Your Road to Wellness

Posts by Dr. Sopler

What factors are playing a role in Alzheimer’s, cognitive decline and cardiovascular disease?

Posted by on 9:58 pm Alzheimer’s, Eating, General Health, Get in shape, Health Risk, Heart disease, Stay healthy, Wellness | 0 comments

Alongside oxidative stress and inflammation, altered cholesterol metabolism and hypercholesterolemia also significantly contribute to neuronal damage and to the progression of Alzheimer’s disease (Gamba P, et.al., 2015).

Levels of  oxysterols derived from cholesterol oxidation and inflammatory mediators have been found to be increased in the brains of Alzheimer’s patients (Testa G, et.al., 2016).

Oxysterols, the major component of oxidized LDL is responsible for the increase in endothelial stiffness and is a key step in atherosclerosis development (Shentu TP, et.al., 2012).

When 70 people with mild cognitive impairment were compared with 140 normal individuals, oxysterol levels were significantly higher in the people with mild cognitive impairment (Liu Q, et.al., 2016).

Where do we find oxidized cholesterol?

Oxidized cholesterol are commonly found in foods with high cholesterol content, such as meat, egg yolk and full fatdairy products (Savage GP, et.al., 2002).

Factors known to increase the production of free radicals and therefore oxidized cholesterol in foods are heat, light, radiation, oxygen, moisture and the storage of food at room temperature.

Processes, such as pre-cooking, freeze-drying, dehydration and irradiation, have all been reported to result in increased production of oxidized cholesterol in meats.

What can you do to reduce oxidized cholesterol?

The most obvious way to do it is to avoid the foods that contain the oxidized cholesterol.

The best way to do that is to eat plant based foods, since animal source protein is where you find oxidized cholesterol.

It would also be beneficial to take S-Acetyl Gutathione and Curcumin to reduce free radical damage and inflammation further.

References

Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G.Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease. Front Aging Neurosci. 2015 Jun 19;7:119.

Liu Q, An Y, Yu H, Lu Y, Feng L, Wang C, Xiao R.Relationship between oxysterols and mild cognitive impairment in the elderly: a case-control study.Lipids Health Dis. 2016 Oct 10;15(1):177.

Savage GP1, Dutta PC, Rodriguez-Estrada MT, Cholesterol oxides: their occurrence and methods to prevent their generation in foods. Asia Pac J Clin Nutr. 2002;11(1):72-8

Shentu TP, Singh DK, Oh MJ, Sun S, Sadaat L, Makino A, Mazzone T, Subbaiah PV, Cho M, Levitan I.The role of oxysterols in control of endothelial stiffness.J Lipid Res. 2012 Jul;53(7):1348-58.

Testa G, Staurenghi E, Zerbinati C, Gargiulo S, Iuliano L, Giaccone G, Fantò F, Poli G, Leonarduzzi G, Gamba P.Changes in brain oxysterols at different stages of Alzheimer’s disease: Their involvement in neuroinflammation.Redox Biol. 2016 Dec;10:24-33.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more

 

 

 

 

 

 

Glutathione helps your cells reduce free radical damage and also helps lower inflammation.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

How and when does cardiovascular disease start?

Posted by on 8:55 pm Anti-aging, Cardiovascular Disease, Cholesterol, Eating, Fat, HDL, Heart disease | 0 comments

 

The clogged pipe analogy is the old, but outdated model of explaining cardiovascular disease which still is used most of the time because of lack of understanding and lack of exposure to research (Rothberg MB, 2013).

According to this model, cholesterol plaque in the arterial walls slowly reduce the opening of the artery, first causing decreased blood flow without symptoms, then it causes angina (chest pain), and eventually it results in an infarction.

Treatments based on this theory include both coronary bypass surgery and angioplasty opening the blood vessel with a stent or a balloon.

While a massive plaque eventually can close up an artery, a heart attack is usually caused by unstable plaque thatmay not be easily detected, but can rupture and form a clot.

This is what happens according to more in depth research.

Low-density lipoprotein (LDL) mainly produced in the liver may infiltrate the vascular endothelium (the inner wall of the blood vessel), where it can initiate a complex inflammatory response. This inflammatory response can lead to arterial remodeling, in which plaque growth within the vessel walls is accommodated by outward enlargement of the vessel.

In that case, large plaques may not reduce the opening of the blood vessel and are therefore hidden from angiography.

These plaques are particularly dangerous both because they are prone to rupture, they are unstable, and because before rupture they do not limit the blood flow and therefore do not induce formation of protective collaterals.

If the blood flow slowly gets restricted as in stable plaque, the body will compensate by making new blood vessels to support the area in need, that’s why stable plaque is less dangerous.

A lot of people apparently have several plaque ruptures in their vascular system without symptoms.These ruptures can heal and is later impossible to detect.

