Your Road to Wellness

Anti-aging

What can we do to reduce oxidative stress as we get older?

Posted by on 1:48 am Anti-aging, Antioxidents, General Health, Health, Health Risk, Stress | 0 comments

We know that aging is associated with oxidative stress.  This research tested whether glutathione deficiency occurs because of diminished synthesis and contributes to oxidative stress and what could be done about it (Sekhar RV, et.al., 2011).

Two groups that were divided into age groups made up the participants.  Both older and younger participants were infused with glycine and measured for red blood cell (RBC) glutathione synthesis and concentrations, plasma oxidative stress, and markers of oxidative damage.

Compared with the younger participants, the elderly participants had markedly lower RBC concentrations of glycine, cysteine and glutathione synthesis and higher oxidative stress.

After infusion with glycine, glutathione synthesis increased significantly and oxidative stress decreased significantly. No difference was found between the older and the younger participants after the infusion.                                                                  

The researcher stated that glutathione deficiency in elderly humans occurs because of a marked reduction in synthesis.

Does this mean that you have to go and have infusions all the time?

No, it’s not that complicated anymore.  You can supplement with S-Acetyl Glutathione, which is a very effective form of glutathione and gets it into the cells where it’s needed (Cacciatore I, et.al., 2010).   Don’t make the mistake and supplement with reduced glutathione–which is the most common form on the market. No significant changes were observed in biomarkers of oxidative stress, including glutathione status of oral glutathione supplementation (Allen J, Bradley RD, 2011).

References

Allen J, Bradley RD.Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33.

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels.Molecules. 2010 Mar 3;15(3):1242-64.

Sekhar RV1, Patel SG, Guthikonda AP, Reid M, Balasubramanyam A, Taffet GE, Jahoor F, Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. Am J Clin Nutr. 2011 Sep;94(3):847-53.

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

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What can blueberries do for you?

Posted by on 1:49 am Anti-aging, Antioxidents, Diet, Eating, General Health, General Health, Stay healthy, The Learn to Eat Plan, Tissue Recovery Blog, Wellness | 0 comments

Blueberries contain flavonoids and it is the flavonoids that provide all the health benefits.

The following study showed that daily 1-month blueberry consumption increased flow-mediated dilation as well as lowered systolic blood pressure (Rodriguez-Mateos A, et.al., 2019).

The more blueberries are researched, the more impressive they look.

Flow-mediated dilation is a measurement of endothelial function (the endothelium is the inner lining of the blood vessels).

When flow-mediated dilation was measured in healthy men after blueberry flavonoid intake, the researchers found a dose-dependent increase up to an intake of 766 mg polyphenols (Rodriguez-Mateos A, et.al., 2013). The increase was seen from 1-6 hours after the intake.

Blueberries can be used to help protect the blood vessels from damage as the following study shows.

Human aortic endothelial cells showed a reduced expression of inflammatory markers after being exposed to substances found from blueberry consumption (Cutler BR, et.al., 2018).

100 g of blueberries twice daily would give you protection the whole day. While fresh blueberries are expensive, frozen blueberries are better priced.  Adding blueberries to your diet daily would give you these benefits.

References

Cutler BR, Gholami S, Chua JS, Kuberan B, Anandh Babu PV.Blueberry metabolites restore cell surface glycosaminoglycans and attenuate endothelial inflammation in diabetic human aortic endothelial cells. Int J Cardiol. 2018 Jun 15;261:155-158.

Rodriguez-Mateos A, Istas G, Boschek L, Feliciano RP, Mills CE, Boby C, Gomez-Alonso S, Milenkovic D, Heiss C,Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics. J Gerontol A Biol Sci Med Sci. 2019 Feb 16. pii: glz047.

Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, Spencer JP.Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr. 2013 Nov;98(5):1179-91.

 

 

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Improve your genetic potential

Posted by on 8:50 am Anti-aging, General Health, Happiness, Meditation, Research, Stress, Wellness | 0 comments

While we can’t change our genes yet, we can however improve the expression of our genes.  There are several factors that affect how we express our genes.

One of the more important factors is stress.

In this study, researchers tested several functions after a practice session of healthy individuals who had practiced meditation for many years and participants that had only practiced for eight weeks, comparing it with participants who listen to health education (Bhasin MK, et.al., 2013).

The practice of meditation enhanced expression of genes associated with energy metabolism, mitochondrial function, insulin secretion and telomere maintenance, and reduced expression of genes linked to inflammatory response and stress-related pathways.

