Your Road to Wellness

Anti-aging

Improve your genetic potential

Posted by on 8:50 am Anti-aging, General Health, Happiness, Meditation, Research, Stress, Wellness | 0 comments

While we can’t change our genes yet, we can however improve the expression of our genes.  There are several factors that affect how we express our genes.

One of the more important factors is stress.

In this study, researchers tested several functions after a practice session of healthy individuals who had practiced meditation for many years and participants that had only practiced for eight weeks, comparing it with participants who listen to health education (Bhasin MK, et.al., 2013).

The practice of meditation enhanced expression of genes associated with energy metabolism, mitochondrial function, insulin secretion and telomere maintenance, and reduced expression of genes linked to inflammatory response and stress-related pathways.

The response was stronger in those who had been practicing meditation for a long time.

In another study the researchers found that practitioners of “Loving-Kindness Meditation” had significantly longer telomere length than controls when Genomic DNA was tested (Hoge EA, et.al., 2013).

Telomeres relates to how fast we age.

Shorter telomeres have been linked to chronic stress and shorter telomere length can serve as a marker of accelerated aging.

When telomerase was measured in participants practising meditation at a retreat, an increase in telomerase activity was found compared to the control group (Jacobs TL, et.al., 2011).

This was also very interesting. Increases in “Purpose in Life” directly mediated the telomerase group difference, whereas increases in Mindfulness did not.

So the research shows that not all meditation produces the same results.

References

Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, Libermann TA.Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013 May 1;8(5):e62817.

Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, MacLean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD. Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology. 2011 Jun;36(5):664-81.

Hoge EA, Chen MM, Orr E, Metcalf CA, Fischer LE, Pollack MH, De Vivo I, Simon NM.Loving-Kindness Meditation practice associated with longer telomeres in women. Brain Behav Immun. 2013 Aug;32:159-63.

 

 

 

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What can you do to help your immune system to better protect yourself from pathogens like viruses?

Posted by on 9:52 am Anti-aging, General Health, General Health, Health, Supplements, Wellness | 0 comments

We are exposed to pathogens–especially viruses–all the time and our immune system is very effective at protecting us.  This means that most of the time, we don’t get sick.

Research has, however, found evidence of decreased levels of glutathione in several diseases–such as cancer, viral infections and immune dysfunction–as well as in aging (Fraternale A, et.al., 2006, Fraternale A, et. al., 2017).

Intra-cellular glutathione levels influence the Th1/Th2 immune response and the effectiveness of the immune system.

The body makes glutathione, which is involved in many cellular functions such as detoxification, amino acid transport, production of coenzymes, and the recycling of vitamins E and C.

Glutathione has also been found to inhibit viral replication (Fraternale, et.al., 2006).

It’s no doubt that glutathione is very important, and as long as your body is able to make what’s necessary to protect you, everything is fine.

The problem, however, is that the body is not able to provide adequate amounts of glutathione as we get older. The decrease is gradual.  Additionally, the rate of decrease depends on our exposure to pathogens, toxins, and oxidative stressors that require the protection of glutathione.  

You would not usually need to supplement with glutathione in your twenties, but as you get into your forties, the need for supplementation will increase.

Reduced glutathione–which is the most common form on the market–is not very effective since it is oxidized in your stomach and very little is absorbed.

S-Acetyl Glutathione a patented substance is however very effective and gets into the cells where it is needed (Cacciatore I, et.al., 2010).

Researchers have proposed molecules able to increase glutathione levels as new tools to more effectively hinder different pathogens by acting as both immunomodulators and antimicrobials.

References

Cacciatore I1, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levelsMolecules. 2010 Mar 3;15(3):1242-64.

Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55.

Fraternale A, Brundu S, Magnani M. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275.

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

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Does milk help prevent fractures?

Posted by on 9:28 am Anti-aging, Bone density, bone loss, Diet, Diseases, Eating, General Health, The Learn to Eat Plan | 0 comments

Milk is by most people believed to help support bone formation and reduce the risk for fractures, but is that true?

The following research investigated milk intake and the risk of mortality and fractures in women and men (Michaelsson K, et.al., 2014).

This study was done in Sweden and included 61,433 women and 45,339 men. The average follow up for the women was 20.1 year and for the men 11.2 years.

High milk intake was associated with higher mortality for both women and men, and with a higher fracture

incidence in women.

It’s common to recommend milk for teenagers to promote increased bone mass.

