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Your Road to Wellness

Alzheimer’s

The neurovascular system, oxidative stress and neurodegenerative diseases like Alzheimer’s. What can you do to protect yourself?

Posted by on 7:31 am Alzheimer’s, Cardiovascular Disease, Dementia, Nervous System | 0 comments

oxidative stress

 

It is very important to have a good blood supply to every tissue in the body.  All tissues, but especially the brain, depending on the good blood supply to function properly.  This is most important for the brain because it has a very high energy demand.

Neurons, glial cells, and blood vessels communicate with each other to regulate cerebral blood flow.

This study gathered information on the importance of oxidative stress as it relates to vascular changes observed in brain aging and neurodegenerative conditions like Alzheimer’s (Carvalho C, Moreira PI, 2018).

One of the emerging causative factors associated with Alzheimer’s pathology is oxidative stress.  This Alzheimer’s-related increase in oxidative stress has been attributed to decreased levels of the brain antioxidant, glutathione (Saharan S, Mandal PK, 2014).

Glutathione protects cells against oxidative stress, and protecting brain endothelial cells under oxidative stress is key to treating cerebrovascular diseases and neurodegenerative diseases including Alzheimer’s disease (Song J, et.al., 2014).  The endothelium is the inner layer of the blood vessel wall.

The body makes glutathione, but it is making less as we get older, and that’s when we need more.

We can, however, take glutathione orally.   Regularly reduced glutathione which is the most common form you will find for sale is not very bioavailable, most of it is oxidized in the stomach and is not going to provide much protection.

You can instead take S-Acetyl Glutathione which gets into the cells and provides very valuable protection from free radical damage.

 

References:

Carvalho C, Moreira PI, Oxidative Stress: A Major Player in Cerebrovascular Alterations Associated to Neurodegenerative Events.Front Physiol. 2018 Jul 3;9:806.

Saharan S, Mandal PK. The emerging role of glutathione in Alzheimer’s disease. J Alzheimers Dis. 2014;40(3):519-29.

Song J, Kang SM, Lee WT, Park KA, Lee KM, Lee JE.Glutathione protects brain endothelial cells from hydrogen peroxide-induced oxidative stress by increasing nrf2 expression.Exp Neurobiol. 2014 Mar;23(1):93-103. 

 

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Can being exposed to heat help your memory, and reduce your risk for Alzheimer’s disease?

Posted by on 9:00 am Alzheimer’s, Cardiovascular Disease, Dementia | 0 comments

 

If you follow us regularly you saw that the stress of high heat as in sauna use provided protection against cardiovascular disease. Cardiovascular disease and memory disorders share some of the same risk factors. Does that mean sauna use would provide some protection from Alzheimer’s disease as well? The following research investigated just that.

 

 

2,315 apparently healthy men aged 42-60 years at the start of the study, were followed for an
average of 20.7 years (LaukkanenT, et al., 2017). Of these men, 204 ended up being diagnosed with dementia and 123 were diagnosed with
Alzheimer’s disease. 4-7 sauna bathing sessions per week were found to be associated with lowered risks of
dementia and Alzheimer’s disease. This was the same frequency of sauna use that helped prevent death from cardiovascular
disease. Sauna baths also make you very relaxed afterward. Give it a try.

 

Reference:
Laukkanen T, Kunutsor S, Kauhanen J, Laukkanen JA, Sauna bathing is inversely associated
with dementia and Alzheimer’s disease in middle-aged Finnish men. Age Ageing. 2017 Mar
1;46(2):245-249.

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Oxidised cholesterol and Alzheimer’s disease

Posted by on 6:46 am Alzheimer’s, Cholesterol | 0 comments

 

Increasing evidence is now supporting the hypothesis that oxidized cholesterol is the driving force behind the development of Alzheimer’s disease and oxysterols, which are the oxidized form of cholesterol, are the link connecting the disease to altered cholesterol metabolism in the brain and to high cholesterol; this is because of the ability of oxysterols, unlike cholesterol, to cross the blood brain barrier (Gamba, et.al., 2015).

 

 

Oxidative stress is associated with neuroinflammation, and a vicious circle has been found to connect oxidative stress and inflammation in Alzheimer’s disease.

 

Analysis of published data shows that the levels of cholesterol are increased in people with mild cognitive impairment,  and 24-hydroxycholesterol and 27-hydroxycholesterol are elevated in patients with Alzheimer’s disease and mild cognitive impairment compared to controls (Wang, et.al., 2016).

24-hydroxycholesterol and 27-hydroxycholesterol are types of oxysterols.

The following research found that study participants with mild cognitive impairment had significantly higher levels of 27-hydroxycholesterol when compared to participants with normal cognition (Liu Q, et.al., 2016).

