Your Road to Wellness

Posts by Dr. Sopler

What is an effective immune regulator the body is making to protect itself, which you can take?

Posted by on 9:00 am Glutathione | 0 comments


Why would we need to take glutathione if the body is making it?
The reason is that we make less as we get older, and under certain circumstances, we also use more.
Altered intracellular glutathione levels are observed in a wide range of pathologies, including
several viral infections, as well as in aging (Fraternale A., 2017).
Glutathione is a very powerful antioxidant the body is making, but glutathione does a lot more
than reducing free radical damage.



This is what the researchers of this article say about glutathione.
Glutathione is often referred to as “the master antioxidant,” and it participates not only in antioxidant defense systems, but many metabolic processes, and therefore its role cannot be
overstated (Teskey G.,, 2018).

The following research showed that the depletion of glutathione prevented the activation of the antiviral response and its inhibition of influenza virus infection (Diotallevi M,, 2017).

The researchers of this study write that their data suggest the antioxidant glutathione has an
anti-influenza activity in vitro and in vivo (Cai J,, 2003). Oxidative stress or other conditions
that deplete glutathione in the epithelium of the oral, nasal, and upper airway may, therefore,
enhance susceptibility to influenza infection.

Reduced glutathione, the most common form found on the market, is not well absorbed.
S-Acetyl-glutathione is a glutathione precursor, it is more stable than glutathione itself in plasma and is taken up directly by cells and later converted to
glutathione (Fanelli S,, 2018)
The acetylation prevents the decomposition of glutathione and facilitates its absorption through
the intestinal wall as-is, thus enabling the molecule to pass extensively into the cells.
S-Acetyl-Glutathione has been found to be more bioavailable (Cacciatore I,, 2010).

When supplementing with glutathione, it is important to use a form that is well absorbed, if you
want to get the benefits.
How much we need varies from person to person. 400 mg daily of S-Acetyl-Glutathione taken in
2 divided doses are probably the minimum of what most people need to take, to notice a difference.
When we experience an immune response the body will use more glutathione and somebody who has insulin resistance will also need more.


⏬ Scroll down for more information ⏬



Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing
cellular glutathione levels. Molecules. 2010 Mar 3;15(3):1242-64.


Cai J, Chen Y, Seth S, Furukawa S, Compans RW, Jones DP. Inhibition of influenza infection by
glutathione. Free Radic Biol Med. 2003 Apr 1;34(7):928-36.


Sergio Fanelli, Antonio Francioso, Rosaria A. Cavallaro, Maria d’Erme, Pietro Putignano,
Niccolò Miraglia and Luciana Mosca, Oral Administration of S-acetyl-glutathione: Impact on the
Levels of Glutathione in Plasma and in Erythrocytes of Healthy Volunteers,Int J Clin Nutr Diet
2018,Published: July 06, 2018. Fraternale A, Brundu S, Magnani M. Glutathione and glutathione derivatives in immunotherapy. Biol Chem. 2017 Feb 1;398(2):261-275


Teskey G, Abrahem R, Cao R, Gyurjian K, Islamoglu H, Lucero M, Martinez A, Paredes E,
Salaiz O, Robinson B, Venketaraman V. Glutathione as a Marker for Human Disease. Adv Clin
Chem. 2018;87:141-159.


Diotallevi M, Checconi P, Palamara AT, Celestino I, Coppo L, Holmgren A, Abbas K, Peyrot F,
Mengozzi M, Ghezzi P. Glutathione Fine-Tunes the Innate Immune Response toward Antiviral
Pathways in a Macrophage Cell Line Independently of Its Antioxidant Properties. Front Immunol.
2017 Sep 29;8:1239.



  • Glutathione defends you if you get enough of it into your cells.
  • Under certain conditions, we need more, because the body is using more.


  • Glutathione is your primary defense against aging.
  • The challenge is getting glutathione into your system.
  • Glutathione helps detoxify your body.
  • Why not start turning back the clock, little by little?

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How does exercise compare with other activities for affecting memory?

