. 2011).

A plant based diet will reduce theses fats since saturated fat and trans fat are mostly found in protein from animal sources.

In summary this is what you can do to reduce your risk for breast cancer.

  • Eliminate alcohol.
  • Reduce IGF-1 a growth factor.
  • Reduce mTORC a regulator of cellular metabolism and growth.
  • Reduce low grade inflammation.
  • Reduce the intake of saturated fat and trans fat.
  • A plant based diet will accomplish that.

 

Learn to Eat:  Recommendations that work. This is not a regular diet program.

 

Beasley JM1, Newcomb PA, Trentham-Dietz A, Hampton JM, Bersch AJ, Passarelli MN, Holick CN, Titus-Ernstoff L, Egan KM, Holmes MD, Willett WC. Post-diagnosis dietary factors and survival after invasive breast cancer. Breast Cancer Res Treat. 2011 Jul;128(1):229-36. doi: 10.1007/s10549-010-1323-z. Epub 2011 Jan 1.
Link LB1, Canchola AJ, Bernstein L, Clarke CA, Stram DO, Ursin G, Horn-Ross PL. Dietary patterns and breast cancer risk in the California Teachers Study cohort. Am J Clin Nutr. 2013 Dec;98(6):1524-32. doi: 10.3945/ajcn.113.061184. Epub 2013 Oct 9.
McCarty MF1. mTORC1 activity as a determinant of cancer risk–rationalizing the cancer-preventive effects of adiponectin, metformin, rapamycin, and low-protein vegan diets. Med Hypotheses. 2011 Oct;77(4):642-8. doi: 10.1016/j.mehy.2011.07.004.
Wazir U1, Newbold RF, Jiang WG, Sharma AK, Mokbel K. Prognostic and therapeutic implications of mTORC1 and Rictor expression in human breast cancer. Oncol Rep. 2013 May;29(5):1969-74. doi: 10.3892/or.2013.2346. Epub 2013 Mar 13.

 

 

Breast cancer and low grade inflammation

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Inflammation increase the risk of cancer particularly breast cancer as an initiator or promoter (Hung RJ, et al. 2015).

A study of 49,258 Swedish women indicated that a pro-inflammatory diet increased the risk of developing breast cancer especially in postmenopausal women (Shivappa N, et al. 2015).

Why does inflammation stimulate cancer growth?

Acute inflammation is protective and involved in the healing of injuries as well as preventing infections.

Chronic low grade inflammation on the other hand can lead to a variety of diseases cancer being one (Aggarwal BB, et al. 2006).

Several pro-inflammatory cytokines have been identified being involved in the suppression of apoptosis (regulated cell death), invasion and metastasis.

There are several ways the diet can trigger inflammation.

One way it can do it which is very interesting and unknown to many, is by a substance called Neu5Gc which is not produced by humans anymore, but is found in dietary sources from animals especially in red meat and milk products (Hedlund M, et al. 2008).

Our bodies produce antibodies to Neu5Gc, human tumors accumulate Neu5Gc, and the resulting low grade inflammation stimulates tumor growth ( Hedlund M, et al. 2008).

It has been proposed that maybe tumors have antigens because they don’t develop in the absence of at least a minimal immune reaction (inflammatory reaction) (Phren RT, Phren LM, 2008).

Now you have even more reasons to incorporate a plant based diet.

I will review more research related to this topic.

 

Learn to Eat:  Recommendations that work. This is not a regular diet program.

 

