Your Road to Wellness

Posts by Dr. Sopler

What is one of the major contributing factors for Alzheimer’s disease, and what can you do about it?

Posted by on 9:00 am General Health | 0 comments

Alzheimer tree

 

There are several contributing factors for Alzheimer’s disease, but there is one thing that really
stands out, and that is neuroinflammation.
Neuroinflammation is an inflammation of the nervous system.
While inflammation is how the immune system protects us from pathogens, chronic
inflammation is causing tissue damage.
If we have chronic inflammation triggered in the brain, it is going to damage the nervous system.
That is exactly what has been found to be involved in neurodegenerative conditions like
Alzheimer’s disease and Parkinson’s disease.

TNF-alpha is a major inflammatory marker involved in neurodegenerative conditions like
Alzheimer’s disease (Frankola KA, et al.,2011).

 

 

According to other researchers, there is evidence pointing towards a beneficial role of
anti-TNF-alpha therapies to prevent or slow the progression of Alzheimer’s disease (Decort B,
et al., 2017).
The problem is that the available drugs inhibiting TNF-alpha also produce serious side effects,
and are not a good solution for that reason.
What can we do to reduce TNF-alpha induced inflammation without producing side effects?

There are 2 things you can implement now.

The following study found that berberine may inhibit the expression and production of
TNF-alpha, MCP-1, and IL-6, in macrophages (Chen FL, et al, 2008).
These are all inflammatory cytokines (substances). Macrophages are a type of white blood cell
capable of producing large quantities of proinflammatory cytokines like TNF-alpha.

Curcumin has also been investigated for TNF-alpha inhibition. This study showed that patients
receiving curcumin showed significant reductions in the levels of malondialdehyde, ET-1, IL-6
and TNFalpha (Usharani P, et al, 2008).

The following research also found that curcumin administration decreased serum TNF-alpha
levels (He ZY, et al., 2011).

Berberine and a well-absorbed form of curcumin are the 2 things you should start to take now.

 

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References:

Boris Decourt, Debomoy K Lahiri , Marwan N Sabbagh, Targeting Tumor Necrosis Factor Alpha
for Alzheimer’s Disease, Curr Alzheimer Res. 2017;14(4):412-425.

F L Chen 1, Z H Yang, Y Liu, L X Li, W C Liang, X C Wang, W B Zhou, Y H Yang, Ren-Ming
Hu,Berberine Inhibits the Expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated
Macrophages Through PPARgamma Pathway,Endocrine. 2008 Jun;33(3):331-7.

Kathryn A Frankola, Nigel H Greig, Weiming Luo, David Tweedie,
Targeting TNF-α to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative
Diseases,CNS Neurol Disord Drug Targets. 2011 May;10(3):391-403.

He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang J. Upregulation of p53 expression in patients
with colorectal cancer by administration of curcumin. Cancer Invest. 2011 Mar;29(3):208-13.

Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra N,
Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and
inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group,
placebo-controlled, 8-week study, Drugs R D. 2008;9(4):243-50.

 

Glucose Metabolism Support

Curcumin-4

Can green tea extract help prevent influenza virus?

Posted by on 9:00 am Antioxidents, Cholesterol, Green tea, Inflammation | 0 comments

influenza virus

 

Viral infections are a constant threat. Every year people get sick from the influenza virus.
In addition to eating healthy and being physically active, what else can you do?
How about using green tea.
Researchers in Japan tried to find additional resources and investigated if capsules with green
tea extract including catechins and theanine could be effective in preventing the flu (Matsumoto
K, et al, 2011).
This was a randomized, double-blind, placebo-controlled trial of 200 healthcare workers
conducted for 5 months.
The researchers found that the incidence of clinically defined influenza infection was
significantly lower in the catechin/theanine group.

 

 

Research has also shown that green tea extract lowers blood pressure, total cholesterol, LDL
(the bad cholesterol), and inflammation (Nantz MP, et al 2009). These are all risk factors for
cardiovascular disease.
It is also important what green tea can do for the brain. Green tea may provide neuroprotection
and has been associated with a lower prevalence of cognitive impairment (Kuriyama S, et al
2006).