Posted by on 9:00 am Exercise, Memory | 0 comments

Young woman running in green park


Brain-derived neurotrophic factor (BDNF) which is a protein, plays an important role in neuronal
survival and growth which is essential for learning and memory (Bathina S, Das UN, 2015).

Research suggests that physical exercise can affect BDNF levels both in the blood and the
brain, but how effective is exercise when compared with cognitive training, and mindfulness



That’s exactly what the following study investigated.
The participants were nineteen healthy older adults (Hakansson K,, 2017).
They participated in 35-minute sessions of physical exercise, cognitive training, and mindfulness
practice in a crossover study.




The researchers showed that a single bout of physical exercise had a significantly larger
impact on blood BDNF levels than either cognitive training or mindfulness practice in the same persons.


Exercise needs to be a part of a healthy lifestyle for several reasons, memory is one.



Bathina S, Das UN, Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci.
2015 Dec 10;11(6):1164-78.


Håkansson K, Ledreux A, Daffner K, Terjestam Y, Bergman P, Carlsson R, Kivipelto M, Winblad
B, Granholm AC, Mohammed AK. BDNF Responses in Healthy Older Persons to 35
Minutes of Physical Exercise, Cognitive Training, and Mindfulness: Associations with
Working Memory Function. J Alzheimers Dis. 2017;55(2):645-657.

Can fish oil provide protection against air pollution?

Posted by on 9:00 am Fish Oil, Omega-3, fish oil | 0 comments


This study evaluated whether dietary fish-oil supplementation can protect the cardiovascular system against damage from exposure to air pollution (Lin Z,, 2019).
It was a randomized, double-blinded, placebo-controlled trial with 65 healthy college students in Shanghai, China.
Blood pressure and 18 biomarkers of systemic inflammation, coagulation, endothelial function, oxidative stress, antioxidant activity, cardiometabolism, and neuroendocrine stress response were measured.



The participants were given 2.5 g of fish oil daily or a placebo for 4 months.
The researchers observed beneficial effects of fish-oil supplementation on 5 biomarkers of inflammation, coagulation, endothelial function, oxidative stress, and neuroendocrine stress response in the fish-oil group.

Even if you are not exposed to as much air pollution as the participants of this study, taking a high-quality fish oil formula is an easy way to protect yourself from some of the harm of polluted air.
Fish oil in the form of triglycerides is more stable than oil in the form of ethyl esters which is more common.
Fish oil in a triglyceride form is also better absorbed than oil from ethyl esters (Beckerman B,, 1990).



Beckermann B, Beneke M, Seitz I. Comparative bioavailability of eicosapentaenoic acid and
docasahexaenoic acid from triglycerides, free fatty acids and ethyl esters in volunteers .
Arzneimittelforschung. 1990 Jun;40(6):700-4.


Lin Z, Chen R, Jiang Y, Xia Y, Niu Y, Wang C, Liu C, Chen C, Ge Y, Wang W, Yin G, Cai J,
Clement V, Xu X, Chen B, Chen H, Kan H. Cardiovascular Benefits of Fish-Oil Supplementation
Against Fine Particulate Air Pollution in China. J Am Coll Cardiol. 2019 Apr


Better Fish Oil

The anti-inflammatory effects of Omega 3 fatty acids are well known. Most people that eat a western diet can benefit from increasing the intake of Omega 3 fatty acid since their diet usually contains too much Omega 6 from vegetable oils and saturated fat from dairy and other animal sources. Most fish oils on the market are ethyl esters because that’s cheaper to produce. Fish oil in a triglyceride form is also better absorbed than ethyl esters.




Can reduction of inflammation improve the recovery of low back pain?

Posted by on 9:00 am Inflammation, Lower Back Pain and Neck Pain, Supplements List | 0 comments

lower back pain


This research included 155 women 65 years or older with acute low back pain (Queiroz BZ,, 2017).
The researchers showed a relationship between inflammation and low back pain, establishing that low IL-6 levels (an inflammatory marker) preceded the recovery. This supports that proinflammatory cytokines promote pain.