To determine whether milk consumption during teenage years influences the risk of hip fracture in older adults, the researchers of this study included both women and men and did 22 years of follow-up (Feskanich D, et.al., 2014).

After controlling for known risk factors and current milk consumption, each additional glass of milk per day during teenage years was associated with a significant 9% higher risk of hip fracture in men.

It was concluded that greater milk consumption during teenage years was not associated with a lower risk of hip fracture in older adults.

These studies were population studies using food frequency questionnaires which is not as accurate as double blinded research comparing 2 groups.

However, when the research includes large population groups and both show the same results, it’s worthwhile to pay attention to the results.

References

Michaëlsson K, Wolk A, Langenskiöld S, Basu S, Warensjö Lemming E, Melhus H, Byberg L. Milk intake and risk of mortality and fractures in women and men: cohort studies.BMJ. 2014 Oct 28;349:g6015.

Feskanich D, Bischoff-Ferrari HA, Frazier AL, Willett WC. Milk consumption during teenage years and risk of hip fractures in older adults. JAMA Pediatr. 2014 Jan;168(1):54-60.

 

 

Learn to Eat Program

Based on the most effective scientific strategies, this program was created to help
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How and when does cardiovascular disease start?

Posted by on 8:55 pm Anti-aging, Cardiovascular Disease, Cholesterol, Eating, Fat, HDL, Heart disease | 0 comments

 

The clogged pipe analogy is the old, but outdated model of explaining cardiovascular disease which still is used most of the time because of lack of understanding and lack of exposure to research (Rothberg MB, 2013).

According to this model, cholesterol plaque in the arterial walls slowly reduce the opening of the artery, first causing decreased blood flow without symptoms, then it causes angina (chest pain), and eventually it results in an infarction.

Treatments based on this theory include both coronary bypass surgery and angioplasty opening the blood vessel with a stent or a balloon.

While a massive plaque eventually can close up an artery, a heart attack is usually caused by unstable plaque thatmay not be easily detected, but can rupture and form a clot.

This is what happens according to more in depth research.

Low-density lipoprotein (LDL) mainly produced in the liver may infiltrate the vascular endothelium (the inner wall of the blood vessel), where it can initiate a complex inflammatory response. This inflammatory response can lead to arterial remodeling, in which plaque growth within the vessel walls is accommodated by outward enlargement of the vessel.

In that case, large plaques may not reduce the opening of the blood vessel and are therefore hidden from angiography.

These plaques are particularly dangerous both because they are prone to rupture, they are unstable, and because before rupture they do not limit the blood flow and therefore do not induce formation of protective collaterals.

If the blood flow slowly gets restricted as in stable plaque, the body will compensate by making new blood vessels to support the area in need, that’s why stable plaque is less dangerous.

A lot of people apparently have several plaque ruptures in their vascular system without symptoms.These ruptures can heal and is later impossible to detect.

For these reasons it’s very difficult to use available scanning methods as reliable tools to predict  a deadly plaque rupture.

There is however strong evidence that addressing the extent and activity of the atherosclerotic burden and thrombosis-promoting risk factors will improve risk (Arbab-Zadeh A, et.al., 2015).

Oxidized LDL is especially damaging to the endothelium, the inner lining of the blood vessels (Gradinaru D, et al., 2015).

Oxidized LDL cholesterol is associated with early atherosclerosis (Calmarza P, et.al., 2014).

When does atherosclerosis start?

It start at a very young age.

Atherosclerosis varied from 17% in individuals less than 20 years old to 85% in people 50 years old or older (Tuzcu EM, et.al., 2001).

If you have children, this is something to keep in mind. It is very important to have a healthy diet even for a child.

References

Arbab-Zadeh A, Fuster V.The myth of the “vulnerable plaque”: transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment.J Am Coll Cardiol. 2015 Mar 3;65(8):846-855.

Calmarza P1, Trejo JM, Lapresta C, López P,LDL oxidation and its association with carotid artery intima-media thickness and other cardiovascular risk factors in a sample of Spanish general population.Angiology. 2014 Apr;65(4):357-62.

Gradinaru D, Borsa C, Ionescu C, Prada GI,Oxidized LDL and NO synthesis–Biomarkers of endothelial dysfunction and ageing.Mech Ageing Dev. 2015 Nov;151:101-13.

Rothberg MB,Coronary artery disease as clogged pipes: a misconceptual model.Circ Cardiovasc Qual Outcomes. 2013 Jan 1;6(1):129-32.

