Your Road to Wellness

Antioxidents

Antioxidants in joint fluid are reduced in osteoarthritis. This is what you can do.

Posted by on 6:50 am Antioxidents, Arthritis, Exercise, General Health, Joint health, Supplements, Supplements for Conditions, Supplements List | 0 comments

Excess reactive oxygen species and oxidative damage have been associated with the pathogenesis of osteoarthritis.  Joint fluid from patients with osteoarthritis is characterized by significantly decreased extracellular superoxide dismutase (SOD) levels, a significantly decreased glutathione level, and ascorbate when compared to knee joints with intact cartilage (Regan EA, et.al., 2008).

SOD is one of the body’s antioxidant enzymes and glutathione is the body’s most effective antioxidant.  These changes in joint fluid antioxidants are likely to accelerate the oxidative damage of the cartilage.

The body needs copper, zinc, and manganese to produce SOD, so one of the things you can do to help prevent cartilage degeneration is to take these minerals.  The glutathione level was also reduced, and you can also take S-Acetyl Glutathione to increase cellular glutathione (Cacciatore I, et.al., 2010).

Don’t make the mistake and supplement with reduced glutathione which is the most common form on the market.  No significant changes were observed in biomarkers of oxidative stress, including glutathione status of oral glutathione supplementation (Allen J, Bradley RD, 2011).

References

Allen J, Bradley RD.Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33.

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels. Molecules. 2010 Mar 3;15(3):1242-64.

Regan EA, Bowler RP, Crapo JD.Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injuryOsteoarthritis Cartilage. 2008 Apr;16(4):515-21.

 

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

 

 

 

 

 

You may know that you need calcium, but maybe you have heard that taking calcium may cause calcification of blood vessels.

Taking calcium by itself is not a good idea. You need to take calcium in a formula that includes multiple nutrients, and it needs to include magnesium. That’s one of the reasons the BMJ contains a large amount of magnesium in a very well absorbed form.

Click here to improve your bone, muscle, and joint health!

What can we do to reduce oxidative stress as we get older?

Posted by on 1:48 am Anti-aging, Antioxidents, General Health, Health, Health Risk, Stress | 0 comments

We know that aging is associated with oxidative stress.  This research tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress and what could be done about it (Sekhar RV, et.al., 2011).

Two groups that were divided into age groups made up the participants.  Both older and younger participants were infused with glycine and measured for red blood cell (RBC) glutathione synthesis and concentrations, plasma oxidative stress, and markers of oxidative damage.

Compared with the younger participants, the elderly participants had markedly lower RBC concentrations of glycine, cysteine and glutathione synthesis and higher oxidative stress.

After infusion with glycine, glutathione synthesis increased significantly and oxidative stress decreased significantly. No difference was found between the older and the younger participants after the infusion.                                                                  

The researcher stated that glutathione deficiency in elderly humans occurs because of a marked reduction in synthesis.

Does this mean that you have to go and have infusions all the time?

No, it’s not that complicated anymore.  You can supplement with S-Acetyl Glutathione, which is a very effective form of glutathione and gets it into the cells where it’s needed (Cacciatore I, et.al., 2010).   Don’t make the mistake and supplement with reduced glutathione–which is the most common form on the market. No significant changes were observed in biomarkers of oxidative stress, including glutathione status of oral glutathione supplementation (Allen J, Bradley RD, 2011).

References

Allen J, Bradley RD.Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33.

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels.Molecules. 2010 Mar 3;15(3):1242-64.

Sekhar RV1, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F, Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011 Sep;94(3):847-53.

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

What can blueberries do for you?

Posted by on 1:49 am Anti-aging, Antioxidents, Diet, Eating, General Health, General Health, Stay healthy, The Learn to Eat Plan, Tissue Recovery Blog, Wellness | 0 comments

Blueberries contain flavonoids and it is the flavonoids that provide all the health benefits.

The following study showed that daily 1-month blueberry consumption increased flow-mediated dilation as well as lowered systolic blood pressure (Rodriguez-Mateos A, et.al., 2019).

The more blueberries are researched, the more impressive they look.

Flow-mediated dilation is a measurement of endothelial function (the endothelium is the inner lining of the blood vessels).

