Your Road to Wellness

Anti-aging

How and when does cardiovascular disease start?

Posted by on 8:55 pm Anti-aging, Cardiovascular Disease, Cholesterol, Eating, Fat, HDL, Heart disease | 0 comments

 

The clogged pipe analogy is the old, but outdated model of explaining cardiovascular disease which still is used most of the time because of lack of understanding and lack of exposure to research (Rothberg MB, 2013).

According to this model, cholesterol plaque in the arterial walls slowly reduce the opening of the artery, first causing decreased blood flow without symptoms, then it causes angina (chest pain), and eventually it results in an infarction.

Treatments based on this theory include both coronary bypass surgery and angioplasty opening the blood vessel with a stent or a balloon.

While a massive plaque eventually can close up an artery, a heart attack is usually caused by unstable plaque thatmay not be easily detected, but can rupture and form a clot.

This is what happens according to more in depth research.

Low-density lipoprotein (LDL) mainly produced in the liver may infiltrate the vascular endothelium (the inner wall of the blood vessel), where it can initiate a complex inflammatory response. This inflammatory response can lead to arterial remodeling, in which plaque growth within the vessel walls is accommodated by outward enlargement of the vessel.

In that case, large plaques may not reduce the opening of the blood vessel and are therefore hidden from angiography.

These plaques are particularly dangerous both because they are prone to rupture, they are unstable, and because before rupture they do not limit the blood flow and therefore do not induce formation of protective collaterals.

If the blood flow slowly gets restricted as in stable plaque, the body will compensate by making new blood vessels to support the area in need, that’s why stable plaque is less dangerous.

A lot of people apparently have several plaque ruptures in their vascular system without symptoms.These ruptures can heal and is later impossible to detect.

For these reasons it’s very difficult to use available scanning methods as reliable tools to predict  a deadly plaque rupture.

There is however strong evidence that addressing the extent and activity of the atherosclerotic burden and thrombosis-promoting risk factors will improve risk (Arbab-Zadeh A, et.al., 2015).

Oxidized LDL is especially damaging to the endothelium, the inner lining of the blood vessels (Gradinaru D, et al., 2015).

Oxidized LDL cholesterol is associated with early atherosclerosis (Calmarza P, et.al., 2014).

When does atherosclerosis start?

It start at a very young age.

Atherosclerosis varied from 17% in individuals less than 20 years old to 85% in people 50 years old or older (Tuzcu EM, et.al., 2001).

If you have children, this is something to keep in mind. It is very important to have a healthy diet even for a child.

References

Arbab-Zadeh A, Fuster V.The myth of the “vulnerable plaque”: transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment.J Am Coll Cardiol. 2015 Mar 3;65(8):846-855.

Calmarza P1, Trejo JM, Lapresta C, López P,LDL oxidation and its association with carotid artery intima-media thickness and other cardiovascular risk factors in a sample of Spanish general population.Angiology. 2014 Apr;65(4):357-62.

Gradinaru D, Borsa C, Ionescu C, Prada GI,Oxidized LDL and NO synthesis–Biomarkers of endothelial dysfunction and ageing.Mech Ageing Dev. 2015 Nov;151:101-13.

Rothberg MB,Coronary artery disease as clogged pipes: a misconceptual model.Circ Cardiovasc Qual Outcomes. 2013 Jan 1;6(1):129-32.

Tuzcu EM1, Kapadia SR, Tutar E, Ziada KM, Hobbs RE, McCarthy PM, Young JB, Nissen SE.High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound.Circulation. 2001 Jun 5;103(22):2705-10.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more

 

Reduce memory loss by taking this

Posted by on 11:55 pm Anti-aging, Brain, General Health, Memory | 0 comments

Homocysteine, a toxic amino acid, is a risk factor for brain atrophy, cognitive impairment and dementia. Homocysteine can however be lowered by using certain B vitamins.

The reason for the following research was to investigate if B vitamins can slow the rate of brain atrophy in subjects with mild cognitive impairment (Smith AD, et.al., 2017).

The participants were over 70 years old and had mild cognitive impairment. MRI scans of the brain were used to measure the rate of atrophy over 2 years.

The treatment group was given vitamin B12, folic acid and B6 and compared to a placebo group.

The researchers concluded that elderly people with mild cognitive impairment can slow brain atrophy using homocysteine lowering B vitamins.

Research with a 3 year follow up on men, found that high homocysteine levels were associated with cognitive decline (Tucker KL, et.al., 2005).

Blood levels of vitamin B6, B12 and folate were associated with cognitive decline and especially folate was found to be protective in this study.

Taking a high-quality vitamin B complex can be very helpful. Ideally you should take a formula which contains the metabolite of folic acid, 5-methyltetrahydrofolate, since it is quite common not to metabolize folic acid well.

References
Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010 Sep 8;5(9):e12244.

Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A 3rd. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005 Sep;82(3):627-35

 

 

This is not a regular B vitamin formula.

The B1 (thiamine), B2 (riboflavin), B6 (pyridoxine), and B12 (cobalamin) comes in their physiologically active form, making them easier to absorb.

To get your bottle, click here.

Protect your cardiovascular health and your joint health with one substance

Posted by on 10:47 pm Anti-aging, Brain, General Health, Memory | 0 comments

Interesting and surprising research suggests you can reduce cardiovascular risk and protect your joints
by taking the same substance.

More and more research provides evidence that oxidative stress alters many functions of the endothelium, the inner layer of the blood vessels (Cai H, Harrison DG, 2000).

Nitric oxide which opens blood vessels and improves circulation is inactivated by free radicals. This seems to occur in conditions such as hypertension, high cholesterol, diabetes, and smoking.

The use of glucosamine has been associated with reduced total mortality and a significant decreased risk of death from cancer and with a large risk reduction for death from respiratory diseases (Bell GA, et.al.,
2012).

Glucosamine sulfate has for many years been used to support joint cartilage and treat osteoarthritis.

The following study is interesting because the researchers investigated if glucosamine could improve endothelial function (Katoh A, et.al., 2017).They stated that vascular endothelial function is a potent surrogate marker of atherosclerosis and cardiovascular mortality where oxidative stress could be involved.

Endothelial function was evaluated using flow mediated dilation and oxidative, antioxidant status was evaluated by measuring the ratio of glutathione to the oxidized form of glutathione.

The results showed that glucosamine administration improved endothelial function and the ratio of
glutathione to the oxidized form of glutathione.

According to this research by reducing oxidative stress, the vascular function improved.

What if you could take both glucosamine and an effective form of glutathione?

It looks like that would be even more effective.

The patented form of S-Acetyl Glutathione is an effective form of glutathione shown to enter the cell.

References
Bell GA, Kantor ED, Lampe JW, Shen DD, White E. Use of glucosamine and chondroitin in relation to
mortality. Eur J Epidemiol. 2012 Aug;27(8):593-603.

Cai H1, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ
Res. 2000 Nov 10;87(10):840-4.

Katoh A, Kai H, Harada H, Niiyama H, Ikeda H, Oral Administration of Glucosamine Improves Vascular
Endothelial Function by Modulating Intracellular Redox State. Int Heart J. 2017 Dec 12;58(6):926-932.

 

 

 

 

Glutathione helps your cells function and supports a healthy immune system

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to maintain your levels of glutathione!

 

 

 

 

You may know that you need calcium, but maybe you have heard that taking calcium may cause calcification of blood vessels.

Taking calcium by itself is not a good idea. You need to take calcium in a formula that includes multiple nutrients, and it needs to include magnesium. That’s one of the reasons the BMJ contains a large amount of magnesium in a very well absorbed form.

Click here to improve your bone, muscle, and joint health!

 

 

 

This substance is decreased in neurodegeneration and Alzheimer’s disease.

Posted by on 10:18 pm Anti-aging, Brain, General Health, Memory | 0 comments

 

This substance is decreased in neurodegeneration and Alzheimer’s disease.

There is especially 1 substance which is very important for the brain and the nervous system, and that is
glutathione, a very effective antioxidant as well as an immune system regulator.

Glutathione is a substance the body is producing, and it is involved in many functions throughout the body. The body is however producing less as we get older, and that’s when we need more.

In the brain glutathione also regulates cell signaling, protein function, gene expression, and cell differentiation/proliferation.

Decreased levels of glutathione and increased oxidative stress are common in major neurodegenerative diseases (Ayoama K, Nakaki T, 2013).

In the following study proton magnetic resonance spectroscopy was used to measure brain glutathione levels in healthy controls, in patients with mild cognitive decline and in patients with Alzheimer’s disease
(Mandal PK, et.al., 2015).

The researchers concluded that the present study provided compelling evidence that glutathione levels in specific brain regions is a clinically relevant biomarker for mild cognitive decline and Alzheimer’s disease.

It is very important to do what we can early on to help prevent memory problems and Alzheimer’s disease, as these neurological problems are getting more and more common.

Changes in the brain start to occur many years before any symptoms are noticed.

Some years ago, glutathione could only be supplied by IV because the only oral form available, reduced glutathione is not very bioavailable, and does not produce results.

That however changed when S-Acetyl Glutathione, a patented form of glutathione, became available. S-Acetyl Glutathione gets transferred into the cells where it is needed.

References
Aoyama K, Nakaki T. Impaired glutathione synthesis in neurodegeneration. Int J Mol Sci. 2013 Oct
18;14(10):21021-44.
Mandal PK, Saharan S, Tripathi M, Murari G. Brain glutathione levels–a novel biomarker for mild
cognitive impairment and Alzheimer’s disease. Biol Psychiatry. 2015 Nov 15;78(10):702-10.