Tuzcu EM1, Kapadia SR, Tutar E, Ziada KM, Hobbs RE, McCarthy PM, Young JB, Nissen SE.High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound.Circulation. 2001 Jun 5;103(22):2705-10.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more

 

Reduce memory loss by taking this

Posted by on 11:55 pm Anti-aging, Brain, General Health, Memory | 0 comments

Homocysteine, a toxic amino acid, is a risk factor for brain atrophy, cognitive impairment and dementia. Homocysteine can however be lowered by using certain B vitamins.

The reason for the following research was to investigate if B vitamins can slow the rate of brain atrophy in subjects with mild cognitive impairment (Smith AD, et.al., 2017).

The participants were over 70 years old and had mild cognitive impairment. MRI scans of the brain were used to measure the rate of atrophy over 2 years.

The treatment group was given vitamin B12, folic acid and B6 and compared to a placebo group.

The researchers concluded that elderly people with mild cognitive impairment can slow brain atrophy using homocysteine lowering B vitamins.

Research with a 3 year follow up on men, found that high homocysteine levels were associated with cognitive decline (Tucker KL, et.al., 2005).

Blood levels of vitamin B6, B12 and folate were associated with cognitive decline and especially folate was found to be protective in this study.

Taking a high-quality vitamin B complex can be very helpful. Ideally you should take a formula which contains the metabolite of folic acid, 5-methyltetrahydrofolate, since it is quite common not to metabolize folic acid well.

References
Smith AD, Smith SM, de Jager CA, Whitbread P, Johnston C, Agacinski G, Oulhaj A, Bradley KM, Jacoby R, Refsum H. Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One. 2010 Sep 8;5(9):e12244.

Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A 3rd. High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr. 2005 Sep;82(3):627-35

 

 

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Protect your cardiovascular health and your joint health with one substance

Posted by on 10:47 pm Anti-aging, Brain, General Health, Memory | 0 comments

Interesting and surprising research suggests you can reduce cardiovascular risk and protect your joints
by taking the same substance.

More and more research provides evidence that oxidative stress alters many functions of the endothelium, the inner layer of the blood vessels (Cai H, Harrison DG, 2000).

Nitric oxide which opens blood vessels and improves circulation is inactivated by free radicals. This seems to occur in conditions such as hypertension, high cholesterol, diabetes, and smoking.

The use of glucosamine has been associated with reduced total mortality and a significant decreased risk of death from cancer and with a large risk reduction for death from respiratory diseases (Bell GA, et.al.,
2012).

Glucosamine sulfate has for many years been used to support joint cartilage and treat osteoarthritis.

The following study is interesting because the researchers investigated if glucosamine could improve endothelial function (Katoh A, et.al., 2017).They stated that vascular endothelial function is a potent surrogate marker of atherosclerosis and cardiovascular mortality where oxidative stress could be involved.

Endothelial function was evaluated using flow mediated dilation and oxidative, antioxidant status was evaluated by measuring the ratio of glutathione to the oxidized form of glutathione.

The results showed that glucosamine administration improved endothelial function and the ratio of
glutathione to the oxidized form of glutathione.

According to this research by reducing oxidative stress, the vascular function improved.

What if you could take both glucosamine and an effective form of glutathione?

It looks like that would be even more effective.

The patented form of S-Acetyl Glutathione is an effective form of glutathione shown to enter the cell.

References
Bell GA, Kantor ED, Lampe JW, Shen DD, White E. Use of glucosamine and chondroitin in relation to
mortality. Eur J Epidemiol. 2012 Aug;27(8):593-603.

Cai H1, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ
Res. 2000 Nov 10;87(10):840-4.

Katoh A, Kai H, Harada H, Niiyama H, Ikeda H, Oral Administration of Glucosamine Improves Vascular
Endothelial Function by Modulating Intracellular Redox State. Int Heart J. 2017 Dec 12;58(6):926-932.

 

 

 

 

Glutathione helps your cells function and supports a healthy immune system

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

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You may know that you need calcium, but maybe you have heard that taking calcium may cause calcification of blood vessels.

Taking calcium by itself is not a good idea. You need to take calcium in a formula that includes multiple nutrients, and it needs to include magnesium. That’s one of the reasons the BMJ contains a large amount of magnesium in a very well absorbed form.

Click here to improve your bone, muscle, and joint health!