When flow-mediated dilation was measured in healthy men after blueberry flavonoid intake, the researchers found a dose-dependent increase up to an intake of 766 mg polyphenols (Rodriguez-Mateos A, et.al., 2013). The increase was seen from 1-6 hours after the intake.

Blueberries can be used to help protect the blood vessels from damage as the following study shows.

Human aortic endothelial cells showed a reduced expression of inflammatory markers after being exposed to substances found from blueberry consumption (Cutler BR, et.al., 2018).

100 g of blueberries twice daily would give you protection the whole day. While fresh blueberries are expensive, frozen blueberries are better priced.  Adding blueberries to your diet daily would give you these benefits.

References

Cutler BR, Gholami S, Chua JS, Kuberan B, Anandh Babu PV.Blueberry metabolites restore cell surface glycosaminoglycans and attenuate endothelial inflammation in diabetic human aortic endothelial cells. Int J Cardiol. 2018 Jun 15;261:155-158.

Rodriguez-Mateos A, Istas G, Boschek L, Feliciano RP, Mills CE, Boby C, Gomez-Alonso S, Milenkovic D, Heiss C,Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics. J Gerontol A Biol Sci Med Sci. 2019 Feb 16. pii: glz047.

Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, Spencer JP.Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr. 2013 Nov;98(5):1179-91.

 

 

Learn to Eat Program

Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more…

Can nuts reduce the formation of vascular plaque?

Posted by on 9:54 pm Antioxidents, Cholesterol, Diet, Eating, Fat, Health, Low glycemic meals, The Learn to Eat Plan, Wellness | 0 comments

 

Plaque formation in the vascular system is something we are better off without, not only because it will increase cardiovascular risk, but we need good blood circulation to all tissue we have. Blood vessels in the brain of Alzheimer’s patients have, for example, been found to have a lot of plaque.

What can we do to help reduce plaque formation?

A high nutrient, low-glycemic index plant-based diet is a good choice, but is it possible to only add one food, and see a significant reduction in vascular plaque?

That’s exactly what the researchers of the following study investigated.

They measured the internal carotid intima-media thickness and plaque height using ultrasound at the start and after an average follow up of 2.4 years(Sala-Vila A, et.al, 2014).

Carotid intima-media thickness is the thickness of the inner layer of the blood vessel.

The participants consumed a Mediterranean diet. One group added either virgin olive oil or 30 grams of nuts every day to their diet. The control group consumed a low fat diet.

These were the results:

Compared with the control diet, consumption of a Mediterranean diet supplemented with nuts was associated with delayed progression of  intima-media thickness and plaque.

It is also interesting that there were no changes after the Mediterranean diet with the added virgin olive oil.

What could be the reason for that?

A good assumption would be that nuts contain nutrients the olive oil is missing, especially antioxidants.

Oil even if it is a good oil is not as good as natural unprocessed food.

30 grams of nuts is only one big handful.

Get in the habit of reducing your intake of grains and use some nuts instead. That will work a lot better for you (unless you are allergic to nuts). 

Reference

Sala-Vila A, Romero-Mamani ES, Gilabert R, Núñez I, de la Torre R, Corella D, Ruiz-Gutiérrez V, López-Sabater MC, Pintó X, Rekondo J, Martínez-González MÁ, Estruch R, Ros E.Changes in ultrasound-assessed carotid intima-media thickness and plaque with a Mediterranean diet: a substudy of the PREDIMED trial.Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):439-45.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more

How can you protect yourself from the neurotoxicity of mercury?

Posted by on 6:30 am Antioxidents, Diet, Eating, General Health, mercury | 0 comments

Everybody agrees that having a well-functioning nervous system is of great importance if we are going to function well and be healthy.

There are several things that can damage the nervous system, and mercury is one of these toxins. Contamination of the environment and subsequently our food is common, mercury in fish is one example.

Contaminated fish is one way mercury enters our body.

One way of avoiding the mercury in fish is of course not to eat fish, but we can be exposed to mercury from other sources as well. It is difficult not to be exposed to mercury at all. Mercury has been found to cause oxidative damage and induce neurotoxic damage with involvement of the mitochondria (Aschner M, et.al., 2007). The mitochondria is the energy producing component of the cell.