For these reasons it’s very difficult to use available scanning methods as reliable tools to predict  a deadly plaque rupture.

There is however strong evidence that addressing the extent and activity of the atherosclerotic burden and thrombosis-promoting risk factors will improve risk (Arbab-Zadeh A, et.al., 2015).

Oxidized LDL is especially damaging to the endothelium, the inner lining of the blood vessels (Gradinaru D, et al., 2015).

Oxidized LDL cholesterol is associated with early atherosclerosis (Calmarza P, et.al., 2014).

When does atherosclerosis start?

It start at a very young age.

Atherosclerosis varied from 17% in individuals less than 20 years old to 85% in people 50 years old or older (Tuzcu EM, et.al., 2001).

If you have children, this is something to keep in mind. It is very important to have a healthy diet even for a child.

References

Arbab-Zadeh A, Fuster V.The myth of the “vulnerable plaque”: transitioning from a focus on individual lesions to atherosclerotic disease burden for coronary artery disease risk assessment.J Am Coll Cardiol. 2015 Mar 3;65(8):846-855.

Calmarza P1, Trejo JM, Lapresta C, López P,LDL oxidation and its association with carotid artery intima-media thickness and other cardiovascular risk factors in a sample of Spanish general population.Angiology. 2014 Apr;65(4):357-62.

Gradinaru D, Borsa C, Ionescu C, Prada GI,Oxidized LDL and NO synthesis–Biomarkers of endothelial dysfunction and ageing.Mech Ageing Dev. 2015 Nov;151:101-13.

Rothberg MB,Coronary artery disease as clogged pipes: a misconceptual model.Circ Cardiovasc Qual Outcomes. 2013 Jan 1;6(1):129-32.

Tuzcu EM1, Kapadia SR, Tutar E, Ziada KM, Hobbs RE, McCarthy PM, Young JB, Nissen SE.High prevalence of coronary atherosclerosis in asymptomatic teenagers and young adults: evidence from intravascular ultrasound.Circulation. 2001 Jun 5;103(22):2705-10.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more

 

What is the best predictor of aging?

Posted by on 3:10 am Anti-Aging, Diet, Eating, Health, Inflammation, Low glycemic meals, Vegetables | 0 comments

 

Chronological and physiological age is not the same.

You can be younger than your actual years or you can be older. This depends a lot on your diet and lifestyle.

The referenced research was conducted to figure out the most important drivers for successful aging (Arai Y, et.al., 2015). This is important because you don’t want to just live for a long time, you want to stay healthy as you get older.

1554 individuals were included in the study, and 684 were 100-105 years old and 105-109 years old. There were also 536 who were 85-99 year old and some children of the 100-105 years old.

The researchers looked at multiple biomarkers and this is what they found.

Inflammation predicted all-cause mortality in the 85-99 years old and in the 105-109 years old.

Inflammation also predicted capability and cognition in 105-109 year olds better than chronologic age.

The inflammation score was also lower in the children of these individuals compared to age-matched controls.

if you want to function well  as you get older, Inflammation is the most important factor to keep low. 

It is important to keep in mind that oxidative stress is also involved in inflammation.

Oxidative stress due to oxidant/antioxidant imbalance, and also due to environmental oxidants is an important component during inflammation and respiratory diseases, asthma being one of those conditions (Biswas SK, Rahman I, 2009).

This is what you can do to keep inflammation low.  Implement a high nutrient, low glycemic index, plant based diet.

Take a well absorbed form of  Curcumin and Boron. Both of these compounds have shown to reduce inflammation.

Take S-Acetyl Glutathione which is a form of Glutathione shown to get into the cells. Glutathione is the body’s most effective protection against free radical damage. It also regulates the immune function.

References

Arai Y1, Martin-Ruiz CM, Takayama M, Abe Y, Takebayashi T, Koyasu S, Suematsu M, Hirose N, von Zglinicki T,Inflammation, but not Telomere length, predicts successful ageing at extreme old age: A Longitudinal Study of Semi-supercentenarians.EBioMedicine. 2015 Jul 29;2(10):1549-58.

Biswas SK, Rahman I.Environmental toxicity, redox signaling and lung inflammation: The role of glutathioneMol Aspects Med. 2009 Feb-Apr;30(1-2):60-76.

 

 

Glutathione helps your cells function and supports healthy aging.

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

How can you protect yourself from the neurotoxicity of mercury?

Posted by on 6:30 am Antioxidents, Diet, Eating, General Health, mercury | 0 comments

Everybody agrees that having a well-functioning nervous system is of great importance if we are going to function well and be healthy.

There are several things that can damage the nervous system, and mercury is one of these toxins. Contamination of the environment and subsequently our food is common, mercury in fish is one example.

Contaminated fish is one way mercury enters our body.

