Health and Nutrition Info
By Didrik J. Sopler, Ph.D, L.Ac.
02-12-07

 

Magnesium and zinc lowers risk for insulin resistance, metabolic syndrome and inflammation.

Metabolic syndrome is very common and is increasing the risk for many chronic diseases, cardiovascular disease and diabetes being two.

The National Cholesterol Education Program has defined certain criteria for the metabolic syndrome. They are the following:

  • Abdominal obesity defined as waist circumference over 40 inches (102cm) for men and over 35 inches (88cm) for women.
  • Triglycerides 150 mg/dl or above.
  • HDL (the good cholesterol) 40 mg/dl or lower for men and 50 mg/dl or lower for women.
  • Blood pressure of 130/85 or more
  • Fasting glucose 110 mg/dl or more, other groups use a criteria for glucose of 100 mg/dl or more.

Not all of these criteria however need to be present to be labeled having metabolic syndrome.

There are many risk factors related to the metabolic syndrome, but the following two concerning magnesium and zinc deficiencies are easy to take care of. 

Magnesium is required for both proper glucose utilization and insulin signaling. Intracellular magnesium deficiency may therefore affect the development of insulin resistance and alter the glucose entry into the cell (Takaya J, et al, 2004).

When data from 11,686 women were analyzed, magnesium intake was inversely associated with plasma C-reactive protein concentration (CRP) (Song Y, et al.2005). CRP is a marker of inflammation.  CRP concentrations were 12% lower in the highest quintile of magnesium when compared to the lowest quintile.  It was also found that the women in the highest quintile of magnesium intake also had a 27% lower risk of the metabolic syndrome.  The conclusion of the study was that magnesium intake is inversely associated with systemic inflammation and the prevalence of the metabolic syndrome.

Other researchers have also confirmed the relationship between magnesium deficiency and the metabolic syndrome (Guerro-Romero F, Rodriguez-Moran M. 2002).  Magnesium intake has also been found to be inversely related to individual components of the metabolic syndrome and fasting insulin levels (He K, et al. 2006).  Even young adults with higher magnesium intake have a lower risk of developing the metabolic syndrome according to this last study.

Insulin resistance occurs when the tissue is no longer as responsive to insulin as it used to be.  In this case the insulin is no longer able to transfer the blood glucose (sugar) into the cells as effectively.  

Zinc is a mineral participating in the metabolic pathways involving both carbohydrate and fat metabolism and the protein synthesis.  It is interesting that after supplementation with zinc, improvement in insulin sensitivity has been detected (Marreiro DN, et al. 2004).

When supplementing with magnesium and zinc it is important to use an easy absorbable and bioavailable source of these minerals.  We have a good source of these minerals and that is the BMJ formula which provides excellent support for the musculoskeletal system.  The minerals used in the BMJ formula are patented amino acids chelates which research has shown to be much better absorbed than regular mineral salts.

For more information or to order log on to www.TissueRecovery.com and click on BMJ "the ultimate tissue support" or call us at 800-883-1252.

Wishing you the best of health,

Didrik

 

References:

Guerrero-Romero F, Rodriguez-Moran M. Low serum magnesium levels and metabolic síndrome. Acta Diabetol. 2002 Dec;39(4):209-13.

He K, Liu K, Daviglus ML, Morris SJ, Loria CM, et al. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation. 2006 Apr 4;113(13):1675-82. Epub 2006 Mar 27.

Marreiro DN, Geloneze B, Tambascia MA, et al. Role of zinc in insulin resistance. Arq Bras Endocrinol Metabol. 2004 Apr;48(2):234-9. Epub 2004 Jul 7.

Song Y, Ridker PM, Manson JE, Cook NR, Buring JE, Liu S. Magnesium intake, C-reactive protein, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care. 2005 Jun;28(6):1438-44.

Takaya J, Higashino H, Kobayashi Y. Intracellular magnesium and insulin resistance. Magnes Res. 2004 Jun;17(2):126-36.