In the first year after an acute episode of low back pain, there was a decrease in the severity of low back pain corresponding to decreased levels of IL-6 and TNF-α, another inflammatory marker.



The researcher concluded that the probability of occurrence of pain relief at the 12-month
follow-up was 2.22 times higher in elderly women who had low levels of IL-6.

Systemic inflammation is linked with the development and persistence of many pathological pain states (Klyne DM,, 2017).
Both CRP, an inflammatory marker, and IL-6 were higher in study participants with acute low back pain compared with controls, and they were also higher in the participants with more pain compared with those who had less pain?
The researchers said these findings suggest systemic CRP and IL-6 are important contributors to
inflammation in the early phase of low back pain and that various factors can shape these responses.

A plant-based low glycemic index diet can be very effective in reducing systemic inflammation.
Research has also shown plant-derived compounds in supplemental form to reduce free radicals and inflammation.



Klyne DM, Barbe MF, Hodges PW. Systemic inflammatory profiles and their relationships with
demographic, behavioral and clinical features in acute low back pain. Brain Behav Immun. 2017

Queiroz BZ, Pereira DS, Rosa NMB, Lopes RA, Andrade AGP, Felício DC, Jardim RMFVS, Leopoldino
AAO, Silva JP, Pereira LSM. Inflammatory Mediators and Pain in the First Year After Acute
Episode of Low-Back Pain in Elderly Women: Longitudinal Data from Back Complaints in the
Elders-Brazil. Am J Phys Med Rehabil. 2017 Aug;96(8):535-540.


Do you feel stiff or experience aches and pain?

If you do, you have increased free radical damage and low-grade inflammation which is getting more and more common as we get older.

When free radicals damage tissue, inflammation is triggered. This type of inflammation spreads throughout the body and can be measured in the blood.

Not only can this create discomfort, but science recognizes this type of inflammation as a risk factor for cardiovascular disease and other chronic conditions.

That’s the reason the Curcumin-4 was developed.

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When is it easier for your body to transfer blood glucose from a meal into your cells?

Posted by on 9:00 am Bloodsugar, Eating, Glucose, High glycemic index | 0 comments

glucose level


We know it’s better to avoid high blood glucose levels since that can cause tissue damage.

Several things can affect blood glucose levels, one important factor is the type of food we eat.


It’s logical that the food we eat will have an impact on our blood glucose level, but can it also make a difference when we eat?

Yes, it can make a difference. Research has shown that the circadian rhythm which is affected by the light cycle regulates glucose, lipid, and energy metabolism in humans (Poggiogalle E,, 2018).



We have known for many years that the body metabolizes glucose differently in the morning compared to the evening.

When the participants of this study received three oral glucose tolerance tests, one in the morning, one in the afternoon, and one in the evening on separate days, this is what the researchers found (Jarrett RJ,, 1972).

The average blood sugar levels in the afternoon and evening tests were similar, but they were both significantly higher than those in the morning test.


For somebody who already has a tendency to have high blood glucose levels, it’s even more important to take this into consideration when eating.

These researchers found that glycemic control was dramatically impaired in the evening in people with prediabetes (Sonnier T,, 2014).


glycemic index


Most people would benefit by keeping this in mind when eating.

We will usually metabolize a meal better and keep the blood glucose levels lower in the morning.

This is one of the reasons why it’s better to eat more in the morning and less in the evening.




Jarrett RJ, Baker IA, Keen H, Oakley NW..Diurnal variation in oral glucose tolerance: blood sugar and plasma insulin levels morning, afternoon, and evening.Br Med J. 1972 Jan 22;1(5794):199-201.


Poggiogalle E, Jamshed H, Peterson CM.Circadian regulation of glucose, lipid, and energy metabolism in humans.Metabolism. 2018 Jul;84:11-27.


Sonnier T, Rood J, Gimble JM, Peterson CM.Glycemic control is impaired in the evening in prediabetes through multiple diurnal rhythms. J Diabetes Complications. 2014 Nov-Dec;28(6):836-43.