One way of avoiding the mercury in fish is of course not to eat fish, but we can be exposed to mercury from other sources as well. It is difficult not to be exposed to mercury at all. Mercury has been found to cause oxidative damage and induce neurotoxic damage with involvement of the mitochondria (Aschner M, et.al., 2007). The mitochondria is the energy producing component of the cell.

The body has mechanisms in place to deal with toxins and oxidative stress, otherwise we would not have survived. The protection we have is not always enough, even if we eat food that includes a lot of plants which can help to provide antioxidant protection.

The most effective antioxidant the body is making is glutathione, and it works very well if we have enough of it to deal with the toxins and free radicals we are exposed to. Data indicates however that the availability of glutathione to the cells may not be sufficient to provide protection against mercury toxicity (Becker A, Soliman KF, 2009). As we get older we make less glutathione each year, and after we turn 40, we can use some additional help. In some cases, even younger people can benefit from some assistance, it depends on how much toxins and free radicals the body has been exposed to through the years.

We now have an effective form of glutathione we can take in capsule form, and that is S-Acetyl Glutathione.
The most common form on the market, reduced glutathione, is not a very effective form since it is oxidized in the stomach and offer very little protection. S-Acetyl Glutathione is however transferred into the cells where it is needed. (Cacciatore I, et.al., 2010).

References

Aschner M, Syversen T, Souza DO, Rocha JB, Farina M. Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity. Braz J Med Biol Res. 2007 Mar;40(3):285-91.

Becker A, Soliman KF. The role of intracellular glutathione in inorganic mercuryinduced toxicity in neuroblastoma cells. Neurochem Res. 2009 Sep;34(9):1677-84.

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A. Prodrug approach for increasing cellular glutathione levels. Molecules. 2010 Mar 3;15(3):1242-64.

 

 

 

Glutathione helps your cells function and supports a healthy immune system

BioPro, Inc. Tissue Recovery is using the patented form of S-Acetyl Glutathione from the Italian company that has the patent for S-Acetyl Glutathione.

Click here to get your bottle of the most effective form of glutathione!

How meal times and light exposure affects cancer risk

Posted by on 6:08 am cancer risk, Eating, General Health | 0 comments

 

When the timing of meals was assessed to see if it affected the risk for breast and prostate cancer, something interesting was found.

The research was carried out between 2008 and 2013 in Spain (Kogevinas M, et.al., 2018). Included in the study was 621 cases of prostate cancer and 1205 cases of breast cancer compared with controls.

When participants sleeping immediately after dinner were compared to those sleeping 2 or more hours after dinner, the ones waiting 2 or more hours after dinner before they went to sleep had a 20% reduction in cancer risk for breast and prostate cancer combined.

A similar protection was observed in subjects having dinner before 9 pm compared with those having dinner after 10 pm. Not only does the food we eat affect cancer risk, but how late we eat and how long we wait before we go to bed after the last meal are all factors associated with cancer risk.

How does light exposer during the night affect cancer risk? Exposure to outdoor light in the blue spectrum during the night was associated with breast cancer when comparing the highest versus the lowest tertile (Garcia-Saenz A, et.al., 2018).

Men who slept in “quite illuminated” bedrooms had a higher risk of prostate cancer than men who slept in total darkness.

These are factors most of us can easily control.

References

Kogevinas M, Espinosa A, Castelló A, Gómez-Acebo I, Guevara M, Martin V, Amiano P, Alguacil J, Peiro R, Moreno V, Costas L, Fernández-Tardón G, Jimenez JJ, Marcos-Gragera R, Perez-Gomez B, Llorca J, Moreno-Iribas C, Fernández-Villa T, Oribe M, Aragones N, Papantoniou K, Pollán M4, Castano-Vinyals G, Romaguera
D. Effect of mistimed eating patterns on breast and prostate cancer risk (MCCSpain Study). Int J Cancer. 2018 Jul 17.

Garcia-Saenz A, Sánchez de Miguel A, Espinosa A, Valentin A, Aragonés N, Llorca J, Amiano P, Martín Sánchez V, Guevara M, Capelo R, Tardón A, Peiró-Perez R, Jiménez-Moleón JJ, Roca-Barceló A, Pérez-Gómez B, Dierssen-Sotos T, FernándezVilla T, Moreno-Iribas C, Moreno V, García-Pérez J, Castaño-Vinyals G, Pollán M, Aubé M, Kogevinas M, Evaluating the Association between Artificial Light-at-Night Exposure and Breast and Prostate Cancer Risk in Spain (MCC-Spain Study). Environ Health Perspect. 2018 Apr 23;126(4):047011.

 

 

Learn to Eat Program


 Based on the most effective scientific strategies, this program was created to help
you reduce inflammation and feel great.

Read more