What is one of the major contributing factors for Alzheimer’s disease, and what can you do about it?
There are several contributing factors for Alzheimer’s disease, but there is one thing that really
stands out, and that is neuroinflammation.
Neuroinflammation is an inflammation of the nervous system.
While inflammation is how the immune system protects us from pathogens, chronic
inflammation is causing tissue damage.
If we have chronic inflammation triggered in the brain, it is going to damage the nervous system.
That is exactly what has been found to be involved in neurodegenerative conditions like
Alzheimer’s disease and Parkinson’s disease.
TNF-alpha is a major inflammatory marker involved in neurodegenerative conditions like
Alzheimer’s disease (Frankola KA, et al.,2011).
According to other researchers, there is evidence pointing towards a beneficial role of
anti-TNF-alpha therapies to prevent or slow the progression of Alzheimer’s disease (Decort B,
et al., 2017).
The problem is that the available drugs inhibiting TNF-alpha also produce serious side effects,
and are not a good solution for that reason.
What can we do to reduce TNF-alpha induced inflammation without producing side effects?
There are 2 things you can implement now.
The following study found that berberine may inhibit the expression and production of
TNF-alpha, MCP-1, and IL-6, in macrophages (Chen FL, et al, 2008).
These are all inflammatory cytokines (substances). Macrophages are a type of white blood cell
capable of producing large quantities of proinflammatory cytokines like TNF-alpha.
Curcumin has also been investigated for TNF-alpha inhibition. This study showed that patients
receiving curcumin showed significant reductions in the levels of malondialdehyde, ET-1, IL-6
and TNFalpha (Usharani P, et al, 2008).
The following research also found that curcumin administration decreased serum TNF-alpha
levels (He ZY, et al., 2011).
Berberine and a well-absorbed form of curcumin are the 2 things you should start to take now.
Boris Decourt, Debomoy K Lahiri , Marwan N Sabbagh, Targeting Tumor Necrosis Factor Alpha
for Alzheimer’s Disease, Curr Alzheimer Res. 2017;14(4):412-425.
F L Chen 1, Z H Yang, Y Liu, L X Li, W C Liang, X C Wang, W B Zhou, Y H Yang, Ren-Ming
Hu,Berberine Inhibits the Expression of TNFalpha, MCP-1, and IL-6 in AcLDL-stimulated
Macrophages Through PPARgamma Pathway,Endocrine. 2008 Jun;33(3):331-7.
Kathryn A Frankola, Nigel H Greig, Weiming Luo, David Tweedie,
Targeting TNF-α to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative
Diseases,CNS Neurol Disord Drug Targets. 2011 May;10(3):391-403.
He ZY, Shi CB, Wen H, Li FL, Wang BL, Wang J. Upregulation of p53 expression in patients
with colorectal cancer by administration of curcumin. Cancer Invest. 2011 Mar;29(3):208-13.
Usharani P, Mateen AA, Naidu MU, Raju YS, Chandra N,
Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and
inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group,
placebo-controlled, 8-week study, Drugs R D. 2008;9(4):243-50.