The response was stronger in those who had been practicing meditation for a long time.

In another study the researchers found that practitioners of “Loving-Kindness Meditation” had significantly longer telomere length than controls when Genomic DNA was tested (Hoge EA, et.al., 2013).

Telomeres relates to how fast we age.

Shorter telomeres have been linked to chronic stress and shorter telomere length can serve as a marker of accelerated aging.

When telomerase was measured in participants practising meditation at a retreat, an increase in telomerase activity was found compared to the control group (Jacobs TL, et.al., 2011).

This was also very interesting. Increases in “Purpose in Life” directly mediated the telomerase group difference, whereas increases in Mindfulness did not.

So the research shows that not all meditation produces the same results.

References

Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, Libermann TA.Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013 May 1;8(5):e62817.

Jacobs TL, Epel ES, Lin J, Blackburn EH, Wolkowitz OM, Bridwell DA, Zanesco AP, Aichele SR, Sahdra BK, MacLean KA, King BG, Shaver PR, Rosenberg EL, Ferrer E, Wallace BA, Saron CD. Intensive meditation training, immune cell telomerase activity, and psychological mediators. Psychoneuroendocrinology. 2011 Jun;36(5):664-81.

Hoge EA, Chen MM, Orr E, Metcalf CA, Fischer LE, Pollack MH, De Vivo I, Simon NM.Loving-Kindness Meditation practice associated with longer telomeres in women. Brain Behav Immun. 2013 Aug;32:159-63.

 

 

 

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What can you do to help your immune system to better protect yourself from pathogens like viruses?

Posted by on 9:52 am Anti-aging, General Health, General Health, Health, Supplements, Wellness | 0 comments

We are exposed to pathogens–especially viruses–all the time and our immune system is very effective at protecting us.  This means that most of the time, we don’t get sick.

Research has, however, found evidence of decreased levels of glutathione in several diseases–such as cancer, viral infections and immune dysfunction–as well as in aging (Fraternale A, et.al., 2006, Fraternale A, et. al., 2017).

Intra-cellular glutathione levels influence the Th1/Th2 immune response and the effectiveness of the immune system.

The body makes glutathione, which is involved in many cellular functions such as detoxification, amino acid transport, production of coenzymes, and the recycling of vitamins E and C.

Glutathione has also been found to inhibit viral replication (Fraternale, et.al., 2006).

It’s no doubt that glutathione is very important, and as long as your body is able to make what’s necessary to protect you, everything is fine.

The problem, however, is that the body is not able to provide adequate amounts of glutathione as we get older. The decrease is gradual.  Additionally, the rate of decrease depends on our exposure to pathogens, toxins, and oxidative stressors that require the protection of glutathione.  

You would not usually need to supplement with glutathione in your twenties, but as you get into your forties, the need for supplementation will increase.

Reduced glutathione–which is the most common form on the market–is not very effective since it is oxidized in your stomach and very little is absorbed.

S-Acetyl Glutathione a patented substance is however very effective and gets into the cells where it is needed (Cacciatore I, et.al., 2010).

Researchers have proposed molecules able to increase glutathione levels as new tools to more effectively hinder different pathogens by acting as both immunomodulators and antimicrobials.

References

Cacciatore I1, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levelsMolecules. 2010 Mar 3;15(3):1242-64.

Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M. Antiviral and immunomodulatory properties of new pro-glutathione (GSH) molecules. Curr Med Chem. 2006;13(15):1749-55.

Fraternale A, Brundu S, Magnani M. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275.

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

Does milk help prevent fractures?

Posted by on 9:28 am Anti-aging, Bone density, bone loss, Diet, Diseases, Eating, General Health, The Learn to Eat Plan | 0 comments

Milk is by most people believed to help support bone formation and reduce the risk for fractures, but is that true?

The following research investigated milk intake and the risk of mortality and fractures in women and men (Michaelsson K, et.al., 2014).

This study was done in Sweden and included 61,433 women and 45,339 men. The average follow up for the women was 20.1 year and for the men 11.2 years.

High milk intake was associated with higher mortality for both women and men, and with a higher fracture

incidence in women.

It’s common to recommend milk for teenagers to promote increased bone mass.

To determine whether milk consumption during teenage years influences the risk of hip fracture in older adults, the researchers of this study included both women and men and did 22 years of follow-up (Feskanich D, et.al., 2014).