References:

Kuriyama S, Hozawa A, Ohmori K, Shimazu T, Matsui T, Ebihara S, Awata S, Nagatomi R, Arai H,
Tsuji I. Green tea consumption and cognitive function: a cross-sectional study from the Tsurugaya
Project. American Journal of Clinical Nutrition, Vol. 83, No. 2, 355-361, February 2006.

Matsumoto K, Yamada H, Takuma N, Niino H, Sagesaka YM.
Effects of green tea catechins and theanine on preventing influenza infection among
healthcare workers: a randomized controlled trial. BMC Complement Altern Med. 2011
Feb 21;11:15.

Nantz MP, Rowe CA, Bukowski JF, Percival SS. Standardized capsule of Camellia sinensis lowers
cardiovascular risk factors in a randomized, double-blind, placebo-controlled study. Nutrition. 2009
Feb; 25(2):147-54. Epub 2008 Oct 9.

 

BETTER GREEN TEA

better green tea

Polyphenols (catechins) are the active ingredients in green tea providing a variety of benefits.

Green tea extract has been documented to lower blood pressure, reduce total cholesterol and LDL (the bad cholesterol), reduce serum amyloid-alpha (a marker of chronic inflammation) and reduce malondialdehyde (a marker of oxidative stress) (Nantz MP, et al. 2009). These are all cardiovascular risk factors and they were reduced in only 3 weeks.

Green tea may provide neuroprotection and has been associated with a lower prevalence of cognitive impairment.

A study including 41,761 participants found that green tea consumption was associated with a reduced risk of liver cancer.

Green tea polyphenols have been documented to reduce serum biomarkers in patients with prostate cancer.

Regular drinking of green tea has been associated with a slightly decreased risk of breast cancer (Shrubsole MJ, et al. 2008).

Green tea consumption was inversely associated with psychological distress in an assessment of 42,093 individuals. Consumption of 4 cups or more of green tea has been associated with a lower prevalence of depressive symptoms.

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What is an easy way to reduce calcification of your arteries?

Posted by on 9:00 am BMJ Formula, Cardiovascular Disease, Health, Health Risk, magnesium, Supplements | 0 comments

Artery calcification

 

Most people get some degree of buildup, calcification of their arteries as they get older which is
not a good thing.
To stay healthy and live longer, it is crucial to have a good blood supply to all tissue, because that
is how we get nutrients and oxygen to the tissue.
We have all had the experience of a temporary restriction of the blood flow to an arm or a leg by
unknowingly laying in a position that cut off the circulation. It does not feel good.
If the heart muscle is not getting enough blood, we get a heart attack.
We know that eating a healthy diet and exercising regularly is important, but what else can you
do?
The following study investigated if magnesium may prevent calcification of the coronary arteries
(Hruby A, et al, 2014).
2,695 participants with an average age of 53 years who were free of cardiovascular disease
underwent Multi-Detector Computed Tomography of the heart and abdomen.
Multiple risk factors were accounted for in the evaluation.
Even the intake of vitamin K which has shown to help prevent artery calcification was accounted for.

 

 

The researchers found that the odds of having any coronary artery calcification were 58%
lower and having any abdominal aortic calcification were 34% lower, in those with the
highest compared to those with the lowest magnesium intake.

The authors said this may play a contributing role in magnesium’s protective associations in
stroke and fatal coronary heart disease.

When supplementing with magnesium, an amino acid chelate like magnesium glycinate is
recommended. The most common form of magnesium used in supplements is magnesium
oxide which is not absorbed well and can cause gastrointestinal irritation.

Magnesium is also important for many other reasons such as energy production and bone
formation. Ideally, it is better to combine magnesium with other important minerals since
supplementing with only one may cause an imbalance, and the other minerals are also
important for a variety of reasons.

Reference

Adela Hruby, Christopher J O’Donnell, Paul F Jacques, James B Meigs, Udo Hoffmann, Nicola
M McKeown, Magnesium Intake Is Inversely Associated With Coronary Artery Calcification: The
Framingham Heart Study,JACC Cardiovasc Imaging. 2014 Jan;7(1):59-69.