 

 

 

 

Glutathione helps your cells function and supports a healthy immune system

BioPro, Inc. Tissue Recovery is using  the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to maintain your levels of glutathione!

 

Improve Your Memory By Improving Brain Circulation

Posted by on 10:23 am Anti-aging, General Health, Health, Memory, Resveratrol, Womens health | 0 comments

 

Resveratrol supplementation has shown to improve executive function and memory in older adults (Thaung Zaw JJ., et.al., 2017).

The benefits were due to improved cerebral perfusion, circulation in the brain.

When 80 post-menopausal women were supplementing with trans-resveratrol or a placebo for 14 weeks, the researchers found that the women taking the resveratrol had significant improvements in verbal memory and overall cognitive function (Evans HM, et.al., 2017).

The researchers also measured cerebrovascular responsiveness and found an increase of 17% in the women taking resveratrol.

The dosage producing the improvements was low.

 

Only 75 mg of resveratrol taken twice a day was required to produce the results.

Post-menopausal women are at a higher risk for memory loss because of hormonal changes.

The bioavailability of resveratrol is low. That can, however, be greatly improved by using a methylated form of resveratrol (Wen X, Walle T, 2017).

 

 

References:

Evans HM, Howe PR, Wong RH. Clinical Evaluation of Effects of Chronic Resveratrol Supplementation on Cerebrovascular Function, Cognition, Mood, Physical Function and General Well-Being in Postmenopausal Women-Rationale and Study Design. Nutrients. 2016 Mar 9;8(3):150.

 

Thaung Zaw JJ, Howe PRC, Wong RHX. Does phytoestrogen supplementation improve cognition in humans? A systematic review. Ann N Y Acad Sci. 2017 Sep;1403(1):150-163.

 

Wen X, Walle T. Methylated flavonoids have greatly improved intestinal absorption and metabolic stability. Drug Metab Dispos. 2006 Oct;34(10):1786-92.

Resveratrol SC

Anti-Aging Formula

Resveratrol is found in the skin of grapes, but also in other various plants. It is known as an antioxidant and got a lot of attention when a study on mice showed that resveratrol increased their lifespan spite of a high fat, high-calorie diet. Some of the changes included improved insulin sensitivity, increased number of mitochondria (the energy producing entity of the cell) and improved motor function (they moved better).

READ MORE…

Reduce Inflammation By Adding 1 Food

Posted by on 9:52 am Anti-aging, General Health, Health Risk, Inflammation, Inflammatory factor | 0 comments

You can reduce inflammation by adding just 1 type of food to your diet.

If you also remove another food, you will get even better results.

When a group of type 2 diabetes patients replaced 2 servings of red meat with different types of legumes like lentils, chickpeas, peas and beans for only 3 days per week for 8 weeks, this was the result (Hosseinpour-Niazi S, et.al., 2015).

 

heart shape by various vegetables and fruits

The legumes resulted in significantly reduced levels of the inflammatory markers hs-CRP, IL-6 and TNF-alpha, compared to when they ingested the red meat instead of the legumes.

 

After consuming a legume diet for 6 weeks, comparing it to their regular diet, first-degree relatives of patients with diabetes had significantly reduced levels of hs-CRP (Saraf-Bank F, et.al., 2015).

Women with the highest legume intake had lower levels of hs-CRP, IL-6 and TNF-alpha compared to the ones with the lowest intake (Ezmaillzadeh A, Azakbakht L, 2012).

 

Just by adding beans or lentils to your meals, you can reduce low-grade inflammation significantly.

That is not difficult. Adding beans to a salad is easy, and if you substitute potatoes or rice with beans or lentils, you should notice a nice difference in your inflammatory markers.

Not only will you see a difference there, but most likely you will also see a reduction in cholesterol and triglyceride levels as well.

 

 

References:

  1. Hosseinpour-Niazi, S., Mirmiran, P., Fallah-Ghohroudi, A., & Azizi, F. (2015). Non-soya legume-based therapeutic lifestyle change diet reduces inflammatory status in diabetic patients: a randomised cross-over clinical trial. British Journal of Nutrition, 114(2), 213-219.
  2. Saraf-Bank, S., Esmaillzadeh, A., Faghihimani, E., & Azadbakht, L. (2015). Effect of non-soy legume consumption on inflammation and serum adiponectin levels among first-degree relatives of patients with diabetes: A randomized, crossover study. Nutrition, 31(3), 459-465.
  3. Esmaillzadeh, A., & Azadbakht, L. (2012). Legume consumption is inversely associated with serum concentrations of adhesion molecules and inflammatory biomarkers among Iranian women. The Journal of nutrition, 142(2), 334-339.

Learn To Eat Program:

Recommendations that work. Foods that can reduce inflammation. This is not a regular diet.