It may look like taking statin drugs to lower cholesterol could be a solution to prevent memory loss later in life, but that does not work.

 

In this study the authors concluded that there is good evidence that statins given in late life to people at risk of vascular disease do not prevent cognitive decline or dementia (McGuinness B, et.al., 2016).

 

Dietary changes are a better choice.

 

This research indicated that adherence to the meditranean diet was associated with better cognitive performance and lower dementia rates (Anastasiou CA, et.al., 2017).

 

References:

 

Anastasiou CA, Yannakoulia M, Kosmidis MH, Dardiotis E, Hadjigeorgiou GM, Sakka P, Arampatzi X, Bougea A, Labropoulos I, Scarmeas N, Mediterranean diet and cognitive health: Initial results from the Hellenic Longitudinal Investigation of Ageing and Diet.PLoS One. 2017 Aug 1;12(8):e0182048.

 

Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G.Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease.Front Aging Neurosci. 2015 Jun 19;7:119. 

 

Liu Q, An Y, Yu H, Lu Y, Feng L, Wang C, Xiao R.Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.Lipids Health Dis. 2016 Oct 10;15(1):177.

 

McGuinness B1, Craig D, Bullock R, Passmore P.Statins for the prevention of dementia. Cochrane Database Syst Rev. 2016 Jan 4;(1):CD003160.

Wang HL, Wang YY, Liu XG, Kuo SH, Liu N, Song QY, Wang MW.Cholesterol, 24-Hydroxycholesterol, and 27-Hydroxycholesterol as Surrogate Biomarkers in Cerebrospinal Fluid in Mild Cognitive Impairment and Alzheimer’s Disease: A Meta-Analysis.J Alzheimers Dis. 2016;51(1):45-55.

 

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Oxidative stress is involved in cognitive impairment and Alzheimer’s Disease

Posted by on 8:28 am Alzheimer’s, Anti-Aging, Cognition, Diseases, General Health, Health Risk, Research, Stress, Wellness | 0 comments

Increased oxidative stress has been documented in the frontal cortex in individuals with Alzheimer’s disease and in patients with mild cognitive impairment (Ansari, MA 2010).  One of the emerging causative factors associated with Alzheimer’s pathology is oxidative stress. This AD-related increase in oxidative stress has been attributed to decreased levels of the brain antioxidant, glutathione (Saharan and Mandal, 2014). 

The body uses antioxidants to limit the damage done by oxidative stress and glutathione is the body’s most effective self-made antioxidant.  Glutathione is a part of the body’s natural defense against free radical damage.

The following study used proton magnetic resonance spectroscopy to measure glutathione levels in both healthy individuals and patients with alzheimer’s disease (Mandal PK et. al, 2015).

The researchers found a reduction of glutathione in both the hippocampus and frontal cortex–which are two different areas of the brain–in Alzheimer’s patients.  It is interesting to note that glutathione reduction in those regions correlated with a decline in cognitive function.  The researchers concluded that the study provides compelling evidence that the glutathione levels in specific brain regions are relevant markers for mild cognitive impairment and Alzheimer’s disease.  

So how can we ensure that our glutathione levels remain at healthy levels?  One way is to add it into our daily routine via supplementation.  It is now possible to supply glutathione in a bioavailable form–which gets it into the cells where it is needed–and that is by using S-Acetyl Glutathione (Cacciatore et. al., 2010).

The body is making less glutathione as we get older, that happens to everybody, but some are making less than others.

References

Ansari, A, and S W Scheff. “Oxidative Stress in the Progression of Alzheimer Disease in the Frontal Cortex.OUP Academic, Journal of Neuropathology and Experimental Neurology , 1 Feb. 2010, academic.oup.com/jnen/article/69/2/155/2917186.

Cacciatore I1, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. “Prodrug approach for increasing cellular glutathione levels.” Molecules, 3 Mar. 2010, https://www.mdpi.com/1420-3049/15/3/1242

Mandal PK, Saharan S., Tripathi M., and Murari G. “Brain glutathione levels–a novel biomarker for mild cognitive impairment and Alzheimer’s disease.” Biol Psychiatry, 15 Nov. 2015,  https://www.sciencedirect.com/ science/article/pii/S0006322315003121

Saharan S., Mandal P.K., “The emerging role of glutathione in Alzheimer’s disease.” J Alzheimers Dis. 23 April 2014. https://content.iospress.com/articles/journal-of-alzheimers-disease/jad132483

 

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

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Do you want a bigger brain and better memory?