 

The BMJ Formula contains a large amount of magnesium in a very well-absorbed form.
.

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Can this prevent early mortality? Let’s look at the research.

Posted by on 9:00 am Fish Oil, General Health, Inflammation, Omega-3, fish oil | 0 comments

telomeres

 

Telomeres are structures found at the end of our chromosomes. They help protect genetic
information.
Shorter telomeres have been associated with poor health behaviors, age-related diseases, and
early mortality.
Telomere length can for that reason be one way to estimate how fast we age. As we age
telomeres get shorter. If we can slow down the process that shortens the telomeres or even
better, lengthens them, we should be better off.
Telomere length is regulated by the enzyme telomerase and is linked to exposure to
proinflammatory cytokines and oxidative stress.

 

 

The following study investigated whether omega 3 fatty acid supplementation could affect
telomere length, telomerase, and oxidative stress (Kiecolt-Glaser, JK, et al., 2013).
The participants were 106 healthy sedentary overweight middle-aged and older adults who
received either 2.5g or 1.25g per day of omega 3 supplements, or placebo capsules that had
the proportions of the fatty acids in a typical American diet.
The results showed that the omega 3 fatty acids significantly lowered oxidative stress.
The researchers also found that telomere length increased with decreasing omega 6 fatty
acid to omega 3 fatty acid ratio.
This suggests that a lower omega 6 fatty acid to omega 3 fatty acid ratio can impact cell aging.

Most people in the western world ingest too much omega 6 fat from vegetable oils and too little
omega 3 fatty acids.
It is the ratio that is really important, because omega 6 fat converts to arachidonic acid, a
precursor for inflammation, while the omega 3 fatty acids EPA and DHA reduce inflammation.
The easiest way to increase the intake of EPA and DHA is by taking omega 3 fish oil capsules.
It is however important that the fish oil is processed correctly to remove toxins since all fish is
now more or less contaminated.
Fish oil in the form of triglycerides is more stable and also better absorbed than the more
a common form of ethyl ester which is cheaper to manufacture.

 

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Reference:

Kiecolt-Glaser JK, Epel ES, Belury MA, Andridge R, Lin J, Glaser R, Malarkey WB, Hwang BS,
Blackburn E. Omega-3 fatty acids, oxidative stress, and leukocyte telomere length: A
randomized controlled trial.Brain Behav Immun. 2013 Feb;28:16-24.

 

Most people that eat a western diet can benefit from increasing the intake of Omega 3 fatty acids since their diet usually contains too much Omega 6 from vegetable oils and saturated fat from dairy and other animal sources. Research has shown many health benefits from Omega 3 fat intake. Several studies are showing evidence that the protective benefits of fish oil prevent death from heart disease

The anti-inflammatory effects of Omega 3 fatty acids are well known. Several studies on rheumatoid arthritis using supplements with EPA/DHA, which is found in fish oil, have shown to decrease morning stiffness and reduce the number of painful and swollen joints. Fish oil has also shown to help in the treatment of colitis

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How do you stay healthy long term and effectively fight off pathogens?

Posted by on 9:00 am Diabetes, Glucose, High glycemic index, Insulin resistance, Insulin resistance, metabolic syndrome, Sugar, Type 1 diabetes, Type 2 diabetes | 0 comments

pathogen

 

At certain times we have to deal with more pathogens like viruses and bacteria, but there will
always be challenges to handle.
The best way to confront that is to be prepared by implementing habits that will make both the
body and mind resilient.
When we take a closer look at why we get sick, and also why we develop chronic conditions,
the major reasons are much the same with some variation of course.
A major health problem today is insulin resistance.
According to the CDC and the National Diabetes Statistics Report, a total of 34.2 million people
have diabetes in the US.
The reason for type 2 diabetes is insulin resistance.
A total of 88 million people aged 18 years or older have prediabetes, that’s 34.5% of the adult
US population.