Aggarwal BB1, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: how hot is the link? Biochem Pharmacol. 2006 Nov 30;72(11):1605-21. Epub 2006 Aug 4.
Hedlund M1, Padler-Karavani V, Varki NM, Varki A. Evidence for a human-specific mechanism for diet and antibody-mediated inflammation in carcinoma progression. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18936-41. doi: 10.1073/pnas.0803943105. Epub 2008 Nov 18.
Hung RJ1, Ulrich CM2, Goode EL2, Brhane Y2, Muir K2, Chan AT2, Marchand LL2, Schildkraut J2, Witte JS2, Eeles R2, Boffetta P2, Spitz MR2, Poirier JG2, Rider DN2, Fridley BL2, Chen Z2, Haiman C2, Schumacher F2, Easton DF2, Landi MT2, Brennan P2, Houlston R2, Christiani DC2, Field JK2, Bickeböller H2, Risch A2, Kote-Jarai Z2, Wiklund F2, Grönberg H2, Chanock S2, Berndt SI2, Kraft P2, Lindström S2, Al Olama AA2, Song H2, Phelan C2, Wentzensen N2, Peters U2, Slattery ML2; for GECCO, Sellers TA2; for FOCI, Casey G2, Gruber SB2; for CORECT, Hunter DJ2; for DRIVE, Amos CI2, Henderson B2; GAME-ON Network. Cross Cancer Genomic Investigation of Inflammation Pathway for Five Common Cancers: Lung, Ovary, Prostate, Breast, and Colorectal Cancer. J Natl Cancer Inst. 2015 Aug 29;107(11). pii: djv246. doi: 10.1093/jnci/djv246. Print 2015 Nov.
Prehn RT1, Prehn LM. The flip side of immune surveillance: immune dependency. Immunol Rev. 2008 Apr;222:341-56. doi: 10.1111/j.1600-065X.2008.00609.x.
Shivappa N1,2, Sandin S3, Löf M4, Hébert JR1,2, Adami HO3,5, Weiderpass E3,6,7,8. Prospective study of dietary inflammatory index and risk of breast cancer in Swedish women. Br J Cancer. 2015 Sep 3. doi: 10.1038/bjc.2015.304. [Epub ahead of print]

 

Breast Cancer: There’s a lot you can do to prevent it

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What are some of the risk factors for breast cancer that you can do something about?

Light alcohol drinking, up to 1 drink per day, has been shown to significantly increase breast cancer and also some other cancers (Bagnardi V, et al. 2013). Heavy alcohol consumption, 3 or more drinks per day, is associated with an even higher risk of 40-50% (Seitz HK, et al. 2012). Alcohol increases estrogen levels and would be especially important to avoid for estrogen receptor positive breast cancer.

When insulin-like growth factor 1 (IGF-1) was investigated for associations with breast cancer using data from 17 studies, it was found that it was positively associated with breast cancer risk (Key TJ, et al. 2010).

IGF-1 is a growth factor and as such it stimulates tissue growth which is needed when we are young.  We don’t need the same tissue stimulation as we get older, that may lead to growth of tumors since it stimulate all tissue.

IGF-1 is also a factor involved in metastasis (Tang X, et al. 2010).

How can you reduce IGF-1?

You can do it by eating a plant based diet. Research has documented that a vegan diet effectively reduced IGF-1 when compared with meat eaters (Allen NE, et al. 2002). The vegan diet also increased IGF-1 binding protein which means that less of the IGF-1 was available to stimulate tissue growth.

The reason the vegan diet reduced IGF-1 is because protein from vegetable sources have a different amino acid profile than protein from animal sources.

 

Learn to Eat:  Recommendations that work. This is not a regular diet program.

Allen NE1, Appleby PN, Davey GK, Kaaks R, Rinaldi S, Key TJ. The associations of diet with serum insulin-like growth factor I and its main binding proteins in 292 women meat-eaters, vegetarians, and vegans. Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1441-8.
Bagnardi V1, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, Scotti L, Jenab M, Turati F, Pasquali E, Pelucchi C, Bellocco R, Negri E, Corrao G, Rehm J, Boffetta P, La Vecchia C. Light alcohol drinking and cancer: a meta-analysis. Ann Oncol. 2013 Feb;24(2):301-8. doi: 10.1093/annonc/mds337. Epub 2012 Aug 21.
Endogenous Hormones and Breast Cancer Collaborative Group, Key TJ, Appleby PN, Reeves GK, Roddam AW. Insulin-like growth factor 1 (IGF1), IGF binding protein 3 (IGFBP3), and breast cancer risk: pooled individual data analysis of 17 prospective studies. Lancet Oncol. 2010 Jun;11(6):530-42. doi: 10.1016/S1470-2045(10)70095-4. Epub 2010 May 14.
Seitz HK1, Pelucchi C, Bagnardi V, La Vecchia C. Epidemiology and pathophysiology of alcohol and breast cancer: Update 2012. Alcohol Alcohol. 2012 May-Jun;47(3):204-12. doi: 10.1093/alcalc/ags011. Epub 2012 Mar 29.
Tang X1, Zhang Q, Shi S, Yen Y, Li X, Zhang Y, Zhou K, Le AD. Bisphosphonates suppress insulin-like growth factor 1-induced angiogenesis via the HIF-1alpha/VEGF signaling pathways in human breast cancer cells. Int J Cancer. 2010 Jan 1;126(1):90-103. doi: 10.1002/ijc.24710.