Posted by on 7:33 am Alzheimer’s, Anti-Aging, Cognition, Dementia, Exercise, General Health, Memory, Research, Stay healthy, Wellness | 0 comments

 

Is it really possible to increase the size of the brain later in life?

Data from a randomized controlled study of 155 older women, who participated in 52 weeks of resistance training showed reduced cortical white matter atrophy on MRI scans when compared with the control  group (Best JR, et.al., 2015).

This means that they ended up with a bigger brain than they would have had if they had not done the resistance exercise.

Twice-weekly resistance training also promoted memory and increased peak muscle power when they were followed up after 2 years.

The control group did balance and toning.

If you instead prefer aerobic type of exercise, that may also improve your cognition.

Research showed that an individual’s cardio-respiratory fitness was a better predictor of cognitive gains than the exercise dose (Vidoni ED, et.al., 2015).

To improve cardio-respiratory function you can do regular aerobic exercise, or you can do high intensity short interval training which will save you time.

This study compared the effects of long slow distance training with high-intensity interval training in rowers (Ní Chéilleachair NJ, et.al., 2017).

High intensity short interval training was more effective than long and slow distance training in improving performance and aerobic characteristics.

References

Best JR, Chiu BK, Liang Hsu C, Nagamatsu LS, Liu-Ambrose T.Long-Term Effects of Resistance Exercise Training on Cognition and Brain Volume in Older Women: Results from a Randomized Controlled Trial. J Int Neuropsychol Soc. 2015 Nov;21(10):745-56.

Vidoni ED, Johnson DK, Morris JK, Van Sciver A, Greer CS, Billinger SA, Donnelly JE, Burns JM,Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled TrialPLoS One. 2015 Jul 9;10(7):e0131647.

Ní Chéilleachair NJ1,2, Harrison AJ2, Warrington GD,HIIT enhances endurance performance and aerobic characteristics more than high-volume training in trained rowers.J Sports Sci. 2017 Jun;35(11):1052-1058

 

Research has shown that sitting for a long time can be bad, but you don’t have to be active for very long to reap huge benefits.

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What factors are playing a role in Alzheimer’s, cognitive decline and cardiovascular disease?

Posted by on 9:58 pm Alzheimer’s, Eating, General Health, Get in shape, Health Risk, Heart disease, Stay healthy, Wellness | 0 comments

Alongside oxidative stress and inflammation, altered cholesterol metabolism and hypercholesterolemia also significantly contribute to neuronal damage and to the progression of Alzheimer’s disease (Gamba P, et.al., 2015).

Levels of  oxysterols derived from cholesterol oxidation and inflammatory mediators have been found to be increased in the brains of Alzheimer’s patients (Testa G, et.al., 2016).

Oxysterols, the major component of oxidized LDL is responsible for the increase in endothelial stiffness and is a key step in atherosclerosis development (Shentu TP, et.al., 2012).

When 70 people with mild cognitive impairment were compared with 140 normal individuals, oxysterol levels were significantly higher in the people with mild cognitive impairment (Liu Q, et.al., 2016).

Where do we find oxidized cholesterol?

Oxidized cholesterol are commonly found in foods with high cholesterol content, such as meat, egg yolk and full fatdairy products (Savage GP, et.al., 2002).

Factors known to increase the production of free radicals and therefore oxidized cholesterol in foods are heat, light, radiation, oxygen, moisture and the storage of food at room temperature.

Processes, such as pre-cooking, freeze-drying, dehydration and irradiation, have all been reported to result in increased production of oxidized cholesterol in meats.

What can you do to reduce oxidized cholesterol?

The most obvious way to do it is to avoid the foods that contain the oxidized cholesterol.

The best way to do that is to eat plant based foods, since animal source protein is where you find oxidized cholesterol.

It would also be beneficial to take S-Acetyl Gutathione and Curcumin to reduce free radical damage and inflammation further.

References

Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G.Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease. Front Aging Neurosci. 2015 Jun 19;7:119.

Liu Q, An Y, Yu H, Lu Y, Feng L, Wang C, Xiao R.Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.Lipids Health Dis. 2016 Oct 10;15(1):177.

Savage GP1, Dutta PC, Rodriguez-Estrada MT, Cholesterol oxides: their occurrence and methods to prevent their generation in foods. Asia Pac J Clin Nutr. 2002;11(1):72-8

Shentu TP, Singh DK, Oh MJ, Sun S, Sadaat L, Makino A, Mazzone T, Subbaiah PV, Cho M, Levitan I.The role of oxysterols in control of endothelial stiffness.J Lipid Res. 2012 Jul;53(7):1348-58.

Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G, Fantò F, Poli G, Leonarduzzi G, Gamba P.Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation.Redox Biol. 2016 Dec;10:24-33.

 

 

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Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!