 

 

People with prediabetes are insulin resistant, but they are not so insulin resistant that they are
diagnosed with diabetes.
Insulin transfers blood glucose into the cells where it can be used for energy.
When the receptors on the cells are exposed to high levels of glucose and insulin for a period of
time, they will get less sensitive to insulin. The result is that the insulin will not be able to
transfer the glucose into the cells as efficiently as before.
This causes free radical damage and inflammation.
The following research has shown that high glycemic index food will with time increase
inflammatory markers CRP, IL-6, and TNF-alpha (Phillips CM, et al., 2018).
The same study also found that high glycemic index food increased LDL ( high density
lipoprotein), a major cardiovascular risk factor.
In addition, advanced glycation end products, formed during hyperglycemia (high blood
glucose), cause inflammation and endothelial damage (de Vries MA, et al., 2014).
Advanced glycation end products are formed when glucose reacts with protein, causing tissue
damage and then inflammation.
It is very important to have an appropriate immune response when exposed to a virus
like COVID-19.
New research is documenting why it is very important to avoid huge surges in blood glucose.
There are at least two reasons why hyperglycemia can be very dangerous during the
SARS-CoV-2 infection (Ceriello A.,2020).
One is that an acute increase in blood glucose is accompanied by a huge increase of
inflammatory mediators.
This author also says knowing the role of the “cytokines storm” in the COVID-19, this is an effect
that must be avoided.
Too much of an inflammatory response is often what leads to death because of massive tissue
damage.
Another reason that seems to be specific for COVID-19 is related to the binding of the virus to a
cell receptor. Glycosylation of the receptor induced by hyperglycemia is needed for the linkage
of the virus to this cellular receptor.

This is what researchers of a new study from China found (Zhu L, et al., 2020).
Well-controlled blood glucose was associated with markedly lower mortality, compared to
individuals with poorly controlled blood glucose. These findings provide clinical evidence
correlating improved glycemic control with better outcomes in patients with COVID-19 and
pre-existing type 2 diabetes.

There are several factors affecting blood glucose control. 4 of the most important ones are the
the food we eat, it should be high nutrient, low glycemic index food.
Physical activity, exercise helps transfer glucose from the blood into the cells.
Not enough sleep will adversely affect the circadian rhythm and make us less insulin sensitive.
Get between 7-8 hours.
Stress will also increase blood glucose. Stay in a good state of mind. Several things can help
you do that, meditation is one.
An easy way to help keep blood glucose in a low normal range is to take berberine, a natural
plant derivative.
In this study fasting blood glucose was reduced with 34.9%, and the blood glucose after a meal
was reduced with 43.9% (Yin J, et al., 2008).

 

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References:

Ceriello A. Hyperglycemia and the worse prognosis of COVID-19. Why fast blood glucose
control should be mandatory. Diabetes Res Clin Pract. 2020 Apr 29;163:108186.

de Vries MA, Klop B, Janssen HW, Njo TL, Westerman EM, Castro Cabezas M. Postprandial
inflammation: targeting glucose and lipids. Adv Exp Med Biol. 2014;824:161-70.

Phillips CM, Shivappa N, Hébert JR, Perry IJ. Dietary Inflammatory Index and Biomarkers of
Lipoprotein Metabolism, Inflammation, and Glucose Homeostasis in Adults. Nutrients. 2018 Aug
8;10(8).

Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism.
2008 May;57(5):712-7. doi: 10.1016/j.metabol.2008.01.013.

Lihua ZhuZhi-Gang SheXu ChengJiao GuoBing-Hong ZhangHongliang L, Association of Blood
Glucose Control and Outcomes In Patients with COVID-19 and Pre-existing Type 2 Diabetes,
Cell Metabolism, Published:April 30,
2020DOI: https://doi.org/10.1016/j.cmet.2020.04.021 Blood Glucose

 

 

glucose metabolism supportThis formula was designed to support healthy glucose metabolism and the cardiovascular system.

  • The research referred to below was conducted with participants who had type 2 diabetes. This does not mean that you have to have type 2 diabetes to take this formula.
  • It’s very important to have a healthy glucose metabolism and keep the blood glucose low. You want to take this formula and keep your glucose metabolism healthy.
  • Healthy glucose metabolism is important to keep your cardiovascular system healthy.

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