 

Can you change your estrogen metabolites by exercising?

Posted by on Breast cancer, Cervical Cancer, Endometrial cancer, Exercise, Exercise, Women, Womens health | 0 comments

Beautiful skinny woman riding a bike in fitnessWhat would be the benefits of changing your estrogen metabolites?
Certain estrogen metabolites are related to a higher risk for estrogen related diseases. Breast cancer is one of those diseases. If you could change the ratio between the harmless metabolites and the ones related to an increased risk for estrogen related problems you would be better off.
The reviewed research investigated if exercise could do that since exercise has shown to reduce the risk for breast cancer.(Smith AJ,et al. 2013).

The participants were healthy young women who were divided into either an exercise group doing 30 minutes of moderate to vigorous aerobic exercise 5 days a week or a sedentary control group.  The study went on for approximately 16 weeks.

Estrogen’s and estrogen metabolites were measured,and the rates of the different metabolites were calculated. The change from the baseline measurements increased significantly in the exercise group for 2-OHE1/16α-OHE1 which is the ratio of the estrogen metabolites associated with a decreased risk for estrogen related diseases. This change was not seen in the control group.
 

The researchers concluded that this may be the mechanism by which increased physical activity is decreasing the risk for breast cancer.

Smith AJ1, Phipps WR, Thomas W, Schmitz KH, Kurzer MS. The effects of aerobic exercise on estrogen metabolism in healthy premenopausal women. Cancer Epidemiol Biomarkers Prev. 2013 May;22(5):756-64. doi: 10.1158/1055-9965.EPI-12-1325.

Tomatoes Influence Breast Cancer Risk

Posted by on Breast cancer, Cancer, Eating, Eye Health, General Health, Stay healthy, Wellness, Women, Womens health | 0 comments

You have probably heard that tomatoes are good for your eyes because of an antioxidant called lycopene. Did you know that tomatoes can make a difference with breast cancer risk? The reviewed research investigated just that (Llanos AA, et al. 2014).

Add tomatoes and fight breast cancer70 postmenopausal women at increased risk for breast cancer participated in the study. Their average age was 57.2 years. First they consumed a tomato-based diet which included at least 25 mg of lycopene daily for 10 weeks, and later they consumed a soy-based diet for 10 weeks which included at least 40 g of soy protein daily. The women were also tested for adiponectin and two other hormones.

Other research has documented a decreased risk for several types of cancers, including breast cancer when adiponectin is increasing(Kishida K, et Al. 2014).

When the subjects consumed the tomato-based diet, it was found that the adiponectin concentration increased. This indicates that tomato-based food is especially beneficial for women who are at higher risk for postmenopausal breast cancer. Don’t forget that tomatoes are beneficial for other things – especially your eyes!

 

 

 

 

Llanos AA1, Peng J, Pennell ML, Krok JL, Vitolins MZ, Degraffinreid CR, Paskett ED. Effects of tomato and soy on serum adipokine concentrations in postmenopausal women at increased breast cancer risk: a cross-over dietary intervention trial. J Clin Endocrinol Metab. 2014 Feb;99(2):625-32. doi: 10.1210/jc.2013-3222. Epub 2014 Jan 1.
Kishida K1, Funahashi T2, Shimomura I3. Adiponectin as a routine clinical biomarker. Best Pract Res Clin Endocrinol Metab. 2014 Jan;28(1):119-30. doi: 10.1016/j.beem.2013.08.006. Epub 2013 Aug 20.