After controlling for known risk factors and current milk consumption, each additional glass of milk per day during teenage years was associated with a significant 9% higher risk of hip fracture in men.

It was concluded that greater milk consumption during teenage years was not associated with a lower risk of hip fracture in older adults.

These studies were population studies using food frequency questionnaires which is not as accurate as double blinded research comparing 2 groups.

However, when the research includes large population groups and both show the same results, it’s worthwhile to pay attention to the results.

References

Michaëlsson K, Wolk A, Langenskiöld S, Basu S, Warensjö Lemming E, Melhus H, Byberg L. Milk intake and risk of mortality and fractures in women and men: cohort studies.BMJ. 2014 Oct 28;349:g6015.

Feskanich D, Bischoff-Ferrari HA, Frazier AL, Willett WC. Milk consumption during teenage years and risk of hip fractures in older adults. JAMA Pediatr. 2014 Jan;168(1):54-60.

 

 

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Based on the most effective scientific strategies, this program was created to help
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How and when does cardiovascular disease start?

Posted by on 8:55 pm Anti-aging, Cardiovascular Disease, Cholesterol, Eating, Fat, HDL, Heart disease | 0 comments

 

The clogged pipe analogy is the old, but outdated model of explaining cardiovascular disease which still is used most of the time because of lack of understanding and lack of exposure to research (Rothberg MB, 2013).

According to this model, cholesterol plaque in the arterial walls slowly reduce the opening of the artery, first causing decreased blood flow without symptoms, then it causes angina (chest pain), and eventually it results in an infarction.

Treatments based on this theory include both coronary bypass surgery and angioplasty opening the blood vessel with a stent or a balloon.

While a massive plaque eventually can close up an artery, a heart attack is usually caused by unstable plaque thatmay not be easily detected, but can rupture and form a clot.

This is what happens according to more in depth research.

Low-density lipoprotein (LDL) mainly produced in the liver may infiltrate the vascular endothelium (the inner wall of the blood vessel), where it can initiate a complex inflammatory response. This inflammatory response can lead to arterial remodeling, in which plaque growth within the vessel walls is accommodated by outward enlargement of the vessel.

In that case, large plaques may not reduce the opening of the blood vessel and are therefore hidden from angiography.

These plaques are particularly dangerous both because they are prone to rupture, they are unstable, and because before rupture they do not limit the blood flow and therefore do not induce formation of protective collaterals.

If the blood flow slowly gets restricted as in stable plaque, the body will compensate by making new blood vessels to support the area in need, that’s why stable plaque is less dangerous.

A lot of people apparently have several plaque ruptures in their vascular system without symptoms.These ruptures can heal and is later impossible to detect.

For these reasons it’s very difficult to use available scanning methods as reliable tools to predict  a deadly plaque rupture.

There is however strong evidence that addressing the extent and activity of the atherosclerotic burden and thrombosis-promoting risk factors will improve risk (Arbab-Zadeh A, et.al., 2015).

Oxidized LDL is especially damaging to the endothelium, the inner lining of the blood vessels (Gradinaru D, et al., 2015).

Oxidized LDL cholesterol is associated with early atherosclerosis (Calmarza P, et.al., 2014).

When does atherosclerosis start?

It start at a very young age.

Atherosclerosis varied from 17% in individuals less than 20 years old to 85% in people 50 years old or older (Tuzcu EM, et.al., 2001).

If you have children, this is something to keep in mind. It is very important to have a healthy diet even for a child.

References

Arbab-Zadeh A, Fuster V.The myth of the “vulnerable plaque”: transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment.J Am Coll Cardiol. 2015 Mar 3;65(8):846-855.

Calmarza P1, Trejo JM, Lapresta C, López P,LDL oxidation and its association with carotid artery intima-media thickness and other cardiovascular risk factors in a sample of Spanish general population.Angiology. 2014 Apr;65(4):357-62.

Gradinaru D, Borsa C, Ionescu C, Prada GI,Oxidized LDL and NO synthesis–Biomarkers of endothelial dysfunction and ageing.Mech Ageing Dev. 2015 Nov;151:101-13.

Rothberg MB,Coronary artery disease as clogged pipes: a misconceptual model.Circ Cardiovasc Qual Outcomes. 2013 Jan 1;6(1):129-32.

Tuzcu EM1, Kapadia SR, Tutar E, Ziada KM, Hobbs RE, McCarthy PM, Young JB, Nissen SE.High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound.Circulation. 2001 Jun 5;103(22):2705-10.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more