The body has mechanisms in place to deal with toxins and oxidative stress, otherwise we would not have survived. The protection we have is not always enough, even if we eat food that includes a lot of plants which can help to provide antioxidant protection.

The most effective antioxidant the body is making is glutathione, and it works very well if we have enough of it to deal with the toxins and free radicals we are exposed to. Data indicates however that the availability of glutathione to the cells may not be sufficient to provide protection against mercury toxicity (Becker A, Soliman KF, 2009). As we get older we make less glutathione each year, and after we turn 40, we can use some additional help. In some cases, even younger people can benefit from some assistance, it depends on how much toxins and free radicals the body has been exposed to through the years.

We now have an effective form of glutathione we can take in capsule form, and that is S-Acetyl Glutathione.
The most common form on the market, reduced glutathione, is not a very effective form since it is oxidized in the stomach and offer very little protection. S-Acetyl Glutathione is however transferred into the cells where it is needed. (Cacciatore I, et.al., 2010).

References

Aschner M, Syversen T, Souza DO, Rocha JB, Farina M. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz J Med Biol Res. 2007 Mar;40(3):285-91.

Becker A, Soliman KF. The role of intracellular glutathione in inorganic mercuryinduced toxicity in neuroblastoma cells. Neurochem Res. 2009 Sep;34(9):1677-84.

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels. Molecules. 2010 Mar 3;15(3):1242-64.

 

 

 

Glutathione helps your cells function and supports a healthy immune system

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

3 Important Benefits of Flax Seeds

Posted by on 12:26 pm Anti-Aging, Anti-aging, Antioxidents, Blood Pressure, Bloodsugar, Body fat, Bone density, bone loss, Diabetes, Flaxseeds, General Health, General Health, Glucose, Green tea, Happiness, HDL, HDL Level, Health, Health Risk | 0 comments

 

One of the impressive health benefits of flax seeds is the ability to decrease blood pressure (Rodriguez-Leyva D, et.al., 2013).

In a double-blinded, placebo-controlled study, 30 g of flax seeds daily for 6 months reduced the systolic blood pressure of 10 mm Hg and the diastolic blood pressure with 7 mm Hg.

 This is as good as some blood pressure medications, and instead of side-effects, you get even additional benefits.

13 g of flax seeds daily has shown to decrease blood glucose and insulin and improve insulin sensitivity in obese individuals with pre-diabetes (Hutchins AM, et.al., 2013).

Flax seeds can also lower cholesterol. 

In just 7 days a drink made of flax seeds lowered total cholesterol by 12% and LDL cholesterol (the bad cholesterol) 15% (Kristensen M, et.al., 2012).

Even if many people are not aware of these health benefits, it’s been known for a long time that flax seeds can reduce total cholesterol, LDL and decrease the blood glucose after a meal (Cunnane SC, et.al., 1993).

 

It is very important to keep the blood glucose in a good range even after a meal, it is not enough to only have good fasting blood glucose.

I recommend grinding 2 tablespoons of flax seeds in a coffee grinder and put them in a glass with water, stir it and drink it thick. You can of course also sprinkle it on food, like a salad if you prefer.

 

References

Cunnane, S. C., Ganguli, S., Menard, C., Liede, A. C., Hamadeh, M. J., Chen, Z. Y., … & Jenkins, D. J. (1993). High α-linolenic acid flaxseed (Linum usitatissimum): some nutritional properties in humansBritish Journal of Nutrition69(2), 443-453.

Hutchins, A. M., Brown, B. D., Cunnane, S. C., Domitrovich, S. G., Adams, E. R., & Bobowiec, C. E. (2013). Daily flaxseed consumption improves glycemic control in obese men and women with pre-diabetes: a randomized study. Nutrition research33(5), 367-375.

Kristensen, M., Jensen, M. G., Aarestrup, J., Petersen, K. E., Søndergaard, L., Mikkelsen, M. S., & Astrup, A. (2012). Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but the magnitude of the effect depends on food typeNutrition & Metabolism9(1), 8.

Rodriguez-Leyva, D., Weighell, W., Edel, A. L., LaVallee, R., Dibrov, E., Pinneker, R., … & Pierce, G. N. (2013). Potent Antihypertensive Action of Dietary Flaxseed in Hypertensive PatientsNovelty and Significance. Hypertension62(6), 1081-1089.